-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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ASH Poster Walk on What's Hot in Sickle Cell Disease Research 2022

Program: ASH Poster Walks
Hematology Disease Topics & Pathways:
Research, clinical trials, Sickle Cell Disease, adult, epidemiology, elderly, Clinical Research, health outcomes research, health disparities research, Diversity, Equity, and Inclusion (DEI) , Hemoglobinopathies, pediatric, patient-reported outcomes, Diseases, real-world evidence, pregnant, registries, young adult , Study Population, Human
Wednesday, December 14, 2022: 10:00 AM-11:00 AM
(VIRTUAL PROGRAM)
Sickle cell disease (SCD) affects 100,000 people living in the US and 250-300,000 births annually worldwide. Despite its frequency, the natural history of SCD and its complications remain poorly understood. Over the past decade, clinical research has led to much progress in disease management, identifying novel therapeutic targets and FDA approval of two new therapies, crizanlizumab and voxelotor, in the fall of 2019. Numerous clinical trials of novel therapeutics and potential curative therapies are ongoing. Large patient registries from the US and Europe have begun to increase our understanding of the disease and its complications.

This poster walk will highlight six abstracts focused on innovative clinical research and promising ongoing trials in SCD.

Macy L. Early, BA1, A. Kinga Malinowski, MD, MSc, FRCSC2, Marissa Solow, MD3*, Ahizechukwu Eke, MBChB, PhD4,5*, Nadine Shehata, MD, FRCPC, MSc6,7,8, Sana Saif Ur Rehman, MD9*, Kevin H.M. Kuo, MD, MSc, FRCPC10,11,12 and Lydia H. Pecker, MD13

1Division of Hematology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD
2Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mt. Sinai Hospital, Toronto, ON, CAN
3University Health Network, Toronto, ON, Canada
4Division of Clinical Pharmacology, Johns Hopkins School of Medicine, Baltimore, MD
5Division of Maternal-Fetal Medicine, Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD
6Department of Medicine, Toronto, Canada
7Mount Sinai Hospital, Toronto, ON, Canada
8Canadian Blood Services, Toronto, ON, Canada
9Division of Hematology, Washington University School of Medicine, Saint Louis, MO
10Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
11Division of Hematology, Department of Medicine, University of Toronto, Toronto, ON, Canada
12Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, ON, Canada
13Division of Hematology, Department of Medicine, Johns Hopkins Medicine, Baltimore, MD

Keli C Coleman1*, Kenneth McKinley, MD2*, Angela Ellison3*, Amanda M. Brandow, DO, MS4, Blake Nielsen, MS5*, Lawrence Cook, PhD5*, Elizabeth Alpern, MD, MSCE6*, Selena Hariharan, MD7*, Irina Topoz, MD8*, Morgan Wurtz, MD9*, Claudia R. Morris, MD10,11, Andrew D. Campbell, MD12, Robert Liem, MD13, Rachelle Nuss, MD14*, Charles T. Quinn, MD15, Alexis A. Thompson, MD, MPH16, Anthony Villella, MD9*, Ana Baumann, PhD17*, Allison A. King, MD, PhD, MPH18, Warren Frankenberger, PhD16* and David C Brousseau, MD, MS19

1Medical College of Wisconsin and the Children's Research Institute of Children's Wisconsin, Milwaukee, WI
2Children's National Medical Center, Washington, DC
3Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
4Pediatric Hematology/Oncology, Medical College of Wisconsin and Children’s Research Institute of the Children’s Hospital of Wisconsin, Milwaukee, WI
5University of Utah, Salt Lake City, UT
6Lurie Children's Hospital, Chicago, IL
7Cincinnati Children's Hospital, Cincinnati, OH
8Department of Pediatrics, Children's Colorado, Denver, CO
9Nationwide Children's Hospital, Columbus, OH
10Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
11Childrens Healthcare of Atlanta, Atlanta, GA
12Center for Cancer and Blood Disorders, Childrens National Hospital, Washington, DC
13Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
14Center for Cancer and Blood Disorders, University of Colorado Anschutz Medical Campus, Aurora, CO
15Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Med. Ctr., Cincinnati, OH
16Children's Hospital of Philadelphia, Philadelphia, PA
17Washington University School of Medicine, St Louis, MO
18Pediatric Hematology/Oncology, Washington University School of Medicine, Clayton, MO
19Department of Pediatrics, Medical College of Wisconsin and the Children's Research Institute at Children's Wisconsin, Milwaukee, WI

Rajani P Brandsen, MD1*, Roselie MH Diederen, MD PhD1*, Siham Bakhlakh2*, Erfan Nur, MD, PhD2, Reinier O Schlingemann, MD PhD1* and Bart J Biemond2

1Department of Ophthalmology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
2Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands

Kristine Anne Karkoska, MD, MS1, Russell Sawyer, MD2* and Hyacinth I Hyacinth, MD, PhD, MPH3

1Division of Hematology/Oncology, Dept of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH
2Department of Neurology and Rehabilitation Medicine, University of Cincinnati Medical Center, Cincinnati, OH
3Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH

Franklin Njoku, MD, MPH1*, Norma Pugh2*, Marsha Treadwell, PhD3*, Jeffrey A. Glassberg, MD4, Abdullah Kutlar, MD5, Robert Gibson, PhD6*, Nirmish Shah, MD7, Victor R. Gordeuk, MD8, Lewis L. Hsu, MD, PhD9, Jane S Hankins, MD, MS10, Allison A. King, MD, PhD, MPH11 and Julie Kanter, MD12

1Comprehensive Sickle Cell Center, Division of Hematology and Oncology, University of Illinois at Chicago, Chicago, IL
2RTI International, Research Triangle Park, NC
3Children's Hospital and Research Center, Oakland, Oakland, CA
4Division of Hematology and Oncology, Department of Medicine and Department of Emergency Medicine, Mount Sinai Medical Center, New York, NY
5Department of Medicine, Sickle Cell Center, Augusta University, Augusta, GA
6Medical College of Georgia, Augusta University, Augusta, GA
7Department of Medicine, Division of Hematology - Duke Sickle Cell Comprehensive Care Unit, Duke University Hospital, Durham, NC
8Sickle Cell Center, Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL
9Pediatric Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
10Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
11Washington University School of Medicine, St. Louis, MO
12Lifespan Comprehensive Sickle Cell Center, University of Alabama Birmingham, Birmingham, AL

Amy Parker Ruhl, MD, MHS1*, Ruba Shalhoub, MS2*, Neal Jeffries, PhD3*, Alexis Leonard, MD4*, Emily Limerick, MD3*, Amisha Barochia, MBBS, MHS5*, Matthew M. Hsieh, MD4 and Courtney D. Fitzhugh, MD3

1Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Washington, DC
2Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
3National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
4Cellular and Molecular Therapeutics Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
5Pulmonary Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD

See more of: ASH Poster Walks