denotes an abstract that is clinically relevant.
denotes that this is a recommended PHD Trainee Session.
denotes that this is a ticketed session.Hematology Disease Topics & Pathways:
Research, Bleeding and Clotting, Biological therapies, Fundamental Science, Clinical Practice (Health Services and Quality), Translational Research, platelet disorders, Diversity, Equity, and Inclusion (DEI) , Diseases, thrombocytopenias, Therapies, Neonatal, VWD, Biological Processes, Study Population, multi-systemic interactions, Transfusion
Description:
Historically, the major consideration in platelet transfusion therapy was in obtaining the maximal platelet count. However, recent clinical and basic science studies focusing on both transfused and native platelets have increased our understanding of how to obtain the maximum benefit when transfusing platelets and led us to the conclusion that more isn’t always better. This session will highlight some of these recent advances that have great potential to improve clinical management of platelet transfusion therapy.
Dr. Marie Hollenhorst will describe the glycosylation of platelet glycoprotein Iba (GPIba), which plays important roles in hemostasis, platelet clearance, and the anti-platelet immune response. Dr. Hollenhorst will discuss her comprehensive analysis of GPIba glycosylation, which has resulted in a detailed map of glycosites (amino acid sites of glycosylation) and determination of glycan structures at each glycosite. Physiologic implications of GPIba glycans include ABO blood group (ABH) antigen-containing glycans, sialoglycans, Tn antigen, and T antigen.
Dr. Dianne van der Wal will present the various platelet clearance mechanisms currently described in humans and in animal models. She will discuss the role of GPIb and platelet-attached carbohydrates in physiological clearance and (bleeding) disorders including idiopathic thrombocytopenic purpura. Dr van der Wal will discuss her latest findings on the effect of various donor attributes on the quality of platelet components and implications for platelet clearance and hemostatic efficiency post-transfusion. She will also discuss novel in vitro clearance pathways for platelet microparticles and the potential implications for patients, post-transfusion.
Dr. Martin Schreiber will discuss the effects of leukoreduction and the storage lesion on platelet function in whole blood. He will also discuss the benefits of cold platelet transfusion. Finally, Dr. Schreiber will discuss potential alternative therapies including freeze dried platelets and platelet extracellular vesicles.
Dr. Martha Sola-Visner will discuss the incidence and patterns of bleeding in preterm neonates, and the results from randomized trials of platelet transfusion thresholds in this population. She will then describe the developmental differences that exist between neonates and adults in platelet function and primary hemostasis, and the potential “developmental mismatch” that occurs when adult platelets are transfused into sick neonates. Lastly, she will discuss the effects of platelet transfusions on neonatal hemostasis and inflammation, and the potential mechanisms underlying the increased morbidity and mortality associated with platelet transfusions in this vulnerable population.
Dr. Marie Hollenhorst will describe the glycosylation of platelet glycoprotein Iba (GPIba), which plays important roles in hemostasis, platelet clearance, and the anti-platelet immune response. Dr. Hollenhorst will discuss her comprehensive analysis of GPIba glycosylation, which has resulted in a detailed map of glycosites (amino acid sites of glycosylation) and determination of glycan structures at each glycosite. Physiologic implications of GPIba glycans include ABO blood group (ABH) antigen-containing glycans, sialoglycans, Tn antigen, and T antigen.
Dr. Dianne van der Wal will present the various platelet clearance mechanisms currently described in humans and in animal models. She will discuss the role of GPIb and platelet-attached carbohydrates in physiological clearance and (bleeding) disorders including idiopathic thrombocytopenic purpura. Dr van der Wal will discuss her latest findings on the effect of various donor attributes on the quality of platelet components and implications for platelet clearance and hemostatic efficiency post-transfusion. She will also discuss novel in vitro clearance pathways for platelet microparticles and the potential implications for patients, post-transfusion.
Dr. Martin Schreiber will discuss the effects of leukoreduction and the storage lesion on platelet function in whole blood. He will also discuss the benefits of cold platelet transfusion. Finally, Dr. Schreiber will discuss potential alternative therapies including freeze dried platelets and platelet extracellular vesicles.
Dr. Martha Sola-Visner will discuss the incidence and patterns of bleeding in preterm neonates, and the results from randomized trials of platelet transfusion thresholds in this population. She will then describe the developmental differences that exist between neonates and adults in platelet function and primary hemostasis, and the potential “developmental mismatch” that occurs when adult platelets are transfused into sick neonates. Lastly, she will discuss the effects of platelet transfusions on neonatal hemostasis and inflammation, and the potential mechanisms underlying the increased morbidity and mortality associated with platelet transfusions in this vulnerable population.