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Debate: Most/All Patients with Acquired (Immune) Thrombotic Thrombocytopenic Purpura Receive Caplacizumab

Program: Spotlight Sessions
Hematology Disease Topics & Pathways:
Bleeding and Clotting, autoimmune disorders, Clinical Practice (Health Services and Quality), platelet disorders, Diseases, Immune Disorders, thrombocytopenias, Therapies, thrombotic disorders
Monday, December 12, 2022: 10:30 AM-11:45 AM
295-296 (Ernest N. Morial Convention Center)
Mark Crowther, MD, McMaster University
Crowther: Precision Biologics: Consultancy; Syneos Health: Consultancy; Pfizer: Speakers Bureau; Hemostasis reference Laboratories: Consultancy; CSL Behring: Speakers Bureau; Bayer: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; AstraZeneca: Consultancy; ASH: Other: Treasurer.
This ASH spotlight session will feature a debate discussing whether caplacizumab should be a component of the routine treatment of all patients with acute thrombotic thrombocytopenic purpura. Recently introduced, caplacizumab had a modest impact on disease in large clinical trials. Despite this, various guidelines and recommendation documents have suggested its routine use. However, persuasive arguments can be made both for and against its use, in light of its cost/ benefit analysis and its impact on long-term outcomes, particularly in light of other therapeutic advances in this area, including the widespread use of anti CD 20 monoclonal antibodies for patients presenting with TTP.

Camila Masias, MD, MPH

Miami Cancer Institute, Miami Cancer Institute, Miami, FL

George Goshua, MD, MSc

Classical Hematology, Section of Hematology, Yale University School of Medicine, New Haven, CT; Section of Hematology, Yale University School of Medicine, New Haven, CT

See more of: Spotlight Sessions