Session: 102. Iron Homeostasis and Biology I
Hematology Disease Topics & Pathways:
Genetic Disorders, Diseases, Therapies
Methods: This was a single-center retrospective cohort study of all patients with EPP/XLP treated at the MGH Porphyria Center from March 2021 through May 2022. Afamelanotide is administered subcutaneously every two months, with a maximum of 6 implants per year.
Main outcomes: Time until phototoxic reaction and frequency and severity of symptoms pre- versus post-treatment with afamelanotide, changes in quality of life with afamelanotide, and side effects of afamelanotide.
Results: A total of 30 patients with EPP/XLP were evaluated during the period of interest, 24 of whom (n=23 [EPP], n=1 [XLP]) received at least one afamelanotide implant. The median age for patients who received afamelanotide was 40 years (interquartile range [IQR], 32-57), and 19 (79%) were female. The median number of implants received was 4 (IQR, 2-5). Among the 19 patients who received at least 2 implants, the median time to symptom onset after light exposure was 10 minutes (IQR, 5-20) prior to initiation of afamelanotide, and 120 minutes (IQR, 105-300) after initiation of afamelanotide (P<0.001). All patients who received at least 2 doses of afamelanotide reported a decrease in frequency and severity of phototoxic reactions. Among patients who had received afamelanotide within the last two months, 84% reported that their quality of life had improved either “very much” or “a lot.”
Adverse events were generally mild and included nausea, vomiting, flushing, and bruising at the implant site. Of the 6 patients who did not receive afamelanotide, one was scheduled to receive afamelanotide after the data lock period, one was receiving afamelanotide at another center, three were on a clinical trial with an oral α-MESH analogue, and one was unable to afford the medication.
Conclusion: In this U.S. single-center cohort, afamelanotide led to a significant increase in median time to phototoxic reaction in patients with EPP/XLP, decrease in symptom frequency and severity, and improvement in quality of life. Afamelanotide was generally well-tolerated with limited side effects.
Disclosures: Leaf: Mitsubishi Tanabe: Other: Advisory Board member; Recordati: Other: Advisory Board member. Hodges: Alnylam: Other: Advisory Board member. Anderson: Alnylam: Consultancy, Other: Advisory Board member, Research Funding; Mitsubishi Tanabe: Consultancy, Other: Advisory Board member, Research Funding; Recordati: Consultancy, Other: Advisory Board member, Research Funding. Dickey: Disc Medicine: Research Funding; Mitsubishi Tanabe: Consultancy; Recordati: Consultancy.
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