64th ASH Annual Meeting and Exposition: 301. Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational: Thrombosis and the Endothelium

Symposia: Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, clinical trials, Bleeding and Clotting, bleeding disorders, Biological therapies, adult, artificial intelligence (AI), Antibody Therapy, Translational Research, assays, Clinical Research, platelet disorders, bioinformatics, thromboembolism, drug development, Diseases, thrombocytopenias, Immune Disorders, SARS-CoV-2/COVID-19, thrombotic disorders, Therapies, Immunotherapy, computational biology, Biological Processes, emerging technologies, Technology and Procedures, molecular biology, Study Population, Human, pathogenesis, Animal model, imaging, machine learning, omics technologies

293-294 (Ernest N. Morial Convention Center)

Moderators:

Kandace Gollomp, MD, Children's Hospital of Philadelphia and Marie Alice Hollenhorst, MD, PhD, Stanford University

Disclosures:

Hollenhorst: Dova: Consultancy; Sonder Capital: Consultancy; Janssen: Consultancy.

10:30 AM

685

TMEM16E Regulates Endothelial Cell Procoagulant Activity and Thrombosis

Alec A Schmaier, MD, PhD^1,2, Papa Freduah Anderson, BA³^*, Siyu M Chen, MS³^*, Emale Darzi, MS²^*, Kelsey Sack, MD, PhD⁴^*, Criss Hartzell, PhD⁵^*, Robert Flaumenhaft, MD, PhD^6,7, Samir Parikh, MD^8,9^* and Sol Schulman, MD, PhD^2,7

¹Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
²Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
³Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA
⁴Depatment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
⁵Department of Cell Biology, Emory University School of Medicine, Atlanta, GA
⁶Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Newton, MA
⁷Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁸Department of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA
⁹Department of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX

10:45 AM

686

Endothelial Cell Activation Enhances Thromboinflammation in Vitt

Alexander Dupuy^1,2^*, Xiaoming Liu^1,3^*, Jessica Tieng, BSc (Hons)^1,3,4^*, Bede Johnston^1,3^*, Arian Nasser^1,3^*, Paul Coleman^3,4^*, Yingqi Zhang⁵^*, Lining Arnold Ju⁵^*, Huyen Tran, MD, PhD^6,7^*, Vivien M Chen, MBBS, PhD^8,9, Elizabeth E. Gardiner, PhD¹⁰ and Freda H. Passam, MD, PhD^3,11,12

¹Heart Research Institute, Sydney, NSW, Australia
²Central Clinical School, University of Sydney, Camperdown, Australia
³Central Clinical School, University of Sydney, Sydney, NSW, Australia
⁴Centenary Institute, Sydney, NSW, Australia
⁵School of Biomedical Engineering, University of Sydney, Sydney, NSW, Australia
⁶Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia
⁷Alfred Hospital, Melbourne, Australia
⁸Department of Haematology, Concord Repatriation General Hospital, Sydney, NSW, Australia
⁹ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
¹⁰ACRF Department of Cancer Biology and Therapeutics, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
¹¹Haematology Research Group, Heart Research Institute, Sydney, NSW, Australia
¹²Haematology, Royal Prince Alfred Hospital, Sydney, NSW, Australia

11:00 AM

687

Endothelial-Targeted CD39 Ameliorates Pulmonary Hypertension in a Murine Model of Endothelial Toxin Administration

Abbey Willcox, FRACP, FRCPA, MBBS¹^*, Xiaowei Wang, PhD²^*, Carly Selan, BSc³^*, Natsha Lee, BSc (Hons)⁴^*, Ilaria Calvello⁴^*, Viktoria Bongcaron⁵^*, Aidan Walsh⁵^*, Yuyang Song⁶^*, Simon C. Robson, MD, PhD⁷^*, Karlheinz Peter, MD, PhD⁸^*, Maithili Sashindranath, PhD³^* and Harshal Nandurkar, MD, PhD⁹

¹Alfred Health and Monash University, Melbourne, VIC, Australia
²Baker Institute, Melbourne, Australia
³Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
⁴Monash University, Melbourne, VIC, Australia
⁵Baker Heart and Diabetes Institute, Melbourne, AUS
⁶Baker Heart and Diabetes Institute, Melbourne, Australia
⁷Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁸Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, Australia
⁹Australian Centre of Blood Diseases, Monash University and Alfred Health, Melbourne, Australia

11:15 AM

688

Elevated Levels of Low Density Lipoprotein (LDL) Trigger VWF Self-Association into Fibers and Bundles and Potentiate Microvascular Thrombosis

Dominic W. Chung, PhD¹, Kimsey Platten, BS²^*, Koya Ozawa, MD, PhD³^*, Raymond Adili, MD¹, Nathalie Pamir, PhD⁴^*, Forrest D Nussdorfer, MS¹^*, Alexander E St. John, MD⁵^*, Minhua Ling, PhD¹^*, Jennie Le, BS¹^*, Jeff Harris, BS¹^*, Junmei Chen, PhD¹, Sergio Fazio, MD, PhD⁶^*, Jonathan Lindner, MD⁷^* and José A. López, MD¹

¹Bloodworks Research Institute, Seattle, WA
²Washington University, St Louis, MO
³Department of Medicine and Health, the University of Sydney, Kingswood, NSW, AUS
⁴Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR
⁵Department of Emergency Medicine, University of Washington, Seattle, WA
⁶Regeneron, Basking Ridge, NJ
⁷University of Virginia, Charlottesville, VA

11:30 AM

689

The Self-Organizing Thrombus: Spatiotemporal Coordination of Platelets Facilitates Structural Differentiation and Stability In Vivo

Abigail S McGovern, BSc(Hons)¹^*, Pia Larsson, PhD²^*, Volga Tarlac²^*, Juan Nunez-Iglesias, PhD¹^*, Stephen Cody³^*, Lars Faxälv, PhD⁴^*, Justin R Hamilton, PhD² and Niklas Boknäs, MD, PhD⁵^*

¹Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia
²Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
³Monash Micro Imaging, Monash University, Melbourne, Australia
⁴Linköping University, Linköping, Sweden
⁵Department of Hematology and Department of Biomedical and Clinical Sciences, Linköping, Linköping, Sweden

11:45 AM

690

Targeting Activated Neutrophils in Antiphospholipid Antibody-Mediated Thrombosis

Lin Di^1,2^*, Asha Thomas, PhD³^*, Kenneth A Kalikasingh³^*, Stephanie D Lapping, MS²^*, Andrei Maiseyeu^1,2^* and Lalitha Nayak, MD^2,3

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH
²Cardiovascular Research Institute, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH
³Department of Medicine, Division of Hematology and Oncology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH

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^*signifies non-member of ASH

301.O1.6 301. Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational: Thrombosis and the Endothelium