64th ASH Annual Meeting and Exposition: 101. Red Cells and Erythropoiesis, Excluding Iron I

Symposia: Red Cells and Erythropoiesis, Excluding Iron Oral and Poster Abstracts
Oral

Research, Fundamental Science, Translational Research, genomics, bioinformatics, hematopoiesis, Diseases, cell expansion, Biological Processes, molecular biology, Technology and Procedures, gene editing, Study Population, Animal model, molecular testing

391-392 (Ernest N. Morial Convention Center)

Moderators:

Jorg Bungert, PhD, University of Florida and Raffaele Renella, MD, PhD, Lausanne University Hospital

Disclosures:

No relevant conflicts of interest to declare.

Novel mechanisms of gene expression control in early erythrpoiesis and how alterations impact surrounding components of the marrow environment.

4:00 PM

283

KLF1 Acts As a Pioneer Transcription Factor Via SMARCA4 to Open Chromatin and Facilitate Redeployment of an Enhancer Complex Containing GATA1 and SCL

Graham William Magor, BSc¹^*, Kevin R. Gillinder, PhD¹^*, Stephen Huang, BSc²^*, Melissa D. Ilsley, BSc PhD³^*, Charles Bell, BSc⁴^* and Andrew Charles Perkins, MBBS, PhD, FRACP, FRCPA^1,5

¹Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia
²Diamantina Institute, University of Queensland, Brisbane, QLD, Australia
³Mater Research, University of Queensland, Woolloongabba, Australia
⁴Peter MacCallum Cancer Research Institute, Melbourne University, Melbourne, VIC, Australia
⁵Department of Haematology, Alfred Hospital, Melbourne, Australia

4:15 PM

284

Dysplastic Erythropoiesis in Stag2 Loss Exhibits Defective Nuclear Condensation and Hemophagocytosis

Varun S Sudunagunta, BA^1,2,3, Yi Chen, Ph.D¹^*, Jane J Xu, PhD^1,2^*, Laura E Mittelman^1,2^*, Hongxia Yan, MS⁴^*, John Pantazi²^*, Stephanie Braunstein²^*, Besmira Alija²^*, Mohandas Narla, DSc⁴ and Aaron D Viny, MD, MS^1,2

¹Columbia Stem Cell Initiative, Columbia University, New York, NY
²Division of Hematology and Oncology, Department of Medicine, Columbia University, New York, NY
³Vagelos College of Physicians & Surgeons, Columbia University, NEW YORK, NY
⁴Laboratory of Red Cell Physiology, New York Blood Center, New York, NY

4:30 PM

285

The Molecular Pathophysiology of Ineffective Erythropoiesis at Single Cell Resolution

Raymond T. Doty, PhD¹^*, Christopher G. Lausted, MS²^*, Adam D. Munday, PhD¹^* and Janis L. Abkowitz, MD¹

¹Division of Hematology, Department of Medicine, University of Washington, Seattle, WA
²Institute for Systems Biology, Seattle, WA

4:45 PM

286

Anemia-Activated Cis Regulatory Requirements for Erythroid Regeneration

Yichao Zhou, Linda Chee^*, Suhita Ray, Meg Schaefer^*, Venkatasai Rahul Dogiparthi^*, Jordan Rowley^* and Kyle J Hewitt, PhD

Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE

5:00 PM

287

A Putative Erythroid Synapse Linking Developing Erythroblasts and Macrophages in Erythroblastic Islands

Chanukya K Colonne, MBBS, PhD¹, Jia Hao Yeo, BSc (Hon), PhD²^* and Stuart T Fraser, BSc (Hon), PhD³^*

¹Discipline of Physiology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, New South Wales, Australia
²Discipline of Anatomy & Histology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW, Australia
³Discipline of Physiology, School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW, Australia

5:15 PM

288

HEXIM1 Overexpression Alters GATA1 Activity and Promotes Fetal Globin Expression

Xiurui Lv, MBBS, MS¹, Kristin Murphy, PhD²^*, Zachary C. Murphy, PhD¹, Michael Getman, MS¹^* and Laurie A. Steiner, MD³

¹Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY
²Center for Pediatric Biomedical Research, University of Rochester, Rochester, NY
³Department of Pediatrics, University of Rochester, Rochester, NY

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^*signifies non-member of ASH

101.O1.6 101. Red Cells and Erythropoiesis, Excluding Iron I