64th ASH Annual Meeting and Exposition: ASH Poster Walk on The Spectrum of Hemostasis and Thrombosis Research

ASH Poster Walks

Research, Fundamental Science, clinical trials, Bleeding and Clotting, bleeding disorders, adult, Translational Research, epidemiology, Clinical Practice (Health Services and Quality), hemophilia, elderly, Clinical Research, health outcomes research, platelet disorders, thromboembolism, pediatric, Diseases, thrombocytopenias, thrombotic disorders, VWD, Study Population, Human

(VIRTUAL PROGRAM)

Non-malignant hematology covers a broad range of topics. This poster walk will highlight basic/translational as well as clinical research abstracts in hemostasis, thrombosis, and platelet disorders to foster discussion across disciplines and to encourage young investigators to pursue this career path.

Trainees/junior faculty will have a unique opportunity to meet with leaders in the field of hemostasis and thrombosis, to get exposure to various topics within non-malignant hematology, and to learn how to interpret the data presented in a poster.

2451

Eltrombopag Causes Cell Cycle Arrest of T Cells through Iron Chelation and Could Modulate the Immune Response in ITP

Michelle MH Tan, MSc, BSc¹^*, Amna Malik, PhD¹^*, Anwar A Sayed, PhD, MBBS, MSc^1,2,3, Rocel C. Saputil, MSc¹^*, Sara Zafar, MSc, BSc⁴^*, Yunchuan Ding, PhD^1,5^*, Emma Thorley, MB BChir, BA⁶^*, Ariam Teklemichael, BSc⁶^*, Camelia Vladescu⁶^*, Alice C J Hart, MBBS, BSc, MRCP, FRCPath⁶^*, Christine Ademokun, MBBS, FRCPath⁶^*, Deena Paul⁶^*, Naghma Rizvi⁶^*, Vashti Ragoonanan⁶^* and Nichola Cooper, MD¹

¹Centre For Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
²Department of Medical Microbiology and Immunology, Taibah University, Medina, Saudi Arabia
³Department of Surgery and Cancer, Imperial College London, London, United Kingdom
⁴Department of Medicine, Kings College London, London, United Kingdom
⁵Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⁶Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom

2447

Cognitive Impairment in Patients with Immune Thrombocytopenia

Camelia Vladescu, MSc¹^*, Alice C J Hart, MBBS, BSc, MRCP, FRCPath²^*, Deena Paul³^*, Christine Ademokun, MBBS, FRCPath³^*, Ariam Teklemichael, BSc³^*, Bridget Chivers, RN, MSc⁴^*, Billy Hopkins⁴^*, Richard Syzdlo⁵^*, Naghma Rizvi³^*, Vashti Ragoonanan, CNS⁴^*, Sandra Sigudu, CNS⁴^*, James B. Bussel, MD^6,7, Anastastia Gontsarova, Dr⁴^*, Adam Waldman, PhD, FRCP, FRCR⁸^* and Nichola Cooper, MA, MBBS, FRCP FRCPath⁹^*

¹Imperial College Healthcare NHS Trust, London, United Kingdom
²Centre For Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
³Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom
⁴Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
⁵Centre for Haematology, Department of Medicine, Imperial College London, London, United Kingdom
⁶Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
⁷Department of Pediatrics, Weill Cornell Medicine, New York, NY
⁸Imperial College London, London, United Kingdom
⁹Center for Haematology Department of immunology and inflammation, Imperial College London, London, United Kingdom

2456

Factor VIII Mimetic Rescue of Hemophilia B Causing Factor IX Variants

Kyumin Lee¹^*, Julia Q Chau¹^*, Anna R Sternberg, PhD¹^*, Allyson M Pishko, MD^2,3, Lindsey George, M.D.^4,5^* and Ben J Samelson-Jones, MD, PhD^6,7,8

¹The Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA
³Department of Medicine, University of Pennsylvania, Philadelphia, PA
⁴Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁵Children’s Hospital of Philadelphia, Philadelphia, PA
⁶Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
⁷Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA
⁸Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

3775

Novel Snake Venom Derived Hemocoagulase Reverses Anticoagulant Effect of Factor Xa Inhibitors, Restores Hemostatic Clot Formation, and Limits Bleeding in Vitro and In Vivo

Nicole Rhoads¹^*, Michael Wong, PhD²^*, Benjamin Li, MD²^*, Michael Holinstat, PhD³ and Raymond Adili, MD³

¹Research Institute, Bloodworks Northwest, Seattle, WA
²Lee’s Pharmaceutical Holdings Ltd., Shatin, Hong Kong
³Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI

1182

Thrombotic Manifestations in Patients with Vexas Syndrome

Pedro E. Alcedo Andrade, MD¹, Ruba Shalhoub, MS¹^*, Alina Dulau-Florea, MD²^*, Khanh Nghiem, BS, MT²^*, Marcela Ferrada, MD³^*, Lorena Wilson, NP, PhD⁴^*, Ivana Darden, RN⁵^*, Wendy Goodspeed, RN³^*, Katherine R. Calvo, MD, PhD², David B. Beck^4,6,7^*, Daniel L. Kastner, MD PhD⁴^*, Peter C. Grayson, MD, Msc³^*, Neal S. Young, MD¹, Colin O. Wu, PhD⁸^*, Yogendra Kanthi, MD^1,9^*, Bhavisha A. Patel, MD¹ and Emma M. Groarke, MD⁵

¹Hematology Branch, National Heart, Lung, and Blood Institute. National Institutes of Health, Bethesda, MD
²Hematology Section, Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD
³Vasculitis Translational Research Program, National Institute of Arthritis, Musculoskeletal, and Skin Diseases. National Institutes of Health, Bethesda, MD
⁴Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
⁵Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁶Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY
⁷Center for Human Genetics and Genomics, New York University School of Medicine, New York, NY
⁸Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁹Laboratory of Vascular Thrombosis and Inflammation, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

Panel Discussion

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