-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

2526 Defining Current Patterns of Blood Product Use during Intensive Induction Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia Patients

Program: Oral and Poster Abstracts
Session: 401. Blood Transfusion: Poster II
Hematology Disease Topics & Pathways:
Acute Myeloid Malignancies, AML, Clinical Practice (Health Services and Quality), blood banking, Diseases, Myeloid Malignancies, Technology and Procedures
Sunday, December 11, 2022, 6:00 PM-8:00 PM

Liron Miller, PhD1*, Mor Freed-Freundlich1*, Tamer Hellou, MD1*, Avichai Shimoni, MD2*, Abraham Avigdor, MD3, Mudi Misgav4* and Jonathan Canaani, MD5

1Sheba Medical Center, Tel Hashomer, Israel
2Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Ramat Gan, Israel
3Chaim Sheba Medical Center, Ramat Gan, Israel
4National Hemophilia Center and Institute of Thrombosis & Hemostasis, Sheba Medical Center, Tel-Hashomer, Israel
5Hematology Division, Sheba Medical Center, Givatayim, Central, Israel


Blood product transfusion continues to retain a critical role in the supportive care of patients with acute myeloid leukemia (AML) particularly during the initial phase of intensive induction chemotherapy. Whereas previous studies have shown increased transfusion dependency to portend inferior outcome, clinical and disease features predictive of an increased transfusion burden and the overall prognostic impact of transfusion support in this setting have not been determined as of yet. Herein, we evaluated the various blood product components administered during induction aiming to delineate current transfusion practices in AML patients.


We reviewed the medical records of 180 consecutive adult patients with newly diagnosed AML, who were treated with intensive chemotherapy from December 2014 through January 2022 at the Sheba Medical Center. Clinical data extraction and exploration were done with the MDClone big data platform. All patients assessed in the study received standard anthracycline and cytarabine-based intensive induction chemotherapy or CPX-351. Patients received irradiated and leukodepleted blood products. Alloimmunization was defined according to the National Heart, Lung, and Blood Institute working group criteria.


The analysis comprised 180 patients with a median age of 57 years (range 19-77) with 80% designated as de novo AML and the remainder as secondary AML. Fifty-four patients (31%) were FLT3-ITD mutated and 73 patients (42%) harbored NPM1. Favorable risk and intermediate risk ELN 2017 patients accounted for 43% and 34% of patients, respectively. The median number of red blood cell (RBC) and platelet units given during induction were 9 units and 7, respectively. Seventeen patients (9%) received cryoprecipitate and fresh frozen plasma (FFP) was given to 12 patients (7%). Lower initial hemoglobin and platelet levels were predictive of increased use of RBC (p<0.0001) and platelet transfusions (p<0.0001). Use of FFP was significantly associated with induction related mortality (42% versus 5%; p<0.0001) and with FLT3-ITD status (72% versus 28%; p=0.004). Transfusion associated alloimmunization was seen in 7 patients (4%) with patients with lower mean initial platelet counts being more likely to experience alloimmunization (38 X 109/l versus 83 X 109/l; p=0.01). Alloimmunized patients had significantly higher RBC transfusion (14 units versus 9.5 units; p=0.012) and prestorage leukodepleted filtered RBC (6.1 units versus 1.6 units; p<0.0001) requirements during induction compared with non-alloimmunized patients. Blood group AB experienced improved mean overall survival compared to blood group O patients (4.1 years versus 2.8 years; p=0.025). In multivariate analysis, increased number of FFP [hazard ratio (HR), 4.23; 95% confidence interval (CI), 2.1-8.6; p<0.001) and RBC units (HR, 1.8; 95% CI, 1.2-2.8; p=0.008) given was associated with inferior survival.


In this analysis we comprehensively mapped the transfusion trajectory of AML patients during induction therapy and identified clinically meaningful associations impacting the need for the various blood components as well as overall survival. Transfusion needs during induction crucially impact the clinical trajectory of AML patients.

Disclosures: Avigdor: Takeda, Gilead, Novartis, Roche, BMS: Consultancy; AbbVie: Honoraria. Canaani: AbbVie: Consultancy; Astellas: Consultancy; Medison: Consultancy.

<< Previous Abstract | Next Abstract
*signifies non-member of ASH