64th ASH Annual Meeting and Exposition: ASH Poster Walk on Platelets from Bench to Bedside

ASH Poster Walks

Research, Fundamental Science, clinical trials, Bleeding and Clotting, bleeding disorders, Biological therapies, Translational Research, epidemiology, Clinical Research, platelet disorders, thromboembolism, patient-reported outcomes, Diseases, thrombocytopenias, real-world evidence, thrombotic disorders, Therapies, VWD, Transfusion

(VIRTUAL PROGRAM)

Platelets are anucleate cellular fragments that play a central role in hemostasis and thrombosis. Beyond these fundamental functions, platelets also are important in other biological contexts, including cancer progression, immunity, and inflammation.

This poster walk will highlight platelet research across the bench to bedside spectrum. Featured abstracts will highlight studies of platelet biology, clinical/translational studies of disorders of platelet number/function, and studies of platelet transfusion.

Lastly, this poster walk aims to: highlight key knowledge gaps in the field; highlight methods used to address these knowledge gaps; and encourage early career physicians and scientists to pursue research on platelets and platelet disorders.

3837

Deletion of 12-Lipoxygenase Improves Platelet Function after Storage and Transfusion in Thrombocytopenic Mice

Moritz Stolla, MD^1,2, Hannah Johnson³^*, Massiel Chavez Stolla, PhD⁴^*, Shawn Lawrence Bailey, BS¹^*, Daire Byrne¹^*, Michael Holinstat, PhD⁵ and Xiaoyun Fu, PhD^1,2

¹Bloodworks Northwest Research Institute, Seattle, WA
²Department of Medicine, University of Washington, Seattle, WA
³Bloodworks NW Research Institute, Seattle, WA
⁴Division of Hematology, University of Washington, Seattle, WA
⁵Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI

1202

CD4+ T Cells Are Required for Production of Disease-Causing Antibodies in an Alloantigen-Specific Murine Model of Fetal/Neonatal Alloimmune Thrombocytopenia

Huiying Zhi, PhD¹, Guoping Fu, PhD²^*, Renren Wen, PhD², Demin Wang, PhD², Peter J. Newman, PhD³ and Debra K. Newman, PhD²

¹Blood Center of Wisconsin, Milwaukee, WI
²Blood Research Institute, Versiti, Milwaukee, WI
³BLOOD CENTER OF WISCONSIN, Milwaukee, WI

1113

Predictive Value of Platelet Sequestration Studies in Splenectomy Response

Ana Mendoza¹^*, Nora V. Butta, PhD^2,3^*, Elena Monzón Manzano, PhD^2,4^*, Paula Acuña, BSc^2,4^*, Elena G Arias-Salgado, PhD^2,4^*, María Isabel Rivas Pollmar, MD, PhD^2,4^*, Mónica Martín Salces, MD, PhD^2,4^*, Mar Gutierrez, MD^2,4^*, Eduardo Garcia Perez, MD^2,4^*, Andres Ramirez Lopez^4,5^*, Leticia Gómez Serrano, PG⁴^*, Jose Manuel Martin de Bustamante Gonzalez-Iglesias, PG⁴^*, Barbara Martínez de Miguel, MD⁴^*, Elena Martínez Montalbán, MD⁴^*, Elena Dobra, MD⁴^*, Cédric Hermans, MD, MRCP, PhD⁶, Víctor Jiménez-Yuste, MD, PhD^2,4,7^* and María Teresa Alvarez Román, MD, PhD^2,4,7^*

¹Hematology Division, Hospital Universitario La Paz, Madrid, AL, Spain
²IdiPAZ, Madrid, Spain
³Hospital Universitario La Paz, Madrid, Madrid, Spain
⁴Hospital Universitario La Paz, Madrid, Spain
⁵Hospital General La Mancha Centro, Alcazar de San Juan, Spain
⁶Division of Hematology, Cliniques Univ. Saint-Luc, Brussels, Belgium
⁷Universidad Autónoma de Madrid, Madrid, Spain

2425

Actin Bundling Protein L-Plastin Regulates Megakaryocyte Membrane Rigidity and Platelet Spreading

Li Guo, MD, PhD¹, Seema Bhatlekar, PhD¹^*, Shancy P Jacob, PhD¹^*, Bhanu Kanth Manne, PhD²^*, Elizabeth Kolawole³^*, Emilia A Tugolukova, BS¹^*, Siqi Guo²^*, Yasuhiro Kosaka, PhD¹^*, Cindy Barba²^*, Brian Evavold⁴^*, Sharon Celesty Morley⁵^*, Robert A. Campbell, PhD² and Paul F. Bray, MD⁶

¹Molecular Medicine Program, University of Utah, Salt Lake City, UT
²University of Utah, Salt Lake City, UT
³Microbiology & Immunology, University of Utah, Salt Lake City, UT
⁴Department of Microbiology & Immunology, University of Utah, Salt Lake City, UT
⁵University of Washington at St. Louis, St. Louis, MO
⁶Division of Hematology and Hematologic Malignancies, University of Utah, Eccles Institute of Human Genetics, Salt Lake City, UT

2427

A Common Variant in GRK5 Reveals a PAR1-Specific Mechanism for Its Regulation of Platelet Function

Yanki Yarman¹, Xuefei Zhao², Matthew Cooper³^*, Hannah Thomson⁴^* and Peisong Ma, PhD^3,4

¹Thomas Jefferson University, PHILADELPHIA, PA
²Department of Medicine, THOMAS JEFFERSON UNIVERSITY, PHILADELPHIA, PA
³Department of Medicine, Thomas Jefferson University, Philadelphia, PA
⁴Thomas Jefferson University, Philadelphia, PA

Panel Discussion

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