denotes an abstract that is clinically relevant.
denotes that this is a recommended PHD Trainee Session.
denotes that this is a ticketed session.Hematology Disease Topics & Pathways:
Biological therapies, Lymphoid Leukemias, Acute Myeloid Malignancies, ALL, AML, Clinical Practice (Health Services and Quality), Non-Biological therapies, Workforce, Combination therapy, Diversity, Equity, and Inclusion (DEI) , drug development, Diseases, Therapies, therapy sequence, Lymphoid Malignancies, Myeloid Malignancies, Study Population
Description:
In this case-based session, Dr Sarah Tasian will review the biology of Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) and current genetic testing approaches to identify patients with this high-risk leukemia subtype. She will then discuss indications for integration of tyrosine kinase inhibitors (TKIs) into the therapy of patients with Ph-like ALL. Finally, she will highlight recently-completed, current, and planned TKI-based clinical trials for children and adolescents/young adults with Ph-like ALL.
Dr. Katherine Tarlock will discuss targeted therapies in children with AML including targeted small molecule inhibitors as well as immunotherapeutic agents. She will focus on single gene mutations and aberrantly activated oncogenic pathways, and review some of challenges of mutation targeting and drug development in pediatric versus adult AML. She will also discuss the evolution of targeting cell surface antigens with a variety of immunotherapeutic strategies in pediatric AML. This talk will focus on targeted agents currently available and with active clinical trials, and will also touch on those in clinical trial development.
Dr. Rishi Kotecha will highlight the challenges of treating infants with acute lymphoblastic leukemia (ALL). This talk will focus on targeted agents that are being primed for clinical use and provide insight into the landscape of clinical trials that are currently in development for infants with ALL. In addition, Dr. Kotecha will review the outcomes from preclinical studies that have investigated novel targeted agents for infants with KMT2A-rearranged ALL and their potential for future clinical translation.
Dr. Katherine Tarlock will discuss targeted therapies in children with AML including targeted small molecule inhibitors as well as immunotherapeutic agents. She will focus on single gene mutations and aberrantly activated oncogenic pathways, and review some of challenges of mutation targeting and drug development in pediatric versus adult AML. She will also discuss the evolution of targeting cell surface antigens with a variety of immunotherapeutic strategies in pediatric AML. This talk will focus on targeted agents currently available and with active clinical trials, and will also touch on those in clinical trial development.
Dr. Rishi Kotecha will highlight the challenges of treating infants with acute lymphoblastic leukemia (ALL). This talk will focus on targeted agents that are being primed for clinical use and provide insight into the landscape of clinical trials that are currently in development for infants with ALL. In addition, Dr. Kotecha will review the outcomes from preclinical studies that have investigated novel targeted agents for infants with KMT2A-rearranged ALL and their potential for future clinical translation.