-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

Late-Breaking Abstracts Session

PhD Trainee
Program: General Sessions
Tuesday, December 14, 2021: 9:00 AM-10:30 AM
Co-chairs:
Anita Rajasekhar, MD, University of Florida - Shands Hospital and Alison W. Loren, MD, Perelman Center for Advanced Medicine
Disclosures:
Rajasekhar: Janssen: Research Funding; Genentech: Research Funding; Baxalta: Research Funding; Dimensions Therapeutics: Research Funding; Sanofi: Research Funding; Biomarin Pharmaceutical: Research Funding; Kedrion Biopharma: Research Funding.
This highly anticipated session highlights the Program Committee's selections of the highest-impact abstracts, featuring substantive, novel, and groundbreaking data that were not available by the general abstract submission deadline and would otherwise not be presented at the ASH annual meeting.

Hervé Tilly, MD1, Franck Morschhauser, MD, PhD2*, Laurie H. Sehn, MD3, Jonathan W. Friedberg, MD 4, Marek Trněný, MD5, Jeff P. Sharman, MD6, Charles Herbaux, MD7, John M. Burke, MD8, Matthew Matasar, MD9,10, Shinya Rai, MD, PhD11*, Koji Izutsu, MD, PhD12*, Neha Mehta-Shah, MD13, Lucie Oberic, MD14*, Adrien Chauchet, MD15*, Wojciech Jurczak, PhD, MD16, Yuqin Song, MD17*, Richard Greil, MD18, Larysa Mykhalska, MD19*, Juan Miguel Bergua Burgués, MD20*, Matthew C. Cheung, MD21, Antonio Pinto, MD22*, Ho-Jin Shin, MD, PhD23*, Greg Hapgood, MD, PhD24*, Eduardo Munhoz, MD25*, Pau Abrisqueta Costa, MD, PhD26*, Jyh-Pyng Gau, MD27*, Jamie Hirata, PharmD28, Yanwen Jiang, PhD28*, Mark Yan, PhD29*, Calvin Lee, MD28, Christopher R. Flowers, MD30 and Gilles Salles, MD, PhD31

1Department of Hematology and U1245, Centre Henri Becquerel and University of Rouen, Rouen, France
2Univ. Lille, CHU Lille, ULR 7365 - GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées, Lille, France
3BC Cancer Centre for Lymphoid Cancer and University of British Columbia, Vancouver, BC, Canada
4Wilmot Cancer Institute, University of Rochester, Rochester, NY
5First Faculty of Medicine, Charles University, General Hospital, Prague, Czech Republic
6Willamette Valley Cancer Institute/US Oncology, Eugene, OR
7CHU de Montpellier, Montpellier, France
8Rocky Mountain Cancer Centers/US Oncology, Aurora, CO
9Memorial Sloan Kettering Cancer Center, New York, NY
10Memorial Sloan Kettering Cancer Center, Montvale, NJ
11Department of Hematology and Rheumatology, Kindai University, Faculty of Medicine, Osaka-Sayama City, Japan
12National Cancer Center Hospital, Tokyo, Japan
13Washington University in St. Louis, St. Louis, MO
14Department of Hematology, Institut Universitaire du Cancer, Toulouse-Oncopole, Toulouse, France
15Department of Hematology, CHRU Besançon, Besançon, France
16Maria Skłodowska – Curie National Research Institute of Oncology, Kraków, Poland
17Peking University Cancer Hospital, Beijing, China
183rd Medical Department, Paracelsus Medical University, Salzburg Cancer Research Institute-CCCIT and Cancer Cluster Salzburg, Salzburg, Austria
19Clinical Hospital Feofaniya, Kyiv, Ukraine
20Hospital San Pedro de Alcántara, Cáceres, Spain
21Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
22Hematology-Oncology & Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione ‘G. Pascale’, IRCCS, Naples, Italy
23Division of Hematology-Oncology, Department of Internal Medicine, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea, Republic of (South)
24Princess Alexandra Hospital, Brisbane, QLD, Australia
25Hospital Erasto Gaertner, Curitiba, Brazil
26Department of Hematology, Hospital Vall d’Hebron, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
27Taipei Veterans General Hospital, Taipei, Taiwan
28Genentech, Inc., South San Francisco, CA
29F. Hoffmann-La Roche Ltd, Mississauga, ON, Canada
30MD Anderson Cancer Center, Houston, TX
31Memorial Kettering Cancer Center, New York, NY

Alok Srivastava, MD, FRACP, FRCPA, FRCP1, Savita Rangarajan, MBBS, MD, FRCP, FRCPath2, Kaan Kavakli, MD, PhD3*, Robert Klamroth, MD4*, Gili Kenet, MD5, Liane Khoo, MD, MBBS, PhD, FRACP, FRCPA6*, Chur-Woo You, MD, PhD7*, Weiqun Xu, MD, PhD8*, Niel Malan, MD9*, Laurent Frenzel, MD, PhD10, Catherine N. Bagot, MD, FRCPath, MBBS11*, Oleksandra Stasyshyn, MD, PhD12*, Chia-Yau Chang, MD13*, Stacey Poloskey, MD14*, Shauna Andersson, MD, PhD15*, Zhiying Qiu, PhD16*, Baisong Mei, MD, PhD15* and Steven W. Pipe, MD17

1Department of Hematology, Christian Medical College, Vellore, India
2KJ Somaiya Super Specialty Hospital, Mumbai, India
3Department of Hematology, Ege University Faculty of Medicine, Children's Hospital, Izmir, Turkey
4Department for Internal Medicine and Vascular Medicine, Haemophilia Treatment Centre, Vivantes Hospital im Friedrichshain, Berlin, Berlin, Germany
5The National Haemophilia Centre, The Amalia Biron Thrombosis Research Institute, Sheba Medical Centre, Tel Hashomer, Israel
6Haematology Department, Royal Prince Alfred Hospital, NSW Health Pathology, Sydney, NSW, Australia
7Department of Pediatrics, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon, Korea, Republic of (South)
8Department of Hematology and Oncology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
9Phoenix Pharma, Port Elizabeth, South Africa
10Centre de Traitement de l'Hémophilie, AP-HP, Hôpital Necker Enfants Malades, Paris, France
11Department of Haematology, Glasgow Royal Infirmary, Glasgow, United Kingdom
12Institute of Blood Pathology and Transfusion Medicine, Lviv, Ukraine
13Division of Pediatric Hematology/Oncology, Hemophilia Center, Taipei Medical University Hospital, Taipei, Taiwan
14Sanofi, Waltham, MA
15Sanofi, Cambridge, MA
16Sanofi, Bridgewater, NJ
17Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor, MI

Margarete A Fabre1,2,3*, Jose Guillherme de Almeida4*, Edoardo Fiorillo5*, Emily Mitchell1,3,6*, Aristi Damaskou1,3*, Justyna Rak1,3*, Valeria Orru5*, Michele Marongiu5*, MS Vijayabaskar1*, Joanna E Baxter3*, Claire Hardy6*, Federico Abascal6*, Michael Spencer Chapman1,3,6*, Nicholas Williams1,6*, Jyoti Nangalia, MBBChir1,3,7, Inigo Martincorena6*, Peter J Campbell1,6*, Eoin F Mckinney8*, Francesco Cucca5,9*, Moritz Gerstung4* and George S Vassiliou, FRCPath, MRCP, PhD, MBBS1,3,6

1University of Cambridge, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom
2Wellcome Sanger Institute, Cambridge, ENG, United Kingdom
3University of Cambridge, Department of Haematology, Cambridge, United Kingdom
4European Bioinformatics Institute, Cambridge, United Kingdom
5Consiglio Nazionale delle Ricerche, Istituto di Ricerca Genetica e Biomedica, Lanusei, Italy
6Wellcome Sanger Institute, Cambridge, United Kingdom
7Wellcome Sanger Institute, Saffron Walden, ENG, United Kingdom
8University of Cambridge, Cambridge Institute of Therapeutic Immunology & Infectious Disease, Cambridge, United Kingdom
9Università degli Studi di Sassari, Dipartimento di Scienze Biomediche, Sassari, Italy

Masayuki Umeda, MD1*, Jing Ma, PhD1*, Benjamin J. Huang, MD2*, Kohei Hagiwara, MD3*, Tamara Westover, BS1*, Sherif Abdelhamed, PhD1, Juan Martin Barajas, PhD1, Melvin Edward Thomas III, PhD1*, Michael P Walsh, PhD1*, Guangchun Song1*, Liqing Tian, Ph.D3*, Yanling Liu, PhD3*, Xiaolong Chen, PhD3*, Pandurang Kolekar, Ph.D3*, Quang Tran, PhD3*, Scott Foy, PhD3*, Jamie L. Maciaszek, PhD1*, Andrew B Kleist, MD, PhD4*, Amanda R. Leonti, MS5*, Bensheng Ju, PhD3*, John Easton, PhD3*, Huiyun Wu, PhD6*, Virginia Valentine7*, Marc Valentine, BA7*, Yen-Chun Liu1*, Rhonda E. Ries, MA5*, Jenny L. Smith, MSc, MEd5*, Evan Parganas1*, Ilaria Iacobucci, PhD1, Ryan Hiltenbrand, MS1*, Jonathan Miller, MD, PhD8, Jason Myers9*, Evadnie Rampersaud, PhD9*, Delaram Rahbarinia, MSc3*, Michael Rusch, BS3*, Gang Wu, PhD9*, Hiroto Inaba, MD, PhD8, Yi-Cheng Wang, MS10*, Todd A. Alonzo, PhD11*, James R. Downing, MD1, Charles G. Mullighan, MBBS, MD1, Stanley B Pounds, PhD6*, M. Madan Babu, PhD12*, Jinghui Zhang, PhD3*, Jeffrey E. Rubnitz, MD8, Soheil Meshinchi, M.D., Ph.D.5, Xiaotu Ma, PhD3* and Jeffery M. Klco, MD, PhD1

1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
2UCSF, San Francisco, CA
3Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN
4Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI
5Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
6Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
7Cytogenetics, St. Jude Children's Research Hospital, Memphis, TN
8Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
9Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN
10Children's Oncology Group, Monrovia, CA
11Department of Preventive Medicine, University of Southern California, Monrovia, CA
12Department of Structural Biology and the Center for Data Driven Discovery, St. Jude Children’s Research Hospital, Memphis, TN

Lynn Malec1, An Van Damme2, Anthony Chan3, Mariya Spasova4*, Nisha Jain5, Charlotte Sensinger5*, Jennifer Dumont5*, Stefan Lethagen6*, Manuel Carcao7 and Flora Peyvandi8,9

1Versiti Blood Research Institute, Milwaukee, WI
2Paediatric Hémato-oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
3Pediatrics, McMaster Children's University, Hamilton, ON, Canada
4UMHAT Sv Georgi, EAD, Bulgaria
5Sanofi, Cambridge, MA
6Sobi, Stockholm, Sweden
7The Hospital for Sick Children, Toronto, ON, Canada
8Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
9Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

Michael R. Bishop, MD1, Michael Dickinson, MBBS2, Duncan Purtill3*, Pere Barba, MD, PhD4*, Armando Santoro5*, Nada Hamad6, Koji Kato, MD, PhD7, Anna Sureda8, Richard Greil, MD9, Catherine Thieblemont, MD, PhD10, Franck Morschhauser, MD, PhD11*, Martin Janz12*, Ian W. Flinn, MD, PhD13, Werner Rabitsch14*, Yok Lam Kwong15*, Marie José Kersten, MD, PhD16, Monique C. Minnema, MD17, Harald Holte, MD, PhD18, Esther Hian Li Chan19*, Joaquin Martinez-Lopez20*, Antonia MS Mueller, MD21, Richard T. Maziarz, MD22, Joseph P. McGuirk, DO23, Emmanuel Bachy, MD, PhD24*, Steven Le Gouill25, Martin Dreyling, MD26, Hideo Harigae, MD, PhD27, David A. Bond, MD, BS28, Charalambos Andreadis, MD, MS29, Peter A. McSweeney, MD13, Mohamed A. Kharfan-Dabaja, MD, MBA30, Simon Newsome31*, Evgeny Degtyarev31*, Chris Del Corral, PharmD32*, Giovanna Andreola, MD31*, Aisha Masood, MD32, Stephen J Schuster, MD33, Ulrich Jaeger34, Peter Borchmann, MD35 and Jason R. Westin, MD36

1The David and Etta Jonas Center for Cellular Therapy, University of Chicago, Chicago, IL
2Peter MacCallum Cancer Centre and Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
3Fiona Stanley Hospital, Murdoch, Western Australia, Australia
4Hospital Universitari Vall d’Hebron and Universitat Autonoma de Barcelona, Barcelona, Spain
5Department of Biomedical Sciences, Humanitas University and IRCCS Humanitas Research Hospital-Humanitas Cancer Center, Milan, Italy
6Department of Haematology, St Vincent's Hospital Sydney, Australia and St Vincent's Clinical School, Sydney, University of New South Wales, Sydney, NSW, Australia
7Hematology, Oncology, and Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan
8Clinical Hematology Department, Institut Català d’Oncologia – Hospitalet de Llobregat, Barcelona, Spain
9Third Medical Department, Paracelsus Medical University; Salzburg Cancer Research Institute-CCCIT and Cancer Cluster Salzburg, Salzburg, Austria
10APHP, Hemato-Oncology, Hôpital Saint-Louis, Paris, France
11Centre Hospitalier Régional Universitaire de Lille, Lille, France
12Hematology, Oncology and Tumorimmunology, Charité, University Hospital Berlin, Campus Benjamin Franklin, Berlin, Germany
13Sarah Cannon Research Institute-Tennessee Oncology, Nashville, TN
14Internal Medicine I, BMT-Unit, Vienna General Hospital-Medical University of Vienna, Vienna, Austria
15Department of Medicine, Queen Mary Hospital, Hong Kong, China
16Department of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
17Universitair Medisch Centrum Utrecht, Dept Medical Oncology, Utrecht, Netherlands
18Department of Oncology, Oslo University Hospital, Oslo, Norway
19National University Cancer Institute, Signapore, Singapore
20Hospital 12 De Octubre, Complutense University, CNIO, Madrid, Spain
21Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland
22Center for Hematologic Malignancies, Knight Cancer Institute, Oregon Health and Science University, Portland, OR
23Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Cancer Center, Westwoon, KS
24Hospices Civils de Lyon and Université Claude Bernard Lyon 1, Lyon, France
25CRCINA, INSERM and Nantes Medical University, Nantes, France
26Medizinische Klinik III, LMU Klinikum, Munich, Germany
27Tohoku University Hospital, Sendai, Japan
28The Ohio State University, Columbus, OH
29Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
30Division of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapy Program, Mayo Clinic, Jacksonville, FL
31Novartis Pharma AG, Basel, Switzerland
32Novartis Pharmaceuticals Corporation, East Hanover, NJ
33Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
34Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Vienna General Hospital – Medical University of Vienna, Vienna, Austria
35Clinic I for Internal Medicine, University Hospital Cologne, Cologne, Germany
36Department of Lymphoma & Myeloma, M.D. Anderson Cancer Center, Houston, TX

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