-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

703.O1.6 703. Cellular Immunotherapies: Basic and Translational I

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Biological therapies, Research, Clinical Practice (Health Services and Quality), Chimeric Antigen Receptor (CAR)-T Cell Therapies, Diversity, Equity, Inclusion, and Accessibility (DEI/DEIA) , Gene Therapy, Immunotherapy, Therapies, Natural Killer (NK) Cell Therapies
Saturday, December 11, 2021: 12:00 PM-1:30 PM
B405-B407, Level 4, Building B (Georgia World Congress Center)
Moderators:
Mireya Paulina Velasquez, MD, St. Judes Childrens Research Hospital and Marco L. Davila, MD, PhD, H. Lee Moffitt Cancer Center and Research Institute
Disclosures:
Davila: Precigen: Research Funding; Atara Biotherapeutics: Patents & Royalties, Research Funding; CRISPR: Patents & Royalties, Research Funding; Kite Pharma: Research Funding; Novartis: Research Funding.
12:00 PM

Marco Ruella, MD1,2,3,4, Mireia Uribe-Herranz5*, Silvia Beghi5*, Kalpana Parvathaneni, PhD6*, Nektarios Kostopoulos5*, Guido Ghilardi, MD7*, Kimberly Amelsberg5*, Yong Gu Gu Lee, PhD7, Raymone Pajarillo, MS7*, Noelle V Frey, MD, MS8, Simon F Lacey, PhD7, Khatuna Gabunia5*, John Scholler7*, Elise A Chong, MD7,9, Carl H June, MD10, David L. Porter, MD11, Stephen J. Schuster, MD4,11, Vijay Bhoj, MD, PhD12 and Andrea Facciabene, PhD5*

1Division of Hematology-Oncology and Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA
2Center for Cellular Immunotherapies and Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA
3Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
4Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
5University of Pennsylvania, Philadelphia, PA
6Department of Pathology and laboratory medicine, University of Pennsylvania, Philadelphia, PA
7Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA
8Abramson Cancer Center, Hospital of the University of Pennsylvania, Philadelphia, PA
9Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
10Center for Cellular Immunotherapies (CCI), The University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
11Division of Hematology-Oncology/Department of Medicine, University of Pennsylvania, Philadelphia, PA
12Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

12:15 PM

Zachary Jackson1*, Changjin Hong, PhD2*, Robert Schauner3*, Boro Dropulic, PhD, MBA4*, Paolo F. Caimi, MD5, Marcos J.G. de Lima, MD6, Kalpana Gupta, PhD7*, Jane Reese8*, Tae Hyun Hwang, PhD9* and David Wald, MD, PhD10*

1Pathology, Case Western Reserve University, Cleveland, OH
2Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH
3Case Western Reserve University, Cleveland, OH
4Lentigen Technology Inc., A Miltenyi Biotec Company, Gaithersburg, MD
5University Hospitals of Cleveland, Cleveland, OH
6Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
7Case Western Reserve University, Cleveland
8Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, OH
9Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
10Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH

12:30 PM

Brian T. Hill, MD1, Caroline J Roth, MS2*, Rachel Kositsky, BS2*, Tushar Dave, MS2*, Cassandra Love2, Matthew McKinney, MD3, Ahmed Galal, MD4, Jadee L Neff, MD, PhD5*, Agrima Mian, MD6, Ellen Kendall, BS7*, Sarah L. Ondrejka, DO8*, Matthew Chiaramonte, BA9*, Govind Bhagat, M.D.10, Kenneth Ofori, MD, MHS11*, Ran Reshef, MD, MSc12, Alexandra E. Kovach, MD13, Tarsheen Sethi, MD, MBBS14, Emily F Mason, MD, PhD15*, Shakthi Bhaskar, MD15, Olalekan O. Oluwole, MBBS, MPH15, Christopher Pallas, MD16*, Nilanjan Ghosh, MD, PhD17, Robert Ferdman, MD18*, George L. Chen, MD19, Francisco J. Hernandez-Ilizaliturri, MD20, Joanna C. Zurko, MD21, Ashley Cunningham, MD22*, Nirav N. Shah, MD23, Boyu Hu, MD24*, Deborah M. Stephens25, Monalisa Ghosh, MD26, Neil Bailey, MSc27*, Krish Patel, MD28, John M. Pagel, MD, PhD27, Kavya Kannamma Kannan, MBBS29, Eric D. Hsi, MD30, Rakhee Vaidya, MD31, Andrew Ip, MD, MSc32, Andre H. Goy, MD33*, Swetha Kambhampati, MD34*, Robert S. Ohgami, MD, PhD35, Charalambos Andreadis, MD, MS36, Elizabeth Thacker37*, Chrissie Rozzi37*, Clay Parker38*, Lanie Happ37* and Sandeep S. Dave, MD, MS39

1Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, OH
2Duke University Medical Center, Durham, NC
3Division of Hematologic Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC
4Duke Cancer Institute, Durham, NC
5Department of Pathology, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC
6Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
7Case Western Reserve University School of Medicine, Cleveland, OH
8Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH
9Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY
10Columbia University Medical Center, New York, NY
11Department of Pathology & Cell Biology, Columbia University, New York, NY
12Columbia Center for Translational Immunology, Columbia University, New York, NY
13Department of Pathology, Vanderbilt University, Nashville, TN
14Department of Medicine/ Division of Hematology-Oncology, Vanderbilt Medical Center, Nashville, TN
15Vanderbilt University Medical Center, Nashville, TN
16Levine Cancer Institute, Charolotte, NC
17Department of Hematology, Lymphoma Division, Levine Cancer Institute, Charlotte, NC
18Roswell Park Comprehensive Cancer Center, Buffalo, NY
19Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
20Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY
21Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI
22Department of Pathology, Medical College of Wisconsin, Milwaukee, WI
23Medical College of Wisconsin, Milwaukee, WI
24Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
25Huntsman Cancer Institute, Huntsman Cancer Institute, Salt Lake City, UT
26Michigan Medicine University of Michigan, Ann Arbor, MI
27Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA
28Swedish Cancer Institute, Seattle, WA
29Wake Forrest University, Winston Salem, NC
30Department of Pathology, Wake Forest Baptist Medical Center, Winston Salem, NC
31Comprehensive Cancer Center of Wake Forest Baptist Health, Winston-Salem, NC
32Division of Lymphoma, Division of Outcomes and Value Research, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ
33John Theurer Cancer Center Hackensack, Hackensack, NJ
34University of California San Francisco, San Francisco, CA
35Pathology, University of California, San Francisco, San Francisco, CA
36Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
37Data Drive Biosciences, Durham, NC
38Data Driven Bioscience, Durham, NC
39Duke Cancer Institute, Duke University, Durham, NC

12:45 PM

J. Joseph Melenhorst, PhD1,2, Gregory M Chen3*, Meng Wang, BS1*, David L. Porter, MD4*, Peng Gao5*, Shovik Bandyopadhyay6*, Iulian Pruteanu-Malinici, DPhil7*, Christopher L Nobles, PhD8*, Sayantan Maji, PhD9*, Noelle V Frey, MD, MS10, Saar Gill, MD, PhD11, Lifeng Tian, PhD12*, Irina Kulikovskaya12*, Megan M Davis, PhD2*, Joseph A Fraietta, PhD8*, Jennifer L Brogdon, PhD13*, Regina Young12*, David E Ambrose, BS2*, Anne Chew, PhD12*, Bruce L Levine, PhD2, Don L. Siegel, MD, PhD14, Cécile Alanio, PhD15*, E. John Wherry, PhD12*, Frederic D. Bushman, PhD16*, Simon F Lacey, PhD17*, Kai Tan, PhD18* and Carl H June, MD2

1Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
2Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA
3Graduate Group in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA
4Division of Hematology-Oncology/Department of Medicine, University of Pennsylvania, Philadelphia, PA
5Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA
6Graduate Group in Cell & Molecular Biology, University of Pennsylvania, Philadelphia, PA
7Exploratory Immuno-Oncology, Novartis Pharmaceuticals Corporation, Medford, MA
8Department of Microbiology, University of Pennsylvania, Philadelphia, PA
9Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
10Abramson Cancer Center, University of Pennsylvania, Narberth, PA
11Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
12University of Pennsylvania, Philadelphia, PA
13Novartis Institutes for BioMedical Research, Cambridge, MA
14Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
15Institut Curie, Paris, France
16Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
17Center for Cellular Immunotherapies, University of Pennsylvania, Media, PA
18Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

1:00 PM

Caroline Diorio, MD1, Rawan Shraim, MSc2*, Regina M. Myers, MD3, Chakkapong Burudpakdee, BS4*, Allison Barz Leahy, MD3*, Richard Aplenc, MD, PhD5, Michele P. Lambert, MD6, Hamid Bassiri, MD/PhD7*, Edward M Behrens, MD7*, Vanessa E. Gonzalez8*, Fang Chen9*, Bruce L Levine, PhD9, Shannon L. Maude, MD, PhD10,11, Amanda M. DiNofia, MD12*, Alix E. Seif, MD12, J. Joseph Melenhorst, PhD13, Simon F Lacey, PhD9, Carl H June, MD14, David Barrett, MD PhD15*, Stephan A. Grupp, MD, PhD16,17 and David T. Teachey, MD7,18

1Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
2Children's Hospital of Philadelphia, Philadelphia, PA
3Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
4Immune Dysregulation Frontier Program, Children's Hospital of Philadelphia, Philadelphia, PA
5Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
6Department of Pediatrics, Division of Hematology, Children's Hosp. of Phila., Philadelphia, PA
7Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
8Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA
9Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA
10The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
11Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
12Center for Childhood Cancer Research, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
13Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
14Center for Cellular Immunotherapies (CCI), The University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
15Tmunity, Philadelphia, PA
16Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
17Division of Oncology, Center for Childhood Cancer Research and Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Philadelphia, PA
18Perelman School of Medicine University of Pennsylvania, Philadelphia, PA

1:15 PM

Katelyn Burleigh, PhD1*, Anna Kus2*, Alice Long, PhD2*, Michael C. Jensen, MD3*, Seth Masters, PhD4*, James E Vince, PhD4*, Bobbie-Jo Webb-Robertson, PhD5*, Rebecca A Gardner, MD3,6 and Heather Gustafson, PhD1*

1Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA
2Benaroya Research Institute, Seattle, WA
3Seattle Children's Therapeutics, Seattle Children's Research Institute, Seattle, WA
4The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
5Pacific Northwest National Laboratory, Richland, WA
6Division of Hematology-Oncology, Seattle Children's Hospital, Seattle, WA

*signifies non-member of ASH