64th ASH Annual Meeting and Exposition: ASH Poster Walk on Beyond Hematology: Clinical and Mechanistic Links between Clonal Hematopoiesis and Non-Hematological Disorders

ASH Poster Walks

Research, Fundamental Science, clinical trials, adult, Translational Research, epidemiology, Clinical Practice (Health Services and Quality), Non-Biological therapies, CHIP, elderly, Clinical Research, Genetic Disorders, Combination therapy, drug development, hematopoiesis, Diseases, real-world evidence, Therapies, registries, Myeloid Malignancies, Biological Processes, molecular biology, Study Population, Human, pathogenesis

(VIRTUAL PROGRAM)

Clonal hematopoiesis (CH) has emerged as a very common age-associated alteration of hematopoiesis that has manifold associations with inflammatory and cardiovascular disorders. This poster walk will highlight studies from two broad categories:

a) Studies that convincingly demonstrate novel associations between CH and non-hematologic diseases, or offer new insights into the interplay between CH-associated gene mutations, other risk factors, and associated disorders.

b) Abstracts that contribute to our understanding of the underlying biological mechanisms (e.g. inflammatory signaling) linking clonal hematopoiesis to pathologic changes in other organ systems, and/or investigating potential targeted, preventive or therapeutic interventions.

2541

Clonal Hematopoiesis in Vexas Syndrome

Bhavisha A. Patel, MD¹, Fernanda Gutierrez-Rodrigues, PhD², Yael Kusne, MD, PhD³, Jenna A. Fernandez, PhD⁴^*, Terra L. Lasho, PhD⁴, Ruba Shalhoub, MS⁵^*, Xiaoyang Ma, MS⁵^*, Hugh Alessi⁶^*, Christy Finke, BS⁴^*, Matthew Koster, MD⁷^*, Abhishek A. Mangaonkar, MBBS⁴, Kenneth Warrington, MD⁷^*, Kebede H. Begna, MD⁸, Zhuoer Xie, MD, MS⁹, Amanda Ombrello, MD¹⁰^*, David S. Viswanatha, MD¹¹, Marcela Ferrada, MD¹²^*, Lorena Wilson, NP, PhD¹³^*, Ronald Go, MD⁴, Taxiarchis Kourelis, MD⁴, Kaaren K. Reichard, MD¹⁴^*, Horatiu Olteanu, MD, PhD¹⁵^*, Emma M. Groarke, MD¹, Ivana Darden, RN¹^*, Dalton Hironaka, BA¹⁶^*, Sofia Rosenzweig, BS¹³^*, Daniel L. Kastner, MD PhD¹³^*, Katherine R. Calvo, MD, PhD¹⁷, Colin O. Wu, PhD⁵^*, Peter C. Grayson, MD, Msc¹²^*, David B. Beck, MD, PhD¹⁸^*, Mrinal M. M. Patnaik, MD, MBBS⁴ and Neal S. Young, MD¹

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²Hematology Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD
³Department of Hematology and Oncology, Mayo Clinic, Phoenix, AZ
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁶National Institutes of Health, Bethesda, MD
⁷Division of Rheumatology, Mayo Clinic, Rochester, MN
⁸Divison of Hematology, Mayo Clinic, Rochester, MN
⁹Division of Hematology, Mayo Clinic, Lutz, FL
¹⁰National Human Genome Research Institute, NIH, National Institutes of Health, Bethesda, MD
¹¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
¹²Vasculitis Translational Research Program, National Institute of Arthritis, Musculoskeletal, and Skin Diseases. National Institutes of Health, Bethesda, MD
¹³Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
¹⁴Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
¹⁵Mayo Clinic, Rochester, MN
¹⁶Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD
¹⁷Hematology Section, Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD
¹⁸National Institutes of Heath, Bethesda, MD

1225

Clonal Myeloid Heterogeneity in Older Autopsy Patients Determined By Multiple Bone Marrow Site Sequencing

Rohan Kodgule, MD, MBBS¹^*, Joshua Robinson²^*, Sridhar Nonavinkere Srivatsan, MS³^*, Cara Lunn Shirai, PhD², Feiyu Du³^*, Tianjiao Wang², Ajay Khanna³^*, Catrina Fronick, BS⁴^*, Robert Fulton, MS⁴^*, David H Spencer, MD, PhD³, Matthew J Walter, MD³ and Eric Duncavage, M.D.²^*

¹Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO
²Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO
³Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO
⁴McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO

1224

Associations of Clonal Hematopoiesis with Recurrent Vascular Events and Death in Patients with Incident Ischemic Stroke

Christopher M Arends¹^*, Thomas G Liman, MD^2,3,4,5,6^*, Paulina Strzelecka, PhD¹^*, Anna Kufner, MD PhD⁶^*, Shufan Huo, MD⁶^*, Catarina M Stein, MSc¹^*, Sophie Piper, PhD^6,7,8^*, Marlon Tilgner¹^*, Pia S Sperber, MD⁶^*, Savvina Dimitriou¹^*, Peter Heuschmann, MD⁹^*, Raphael Hablesreiter, MSc¹^*, Christoph Harms, MD^2,4,6^*, Lars Bullinger, MD^1,10, Matthias Endres, MD^2,3,4,6^* and Frederik Damm, MD^1,10^*

¹Department of Hematology, Oncology, and Cancer Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
²Center for Stroke Research Berlin (CSB) with Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany
³German Center for Neurodegenerative Diseases, Berlin, Germany
⁴German Center for Cardiovascular Research, Berlin, Germany
⁵Department of Neurology, Carl von Ossietzky-University, Evangelical Hospital Oldenburg, Oldenburg, Germany
⁶Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany
⁷Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité - Universitätsmedizin Berlin, Berlin, Germany
⁸NeuroCure Clinical Research Center, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
⁹University of Wuerzburg, Wuerzburg, Germany
¹⁰German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany

3860

Clonal Hematopoiesis in a Broad Age Spectrum of Systemic Vasculitis

Fernanda Gutierrez-Rodrigues, PhD¹, Adrianna I. Jones²^*, Kristina Wells²^*, Dalton Hironaka, BA³^*, Cameron Rankin²^*, Keith A Sikora, MD²^*, Kaitlin Quinn²^*, Marcela Ferrada, MD⁴^*, Bhavisha A. Patel, MD³, Peter C. Grayson, MD, Msc⁴^* and Neal S. Young, MD⁵

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD
²Systemic Autoimmunity Branch, National Institutes of Arthritis, Musculoskeletal, and Skin Diseases, Bethesda, MD
³Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD
⁴Vasculitis Translational Research Program, National Institute of Arthritis, Musculoskeletal, and Skin Diseases. National Institutes of Health, Bethesda, MD
⁵Hematology Branch, National Heart, Lung, and Blood Institute. National Institutes of Health, Bethesda, MD

3867

Clonal Hematopoiesis and Heart Failure with Preserved Ejection Fraction

Toby Thomas, B.S.¹^*, Yuanyuan Ji, Ph.D.¹^*, Fatma Kalkan, M.D.²^*, Albert Son, B.S.³^*, Ambarish Pandey, M.D.²^*, Vinayak Subramanian, M.D.²^*, Naveen Premnath, M.D.⁴^*, Michalis Agathocleous, PhD⁵, Qing Ding⁶^*, Alexander G. Bick, MD, PhD⁷^*, Benjamin Kroger, BS¹^*, Dan Tong, M.D., Ph.D.⁸^* and Stephen S. Chung, MD¹

¹Division of Hematology and Oncology, Department of Internal Medicine, Children's Research Institute, University of Texas Southwestern, Dallas, TX
²Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
³Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
⁴Division of Hematology and Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
⁵Children's Research Institute, UT Southwestern, Dallas, TX
⁶Children’s Research Institute, University of Texas Southwestern, Dallas, TX
⁷Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
⁸Division of Cardiology, Department of Internal Medicine, Dallas, TX

2542

Detailed Analysis of the Impact of Clonal Hematopoiesis on the Risk of Severe COVID-19 Infection

Ryunosuke Saiki¹^*, Ho Namkoong²^*, Ryuya Edahiro^3,4^*, Kyuto Sonehara^3,5^*, Qingbo S Wang^3,6^*, Takanori Hasegawa⁷^*, Yukihide Momozawa, DVM, Ph.D⁸^*, Hideki Makishima, MD, PhD⁹, Yasuhito Nannya, M.D., Ph.D.¹, Nobuyuki Kakiuchi, MD, PhD¹^*, Chikashi Terao, MD, PhD¹⁰^*, Yuichi Shiraishi, PhD¹¹^*, Kenichi Chiba, PhD¹¹^*, Hiroko Tanaka, B.A.⁷^*, Koichi Matsuda, MD, PhD¹²^*, Takayuki Morisaki, MD, PhD¹³^*, Yoshinori Murakami, MD, PhD¹³^*, Yoichiro Kamatani, MD, Ph.D^10,12^*, Michiaki Kubo, MD, Ph.D¹⁴^*, Akinori Kimura¹⁵^*, Seiya Imoto, PhD¹⁶^*, Satoru Miyano, PhD⁷^*, Takanori Kanai¹⁷^*, Koich Fukunaga¹⁸^*, Yukinori Okada³^* and Seishi Ogawa, MD, PhD^19,20,21

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan
³Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan
⁴Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan
⁵Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan
⁶Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan
⁷M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
⁸Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, KYO, Japan
¹⁰Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
¹¹Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan
¹²Department of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Tokyo, Japan
¹³Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
¹⁴RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
¹⁵Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan
¹⁶Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
¹⁷Division of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
¹⁸Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
¹⁹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto City, Japan
²⁰Center for Hematology and Regenerative Medicine, Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden
²¹Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan

Panel Discussion

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