denotes an abstract that is clinically relevant.
denotes that this is a ticketed session.
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Translational Research, Genetic Disorders, Other Pathogens, pediatric, Diseases, Immune Disorders, Infectious Diseases, white blood cell disorders, Study Population, Human
Description:
In the largest organismal iron flow, macrophages recycle iron from senescent erythrocytes for delivery to erythropoietic marrow where iron is incorporated into heme in hemoglobin of new erythrocytes. This session will present recent advances in the study of mechanisms of iron recycling and discuss the profound influence of malaria on the genetic evolution of such mechanisms.
Dr. Shang Ma will describe mechanistic studies that uncovered novel mechanotransduction processes in erythrocyte and recycling macrophages. These processes are disrupted by mutations in the gene Piezo1 that encodes a mechanosensory protein. Hereditary Xerocytosis, caused by mutations in the Piezo1 gene, is a rare disorder in which red blood cells are dehydrated and patients suffer from anemia, splenomegaly, and iron overload. Dr. Ma will discuss how combined human and mouse genetics strategy enables us to understand the role of mechanical forces in health and disease.
Dr. Robin van Bruggen will discuss new insights into the recycling of iron from senescent erythrocytes in the spleen. The novel mechanism determines the entrapment of red blood cells in the spleen through activation of adhesion molecules on erythrocytes, which is followed by hemolysis and the formation of erythrocyte ghosts. Dr. van Bruggen will discuss how these new insights enhance our understanding of conditions in which exaggerated erythrocyte turnover is observed, such as during severe malarial anemia or sickle cell anemia.
Dr. Sarah Atkinson will review the complex relationship between iron, anemia and malaria, and the unique insights into this relationship offered by novel human genetic variants discovered in Africa. As genetic variations in iron homeostasis influence malaria risk, Dr. Atkinson will address how malaria has shaped the evolution of iron homeostasis in Africa.
Dr. Shang Ma will describe mechanistic studies that uncovered novel mechanotransduction processes in erythrocyte and recycling macrophages. These processes are disrupted by mutations in the gene Piezo1 that encodes a mechanosensory protein. Hereditary Xerocytosis, caused by mutations in the Piezo1 gene, is a rare disorder in which red blood cells are dehydrated and patients suffer from anemia, splenomegaly, and iron overload. Dr. Ma will discuss how combined human and mouse genetics strategy enables us to understand the role of mechanical forces in health and disease.
Dr. Robin van Bruggen will discuss new insights into the recycling of iron from senescent erythrocytes in the spleen. The novel mechanism determines the entrapment of red blood cells in the spleen through activation of adhesion molecules on erythrocytes, which is followed by hemolysis and the formation of erythrocyte ghosts. Dr. van Bruggen will discuss how these new insights enhance our understanding of conditions in which exaggerated erythrocyte turnover is observed, such as during severe malarial anemia or sickle cell anemia.
Dr. Sarah Atkinson will review the complex relationship between iron, anemia and malaria, and the unique insights into this relationship offered by novel human genetic variants discovered in Africa. As genetic variations in iron homeostasis influence malaria risk, Dr. Atkinson will address how malaria has shaped the evolution of iron homeostasis in Africa.