Michael H Kramer, MD, PhD¹, Qiang Zhang, PhD^2*, Robert W. Sprung^2*, Petra Erdmann-Gilmore^2*, Daniel R George^1*, Nichole M Helton^1*, Sharon E Heath^1*, Jacqueline E. Payton, MD, PhD³, Peter Westervelt, MD, PhD¹, Christopher A Miller, PhD^1*, Matthew J. Walter, MD¹, Daniel C. Link, MD¹, John F. DiPersio, MD, PhD¹, R Reid Townsend, MD, PhD^2* and Timothy J Ley, MD¹

¹Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO
²Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Saint Louis, MO
³Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO

Taehyung Kim, MSc^1,2,3, Hyewon Lee, MD^1,4, Jose-Mario Capo-Chichi, PhD^5*, Myung Hee Chang, MD^1,6*, Young Seok Yoo, BSc^1*, Gurbaksh Basi^7*, Troy Ketela, PhD^7*, Adam C. Smith, PhD^8,9*, Anne Tierens, MD, PhD^8,9, Mark D. Minden, MD, PhD¹, Zhaolei Zhang, PhD^2,3,10* and Dennis Dong Hwan Kim, MD, PhD^1,11*

¹Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada
²Department of Computer Science, University of Toronto, Toronto, ON, Canada
³The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada
⁴Center for Hematologic Malignancy, National Cancer Center, Goyang, Korea, Republic of (South)
⁵Department of Clinical Laboratory Genetics, Genome Diagnostics Laboratory Medicine Program, University of Toronto, Toronto, ON, Canada
⁶National Health Insurance Service Ilsan Hospital, Ilsan, Korea, Republic of (South)
⁷Princess Margaret Genomics Centre, University Health Network, Toronto, ON, Canada
⁸Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
⁹Laboratory Medicine Program, University Health Network, Toronto, ON, Canada
¹⁰Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
¹¹Hans Messner Allogeneic Blood and Marrow Transplant Unit, Princess Margaret Cancer Centre, Toronto, Canada

Richard J Marrero, PharmD¹, Abdelrahman H Elsayed, MSc², Xueyuan Cao^3*, Huiyun Wu, PhD^4*, Lei Wang, MS^4*, Raul C Ribeiro, MD³, Jeffrey E. Rubnitz, MD⁵, Stanley B Pounds, PhD^4* and Jatinder K. Lamba, PhD⁶

¹Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, GAINESVILLE, FL
²Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL
³St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁶Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, Pharmacotherapy and Translational Re, Gainesville, FL

Brian Ball, MD¹, Shukaib Arslan, MD², Paul Koller, MD², Joyce Murata-Collins, PhD³, Michelle Afkhami, MD^4*, Raju Pillai, MD^4*, Karl Gaal, MD^1*, Amandeep Salhotra, MD², Monzr M. Al Malki, MD², Ahmed Aribi, MD², Haris Ali, MD², Salman Otoukesh, MD^2*, Idoroenyi Amanam, MD², Ryotaro Nakamura, MD², Eileen P. Smith, MD², Forrest Stewart, MD^1*, Guido Marcucci, MD⁵, Vinod A. Pullarkat, MD⁶ and Ibrahim Aldoss, MD²

¹City of Hope National Medical Center, Duarte, CA
²Department of Hematology/HCT, City of Hope National Medical Center, Duarte, CA
³City of Hope Medical Center, Duarte, CA
⁴Department of Pathology, City of Hope National Medical Center, Duarte, CA
⁵Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁶Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA

Amer M. Zeidan, MD¹, Maya Ridinger, PhD^2*, Peter J.P. Croucher, PhD^2*, Errin Samuëlsz^2*, Mark Erlander, PhD^2*, Katherine L. Ruffner, MD² and Eunice S. Wang, MD³

¹Department of Internal Medicine, Section of Hematology, Yale University School of Medicine, East Haven, CT
²Cardiff Oncology, San Diego, CA
³Roswell Park Comprehensive Cancer Center, BUFFALO, NY

Yazan Numan, MD^1,2, Hamza Tariq, MD³, Jie Fan^1*, Ping Xie^1*, Madelyn Burkart, MD¹, Yasmin Abaza, MD¹, Yi-Hua Chen, MD^3*, Shira Dinner, MD¹, Olga Frankfurt, MD^1*, Jayesh Mehta, MD^4*, Hui Zhang, PhD^5*, Jessica K. Altman, MD^1,2 and Bin Zhang, MD/Ph.D^1*

¹Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL
²Robert H. Lurie Comprehensive Cancer Center, Chicago, IL
³Division of Hematopathology, Northwestern University Feinberg School of medicine, Chicago, IL
⁴Stem Cell Transplantation and Cell Therapy Program, Northwestern University Fienberg School of Medicine, Chicago, IL
⁵Biostatistics, Preventive Medicine; Feinberg School of Medicine; Northwestern University, Chicago, IL

Chad A Hudson, MD, PhD, Laura Pardo^*, Loren L. Lott^*, Michael R. Loken, PhD^* and Lisa Eidenschink Brodersen, PhD

Hematologics, Inc., Seattle, WA

Yahan Li^1,2*, Xue Sun^1,3*, Xin Wang, MD, PhD^1,3,4 and Xiaosheng Fang, MD, PhD^3,5*

¹Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
²Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, AL, China
³Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
⁴School of Medicine, Shandong University, Jinan, China
⁵Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China

Irene Graf, MD^1*, Georg Greiner, MD^2*, Rodrig Marculescu, MD^3*, Karoline V. Gleixner, MD^1,4*, Susanne Herndlhofer^1*, Gabriele Stefanzl^1*, Paul Knoebl, MD^1*, Ulrich Jaeger¹, Alexander Hauswirth, MD^1*, Ilse Schwarzinger, MD^3*, Renate Thalhammer, MD^3*, Michael Kundi^5*, Gregor Hoermann, MD^4,6, Gerlinde Mitterbauer-Hohendanner, MD^3*, Peter Valent, MD^1,4 and Wolfgang R. Sperr, MD^1,4*

¹Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
²Medical Diagnostic Laboratories, Ihr Labor, Vienna, Austria
³Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
⁴Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
⁵Institute of Environmental Health, Medical University of Vienna, Vienna, Austria
⁶MLL Munich Leukemia Laboratory, Munich, Germany

Alessandro Paoli^1*, Daniela Bellarosa, PhD^1*, Alessandro Bressan^1*, Francesco Bertolini, MD, PhD², Scott R. Solomon, MD³, Pau Montesinos, PhD, MD^4*, Sudipto Mukherjee, MD, PhD, MPH⁵, Stephen A Strickland⁶, Giovanni Marconi, MD^7*, Armando Santoro^8*, Roland B. Walter, MD⁹, Rachel J. Cook, MD¹⁰, Maria Calbacho, MD^11*, Susana Vives^12*, Salman Fazal, MD^13*, Farhad Ravandi, MB Bs¹⁴, Krzysztof Brzozka, PhD^15*, Tomasz Rzymski, PhD^15*, Milena Mazan^15*, Simone Baldini, MD^1*, Niccolò Ravenni^1*, Monica Binaschi, PhD^1*, Dirk Laurent, MD^1* and Andrea Pellacani, PhD, MD^1*

¹Menarini Group, Florence, Italy
²European Institute of Oncology, Milano, ITA
³Leukemia Program, Northside Hospital Cancer Center Institute, Atlanta, GA
⁴Hospital Universitari i Politècnic La Fe, Valencia, Spain
⁵Cleveland Clinic, Cleveland, OH
⁶Vanderbilt-Ingram Cancer Center, Nashville, TN
⁷Hematology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy
⁸Humanitas Clinical and Research Center IRCCS, Humanitas University, Milano, Italy
⁹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
¹⁰Knight Cancer Institute, Oregon Health and Science University, Portland, OR
¹¹Department of Hematology, Hospital Universitario 12 de Octubre, Madrid, Spain, Spain
¹²ICO-Hospital Germans Trias i Pujol, Badalona, ESP
¹³Allegheny Health Network Cancer Institute, Pittsburgh, PA
¹⁴MD Anderson Cancer Center, Houston, TX
¹⁵Ryvu Therapeutics, Cracow, Poland

James M. Foran, MD^1,2, Michael G. Heckman, MS^3*, Yesesri Cherukuri^4*, Mikolaj Wieczorek^3*, Zaid Abdel Rahman, MD^5,6, Liuyan Jiang, MD⁷, Hemant S. Murthy, MD⁸, Laura Finn, MD⁹, Talha Badar, MD¹⁰, Lisa Z. Sproat, MD¹¹, Yanyan Lou, MD^12*, James R. Cerhan, MD, PhD¹³ and Yan Asmann, PhD¹⁴

¹Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic Florida, Jacksonville, FL
²Mayo Clinical Cancer Center, Jacksonville, FL
³Biostatistics & Health Sciences Research, Mayo Clinic, Jacksonville, FL
⁴Mayo Clinic, Jacksonville, FL
⁵Stem Cell Transplantation and Cellular therapies, University of Texas MD Anderson Cancer Center, Houston, TX
⁶Stem Cell Transplantation and Cellular Therapies, University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL
⁸Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL
⁹Ochsner Medical Center, New Orleans, LA
¹⁰Division of Hematology and Oncology, Mayo Clinic, Florida
¹¹Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ
¹²Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL
¹³Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
¹⁴Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL

Tommaso Matteuzzi, PhD^1*, Daniele Dall'Olio, PhD^1*, Eric Sträng, PhD^2*, Alessandra Merlotti, PhD^1*, Javier Martinez Elicegui, PhD^3*, Axel Benner, PhD^4*, Maral Saadati, PhD^5*, Julia Krzykalla, PhD^4*, Caroline A. Heckman, PhD⁶, Ana Heredia Casanoves^7*, Jurjen Versluis^8*, María Abáigar^3*, Alberto Hernandez-Sanchez^3*, Laura Jamilis^7*, Peter JM Valk, PhD⁹, Klaus H. Metzeler, MD¹⁰, Rosa Ayala^11*, Joaquin Martinez Lopez^12*, Herve Dombret, MD, PhD¹³, Pau Montesinos, PhD, MD^14*, Jorge Sierra, MD, PhD¹⁵, Claude Preudomme^16*, Frederick Damm^2*, Ken I Mills¹⁷, Raúl Azibeiro Melchor^3*, Jiří Mayer, Prof, MD¹⁸, Christian Thiede, MD¹⁹, Maria Teresa Teresa Voso, MD²⁰, Sergio Amadori, MD²⁰, Guillermo Sanz, MD, PhD²¹, Frederico Calado^22*, Konstanze Döhner, MD²³, Verena I Gaidzik, MD²⁴, Michael Heuser, Prof., MD^25*, Torsten Haferlach, MD²⁶, Marta Sobas^27*, Amin T. Turki, MD²⁸, Dirk Reinhardt, MD²⁸, Rubén Villoria Medina^7*, Michel van Speybroeck, MSc^29*, Renate Schulze-Rath^30*, Jesús M Hernández Rivas, MD, PhD³, Brian J.P Huntly, MB ChB, FRCPath, FMedSci, PhD^31*, Hartmut Döhner, MD³², Gert J. Ossenkoppele, M.D., Ph.D.³³, Castellani Gastone, PhD^34* and Lars Bullinger²

¹Physics and Astronomy Department, University of Bologna, Bologna, Italy
²Charité Universitätsmedizin Berlin, Berlin, Germany
³Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
⁴Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁵Saadati Solutions, Ladenburg, Germany
⁶Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
⁷GMV Innovating Solutions, Valencia, Spain
⁸Erasmus University Medical Center Cancer Institute, Rotterdam, Rotterdam, Netherlands
⁹Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands
¹⁰Department of Hematology, Cell Therapy and Hemostaseology, University of Munich, Leipzig, Germany
¹¹Department of Hematology, Hospital Universitario 12 de Octubre, Madrid, Spain
¹²Hematology Department Hospital 12 de Octubre, Hematological Malignancies Clinical Research Unit H12O-CNIO, Madrid, Spain
¹³Hematology, Hôpital Saint-Louis, Paris, France
¹⁴Hospital Universitario y Politécnico La Fe, Valencia, Spain
¹⁵Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
¹⁶University Hospital, Lille, France
¹⁷Patrick G Johnston Centre for Cancer Research, Queens University Belfast, Belfast, United Kingdom
¹⁸University Hospital Brno, Brno, Czech Republic
¹⁹Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
²⁰University of Roma Tor Vergata, Rome, Italy
²¹Hematology Deparment, Hospital Universitario La Fe, Valencia, Spain
²²Novartis, Oncology Region Europe, Basel, Switzerland
²³Ulm University Hospital, Ulm, Germany
²⁴Internal Medicine III, Internal Medicine III, Ulm, Germany
²⁵Department for Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²⁶MLL Munich Leukemia Laboratory, Munich, Germany
²⁷Department of Hematology, Wroclaw Medical University, Wroclaw, Poland
²⁸Essen University Hospital, Essen, Germany
²⁹Data Sciences, Janssen Pharmaceutica N.V., Beerse, Belgium
³⁰Bayer Pharma AG, Berlin, Berlin, Germany
³¹Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom
³²Internal Medicine III, University of Ulm, Ulm, Germany
³³Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands
³⁴Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, Bologna, Italy

Maria Rodriguez Zabala, MSc^1*, Ramprasad Ramakrishnan, PhD^1*, Katrin Reinbach, BSc^1*, Leal Oburoglu, PhD^2*, Somadri Ghosh, PhD^1*, Ton Falqués, PhD^1*, Pablo Peña-Martínez, PhD^1*, Noelia Puente-Moncada, PhD^1*, Thoas Fioretos, MD^1*, Anna Hagstroem-Andersson, PhD¹, Niels-Bjarne Woods, PhD^2* and Marcus Järås, PhD¹

¹Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden
²Division of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden

Francesca Tiso, MSc^1*, Thessa N. Koorenhof-Scheele^1*, Erik Huys^1*, Joost H.A. Martens^2*, Aniek O. De Graaf, PhD^1*, Bert A. van der Reijden, PhD³, Saskia M. C. Langemeijer, MD, PhD^4*, Frank W. M. B. Preijers^1*, Leonie I. Kroeze^5* and Joop H. Jansen, PhD¹

¹Department of laboratory medicine – laboratory of hematology, Radboudumc, Nijmegen, Netherlands
²Department of Molecular Biology, Radboud Institute of Molecular Life Sciences, Nijmegen, Netherlands
³Department of laboratory medicine – laboratory of hematology, Radboudumc, Nijmegen, GL, Netherlands
⁴Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
⁵Department of Pathology, Radboudumc, Nijmegen, Netherlands

Jamie A Moore, BSc, MSc^1*, Jayna J Mistry, BSc^1*, Charlotte Hellmich^2*, Rebecca H Horton^3*, Edyta Wojtowicz, PhD^4*, Aisha Jibril, BSc^5*, Tom Wileman, PhD^6*, Matthew Jefferson^2*, Naiara Beraza, PhD^7*, Kristian M Bowles, MBBS, PhD^8,9 and Stuart A Rushworth, PhD¹

¹Norwich Medical School, University of East Anglia, Norwich, United Kingdom
²The University of East Anglia, Norwich, GBR
³Norwich Medical School, The University of East Anglia, Norwich, United Kingdom
⁴Norwich Research Park, Earlham Institute, Norwich, ENG, United Kingdom
⁵Norwich Medical School, University of East Anglia, Norwich, ENG, United Kingdom
⁶Quadram Institute, Norwich, United Kingdom
⁷Quadram Institute Bioscience, Norwich, United Kingdom
⁸Norwich Medical School, Norwich, United Kingdom
⁹Department of Haematology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom

Fabio Guolo, MD^1,2*, Paola Minetto, MD¹, Marino Clavio, MD^1*, Maurizio Miglino, PhD^1*, Riccardo Marcolin, MD^1*, Monica Passannante, MD^1*, Carola Riva, MD^1*, Michela Frello, MD^1*, Chiara Vernarecci, MD^1*, Elisabetta Tedone^3*, Nicoletta Colombo, PhD^3*, Enrico Carminati^1*, Girolamo Pugliese^1*, Clara Nurra^1*, Antonia Cagnetta, MD^1*, Michele Cea^1,2*, Marco Gobbi, MD^1* and Roberto M. Lemoli, MD^1,2

¹Clinic of Hematology, Department of Internal Medicine (DiMI), IRCCS Ospedale Policlinico San Martino, Genova, Italy
²Clinic of Hematology, Department of Internal Medicine (DiMI), Policlinico San Martino, IRCCS per l’Oncologia, University of Genoa, Genoa, Italy
³Clinical Flow Cytometry Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy

Muharrem Muftuoglu, MD¹, Li Li, M.D.^2*, Mahesh Basyal, BSc^1*, Shaoheng Liang^3*, Carissa J. Ball^4*, Ken Chen, PhD^3*, Prasanna Kumar, PhD^5*, Arnaud Lesegretain^5*, Naval Daver, MD⁶ and Michael Andreeff, MD, PhD¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston
⁵Daiichi Sankyo Inc., Basking Ridge, NJ
⁶MD Anderson Cancer Center, Houston, TX

Stefan G.C. Mestrum^1,2*, Roanalis B.Y. Vanblarcum^1*, Roosmarie J.M. Drent^3*, Norbert C.J. De Wit^4*, Bert T. Boonen^5*, Wouter L.W. van Hemert^5*, Anton H.N. Hopman^6*, Frans C.S. Ramaekers^6* and Mathie P.G. Leers³

¹Department of Clinical Chemistry & Hematology, Zuyderland Medical Center, Sittard-Geleen, Netherlands
²Department of Molecular Cell Biology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, AL, Netherlands
³Zuyderland Medical Center, Sittard-Geleen, Netherlands
⁴Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, Netherlands
⁵Department of Orthopedic Surgery, Zuyderland Medical Center, Heerlen, Netherlands
⁶Department of Molecular Cell Biology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands

Eunice S. Wang, MD¹, Jessica K. Altman, MD², Mark D. Minden, MD, PhD³, Ruishan Wu, MS^4*, Elizabeth Shima Rich, MD, PhD⁴ and Jason E. Hill, PhD^4*

¹Roswell Park Comprehensive Cancer Center, BUFFALO, NY
²Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
³Princess Margaret Hospital, Toronto, Canada
⁴Astellas Pharma, Inc., Northbrook, IL

Jennifer Lauren Kamens, MD¹, Anitria Cotton, MBA^2*, Jeannie W Lam, BS^1*, Jinjun Dang, PhD^1*, Aman Seth, MS^3*, Baranda S Hansen^4*, Shondra M. Pruett-Miller, PhD^4*, Anang Shelat, PhD^5* and Tanja Andrea Gruber, MD¹

¹Department of Pediatrics; Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Palo Alto, CA
²Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN
³Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN
⁴Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN

Fieke W Hoff, MD^1*, Yihua Qiu^2*, Brandon Brown, MD^3*, Robert B. Gerbing, MA^4*, Alan S. Gamis, MD, MPH⁵, Richard Aplenc, MD, PhD⁶, Edward A. Kolb, MD⁷, Todd A. Alonzo, PhD^8*, Soheil Meshinchi, M.D., Ph.D.⁹, Gaye Jenkins^10*, Terzah M. Horton, MD, PhD¹¹ and Steven Kornblau, MD^12,13

¹UT Southwestern Medical Center, Dallas, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Pediatrics, UT MD Anderson Cancer Center, Houston
⁴Children's Oncology Group, Monrovia, CA
⁵Children's Mercy Kansas City, Kansas City, MO
⁶Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
⁷Division of Oncology, Nemours Alfed I. duPont Hospital For Children, Wilmington, DE
⁸Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA
⁹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
¹⁰Baylor College of Medicine, Houston
¹¹Baylor College of Medicine, Houston, TX
¹²Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹³Leukemia / Stem cell Transplantation & Cellular Therapy, UT MD Anderson Cancer Center, HOUSTON, TX

Antonella Padella, PhD^1*, Stephan Hutter, PhD^2*, Wencke Walter, PhD^2*, Constance Baer, PhD², Andrea Ghelli Luserna Di Rorà, PhD^1*, Martina Ghetti, PhD^1*, Lorenzo Ledda^1*, Matteo Paganelli^1*, Claudia Haferlach, MD², Wolfgang Kern, MD², Giorgia Simonetti, PhD^1*, Giovanni Martinelli, MD³ and Torsten Haferlach, MD²

¹Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy
²MLL Munich Leukemia Laboratory, Munich, Germany
³Scientific Directorate, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy

Pia Michler^1*, Franziska Auer², Rabea Wagener^3*, Triantafyllia Brozou^3*, Ulrike Anne Friedrich^1*, Carolin Walter^4*, Martin Dugas^4,5*, Arndt Borkhardt³, Friedrich Stölzel^6* and Julia Hauer^1,2*

¹Pediatric Hematology and Oncology, Department of Pediatrics, University Hospital "Carl Gustav Carus", TU Dresden, Dresden, Germany
²National Center for Tumor Diseases (NCT), Dresden, Germany
³Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany
⁴Institute of Medical Informatics, University of Muenster, Muenster, Germany
⁵Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany
⁶Department of Hematology and Oncology, University Hospital “Carl Gustav Carus”, TU Dresden, Dresden, Germany

Mihee Kim, MD^1*, Taehyung Kim, MSc^2,3, Seo-Yeon Ahn, MD^1*, Sung-Hoon Jung, MD^1*, Ga-Young Song^1*, Deok-Hwan Yang, MD, PhD^1*, Je-Jung Lee, MD, PhD¹, Seunghyun Choi, PhD^4*, MiYeon Kim^4*, Jae-Sook Ahn, MD, PhD^1,4*, Hyeoung-Joon Kim, MD, PhD^1,4 and Dennis Dong Hwan Kim, MD, PhD^5*

¹Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Jeollanam-do, Korea, Republic of (South)
²The Donnelly Centre for Cellular and Biomolecular Research, Donnelly Centre For Cellular & Biomolecular Research, Toronto, ON, Canada
³The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada
⁴Genomic Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Jeollanam-do, Korea, Republic of (South)
⁵Hans Messner Allogeneic Blood and Marrow Transplant Unit, Princess Margaret Cancer Centre, Toronto, Canada

Adam J. Lamble, MD¹, Robert B. Gerbing, MA^2*, Jenny L. Smith, MSc, MEd^3*, Rhonda E. Ries, MA^3*, Edward A. Kolb, MD⁴, Todd A. Alonzo, PhD^2,5* and Soheil Meshinchi, M.D., Ph.D.³

¹Division of Hematology and Oncology, Seattle Children's Hospital, Seattle, WA
²Children's Oncology Group, Monrovia, CA
³Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁴Division of Oncology, Nemours Alfed I. duPont Hospital For Children, Wilmington, DE
⁵Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA

Sonali P. Barwe, PhD, MSc¹, Erin Lynn Crowgey, PhD^1*, Qinzhuo Zhang^1*, E. Anders Kolb, MD¹ and Anilkumar Gopalakrishnapillai, PhD, MSc²

¹Nemours Center for Cancer and Blood Disorders, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE
²Nemours Center for Cancer and Blood Disorders, Nemours, Wilmington, DE

Agnieszka Wierzbowska, MD, PhD¹, Agnieszka Pluta, MD, PhD^2*, Anna Czyz, MD PhD^3*, Marta Antonina Libura, MD PhD^4*, Sebastian Giebel, MD, PhD^5*, Magdalena Czemerska, MD PhD^2*, Piotr Stelmach, MD PhD^2*, Michal Soin, M.Sc.^2*, Anna Kopinska, MD^6*, Krzysztof Wozniczka, MD PhD^6*, Grzegorz Helbig, MD PhD^6*, Marta Sobas^3*, Tomasz Wróbel, MD, PhD³, Andrzej Szczepaniak, MD PhD^7*, Lidia Gil, MD, PhD⁷, Karol Wojcik, MD^8*, Malgorzata Razny, MD PhD^8*, Magdalena Dutka, MD, PhD^9*, Maria Bieniaszewska, MD, PhD^10*, Janusz Halka, MD PhD^11*, Tomasz Gromek, MD PhD^12*, Marek Hus, MD PhD^12*, Elzbieta Patkowska, MD, PhD^13*, Jolanta Wozniak, PhD^14*, Edyta Cichocka, MD PhD^15*, Agata Obara, MD^16*, Agnieszka Kopacz, MD, PhD^17*, Katarzyna Dulik, MD^5*, Jerzy Holowiecki, MD PhD^5*, Damian Mikulski^18*, Ewelina Perdas, Ph.D.^19*, Wojciech Fendler, M.D., Ph.D.^19*, Nicole M. Cruz, MD²⁰, Nuria Mencia-Trinchant, PhD^20*, Pinkal Desai, MD, MPH²¹, Sangmin Lee, MD²¹, Michael B. Samuel, MD^22*, Justin D. Kaner, MD²³, Ellen Ritchie, MD ²⁴, Monica L. Guzman, PhD²¹ and Gail J. Roboz, MD²⁵

¹Department of Hematology, Copernicus Memorial Hospital, Łódź, Poland
²Department of Hematology, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland
³Department of Hematology, Wroclaw Medical University, Wroclaw, Poland
⁴Department of Hematology, Oncology and Internal Medicine, Warsaw Medical University, Warsaw, Poland
⁵Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
⁶Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Katowice, Poland
⁷Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, Poland
⁸Department of Hematology, Rydygier Specialist Hospital, Krakow, Poland
⁹Department of Hematology, Medical University of Gdansk, Gdansk, Poland
¹⁰Department of Hematology, Medical University of Gdansk, Gdańsk, Poland
¹¹Department of Hematology, Warmian-Masurian Cancer Center of The Ministry of the Interior and Administration’s Hospital, Olsztyn, Poland
¹²Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland
¹³Hematology Department, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
¹⁴Division of Hematological Diagnostics, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
¹⁵Department of Hematology and Bone Marrow Transplantation, Copernicus Memorial Hospital, Torun, Poland
¹⁶Department of Hematology, Holly Cross Oncology Center, Kielce, Poland
¹⁷Department of Hematology, Medical University of Rzeszow, Rzeszow, Poland
¹⁸Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland
¹⁹Department of Biostatistics and Translational Medicine, Medical University of Lodz, Łódź, Poland
²⁰Division of Hematology and Oncology, Weill Cornell Medicine and The New York-Presbyterian Hospital, New York, NY
²¹Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY
²²Division of Hematology and Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
²³Department of Internal Medicine, Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY
²⁴Division of Hematology and Oncology, Weill Cornell Medical College New York Presbyterian, New York, NY
²⁵Division of Hematology Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY

Katherine Tarlock, MD^1,2, Leila Robinson^2*, Todd A. Alonzo, PhD^3,4*, Robert B. Gerbing, MA^3*, Yi-Cheng Wang, MS^3*, Rhonda E. Ries, MA^2*, Amanda R. Leonti, MS^2*, Jenny L. Smith, MSc, MEd^2*, Tiffany A. Hylkema, BS^2*, Quy Le, PhD^2*, Xiaotu Ma, PhD^5*, E. Anders Kolb, MD⁶, Richard Aplenc, MD, PhD⁷, Jessica A. Pollard, MD^8,9 and Soheil Meshinchi, M.D., Ph.D.^2,10

¹Division of Hematology and Oncology, Seattle Children's Hospital, Seattle, WA
²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
³Children's Oncology Group, Monrovia, CA
⁴Department of Preventive Medicine, University of Southern California, Monrovia, CA
⁵Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN
⁶Nemours Center for Cancer and Blood Disorders, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE
⁷Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁸Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA
⁹Harvard Medical School, Boston, MA
¹⁰Department of Pediatrics, University of Washington, Seattle, WA

Hope L Mumme, BSc^1*, Swati S Bhasin, PhD², Beena E Thomas, Ph.D^1*, Deborah DeRyckere, BS, PhD^1,2, Sharon M. Castellino, MD, MSc^2,3, Douglas K Graham, MD, PhD^2,3, Sunil S. Raikar, MD^3,4 and Manoj Bhasin, PhD²

¹Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA
²Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
³Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
⁴Aflac Cancer and Blood Disorders Center, Emory University/Children's Healthcare of Atlanta, Atlanta, GA

Vivek M. Shastri, PhD¹, Lata Chauhan, PhD^1*, Todd A. Alonzo, PhD^2*, Yi-Cheng Wang, MS^3*, Richard Aplenc, MD, PhD⁴, Betsy A Hirsch, PhD^5*, Alan S. Gamis, MD, MPH⁶, Soheil Meshinchi, M.D., Ph.D.⁷ and Jatinder K. Lamba, PhD⁸

¹Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL
²Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA
³Children's Oncology Group, Monrovia, CA
⁴Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁵Division of Molecular Pathology and Genomics, University of Minnesota, Minneapolis, MN
⁶Hematology/Oncology, Children's Mercy Hospitals and Clinics, Kansas City, MO
⁷Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁸Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, Pharmacotherapy and Translational Re, Gainesville, FL

Anne-Sofie Skou, MD^1*, Kristian Løvvik Juul-Dam, MD, PhD^2*, Erik Delsing Malmberg, MD, PhD^3*, Anna Rehammar^4*, Anastasia Soboli^5*, Azadeh Anbarlou, MA^6*, Erik Kristiansson^7*, Jonas Abrahamsson, MD, PhD^8*, Bernward Zeller, MD, PhD^9*, Kirsi Jahnukainen, MD, PhD^10*, Edwin Sonneveld, MSc, PhD^11*, Birgitte Lausen, MD, PhD¹², Anni Aggerholm, MSc, PhD^13*, Hans Beier Ommen, MD, PhD^13*, Henrik Hasle, MD, PhD² and Linda Fogelstrand, MD, PhD⁵

¹Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus N, Denmark
²Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
³Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden
⁴School of Public Health and Community Medicine/Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
⁵Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
⁶Department of Laboratory Medicine, University of Gothenburg, Gothenburg, Sweden
⁷Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden
⁸Department of Pediatrics, Queen Silvia Children's Hospital, Gothenburg, Sweden
⁹Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway
¹⁰Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
¹¹Princess Máxima Center for Pediatric Oncology and Dutch Childhood Oncology Group, Utrecht, Netherlands
¹²Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark
¹³Department of Hematology, Aarhus University Hospital, Aarhus, Denmark

Tsz-Kwong Man, PhD^*, Mohammad Javad Najaf Panah, MS^*, Jessica L. Elswood, PhD^*, Pavel Sumazin, PhD^* and Michele S. Redell, MD PhD

Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX

Tong-Yoon Kim, MD^1*, Byung Sik Cho, M.D., Ph.D.^2*, Gi June Min, M.D., Ph.D.², Sung-Soo Park, M.D., Ph.D.^2*, Silvia Park, M.D., Ph.D.^3*, Jae-Ho Yoon, MD², Sung-Eun Lee, M.D., Ph.D.^4*, Ki-Seong Eom, M.D., Ph.D.^2*, Yoo-Jin Kim, M.D., Ph.D.², Seok Lee, M.D., Ph.D.², Chang-Ki Min, M.D., Ph.D.^2*, Seok-Goo Cho, M.D., Ph.D.^5*, Dong-Wook Kim, M.D., Ph.D.⁵, Jong-Wook Lee, MD⁵ and Hee-Je Kim, M.D., Ph.D.²

¹Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
²Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
³Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Gangnam-Gu, Korea, Republic of (South)
⁴Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, TX, Korea, Republic of (South)
⁵Department of Hematology, The Catholic University of Korea, Seoul, Korea, Republic of (South)

Sarah Grasedieck^1*, Ariene Cabantog^2*, Liam MacPhee², Junbum Im³, Christoph Rueß, MSc^4*, Burcu Demir^5*, Nadine Sperb, PhD^4*, Frank G. Rücker, MD^6*, Konstanze Döhner, MD⁷, Tobias Herold, MD⁸, Jonathan R. Pollack, MD, PhD^9*, Lars Bullinger¹⁰, Arefeh Rouhi, PhD^11* and Florian Kuchenbauer, MD, PhD, FRCPC¹¹

¹Michael Smith Laboratories, Dept of Microbiology and Immunology, 2125 East Mall, University of British Columbia, Vancouver, Canada
²BC Cancer Agency, Terry Fox Laboratory, Vancouver, BC, Canada
³BC Cancer Agency, Terry Fox Laboratory, Vancouver, BC, CAN
⁴Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
⁵Dept of Internal Medicine III, Ulm University Hospital, Ulm, Germany
⁶Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
⁷University Hospital of Ulm, Ulm, Germany
⁸Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, LMU, Munich, Germany
⁹Stanford Univ., Stanford, CA
¹⁰Department of Hematology, Oncology and Tumor Immunology, Campus Virchow, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
¹¹Terry Fox Laboratory BC Cancer Agency, Vancouver, BC, Canada

Stuart Scott, BSc^1,2*, Richard Dillon, MD PhD^3,4, Christian Thiede, MD^5,6, Sadia Sadiq, BSc^7*, Ashley Cartwright, PhD^8*, Clouston Hazel, PhD^9*, Debbie Travis, PhD^9*, Andrew D Chantry, PhD, MD^10,11* and Liam Whitby, BSc^9*

¹Department of Oncology and Metabolism, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom
²UK NEQAS for Leucocyte Immunophenotyping, University of Sheffield, Sheffield, ENG, United Kingdom
³Department of Medical and Molecular Genetics, King's College, London, United Kingdom
⁴Department of Haematology, Guy's International Centre of Excellence in Myeloid Disorders, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
⁵Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Dresden, Germany
⁶AgenDix, Angewandte molekulare Diagnostik mbH, Dresden, Germany
⁷UK NEQAS for Leucocyte Immunophenotyping, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
⁸UK NEQAS for Leucocyte Immunophenotyping, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffied, United Kingdom
⁹UK NEQAS for Leucocyte Immunophenotyping, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
¹⁰Department of Haematology, Sheffield Teaching Hospitals, Sheffield, United Kingdom
¹¹Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom

Luis Miguel Veiga Veiga Nobre, PhD^1*, Salvatore Federico Pedicona, PhD^2*, Arran Dokal, MSc, PhD^3,4*, Andrea Arruda, MSc^5*, Ryan Smith, PhD^3,4*, Calum Greenhalgh, PhD^6*, Francesca Patella^7*, Pedro Casado-Izquierdo^8*, Bela Wrench, MBBS, MD^3*, Jane Theaker^1*, Andrew Thompson^1*, Mark D. Minden, MD, PhD⁹, John G. Gribben, MD, DSc, FRCP, FMedSci, FRCPath⁸, David James Britton, BSc, PhD^3,4* and Pedro Cutillas, PhD^10*

¹Kinomica Ltd, Macclesfield, United Kingdom
²Barts Cancer Institute, QMUL, London, United Kingdom
³Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⁴Kinomica Ltd., Macclesfield, United Kingdom
⁵Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁶Kino, Macclesfield, United Kingdom
⁷Kinomica, Macclesfield, GBR
⁸Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⁹Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
¹⁰Centre for Genomics and Computational Biology, Queen Mary University of London, London, United Kingdom

Maher Albitar, MD^1*, Andrew Ip, MD, MSc², Andre H. Goy, MD^3*, Jeffrey Justin Estella, BS, MS^1*, Ivan De Dios, BS^1*, Wanlong Ma^1*, Andrew L. Pecora, MD^4*, Jamie Koprivnikar, MD^5* and James K McCloskey, MD⁵

¹Genomic Testing Cooperative, Irvine, CA
²Division of Lymphoma, Division of Outcomes and Value Research, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ
³Division of Lymphoma, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ
⁴John Theurer Cancer Center, Hackensack Meridian Health, Division of Multiple Myeloma, Hackensack, NJ
⁵Division of Leukemia, John Thuerer Cancer Center at Hackensack University Medical Center, Hackensack, NJ

Markus D Lacher, PhD^1*, Michelle A Richardson, MS^1*, Steven A Schaffert, PhD^1*, Ryosuke Kita, MD, PhD^1*, Marianne T Santaguida, PhD, BSc^1*, Erica K Anderson, MS^1*, Jordan Roselli, MS^1*, Wade Anderson, PhD^1*, Arisa Paul, MS^1*, Christine Gu, MS^1*, Kathryn Vanderlaag, PhD^1*, Zhihong Zeng, MD^2*, Abhishek Maiti, MBBS², Courtney D. DiNardo, MD, MSCE² and Marina Konopleva, MD, PhD²

¹Notable Labs, Foster City, CA
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Pierre Peterlin^1*, Camille Debord, PharmD^2*, Alice Garnier, MD^3*, Amandine Le Bourgeois, MD^3*, Thierry Guillaume, MD, PhD^4*, Marion Eveillard^2*, Yannick Le Bris, PharmD, PhD^5*, Béatrice Mahé, MD^6*, Viviane Dubruille, MD^3*, Nicolas Blin, MD^3*, Anne Lok, MD^3*, Cyrille Touzeau, MD, PhD^7*, Thomas Gastinne, MD^8*, Benoit Tessoulin, MD, PhD^9*, Soraya Wuillème, PharmD, PhD^10*, Catherine Godon^11*, Olivier Theisen, MD^2*, Maxime Jullien, MD^3*, Sophie Vantyghem, MD^3*, Philippe Moreau, MD, PhD^12*, Steven Le Gouill¹³, Marie C Bene, PharmSci, PhD^14* and Patrice Chevallier, MD¹⁵

¹Clinical Hematology, HOPITAL HOTEL DIEU ET HME, NANTES CEDEX 1, France
²Hematology Biology, Nantes University Hospital, Nantes, France
³Clinical Hematology, Nantes University Hospital, Nantes, France
⁴CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France
⁵Department of Biological Hematology, Nantes University Hospital? hEMATOLOGY bIOLOGY, Nantes, France
⁶Centre Hospitalier Universitaire de Nantes, Nantes, France
⁷Hématologie, CHU de Nantes, Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Nantes, France
⁸Clinical Hematology, University Hospital of Nantes,, Nantes Cedex 1, France
⁹Université de Nantes, CNRS, INSERM, CRCINA, Nantes, France, Nantes, France
¹⁰Hematology Biology, University Hospital Hôtel Dieu, Nantes, France
¹¹Hematology Biology, Nantes University Hospital, NANTES, FRA
¹²University Hospital Hôtel-Dieu, Nantes, Nantes, France
¹³Service d’hématologie clinique du CHU de Nantes, INSERM CRCINA Nantes-Angers, NeXT Université de Nantes, Nantes, France
¹⁴Nantes University Hospital, Hematology Biology, Nantes, France
¹⁵Department of Clinical Hematology, Nantes University Hospital, Nantes, France

Steven M. Johnson^1*, Lori Ramkissoon, PhD^1*, James Haberberger^2*, Naomi L Ferguson, MD^2*, Jonathan Galeotti, MD^1*, Daniel R. Richardson, MD, MA, MSc^3,4, Matthew C. Foster, MD^4,5*, Jeffrey Ross, MD^6*, Shakti H. Ramkissoon, MD, PhD^2,7*, Joshua F. Zeidner, MD^5,8, Daniel Duncan, MD^2* and Nathan Montgomery, MD, PhD^1,4

¹Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC
²Foundation Medicine, Inc., Morrisville, NC
³Division of Hematology/Oncology, Department of Medicine, The Ohio State University Wexner Medical Center, Chapel Hill, NC
⁴Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
⁵Division of Hematology/Oncology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC
⁶Foundation Medicine Inc, Cambridge, MA
⁷Wake Forest School Of Medicine, Winston-Salem, NC
⁸Lineberger Comprehensive Cancer Center, UNC - Lineberger Comprehensive Cancer Center, Chapel Hill, NC

Douglas RA Silveira, MD^1*, Prodromos Chatzikyriakou, PhD^2*, Olena Yavorska^3*, Sarah Mackie^2*, Roan Hulks^2*, Paulina Siejka-Zielinska^4*, Anna Corby, B.Sc.^5*, Alastair Smith^6*, Benjamin Brown, B.Sc., PhD^5*, Marlen Metzner, MSc^7*, Thomas A. Milne⁸, Virginie Penard-Lacronique, PhD^9,10*, Chunxiao Song^4*, Maroof Hasan, MD^11*, Anjan Thakurta, PhD^12*, Paresh Vyas, DPhil, FRCP, FRCPath, MRCP, MRCPath^13,14, Skirmantas Kriaucionis, PhD^15* and Lynn Quek, MBBCh, DPhil, MRCP (UK), FRCPath^2,16*

¹School of Cancer and Pharmaceutical Sciences, King's College London, London, ENG, United Kingdom
²School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
³Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
⁴University of Oxford, Oxford, United Kingdom
⁵MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁶MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁷Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁸MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁹Gustave Roussy, INSERM U1170, Université Paris-Saclay, Villejuif, France
¹⁰INSERM U1170, Universit, Villejuif, France
¹¹Bristol Myers Squibb, Princeton, NJ
¹²Translational Development and Diagnostics, Bristol Myers Squibb, Summit, NJ
¹³Department of Clinical Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
¹⁴Weatherall Institute of Molecular Medicine, Weatherall Inst. of Molecular Medicine, Oxford, United Kingdom
¹⁵Ludwig Institute for Cancer Research, University of Oxford, Oxford, United Kingdom
¹⁶Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom

Ruoyang Shao^* and Qifa Liu

Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China

Simon Renders, MD^1,2,3*, Aino-Maija Leppä, MSc^4,5*, Alexander Waclawiczek, PhD^5,6*, Maike Janssen, MD^7*, Elisa Donato, PhD^5,8*, Cecilia Reyneri^5,8*, Julia M. Unglaub, MD^7*, Michael Hundemer, MD^9*, Richard F. Schlenk, MD^9,10,11, Simon Raffel, MD^12,13, Carsten Müller-Tidow, MD^14*, Tim Sauer, MD^9* and Andreas Trumpp, PhD^2,15

¹Heidelberg University Hospital, Department of Internal Medicine V, Heidelberg, Germany
²Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany
³Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmBH), Heidelberg, Germany
⁴German Cancer Research Center (DKFZ), Division of Stem Cells and Cancer, Heideberg, DEU
⁵Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmBH), Heideberg, Germany
⁶DKFZGerman Cancer Research Center (DKFZ), Division of Stem Cells and Cancer, Heideberg, Germany
⁷Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
⁸German Cancer Research Center (DKFZ), Division of Stem Cells and Cancer, Heideberg, Germany
⁹Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
¹⁰German Cancer Research Center, NCT-clinical trials office, Heidelberg, Germany
¹¹National Center of Tumor Diseases, NCT-Trial Center, German Cancer Research Center, Heidelberg, Germany
¹²German Cancer Reseach Center, Heidelberg, Germany
¹³Heidelberg University Hospital, Department of Internal Medicine V, Heideberg, Germany
¹⁴Internal Medicine V - Hematology, Oncology & Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
¹⁵Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany

Cheryl A C Peretz, MD¹, Vanessa E Kennedy, MD², Rhonda E. Ries, MA^3*, Soheil Meshinchi, M.D., Ph.D.³ and Catherine C. Smith, MD⁴

¹Pediatric Oncology, UCSF, San Francisco, CA
²University of California- San Francisco, San Francisco, CA
³Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁴Division of Hematology and Blood and Marrow Transplantation, University of California (San Francisco), San Francisco, CA

Dorian Forte^1*, Roberto Maria Pellegrino^2*, Francesco Fabbri, PhD^3*, Ivan Vannini, PhD^3*, Samantha Bruno, PhD^1*, Giulia Corradi, PhD^1*, Rafael J. Argüello, PhD^4*, Gianluca Cristiano, MD^5*, Sandra Buratta, PhD^2*, Lorena Urbanelli, PhD^2*, Carla Emiliani, PhD^2,6*, Michele Cavo, MD, PhD^1,7* and Antonio Curti, MD, PhD⁷

¹Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology “L. e A. Seràgnoli”, University of Bologna, Bologna, Italy
²Department of Chemistry, Biology and Biotechnology, Biochemistry and Molecular Biology Section, University of Perugia, Perugia, Italy
³Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy
⁴Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France
⁵Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, Bologna, Italy
⁶Centro di Eccellenza sui Materiali Innovativi Nanostrutturati (CEMIN), University of Perugia, Perugia, Italy
⁷IRCCS Azienda ospedaliero-universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy

Isabel Weinhäuser, MSc^1,2*, Diego A Pereira-Martins, MSc^1*, Jacobien R Hilberink, BSc^3*, Luciana Yamamoto Almeida, PhD^4*, Douglas RA Silveira, MD^5,6*, Lynn Quek, MBBCh, DPhil, MRCP (UK), FRCPath^7,8*, Shanna M Hogeling, BSc MSc^1*, Jose Mauricio Mota, MD PhD^9*, Emanuele Ammatuna, MD. PhD^10*, Antonio R. Lucena-Araujo, PhD^11*, Gerwin A. Huls, MD PhD¹², Jan Jacob Schuringa, PhD^13,14* and Eduardo M Rego, MD, PhD^15,16

¹Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
²Center Cell Based Therapy Institution, University of Sao Paulo, Ribeirao Preto, Brazil
³Department of Experimental Hematology, University Medical Center Groningen, Groningen, NLD
⁴Internal Medicine, University of São Paulo, Ribeirão Preto, Brazil
⁵Cancer & Pharmaceutical Sciences, King's College London, London, United Kingdom
⁶AC Camargo, Sao Paulo, BRA
⁷School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
⁸Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom
⁹Campus Universitário, Monte Alegre, Ribeirão Preto, São Paulo, BRA
¹⁰Department of Hematology, University Medical Center Groningen, Groningen, NLD
¹¹Department of Genetic, Federal University of Pernambuco, Recife - PE, AC, BRA
¹²Department of Hematology, University Medical Center Groningen, Groningen, GZ, Netherlands
¹³Department of Hematology, University Medical Center - Groningen, Groningen, Netherlands
¹⁴Department of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, Groningen, Netherlands
¹⁵Medical Research Laboratory on Molecular Hematology (LIM-31), University of São Paulo, Sao Paulo, Brazil
¹⁶Center for Cell-based Therapy and Regional Hemotherapy Center, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Sao Paulo, Brazil

Ja Min Byun, MD¹, Changju Chun^2*, Youngil Koh, MD, PhD³ and Tae-Young Yoon, PhD^4*

¹Seoul National University Hospital, Seoul, South Korea
²Seoul National University, Seoul, AL, Korea, Republic of (South)
³Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
⁴Seoul National University, Seoul, Korea, Republic of (South)

Antonio R. Lucena-Araujo, PhD^1*, Diego A Pereira-Martins, MSc^2,3*, Juan L Coelho-Silva, PhD^4,5*, Isabel Weinhäuser, MSc^2*, Pedro Luis Franca-Neto, PhD^6*, Douglas RA Silveira, MD^7,8*, Marinus M Lima, MD^9*, Jan Jacob Schuringa, PhD^10,11*, Luisa C Koury, MD^4*, Raul Antônio Morais Melo, MD, PhD^12*, Rosane Bittencourt, MD^13*, Katia B Pagnano, MD, PhD^14*, Elenaide C. Nunes, MD^15*, Evandro Maranhão Fagundes, MD¹⁶, Fabio R. Kerbauy, MD^17*, Lorena Figueredo-Pontes, MD, PhD^18,19* and Eduardo M Rego, MD, PhD^19,20

¹Department of Genetic, Federal University of Pernambuco, Recife - PE, AC, BRA
²Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
³Division of Hematology, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
⁴Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
⁵Federal University of Pernambuco, Recife, Pe, BRA
⁶Genetics postgraduate program, Biosciences Center, Federal University of Pernambuco, Recife, Brazil
⁷Cancer & Pharmaceutical Sciences, King's College London, London, United Kingdom
⁸AC Camargo, Sao Paulo, BRA
⁹Department of Genetics, Federal University of Pernambuco, Recife, BRA
¹⁰Department of Hematology, University Medical Center - Groningen, Groningen, Netherlands
¹¹Department of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, Groningen, Netherlands
¹²Department of Internal Medicine, University of Pernambuco and Fundação HEMOPE, Recife, Brazil
¹³Hematology Division, University Hospital of the Federal University of Rio Grande do Sul, Porto Alegre, Brazil
¹⁴Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
¹⁵Hematology Division, University Hospital of the Federal University of Paraná, Curitiba, Brazil
¹⁶Hematology Division, Federal University of Minas Gerais, Belo Horizonte, Brazil
¹⁷Federal University of Sao Paulo, Sao Paulo, Brazil
¹⁸Department of Medical Imaging, Hematology, and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil
¹⁹Center for Cell-based Therapy and Regional Hemotherapy Center, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil
²⁰Medical Research Laboratory on Molecular Hematology (LIM-31), University of São Paulo, Sao Paulo, Brazil

Jacob Higgins, PhD^1*, Megan Othus, PhD², Laura W. Dillon, PhD, DABMGG^3*, Thomas H. Smith, PhD^1*, Elizabeth Schmidt, MS^1*, Jeffry Yaplee, BA^1*, Fang Yin Lo, PhD^1*, Charles C. Valentine III, MS^1*, Jesse J. Salk, MD, PhD¹, Brent L. Wood, MD, PhD⁴, Christopher S. Hourigan, DM DPhil³ and Jerald P. Radich, MD⁵

¹TwinStrand Biosciences, Seattle, WA
²Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA
³Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
⁴Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
⁵Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA