64th ASH Annual Meeting and Exposition: 113. Hemoglobinopathies, Excluding Thalassemia: Basic and Translational: Cognitive Deficit, Pain, and Inflammation in Sickle Cell Disease: What We Learned from Mouse Models

Symposia: Hemoglobinopathies, Excluding Thalassemia: Basic and Translational Oral and Poster Abstracts
Oral

Research, Sickle Cell Disease, Fundamental Science, Translational Research, Hemoglobinopathies, Diseases, immune mechanism, Therapies, Biological Processes, microbiome, Technology and Procedures, Study Population, pathogenesis, imaging, Animal model

275-277 (Ernest N. Morial Convention Center)

Moderators:

Eugene Khandros, MD, PhD, Children's Hospital of Philadelphia and Malgorzata Kasztan, PhD,

Disclosures:

No relevant conflicts of interest to declare.

2:00 PM

175

Neuroinflammation Underlies the Development of Social Stress Induced Cognitive Deficit in Sickle Cell Disease

Oluwabukola Gbotosho, PhD¹, Kat Propsom, BSc¹^*, S’Dravious DeVeaux, BSc²^*, Sofiya Vyshnya, BSc²^*, Edward Botchwey, PhD³^*, David R. Archer, PhD⁴ and Hyacinth I Hyacinth, MD, PhD, MPH⁵

¹Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH
²Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA
³Georgia Institute of Technology, Atlanta, GA
⁴Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA
⁵University of Cincinnati College of Medicine, Cincinnati, OH

2:15 PM

176

Microbial Metabolites Target Histone Deacetylases to Trigger Vascular Inflammation in Sickle Cell Disease

Lidiane S. Torres, PhD^1,2^*, Simone Sidoli, PhD³^*, Huihui Li, PhD^1,2^*, Sofia De Oliveira, PhD⁴^*, Paul S. Frenette, MD^1,2^*, Andres Hidalgo, PhD^5,6^* and Keisuke Ito, MD, PhD^1,2

¹Ruth L. and David S. Gottesman Institute for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY
²Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
³Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY
⁴Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY
⁵Department of Immunobiology, Yale Medical School, New Haven, CT
⁶Area of Cell and Developmental Biology, Centro Nacional De Investigaciones Cardiovasculares, Madrid, ESP

2:30 PM

177

Modulation of Pain-Associated Behaviors in Sickle Mice Using Low-Intensity Transcranial Focused Ultrasound

Min Gon Kim¹^*, Kai Yu, PhD¹^*, Donovan A Argueta, PhD², Stacy B Kiven, BIS³^*, Yunruo Ni, BS¹^*, Kalpna Gupta, PhD³ and Bin He, PhD¹^*

¹Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA
²Department of Medicine, Division of Hematology/Oncology, University of California, Irvine, Los Angeles, CA
³Department of Medicine, Division of Hematology/Oncology, University of California, Irvine, Irvine, CA

2:45 PM

178

Dietary Iron Restriction Alters Microbiota-Host Crosstalk and Protects Against Vaso-Occlusion and Organ Damage in Sickle Cell Disease Mice

Huihui Li, PhD¹^*, Jacob S Kazmi¹^*, Sungkyun Lee, PhD¹^*, Dachuan Zhang, PhD¹^*, Xin Gao, PhD¹^*, Maria Marianovich, PhD²^*, Lidiane S. Torres, PhD³^*, Divij Verma, PhD⁴^*, Libusha Kelly, Ph.D.⁵^*, Yelena Ginzburg, MD⁶, Paul S. Frenette, MD⁷ and Deepa Manwani, MD⁸

¹Albert Einstein College of Medicine, Bronx, NY
²Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
³Ruth L. and David Gottesman Institute for Stem cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY
⁴Department of Cell Biology, Albert Einstein College of Medicine, New York
⁵Albert Einstein College of Medicine, Bronx
⁶Division of Hematology Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁷Albert Einstein College of Medicine, New York, NY
⁸Division of Pediatric Hematology/Oncology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY

3:00 PM

179

White Matter Injury in Sickle Cell Mice Is Associated with Reduced Neurocognitive Function and Activation of Astrocytes

Rimi Hazra¹^*, Hongjan Pu, MD, PhD²^*, Lesley M. Foley³^*, T. Kevin Hitchens, PhD, MBA⁴^*, Lynda Little-Ihrig⁵^*, Samit Ghosh, PhD¹, Solomon Fiifi Ofori-Acquah, PhD¹, Xiaoming Hu, MD²^* and Enrico M. Novelli, MD⁵

¹Center for Translational and International Hematology, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
²Department of Neurology, University of Pittsburgh, Pittsburgh, PA
³McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA
⁴Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA
⁵Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

3:15 PM

180

Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation

Zalaya K Ivy, MD, MS¹, John D Belcher, PhD², Iryna A Khasabova, PhD³^*, Chunsheng Chen, PhD²^*, Joseph P Juliette³^*, Fuad Abdulla²^*, Conglin Ruan²^*, Kaje Allen³^*, Julia Nguyen²^*, Victoria M Rogness³^*, Sergey Khasabov, MD, PhD³^*, Kalpna Gupta, PhD⁴, Donald Simone, PhD³^* and Gregory M. Vercellotti, MD⁵

¹Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Brooklyn Park, MN
²Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
³Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN
⁴Department of Medicine, Division of Hematology/Oncology, University of California, Irvine, Irvine, CA
⁵Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN

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^*signifies non-member of ASH

113.O1.6 113. Hemoglobinopathies, Excluding Thalassemia: Basic and Translational: Cognitive Deficit, Pain, and Inflammation in Sickle Cell Disease: What We Learned from Mouse Models