Angela C. Weyand, MD¹, Martin Chandler^2*, Carol Fedor, RN^2*, Kenneth D. Friedman, MD³, Sweta Gupta, MD^4*, Kristina M. Haley, DO⁵, Chunla He^2*, Nikki Hirsh^2*, Salley Pels, MD⁶, Jonathan C. Roberts, MD⁷, Tung T. Wynn, MD⁸ and Robert F. Sidonio Jr., MD, MSc⁹

¹Pediatrics, University of Michigan Medical School, Ann Arbor, MI
²American Thrombosis and Hemostasis Network, Rochester, NY
³Versiti BloodCenter of Wisconsin, Milwaukee, WI
⁴Indiana Hemophilia & Thrombosis Center, Indianapolis, IN
⁵The Hemophilia Center, Oregon Health Science University, Portland, OR
⁶Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI
⁷Bleeding & Clotting Disorders Institute, Peoria, IL
⁸University of Florida, Gainesville, FL
⁹Hemophilia of Georgia Center for Bleeding and Clotting Disorders, Emory University, Decatur, GA

Robert F. Sidonio Jr., MD, MSc¹, Christine Knoll², Flora Peyvandi^3,4*, Oleksandra Stasyshyn, MD, PhD^5*, Ali Bulent Antmen^6*, Seoh Leng Yeoh^7*, Darintr Sosothikul^8*, Caterina Maggiore^9*, Werner Engl^10*, Geoffrey Allen^11* and Srilatha Tangada¹¹

¹Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA
²Phoenix Children's Hospital, Phoenix, AZ
³Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⁴Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
⁵Academy of Medical Sciences of Ukraine, Lviv, Ukraine
⁶Acibadem Adana Hospital, Adana, Turkey
⁷Department of Pediatrics, Hospital Pulau Pinang, Penang, Malaysia
⁸Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⁹IQVIA, Milan, Italy
¹⁰Baxalta Innovations GmbH, a Takeda company, Vienna, Austria
¹¹Takeda Development Center Americas, Inc., Cambridge, MA

Robert F. Sidonio Jr., MD, MSc¹, Alexis A. Thompson, MD, MPH², Flora Peyvandi^3,4*, Canan Albayrak^5*, Seoh Leng Yeoh^6*, Joyce Lam^7*, Caterina Maggiore^8*, Werner Engl^9*, Geoffrey Allen^10* and Srilatha Tangada¹⁰

¹Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA
²Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
³Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⁴Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
⁵Department of Pediatric Hematology, Ondokuz Mayıs University, Samsun, Turkey
⁶Department of Pediatrics, Hospital Pulau Pinang, Penang, Malaysia
⁷KK Women's and Children's Hospital, Singapore, Singapore
⁸IQVIA, Milan, Italy
⁹Baxalta Innovations GmbH, a Takeda company, Vienna, Austria
¹⁰Takeda Development Center Americas, Inc., Cambridge, MA

Monet Howard^1*, Derrick McKinley^2*, Fabian Sanabria^3*, Richard H. Ko, MD, MHS, MS² and Francis Nissen^3*

¹F. Hoffmann-La Roche Ltd, Mississauga, ON, Canada
²Genentech, Inc., South San Francisco, CA
³F. Hoffmann-La Roche Ltd, Basel, Switzerland

Robert Klamroth^1*, Karin Kurnik^2*, Swee Wenning^3*, Carmen Escuriola-Ettingshausen^4*, Stephan Regensburger^5*, Leilei Tang^6*, Joan Gu^7*, Randy Guerra^8* and Johannes Oldenburg⁹

¹Department for Internal Medicine, Vascular Medicine and Haemostaseology, Vivantes Klinikum im Friedrichshain, Berlin, Germany
²Dr. von Haunersches Kinderspital Klinikum der Universität München, Munich, Germany
³SRH Kurpfalzkrankenhaus, Heidelberg, Germany
⁴Hämophilie-Zentrum Rhein Main GmbH, Moerfelden-Walldorf, Germany
⁵Takeda Pharma Vertrieb GmbH & Co. KG, Berlin, Germany
⁶Takeda Pharmaceuticals International AG, Zürich, Switzerland
⁷Takeda Development Center Americas, Inc., Lexington, MA
⁸Takeda Pharmaceuticals, Cambridge, MA
⁹Institute for Experimental Hematology and Transfusion Medicine, Bonn University Clinic, Bonn, Germany

Claire Anne Murphy, MB^1,2,3*, Elaine Neary, PhD^4,5*, Barry Kevane, PhD^3,6, Daniel O'Reilly, MB^2*, John O'Loughlin, MSc^7*, Afif EL-Khuffash, MD^1,2*, Patricia Maguire, PhD^3*, Fionnuala Ni Ainle, MD, PhD^3,8,9 and Naomi McCallion, MD^1,2*

¹Department of Paediatrics, Royal College of Surgeons in Ireland, Dublin, Ireland
²Department of Neonatology, Rotunda Hospital, Dublin, Ireland
³Conway-SPHERE Research Group, University College Dublin, Dublin, Ireland
⁴Department of Neonatology, Liverpool Women's Hospital, Liverpool, United Kingdom
⁵Department of Health and Life Sciences, University of Liverpool, Liverpool, Ireland
⁶Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
⁷Department of Laboratory Medicine, Rotunda Hospital, Dublin, Ireland
⁸School of Medicine, University College Dublin, Dublin, Ireland
⁹Department of Haematology, Mater Misericordiae University Hospital and Rotunda Hospital, University College Dublin, Dublin, Ireland

Kim Mauer, MD^1*, Travis Helm^2*, Tyler W. Buckner³, Corey Macgregor^2*, Judith A. Boice, PhD², Frank Cerasoli, PhD^2,4*, Tahmid Khan, MPH^4* and Charles Argoff, MD^5*

¹Oregon Health and Science University, Portland, OR
²Tremeau Pharmaceuticals, Inc., Concord, MA
³Divisions of Hematology and Pediatric Hematology/Oncology, Hemophilia and Thrombosis Center, University of Colorado School of Medicine, Aurora, CO
⁴RxMedical Dynamics, LLC, New York, NY
⁵Albany Medical Center, Albany, NY

Koichiro Yoneyama^1*, Kazuo Tokuda, PhD^2*, Tetsuhiro Soeda, PhD^2*, Tomohisa Saito, PhD^1* and Midori Shima, MD, PhD³

¹Chugai Pharmaceutical Co., Ltd., Tokyo, Japan
²Chugai Pharmaceutical Co., Ltd., Kamakura, Japan
³Thrombosis and Hemostasis Research Center, Nara Medical University, Kashihara, Japan

Kelsey Uminski, MD¹, Yan Xu, MD^1*, Amin Zahrai, MSc^2*, Amanda Hodgson^2*, Lisa Duffett, MD^1,3*, Alan Tinmouth, MD, MSc^1,3* and Roy Khalife, MD^1,3

¹Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
²University of Ottawa, Ottawa, ON, Canada
³Ottawa Hospital Research Institute, Ottawa, ON, Canada

Lorenzo G.R. Romano, MD^1*, Viola J.F. Strijbis, MSc^2*, Ka Lei Cheung^2*, Ying Poi Liu, PhD^3*, Andrew C. McCreary^3*, Frank W.G. Leebeek¹ and Mettine H.A. Bos, PhD⁴

¹Dept. of Hematology, Erasmus MC, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
²Div. Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, Netherlands
³uniQure Biopharma B.V., Amsterdam, Netherlands
⁴Div. Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center Einthoven Lab. for Experimental Vascular Med., Leiden, Netherlands

Roberta Gualtierotti^1,2*, Carla Valsecchi, BSc^3*, Chiara Suffritti^3*, Eugenia Biguzzi, MD^3*, Sara Arcudi, MD^3*, Lucia Schiavone^3* and Flora Peyvandi^2,3

¹Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milano, Italy
²Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
³Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milano, Italy

Radoslaw Kaczmarek, PhD^1*, Thais Bertolini, PhD^1*, Roland W Herzog, PhD¹ and Alexandra Sherman, DVM^2*

¹Pediatrics, Indiana University School of Medicine, Indianapolis, IN
²Neurosurgery, University of Florida, Gainesville, FL

Guy Young, MD^1,2, Steven W. Pipe, MD³, Cédric Hermans, MD, MRCP, PhD⁴, Manuel Carcao⁵, Giancarlo Castaman^6*, Joanna A. Davis, MD⁷, Jonathan M. Ducore, MD, MPH⁸, Amy L. Dunn, MD⁹, Miguel A. Escobar, MD^10*, Janna Journeycake, MD, MSCS¹¹, Osman Khan, MD, MSc^11*, Johnny Mahlangu, MD¹², Shannon Meeks, MD¹³, Ismail Haroon Mitha, MD^14*, Claude Négrier, MD¹⁵, Ulrike Nowak-Göttl, MD, PhD^16*, Michael Recht^17,18, Tammuella Chrisentery-Singleton, MD^19*, Oleksandra Stasyshyn, MD, PhD^20*, Kateryna V. Vilchevska, MD^21*, Laura Villarreal Martinez, MD^22*, Michael Wang, MD²³, Jerzy Windyga, MD, PhD^24*, W. Allan Alexander, MD^25*, Ahmad Al-Sabbagh, MD^26*, Daniel Bonzo, PhD^26*, Christopher Macie, MD, MBA^27*, Ian S. Mitchell, PhD^27*, Thomas A. Wilkinson, PhD^28* and Amy D. Shapiro²⁹

¹Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA
²Keck School of Medicine, University of Southern California, Los Angeles, CA
³University of Michigan, Ann Arbor, MI
⁴Cliniques Saint-Luc, Université Catholique de Louvain, Brussels, Belgium
⁵The Hospital for Sick Children, Toronto, ON, Canada
⁶Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Florence, Italy
⁷Pediatric Hemophilia Treatment Center, University of Miami, Miami, FL
⁸UC Davis, Hemostasis and Thrombosis Center, Sacramento, CA
⁹Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH
¹⁰University of Texas Health Science Center at Houston, Houston, TX
¹¹Oklahoma Bleeding and Clotting Disorders Center at OU Health, Oklahoma City, OK
¹²Hemophilia Comprehensive Care Center, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa
¹³Emory University and Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, Atlanta, GA
¹⁴Lakeview Hospital, Benoni, South Africa
¹⁵Edouard Herriot University Hospital, Lyon, France
¹⁶Institute of Clinical Chemistry, University Hospital Schleswig-Holstein, Kiel, Germany
¹⁷American Thrombosis and Hemostasis Network, Rochester, NY
¹⁸Oregon Health & Science University, Portland, OR
¹⁹Louisiana Center for Advanced Medicine, Slidell, LA
²⁰Institute of Blood Pathology and Transfusion Medicine, Lviv, Ukraine
²¹National Specialized Children’s Hospital Okhmatdyt, Kyiv, Ukraine
²²Dr. José Eleuterio González Monterrey University Hospital, Monterrey, NL, Mexico
²³Hemophilia and Thrombosis Center, University of Colorado, Aurora, CO
²⁴Department of Hemostasis Disorders and Internal Medicine, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
²⁵Aoede Associates, Athens, TX
²⁶LFB-USA, Inc., Framingham, MA
²⁷HEMA Biologics, LLC, Louisville, KY
²⁸GLOVAL LLC, Broomfield, CO
²⁹Indiana Hemophilia and Thrombosis Center, Indianapolis, IN

Aisling Barrett, MB BCh BAO MRCPI^1*, Catherine Bergin^1*, Mary Byrne^1*, Kevin Ryan, FRCPath^1*, Niamh M O'Connell, MB, PhD, FRCPath^1*, James S O'Donnell, MD, PhD^1,2 and Michelle Lavin, MB, PhD, FRCPath^1,2*

¹National Coagulation Centre, St James's Hospital, Dublin 8, Ireland
²Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, Dublin 2, Ireland

Viridiana Cano^1*, José Bartelt-Hofer^2*, Wenruo Hu^3*, Shauna Andersson, MD, PhD^4*, Pronabesh Dasmahapatra⁴ and Sylvia Von Mackensen^5*

¹Sanofi Genzyme, Cambridge, MA
²Sanofi Genzyme, Chilly-Mazarin, France
³Sanofi, Beijing, China
⁴Sanofi, Cambridge, MA
⁵University of Hamburg, Hamburg, Germany

Chia-Yau Chang, MD^1,2*, Shiue-Wei Lai, PhD^3*, Mei-Mei Cheng, M.D.^4*, Pei-Yi Lai, B.S.^5*, Jung-Tzu Ku, M.S.^6*, Shu-Hsia Hu, M.S.^7*, Chen-Hua Tsai, M.D.^5,8*, Chao-Neng Cheng, M.D.^9*, Yen-Lin Liu, M.D., PhD^2,10*, Jia-Ruey Tsai, M.D^5,11* and Yeu-Chin Chen, MD^7,12

¹Division of Pediatric Hematology/Oncology, Hemophilia Center, Taipei Medical University Hospital, Taipei, Taiwan
²School of Medicine, Department of Pediatrics, Taipei Medical University, College of Medicine, Taipei, Taiwan
³Hemophilia Care and Research Center, Division of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, AL, Taiwan
⁴Department of Pediatircs, Cheng Hsin General Hospital, Taipei, Taiwan
⁵Hemophilia Center, Taipei Medical University Hospital, Taipei, Taiwan
⁶Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan
⁷Hemophilia Care and Research Center, Tri-Service General Hospital, Taipei, Taiwan
⁸Division of Hematology/Oncology, Cheng Hsin General Hospital, Taipei city, Taiwan
⁹Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan
¹⁰Division of Pediatric Hematology/Oncology, Taipei Medical University Hospital, Taipei, Taiwan
¹¹Division of Hematology/Oncology, Taipei Medical University Hospital, Taipei, Taiwan
¹²Division of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital (TSGH), Taipei, Taipei (City), Taiwan

Chia-Yau Chang, MD^1,2*, Shiue-Wei Lai, PhD^3*, Mei-Mei Cheng, M.D.^4*, Jung-Tzu Ku, M.S.^5*, Shu-Hsia Hu, M.S.^6*, Jia-Ruey Tsai, M.D^7,8*, Chen-Hua Tsai, M.D.^7,9*, Pei-Yi Lai, B.S.^7*, Yen-Lin Liu, M.D., PhD^10*, Chao-Neng Cheng, M.D.^11* and Yeu-Chin Chen, MD^6,12

¹School of Medicine, Department of Pediatrics, Taipei Medical University, College of Medicine, Taipei, Taiwan
²Division of Pediatric Hematology/Oncology, Hemophilia Center, Taipei Medical University Hospital, Taipei, Taiwan
³Hemophilia Care and Research Center, Division of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, AL, Taiwan
⁴Department of Pediatircs, Cheng Hsin General Hospital, Taipei, Taiwan
⁵Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan
⁶Hemophilia Care and Research Center, Tri-Service General Hospital, Taipei, Taiwan
⁷Hemophilia Center, Taipei Medical University Hospital, Taipei, Taiwan
⁸Division of Hematology/Oncology, Taipei Medical University Hospital, Taipei, Taiwan
⁹Division of Hematology/Oncology, Cheng Hsin General Hospital, Taipei city, Taiwan
¹⁰Division of Pediatric Hematology/Oncology, Taipei Medical University Hospital, Taipei, Taiwan
¹¹Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan
¹²Division of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital (TSGH), Taipei, Taipei (City), Taiwan

Anke Adenaeuer^1,2*, Stefano Barco, MD, PhD^1,3*, Alice Trinchero^1,4*, Hanan Nazir^5,6*, Sarah Krutmann^1*, Chiara Ambaglio^7*, Vincenzo Rocco^8*, Ylenia Pancione^8*, Luigi Tomao^9*, Arlette Ruiz de Saez, MD^10*, Marion Echenagucia^10*, Friederike Haeuser^11*, Karl J. Lackner^1,11*, Heidi Rossmann^1,11* and Bernhard Lämmle, MD^1,12,13

¹Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
²Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany
³Clinic of Angiology, University Hospital and University of Zurich, Zurich, Switzerland
⁴Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland
⁵Child Health Department, Sultan Qaboos University Hospital, muscat, Oman
⁶Department of Pediatrics, Alexandria Faculty of Medicine, Alexandria, Egypt
⁷Dipartimento Area Medica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁸Dipartimento di Medicina di Laboratorio, Azienda Ospedaliera G. Rummo, Benevento, Italy
⁹IRCCS Regina Elena National Cancer Institute, Roma, ITA
¹⁰Centro Nacional de Hemofilia, Banco Municipal de Sangre del Distrito Capital, Caracas, Venezuela (Bolivarian Republic of)
¹¹Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
¹²Department of Hematology and Central Hematology Laboratory, Bern University Hospital, University of Bern, Bern, Switzerland
¹³Haemostasis Research Unit, University College London, London, United Kingdom

Tammuella Chrisentery-Singleton^1*, W Allan Alexander, MD^2*, Ahmad Al-Sabbagh, MD^3*, Daniel Bonzo, PhD^3*, Michael U. Callaghan, MD⁴, Miguel A. Escobar, MD^5*, Adam Giermasz, MD, PhD⁶, Nikki Hirsh^7*, Janna Journeycake, MD, MSCS⁸, Sonia Nasr^9*, Doris V. Quon¹⁰ and Michael Recht¹¹

¹Pediatric Hematology, Louisiana Center for Advanced Medicine, Slidell, LA
²Aoede Associates, Athens, TX
³LFB-USA, Inc., Framingham, MA
⁴Division of Pediatric Hematology/Oncology, Central Michigan University SOM, Children’s Hospital of Michigan, Detroit, MI
⁵Department of Hematology, University of Texas Health Science Center, Houston, TX
⁶Hemophilia Treatment Center, University of California Davis, Sacramento, CA
⁷American Thrombosis And Hemostasis Network, Rochester, NY
⁸Jimmy Everest Center for Cancer and Blood Disorders, University of Oklahoma Health Sciences Center, Oklahoma City, OK
⁹GLOVAL, LLC, Broomfield, CO
¹⁰Los Angeles Orthopedic Hemophilia Treatment Center, Orthopedic Institute for Children, Los Angeles, CA
¹¹American Thrombosis and Hemostasis Network, Rochester, NY

Mark Crowther, MD¹ and William Shi, MD^2*

¹McMaster University and St Joseph's Hospital, Hamilton, ON, Canada
²Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada

Beth Boulden Warren, MD MS MSCS¹, Joseph Mah^1*, Niamh Mah, BS^1*, Hana Durkee, BS^1*, Sharon Funk, DPT^1*, Marilyn J Manco-Johnson, MD¹ and James Carollo, PhD^2*

¹Hemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, CO
²Children's Hospital Colorado, Center for Gait and Movement Analysis, University of Colorado Anschutz Medical Campus, Aurora, CO

Meera Sridharan, MD, PhD^1,2, Dawn M Inman, R.N.^1,2* and Rajiv K. Pruthi, M.B.B.S^1,2

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Mayo Comprehensive Hemophilia Center, Mayo Clinic, Rochester, MN

Allison P. Wheeler, MD¹, Miguel A. Escobar, MD^2*, Susan Kearney, MD³, Janice M. Staber⁴, Adam R. Wufsus, PhD^5*, Vlady Ostrow, DO^6* and Steven R. Lentz, MD, PhD⁷

¹Vanderbilt University Medical Center, Nashville, TN
²University of Texas Health Science Center, Houston, TX
³Children's Minnesota, Minneapolis, MN
⁴University of Iowa Stead Family Children’s Hospital, Iowa City, IA
⁵Novo Nordisk, Plainsboro, NJ
⁶Novo Nordisk Inc., Plainsboro, NJ
⁷University of Iowa, Iowa City, IA

Hyunji Kim, MD and Seongsoo Jang, M.D., Ph.D.

Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of (South)