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Hematology Disease Topics & Pathways:
Research, Lymphoid Leukemias, Fundamental Science, Genetic Disorders, bioinformatics, hematopoiesis, Diseases, Lymphoid Malignancies, metabolism, computational biology, Biological Processes, Technology and Procedures, Metabolic Disorders, pathogenesis
Description:
This session will provide an overview of how metabolic control can be regulated in different ways. The speakers will discuss how metabolic regulation can impact normal hematopoiesis and how it can contribute to disease. In addition, the speakers will also discuss how this process can impact the process of red blood cell production of erythropoiesis. This session will provide attendees with a broad perspective on metabolic regulation and also help guide individuals on how metabolism can impact blood cell production in health and disease.
Dr. Navdeep Chandel will discuss data on how mitochondrial electron transport chain is necessary for hematopoietic stem cell function and transformation by oncogene Notch.
Dr. Leonard Zon will discuss the control of metabolic pathways in red blood cells by transcription. He will focus on a chromatin factor, TIF1g, that controls coenzyme Q synthesis and the interaction of ferroptosis and metabolism. Dr. Zon will also discuss how stress and reactive oxygen species regulate erythropoiesis.
Dr. Xu will discuss recent findings on metabolic profiles and mechanisms, in particular a glutamine metabolic switch, that function to control normal and ineffective erythropoiesis.
Dr. Navdeep Chandel will discuss data on how mitochondrial electron transport chain is necessary for hematopoietic stem cell function and transformation by oncogene Notch.
Dr. Leonard Zon will discuss the control of metabolic pathways in red blood cells by transcription. He will focus on a chromatin factor, TIF1g, that controls coenzyme Q synthesis and the interaction of ferroptosis and metabolism. Dr. Zon will also discuss how stress and reactive oxygen species regulate erythropoiesis.
Dr. Xu will discuss recent findings on metabolic profiles and mechanisms, in particular a glutamine metabolic switch, that function to control normal and ineffective erythropoiesis.