Meghna Dua, MD, MS^1*, Winfred C. Wang, MD², R. Clark Brown, MD, PhD³, Melissa A. McNaull, MD⁴, Zora R. Rogers, MD⁵, Martha Barton, PhD^6*, Jane S Hankins, MD, MS^7,8, Jeffrey Gossett, MS^6*, Julie Richardson, PharmD^9*, Jerlym S. Porter, PhD, MPH¹⁰, Guolian Kang, PhD, MS⁶ and Jeremie H. Estepp, MD^1,2

¹Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN
²Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
³Emory University School of Medicine, Atlanta, GA
⁴University of Mississippi Medical Center, Jackson, MS
⁵University of Texas Southwestern Medical Center, Dallas, TX
⁶Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁷Department of Hematology, St. Jude Children's Research Hospital, MEMPHIS, TN
⁸St. Jude Children's Research Hospital - Department of Global Pediatric Medicine, Memphis
⁹Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
¹⁰Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN

Emmanuela E. Ambrose, MD^1,2, Teresa Latham, MA^3*, Primrose Songoro, RN^1*, Mwesige Charles, BScHLS^4*, Adam Lane, PhD^3*, Susan E. Stuber, MA^3,5*, Abel Nkono Makubi, PhD, MD, MSc^6*, Russell E. Ware^3,5,7 and Luke R. Smart, MD^3,5,7

¹Department of Paediatrics and Child Health, Bugando Medical Centre, Mwanza, Tanzania, United Republic of
²Department of Paediatrics and Child Health, Catholic University of Health & Allied Sciences, Mwanza, Tanzania, United Republic of
³Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Department of Laboratory Science, Bugando Medical Centre, Mwanza, Tanzania, United Republic of
⁵Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁶Bugando Medical Centre, Mwanza, Tanzania, United Republic of
⁷Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

Mariane de Montalembert, MD, PhD¹, Frédéric Galactéros, MD, PhD^2*, Lena Oevermann, MD^3*, Giovanna Cannas, MD^4*, Laure Joseph, MD^5*, Gylna Loko, MD^6*, Narcisse Elenga, MD, PhD^7*, Malika Benkerrou, MD^8*, Maryse Etienne-Julan, MD^9*, Marie-Pierre Castex, MD^10*, Regine Grosse, MD^11* and Valentine Brousse, MD, PhD^12*

¹Pediatrics, Hospital Necker, Paris, France
²Unité des Maladies Génétiques du Globule Rouge, CHU Henri Mondor, Créteil, France
³Charité Berlin, Berlin, Be, DEU
⁴Edouard Herriot Hospital, Lyon, France
⁵Biotherapy Department, French National Sickle Cell Referral Center, Hôpital Necker, Assistance-Publique Hôpitaux de Paris, Paris, DC, France
⁶Martinique University Hospital, Le Lamentin, Martinique
⁷CH AndréE Rosemon, Cayenne, FRA
⁸Centre de la Drépanocytose, Service d’Immuno-hématologie, Hôpital Universitaire Robert Debré, APHP, Paris, France
⁹CHU De Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe
¹⁰Pediatrics, Hematology and Oncology department, Children Hospital, Toulouse, FRA
¹¹Clinic of Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
¹²Robert Debré Hospital, Paris, France

Rosa M. Nieves, MD^1*, Teresa Latham, MA^2*, Nicolle Marte, MD^1*, Luisanna Sanchez, MD^1*, Melissa E. Berges, MD^1*, Gabriela S. Urcuyo, MD^1*, Carla Florencio, MD^1*, Carla Gonzalez, MD^1*, Paola Del Villar, MD^1*, Sheena Chen, MD^1*, Paula Reyes, MD^1*, Daniel Ramirez, MD^1*, Euladys Matos, MD^1*, Manuel Marinez, MD^3*, Susan E. Stuber, MA^2,4*, William Schultz, MHS, PA^2*, Adam Lane, PhD^2,5*, Rafael Mena, MD^6* and Russell E. Ware^2,4

¹Robert Reid Cabral Hospital, Santo Domingo, Dominican Republic
²Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Centro de Obstetricia y Ginecologia, Santo Domingo, Dominican Republic
⁴Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵University of Cincinnati - College of Medicine, Cincinnati, OH
⁶Centro de Obstetricia y Ginecología, Santo Domingo, Dominican Republic

Tamara Diesch, MD^1*, Catherine Poirot, MD, PhD^2*, Carlos Sanchez^3*, Andrew Atkinson^3*, Corinne Pondarré^4*, Nathalie Dhedin, MD^5*, Benedicte Neven, MD^6*, France Pirenne, MD, PhD⁷, Gilles Leanour^8*, Isabelle Broncheriou^8*, Françoise Bernaudin, MD⁹ and Jean-Hugues Dalle, MD, PhD^10*

¹Department of Pediatric Hematology/Oncology, University Children's Hospital of Basel, UKBB, Basel, Switzerland
²Department of Hematology, AYA Unit, Saint Louis Hospital, Paris, France, Paris, France
³Pediatric Research Center, University Children`s Hospital Basel, University of Basel, Basel, Switzerland
⁴French Referral Center for Sickle Cell Disease, Centre Hospitalier Intercommunal Créteil, Université Paris XII, Créteil, France
⁵St-Louis Hospital, APHP, Adolescents and Young Adults Hematology Department, Paris, France
⁶Hopital Necker Enfants Malades, Paris, FRA
⁷French Blood Agency Ile de France, INSERM U955, Laboratory of Excellence GR-Ex, IMRB, Paris Est-Creteil University, CRETEIL, France
⁸Groupe Hospitalier Pitié- Salpetrière, Department of pathology, Paris, France
⁹Referral Center for Sickle Cell Disease, Pediatrics, Hopital Intercommunal de Creteil, CRETEIL, France
¹⁰Pediatric Hematology and Immunology Department, Hôpital Robert Debré and Université de Paris, Paris, France

Katherine C Wood, PhD¹, Fabliha A Chowdhury^2*, Seyed M Nouraie, MD, PhD^3,4, Mark T. Gladwin, MD⁵ and Adam C Straub, PhD^1,6*

¹Heart, Lung, Blood and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
²Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
³Department of Medicine, Pulmonary, Allergy, Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA
⁴Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁵Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
⁶Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA