64th ASH Annual Meeting and Exposition: 102. Iron Homeostasis and Biology I

Symposia: Iron Homeostasis and Biology Oral and Poster Abstracts
Oral

Research, Fundamental Science, clinical trials, Iron Deficiency, adult, Biological therapies, Iron Overload, Non-Biological therapies, Translational Research, Clinical Research, Genetic Disorders, Thalassemia, embryo/fetus, Hemoglobinopathies, hematopoiesis, Other Pathogens, Diseases, real-world evidence, Therapies, pregnant, Infectious Diseases, metabolism, Biological Processes, Metabolic Disorders, molecular biology, Study Population, Human, pathogenesis, Animal model, Maternal Health

388-390 (Ernest N. Morial Convention Center)

Moderators:

Maureen Okam Okam Achebe, MD, MPH, Hematology Division Brigham and Women's and Nermi Parrow, PhD, Saint Louis University School of Medicine

Disclosures:

Parrow: Protagonist: Consultancy.

4:30 PM

907

Randomised Controlled Trial of Intravenous Iron (ferric carboxymaltose) for Second Trimester Anaemia in Malawian Pregnant Women (REVAMP)

Sant-Rayn Pasricha, MD, PhD^1,2,3,4, Martin Mwangi, PhD⁵^*, Ernest Moya, BScN, MPH⁶^*, Ricardo Ataide, PhD^7,8^*, Glory Mzembe, MBBS MSc⁵^*, Rebecca Harding, BSc PhD⁹^*, Truwah Zinenani, BSc⁶^*, Danielle Clucas^2,10^*, Sabine Braat, MSc^11,12^* and Kamija S Phiri, MBBS DLSHTM MSc PhD⁵^*

¹Population Health and Immunity, Walter and Eliza Hall Institute of Medical Research, Fitzroy North, VIC, Australia
²Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia
³Diagnostic Haematology, Royal Melbourne Hospital, Parkville, VIC, Australia
⁴Clinical Haematology, Royal Melbourne Hospital & Peter MacCallum Cancer Centre, Parkville, Australia
⁵Kamuzu University of Health Sciences (KUHeS), Training & Research Unit of Excellence (TRUE), Blantyre, Malawi
⁶Kamuzu University of Health Sciences (KUHeS), Training and Research Unit of Excellence, Blantyre, Malawi
⁷Population Health and Immunity, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
⁸Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia
⁹Walter and Eliza Hall Institute of Medical Research, Population Health and Immunity Division, Parkville, Australia
¹⁰Diagnostic Haematology, The Royal Melbourne Hospital, Parkville, VIC, Australia
¹¹Population Health and Immunity, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
¹²Methods and Implementation Support for Clinical and Health Research Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia

4:45 PM

908

Disruption of Hephaestin in the Placenta and Fetus Leads to Fetal Anemia

Sheridan L Helman, BSc¹^*, David M Frazer²^*, Greg J. Anderson, BSc, MSc, PhD³^* and Sarah J Wilkins, BSci³^*

¹QIMR Berghofer Medical Research Institute, Brisbane, Australia
²QIMR Berghofer Medical Research Institute, Herston, QLD, Australia
³QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia

5:00 PM

909

Bone Marrow Tfr2 Deletion Modulates Systemic Metabolism in β-Thalassemic Mice to Sustain Augmented Erythropoiesis

Simona Maria Di Modica, MSc¹^*, Claudia Benelli, BSc^1,2^*, Alessia Pagani, PhD¹^*, Emanuele Tanzi, MSc¹^*, Violante Olivari, MSc^1,2^*, Laura Silvestri, PhD^1,2 and Antonella Nai, PhD^1,2

¹Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy
²Vita-Salute San Raffaele University, Milan, Italy

5:15 PM

910

Characterization of the Erythroferrone Structural Domains Relevant for Its Iron-Regulatory Function

Daniel Srole, Elizabeta Nemeth, PhD and Tomas Ganz, MD, PhD

Center for Iron Disorders, UCLA, Los Angeles, CA

5:30 PM

911

Clinical Experience with Afamelanotide for the Protoporphyrias in the United States

Rebecca Karp Leaf, MD¹, Sarina Elmariah, MD PhD¹^*, Paul Yanning Jiang¹^*, Jennifer Mead, PA¹^*, Pamela Hodges, PhD, ANP¹^*, Sarah Elizabeth Valiante¹^*, Francesca Mernick¹^*, Karl E Anderson, MD²^* and Amy Dickey, MD MSC¹^*

¹Massachusetts General Hospital, Boston, MA
²University of Texas Medical Branch, Galveston

5:45 PM

912

Terminal Erythroid Differentiation Is Regulated By Mitochondrial Translation Via Maintenance of Iron Homeostasis

Tatsuya Morishima, MD, PhD^1,2^*, Md Fakruddin, PhD^2,3^*, Takeshi Masuda, PhD⁴^*, Yuxin Wang³^*, Vivien A. C. Schoonenberg⁵^*, Falk Butter, PhD⁵^*, Yuichiro Arima, MD, PhD⁶^*, Kazuhito Tomizawa, PhD⁷^*, Fan-Yan Wei, PhD⁸^*, Toshio Suda, MD, PhD^9,10 and Hitoshi Takizawa, PhD³

¹Laboratory of Stem Cell Stress, International Research Center for Medical Sciences, Kumamoto University, Kumamoto City, Japan
²Laboratory of Hematopoietic Stem Cell Engineering, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
³Laboratory of Stem Cell Stress, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
⁴Department of Pharmaceutical Microbiology, Faculty of Life Sciences Kumamoto University, Kumamoto, Japan
⁵Quantitative Proteomics, Institute of Molecular Biology, Mainz, Germany
⁶Laboratory of Developmental Cardiology, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
⁷Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⁸Department of Modomics Biology and Medicine, Institite of Development, Aging and Cancer, Tohoku University, Sendai, Japan
⁹Laboratory of Stem Cell Regulation, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
¹⁰Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

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^*signifies non-member of ASH

102.O1.6 102. Iron Homeostasis and Biology I