-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

642.O1.6 642. Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Combination Small Molecules

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Fundamental Science, Lymphoid Leukemias, Translational Research, CLL, Diseases, Lymphoid Malignancies
Saturday, December 11, 2021: 9:30 AM-11:00 AM
Thomas Murphy Ballroom 3-4, Level 5, Building B (Georgia World Congress Center)
Moderators:
Shuo Ma, MD, Northwestern University and Susan M. O'Brien, MD, UCI Cancer Center
Disclosures:
Ma: Loxo: Research Funding; AstraZeneca: Honoraria, Research Funding, Speakers Bureau; Juno: Research Funding; Beigene: Research Funding, Speakers Bureau; Abbvie: Honoraria, Research Funding; Janssen: Research Funding, Speakers Bureau; TG Therapeutics: Research Funding; Pharmacyclics: Research Funding, Speakers Bureau. O'Brien: Kite, Regeneron, Acerta, Caribou, Gilead, Pharmacyclics, TG Therapeutics, Pfizer, Sunesis: Research Funding; Amgen, Astellas, Celgene, GlaxoSmithKline, Janssen Oncology, Aptose Biosciences Inc., Vaniam Group LLC, AbbVie, Alexion, Verastem, Juno Therapeutics, Vida Ventures, Autolus, Johnson and Johnson, Merck, Bristol Myers Squibb, NOVA Research Company, Eli Lill: Consultancy.
9:30 AM

Alessandra Tedeschi, MD1*, Emmanuelle Ferrant, MD2*, Ian W. Flinn, MD, PhD3, Constantine S. Tam, MBBS, MD4,5,6,7*, Paolo Ghia, MD, PhD8, Tadeusz Robak, MD, PhD9, Jennifer R. Brown, MD, PhD10*, Vanitha Ramakrishnan, PhD11*, Tian Tian, PhD11*, Sowmya B. Kuwahara, PharmD11*, Jason C. Paik, MD, PhD11*, Aileen Cohen, MD, PhD11*, Jane Huang, MD11* and Peter Hillmen, p.hillmen@leeds.ac.uk12

1ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
2Centre Hospitalier Lyon-Sud, University Claude Bernard Lyon 1, Pierre-Bénite, France
3Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN
4Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
5Royal Melbourne Hospital, Parkville, VIC, Australia
6University of Melbourne, Parkville, VIC, Australia
7St Vincent’s Hospital Melbourne, Fitzroy, VIC, Australia
8Università Vita-Salute San Raffaele, Milan, Italy
9Medical University of Lodz, Lodz, Poland
10Dana-Farber Cancer Institute, Boston, MA
11BeiGene (Beijing) Co., Ltd., Beijing, China and BeiGene USA, Inc., San Mateo, CA
12St James's University Hospital, Leeds, United Kingdom

9:45 AM

Paolo Ghia, MD, PhD1, John N. Allan, MD, PhD2, Tanya Siddiqi, MD3*, Thomas J. Kipps, MD, PhD4, Bryone J. Kuss, MBBS, PhD, FRACP, FRCPA5*, Stephen Opat, MBBS (Hons), FRACP, FRCPA6*, Ian W. Flinn, MD, PhD7, Xavier C. Badoux, MBBS, FRACP, FRCPA8, Alessandra Tedeschi, MD9*, Eva Gonzalez Barca10*, John M. Pagel, MD, PhD11, Ryan Jacobs, MD12*, Jacqueline Barrientos, MD, MS13, Edith Szafer-Glusman, PhD14*, Cathy Zhou, MS15*, Joi Ninomoto, PharmD15*, James P. Dean, MD, PhD16, Constantine S. Tam, MBBS, MD17* and William G. Wierda18

1Division of Experimental Oncology, Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, Italy
2Weill Cornell Medicine, New York, NY
3City of Hope National Medical Center, Duarte, CA
4UCSD Moores Cancer Center, San Diego, CA
5Flinders University and Medical Centre, Bedford Park, SA, Australia
6School of Clinical Sciences, Monash University, and Haematology Department, Monash Health, Melbourne, VIC, Australia
7Sarah Cannon Research Institute-Tennessee Oncology, Nashville, TN
8Ministry of Health, Kogarah, NSW, Australia
9Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
10Universitat de Barcelona, Institut Catalá d’Oncologia Hospitalet, Barcelona, Spain
11Swedish Cancer Institute Hematologic Malignancies Program, Seattle, WA
12Levine Cancer Institute, Charlotte, NC
13Division of Medical Oncology and Hematology, Northwell Health Cancer Institute Donald & Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY
14AbbVie Inc, Sunnyvale, CA
15Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA
16Pharmacyclics LLC, an AbbVie Company and Janssen Biotech, Inc., Sunnyvale, CA
17Peter MacCallum Cancer Center, Royal Melbourne Hospital, and University of Melbourne, Melbourne, VIC, Australia
18Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX

10:00 AM

Carsten Utoft Niemann, MD, PhD1, Julie Dubois2*, Christian Brieghel, MD, PhD3*, Sabina Kersting4*, Lisbeth Enggaard, MD1*, Gerrit J Veldhuis5*, Rogier Mous, MD, PhD6*, Clemens Mellink7*, Johan A Dobber8*, Christian Bjørn Poulsen, MD9*, Henrik Frederiksen10*, Ann Janssens11*, Ida Schjødt, MD, PhD12*, Ellen C Dompeling13*, Juha Ranti14*, Mattias Mattsson, MD15*, Mar Bellido16*, Kazem Nasserinejad, PhD17*, Hoa Thi Tuyet Tran18*, Mark-David Levin, MD, PhD19 and Arnon P. Kater, MD, PhD20

1Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
2Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
3Department of Hematology, Rigshospitalet, Copenhagen University Hospital, København Ø, Denmark
4HAGA Hospital, Den Haag, Netherlands
5Department of Hematology, Antonius Ziekenhuis, Sneek, Netherlands
6Universitair Medisch Centrum Utrecht, Academic Medical Center, Utrecht, NH, Netherlands
7Department of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands
8Laboratory of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
9Department of Haematology, Zealand University Hospital, Roskilde, Denmark
10Department of Hematology, Odense University Hospital, Odense, Denmark
11Hematology Department, University of Leuven, Leuven, Belgium
12Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
13Isala Ziekenhuis, Zwolle, Netherlands
14Department of Hematology, Turku University Central Hospital, Turku, Finland
15Department of Hematology, Uppsala University Hospital, Uppsala, Sweden
16Department of Hematology, Univerisity Medical Center Groningen, Groningen, Netherlands
17HOVON data center, Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
18Department of Hematology, Akershus University Hospital, Lørenskog, Norway
19Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
20Amsterdam UMC, Amsterdam, NH, Netherlands

10:15 AM

Tahla Munir, MBBS1*, Carol Moreno, MD, PhD2*, Carolyn Owen, MD3*, George A Follows, MD, PhD4*, Ohad Benjamini, MD5*, Ann Janssens6*, Mark-David Levin, MD, PhD7, Anders Österborg, MD, PhD8, Tadeusz Robak, MD, PhD9, Martin Simkovic, MD, PhD10*, Don Stevens, MD11, Sergey Voloshin12*, Vladimir I. Vorobyev, MD, PhD13, Munchi Yagci, MD14*, Loic Ysebaert, MD, PhD15*, Qianaya Qi16*, Andrew Steele17*, Natasha Schuier18*, Kurt Baeten19*, Donne Bennett Caces16*, Carsten Utoft Niemann, MD, PhD20 and Arnon P. Kater, MD, PhD21

1Department of Haematology, St James's University Hospital, Leeds, United Kingdom
2Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
3Tom Baker Cancer Centre, Calgary, Canada
4Addenbrookes Hospital, Cambridge, United Kingdom
5Sheba Medical Center, Ramat Gan, Israel
6UZ Leuven Gasthuisberg, LEUVEN, Belgium
7Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
8Karolinska University Hospital, Stockholm, Sweden
9Medical University of Lodz, Lodz, Poland
10University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
11Norton Cancer Institute, Louisville, KY
12Russian Scientific and Research Institute of Hematology and Transfusiology, St Petersburg, Russian Federation
13S.P. Botkin Moscow City Clinical Hospital, Moscow, Russia
14Gazi Universitesi Tip Fakultesi, Ankara, Turkey
15Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France
16Janssen Research & Development, Raritan, NJ
17Janssen Research & Development, Spring House, PA
18Janssen Research & Development, Dusseldorf, Germany
19Janssen Research & Development, Beerse, Belgium
20Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
21Amsterdam UMC, Amsterdam, NH, Netherlands

10:30 AM

Barbara Eichhorst, MD1, Carsten Niemann2*, Arnon P. Kater, MD, PhD3, Moritz Fürstenau, MD4, Julia Von Tresckow, MD5*, Can Zhang, PhD6*, Sandra Robrecht, PhD1*, Michael Gregor, MD7*, Gunnar Juliusson, MD, PhD8, Patrick Thornton, MB, FRCPath9*, Philipp B. Staber, MD, PhD10, Tamar Tadmor, MD11*, Vesa Lindström, MD12*, Caspar Da Cunha-Bang, MD, PhD13, Christof Schneider, MD14*, Christian Bjørn Poulsen, MD15*, Thomas Illmer, MD16, Björn Schöttker17*, Ann Janssens18*, Ilse Christiansen19*, Thomas Noesslinger20*, Michael Baumann, MD21*, Marjolein van der Klift22*, Ulrich Jaeger23, Henrik Frederiksen24*, Maria B.L. Leijs, MD25*, Mels Hoogendoorn, Dr.26*, Kourosh Lotfi, MD27*, Holger Hebart, MD28, Tobias Gaska, MD29, Harry R. Koene, MD, PhD30*, Florian Simon, MD31*, Nisha De Silva, MBBS, MRCP, FRCPath32*, Anna-Maria Fink, MD33*, Kirsten Fischer, MD34*, Clemens-Martin Wendtner35*, Karl-Anton Kreuzer, MD36*, Matthias Ritgen, MD37*, Monika Brüggemann, Prof., PhD38*, Eugen Tausch, MD14*, Mark-David Levin, MD, PhD39, Marinus H.J. Van Oers, MD, PhD40, Christian H. Geisler, MD, PhD41, Stephan Stilgenbauer, MD42 and Michael Hallek, MD43

1Department I of Internal Medicine and Center of Integrated Oncology Cologne Bonn, University Hospital, Cologne, Germany
2Rigshospitalet, Copenhagen Ø, DNK
3Amsterdam UMC, Amsterdam, NH, Netherlands
4Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, German CLL Study Group, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany
5Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf; Cologne, University of Cologne, Koeln, Germany
6Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, German CLL Study Group, University Hospital, Cologne, Cologne, Germany
7Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland
8Department of Hematology, Lund University, Lund, Sweden
9Department of Haematology, Beaumont Hospital, Dublin, Ireland
10Medical University of Vienna, Department of Medicine I, Division of Hematology & Hemostaseology, Vienna, Austria
11Hematology Unit, Bnai Zion Medical Center, Haifa, Israel
12Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center and University of Helsinki, Helsinki, Finland
13Department of Hematology, Rigshospitalet, Copenhagen University Hospital, København Ø, Denmark
14Department of Internal Medicine III, Ulm University, Ulm, Germany
15Department of Haematology, Zealand University Hospital, Roskilde, Denmark
16BAG/Onkologische Schwerpunktpraxis, Dresden, Germany
17Hämatologisch Onkologische Schwerpunktpraxis, Würzburg, DEU
18Hematology Department, University of Leuven, Leuven, Belgium
19Department of Hematology, Aalborg University Hospital, Aalborg, Denmark
20Hanusch Hospital, Vienna, AUT
21Clinic for Medical Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, St. Gallen, Switzerland
22Department of Internal Medicine, Amphia Hospital, Breda, Netherlands
23Medical University of Vienna, Vienna, AA, Austria
24Department of Hematology, Odense University Hospital, Odense, Denmark
25Department of Internal Medicine/Hematology, Maasstad ziekenhuis, Rotterdam, Netherlands
26Medical Center Leeuwarden, Leeuwarden, Netherlands
27Department of Hematology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
28Stauferklinikum, Mutlangen, DEU
29Hematology und Oncology, Brüderkrankenhaus St. Josef, Paderborn, Germany
30St. Antonius Hospital, Nieuwegein, NLD
31Department I of Internal Medicine, University of Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
32Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, German CLL Study Group, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany, Cologne, Germany
33Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, German CLL Study Group, University Hospital of Cologne, Cologne, Germany
34German CLL Study Group, and Department I of Internal Medicine, and Center of Integrated Oncology ABCD, University of Cologne, Cologne, Germany
35Munich Clinic Schwabing, Academic Teaching Hospital, Ludwig-Maximilians-University, Munich, Germany
36Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, LMHO, University Hospital Cologne, Cologne, Germany
37Department of Internal Medicine II, Campus Kiel, University of Schleswig-Holstein, Kiel, Kiel, Germany
38Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany
39Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
40Department of Hematology, Academic Medical Center, Amsterdam, Netherlands
41Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
42Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
43Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf and German CLL Study Group, University of Cologne, Cologne, Germany

10:45 AM

Moritz Fürstenau, MD1, Anke Schilhabel, PhD2*, Sandra Robrecht, PhD1*, Can Zhang, PhD3*, Julia Von Tresckow, MD4*, Carsten Utoft Niemann, MD, PhD5, Arnon P. Kater, MD, PhD6, Eugen Tausch, MD7*, Florian Simon, MD8*, Nisha De Silva, MBBS, MRCP, FRCPath3*, Anna-Maria Fink, MD9*, Kirsten Fischer, MD9*, Clemens-Martin Wendtner, MD10, Michael Gregor, MD11*, Patrick Thornton, MB, FRCPath12*, Philipp B. Staber, MD, PhD13, Tamar Tadmor, MD14*, Mark-David Levin, MD, PhD15, Marinus H.J. Van Oers, MD, PhD16, Caspar Da Cunha-Bang, MD, PhD17, Christian H. Geisler, MD, PhD5, Stephan Stilgenbauer, MD18, Monika Brüggemann, Prof., PhD19*, Michael Hallek, MD20, Matthias Ritgen, MD21* and Barbara Eichhorst, MD22

1Department I of Internal Medicine and Center of Integrated Oncology ABCD Cologne, German CLL Study Group, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany, Cologne, Germany
2Hämatologie Labor Kiel, University of Kiel, Kiel, Germany
3Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, German CLL Study Group, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany, Cologne, Germany
4Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Essen, Germany
5Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
6Amsterdam UMC, Amsterdam, NH, Netherlands
7Department of Internal Medicine III, University Hospital Ulm, Ulm, Ulm, Germany
8Department I of Internal Medicine, University of Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
9Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, German CLL Study Group, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany
10Department of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine, German CLL Study Group, Munich Clinic Schwabing, Munich, Germany
11Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland
12Department of Haematology, Beaumont Hospital, Dublin, Ireland
13Medical University of Vienna, Department of Medicine I, Division of Hematology & Hemostaseology, Vienna, Austria
14Hematology Unit, Bnai Zion Medical Center, Haifa, Israel
15Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
16Department of Hematology, Academic Medical Center, Amsterdam, Netherlands
17Department of Hematology, Rigshospitalet, Copenhagen University Hospital, København Ø, Denmark
18Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
19Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany
20University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; Center for Molecular Medicine Cologne; CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, Cologne, Germany
21Department of Internal Medicine II, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
22University of Cologne, Cologne, Germany

*signifies non-member of ASH