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Hematology Disease Topics & Pathways:
Research, Acquired Marrow Failure Syndromes, Acute Myeloid Malignancies, AML, MDS, Fundamental Science, Clinical Practice (Health Services and Quality), Bone Marrow Failure Syndromes, MPN, Translational Research, CHIP, CML, Diversity, Equity, and Inclusion (DEI) , hematopoiesis, Other Pathogens, drug development, Chronic Myeloid Malignancies, CMML, Diseases, immune mechanism, Therapies, Infectious Diseases, metabolism, Biological Processes, Myeloid Malignancies, pathogenesis
Description:
Inflammatory signaling is increasingly recognized as a major contributor to human disease, including cancer. The “seed and soil” concept of carcinogenesis underscores our interest in both the cell-intrinsic and cell-extrinsic roles of inflammation in the pathogenesis of myeloid neoplasia. This session will cover dysregulated inflammatory signaling in hematopoietic cells along with the contribution of the microenvironment and will highlight therapeutic implications arising from these newly generated insights.
Dr. Katherine King will discuss evidence that inflammatory signaling contributes to clonal hematopoiesis. She will discuss the current mechanistic understanding of this relationship with a focus on Dnmt3a and Tet2-mutant clones.
Dr. Christina Lo Celso will discuss the contribution of the bone marrow microenvironment to leukemogenesis. Her work has explored the role of extracellular matrix remodeling in regulating Acute Myeloid Leukemia (AML) growth and differentiation, the highly dynamic interactions between AML cells and immune cells, and the impact of infection on the bone marrow microenvironment. Dr. Lo Celso will describe tools developed to capture the complexity of these interactions in the bone marrow microenvironment and discuss our evolving understanding of the dynamics taking place in the bone marrow of healthy humans as they age and as leukemia develops.
Dr. Eric Pietras will discuss the role of dysregulated inflammatory signaling in the pathogenesis of myeloid malignancies. Specifically, his talk will focus on the interplay between inflammation and metabolic dysregulation as potential drivers of selection and expansion of mutant hematopoietic stem and progenitor cells at early stages of myeloid oncogenesis.
Dr. Daniel Starczynowski will describe the role of dysregulated innate immune pathways in pre-leukemic and myelodysplastic syndrome (MDS) hematopoietic cells. He will also discuss the implications of systemic inflammation on the pathogenesis of MDS and on the competitive advantage of MDS cells. Lastly, Dr. Starczynowski will describe emerging therapeutic strategies targeting innate immune and inflammatory pathways in myeloid malignancies.
Dr. Katherine King will discuss evidence that inflammatory signaling contributes to clonal hematopoiesis. She will discuss the current mechanistic understanding of this relationship with a focus on Dnmt3a and Tet2-mutant clones.
Dr. Christina Lo Celso will discuss the contribution of the bone marrow microenvironment to leukemogenesis. Her work has explored the role of extracellular matrix remodeling in regulating Acute Myeloid Leukemia (AML) growth and differentiation, the highly dynamic interactions between AML cells and immune cells, and the impact of infection on the bone marrow microenvironment. Dr. Lo Celso will describe tools developed to capture the complexity of these interactions in the bone marrow microenvironment and discuss our evolving understanding of the dynamics taking place in the bone marrow of healthy humans as they age and as leukemia develops.
Dr. Eric Pietras will discuss the role of dysregulated inflammatory signaling in the pathogenesis of myeloid malignancies. Specifically, his talk will focus on the interplay between inflammation and metabolic dysregulation as potential drivers of selection and expansion of mutant hematopoietic stem and progenitor cells at early stages of myeloid oncogenesis.
Dr. Daniel Starczynowski will describe the role of dysregulated innate immune pathways in pre-leukemic and myelodysplastic syndrome (MDS) hematopoietic cells. He will also discuss the implications of systemic inflammation on the pathogenesis of MDS and on the competitive advantage of MDS cells. Lastly, Dr. Starczynowski will describe emerging therapeutic strategies targeting innate immune and inflammatory pathways in myeloid malignancies.