-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

615.O3.6 615. Acute Myeloid Leukemias: Commercially Available Therapies, Excluding Transplantation and Cellular Immunotherapies: Updates in treatment for high-risk AML Clinically Relevant Abstract

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Acute Myeloid Malignancies, AML, Diseases, Myeloid Malignancies
Monday, December 13, 2021: 6:15 PM-7:45 PM
Thomas Murphy Ballroom 1-2, Level 5, Building B (Georgia World Congress Center)
Moderators:
Justin Watts, MD, University of Miami and Bhumika J. Patel, MD, Cleveland Clinic
Disclosures:
Watts: Celgene/Bristol Myers Squibb: Consultancy; Genentech: Consultancy; Rafael Pharmaceuticals: Consultancy; Takeda: Consultancy, Research Funding.
The session will cover the novelties in treatment of several myeloid malignancies that have in common a high risk of early mortality, relapse and resistance to frontline therapies. Most of data are from clinical trials, some of them updated at a longer follow-up.
6:15 PM

Andrew H. Wei, MBBS, PhD1,2*, Hartmut Döhner, MD3, Hamid Sayar, MD, MSc4, Farhad Ravandi, MB Bs5, Pau Montesinos, PhD, MD6*, Hervé Dombret, MD, PhD7,8, Dominik Selleslag, MD9, Kimmo Porkka, MD, PhD10,11*, Jun Ho Jang, MD, PhD12, Barry Skikne, MD13,14*, C.L. Beach, PharmD14*, Yu (Olivia) Tian, PhD14* and Gail J. Roboz, MD15,16

1Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia
2Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
3Ulm University Hospital, Ulm, Germany
4Indiana University Cancer Center, Indianapolis, IN
5Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
6Hospital Universitario y Politécnico La Fe, Valencia, Spain
7Hôpital Saint-Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
8Institut de Recherche Saint Louis, Université de Paris, Paris, France
9AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium
10Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
11iCAN Digital Precision Cancer Center Medicine Flagship, University of Helsinki, Helsinki, Finland
12Samsung Medical Center, Seoul, Korea, Republic of (South)
13Kansas University Medical Center, Kansas City, KS
14Bristol Myers Squibb, Princeton, NJ
15Weill Cornell Medicine, New York, NY
16New York Presbyterian Hospital, New York, NY

6:30 PM

Christian Recher, MD1, Christoph Rollig, MD, MSC2*, Emilie Berard, MD3*, Sarah Bertoli4*, Pierre-Yves Dumas, MD, PhD5*, Suzanne Tavitian, MD6*, Hubert Serve, MD7, Martin Bornhäuser, MD2*, Uwe Platzbecker, MD8, Carsten Müller-Tidow, MD9*, Claudia D. Baldus, MD10*, David Martínez-Cuadrón, MD11*, Josefina Serrano, MD12*, Pilar Martínez, MD13*, Eduardo Rodríguez-Arbolí, MD14*, Cristina Gil, MD15*, Juan-Miguel Bergua, MD16*, Teresa Bernal, MD17*, Adolfo de la Fuente, MD18*, Eric Delabesse, PharmD, PhD19*, Audrey Bidet, PharmD20*, Arnaud Pigneux, MD, PhD21*, Pau Montesinos, PhD, MD11* and Michael Kramer, MSc22*

1Service d'Hématologie, CHU de Toulouse - Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France
2Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Dresden, Germany
3Service d'Epidémiologie, CHU de Toulouse, Toulouse, France
4Service d'Hématologie, Service d'Hématologie, Toulouse, France
5Service d'Hématologie, CHU de Bordeaux, Pessac, France
6Service d'Hématologie, CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
7Department of Medicine II, Hematology/Oncology, Goethe University, University Hospital, Frankfurt, Germany
8Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
9Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
10Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany
11Instituto de Investigación Sanitaria La Fe (IISLAFE), Hospital Universitari i Politècnic La Fe, Valencia, Spain
12IMIBIC, Hematology, Hospital Universitario Reina Sofía, UCO, Córdoba, Spain
13Hospital Doce De Octubre, Madrid, ESP
14Hospital Universitario Virgen del Rocío, Sevilla, Spain
15Hospital General Universitario de Alicante, Alicante, Spain
16Hospital Universitario San Pedro de Alcántara, Cáceres, Spain
17Hospital Universitario Central De Asturias, Oviedo, ESP
18MD Anderson Cancer Center Madrid, Madrid, Spain
19Laboratoire d'hématologie, CHU de Toulouse - Institut Universitaire du Cancer De Toulouse-Oncopole, Toulouse cedex9, France
20Hematology Biology, CHU de Bordeaux, Bordeaux, France
21Service d'Hématologie, CHU Bordeaux, Bordeaux, France
22Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany

6:45 PM

Hong-hu Zhu, MD, PhD1*, Ya-fang Ma2*, Suning Chen3*, Ying Lu4*, Jiang Huang5*, Huai-Yu Wang6*, Xiaohua Xu7*, Bing-Shou Xie8*, Yinjun Lou, PhD9* and Jie Jin, MD, PhD10

1Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2the First Affiliated Hospital, College of Medicine, Zhejiang University, hangzhou, China
3First Affiliated Hospital of Soochow University, Suzhou, CHN
4The affiliated people's hospital of Ningbo University, Ningbo, China
5The Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, China
6First Hospital of Xi'an Jiaotong University, Xi'an, China
7Department of Hematology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
8Wenzhou People's Hospital, Wenzhou, CHN
9The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 13588865815, CHN
10Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

7:00 PM

Naveen Pemmaraju, MD1, Marina Konopleva, MD, PhD1, Kendra Sweet, MD2, Anthony S. Stein, MD3, Sumithira Vasu, MBBS4, David A. Rizzieri, MD5*, Eunice S. Wang, MD6, Hagop Kantarjian, MD7, Christopher L Brooks, PhD8, Tariq I. Mughal, MD, FRCP8,9* and Andrew A. Lane, MD, PhD10

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2H. Lee Moffitt Cancer Center, Tampa, FL
3City of Hope National Medical Center, Duarte, CA
4Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
5Duke University Medical Center, Durham, NC
6Roswell Park Comprehensive Cancer Center, BUFFALO, NY
7Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX
8Stemline Therapeutics Inc, New York, NY
9Tufts University School of Medicine, Boston, MA
10Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

7:15 PM

Prapti Patel, MD1, Amy S. Ruppert, PhD2, Uma Borate, MD3, Eytan M. Stein, MD4, Maria R. Baer, MD5, Wendy Stock, MD6, Tibor Kovacsovics, MD7, William Blum, MD8, Martha L. Arellano, MD9, Gary J. Schiller, MD10, Rebecca L. Olin, MD11, James M. Foran, MD12, Mark R. Litzow, MD13, Tara L. Lin, MD14, Matthew C. Foster, MD15, Robert L. Redner, MD16, Zeina Al-Mansour, MD17, Christopher R. Cogle, MD18, Michael M. Boyiadzis, MD19, Ronan Swords, MD PhD20, Robert H. Collins, MD21, Jo-Anne Vergilio, MD22*, Nyla A. Heerema, PhD23, Leonard Rosenberg, PhD RPh24*, Ashley Owen Yocum, PhD25*, Sonja Marcus, MPH26*, Timothy Chen, PhD27*, Franchesca Druggan, MSc3*, Mona Stefanos, MBChB28*, Theophilus J Gana, MD PhD29*, Abigail B. Shoben, PhD30*, Brian J. Druker31, Amy Burd, PhD32, John C. Byrd, MD33, Ross L. Levine, MD34 and Alice S. Mims, MD3

1Division of Hematology and Oncology, University of Texas Southwestern, Dallas, TX
2Department of Medicine, The Ohio State University, Gahanna, OH
3The Ohio State University, Columbus, OH
4Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
5University of Maryland Greenebaum Cancer Center, Baltimore, MD
6Section of Hematology/Oncology, Department of Medicine, University of Chicago Medicine, Chicago, IL
7Huntsman Cancer University of Utah, Salt Lake City, UT
8Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
9Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA
10David Geffen School of Medicine at UCLA, Los Angeles, CA
11University of California, San Francisco, San Francisco, CA
12Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic Florida, Jacksonville, FL
13Division of Hematology, Mayo Clinic, Rochester, MN
14University of Kansas, Westwood, KS
15University of North Carolina School of Medicine, Chapel Hill, NC
16UPMC Hillman Cancer Center, Pittsburgh, PA
17Department of Medicine/Division of Hematology Oncology, University of Florida, Gainesville, FL
18Department of Medicine, University of Florida, Gainesville, FL
19Univ. of Pittsburgh Cancer Inst., Pittsburgh, PA
20Oregon Health and Science University, Portland
21Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX
22Foundation Medicine, Inc, Cambridge, MA
23Department of Pathology, The Ohio State University, Columbus, OH
24Leukemia & Lymphoma Society, Mount Laurel, NJ
25Leukemia and Lymphoma Society, New York
26Leukemia & Lymphoma Society, Rye Brook, NY
27Department of Internal Medicine, Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH
28Ohio State, Ohio State, Columbus, OH
29Biopharmatech Consulting, Inc., Leesburg, VA
30The Ohio State University Comprehensive Cancer Center, Columbus, OH
31Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR
32Leukemia and Lymphoma Society, White Plains, NY
33Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
34Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY

7:30 PM

Juliette Lambert1*, Pierre Peterlin2*, Cecile Pautas, MD3*, Emmanuel Raffoux, MD4*, Denis Caillot, MD5,6*, Ollivier Legrand, MD, PhD7*, Magalie Joris, MD8*, Anna Berceanu, MD9*, Jean Valere Malfuson, MD, PhD10*, Sylvain Chantepie, MD11*, Marc Bernard, MD12*, Lauris Gastaud, MD13*, Arnaud Pigneux, MD, PhD14*, Omar Benbrahim, MD15*, Caroline Bonmati, MD16*, Hunault-Berger Mathilde, MD, PhD17*, Hervé Dombret, MD, PhD18, Philippe Rousselot19*, Sylvie Chevret, MD, PhD20* and Sylvie Castaigne, MD1*

1Hematology Department, Versailles Hospital, Le Chesnay, France
2Clinical Hematology, Nantes University Hospital, Nantes, France
3Hematology Department, Henri Mondor University Hospital, CRETEIL, France
4Université de Paris, Hematology department, Saint-Louis hospital, APHP, Paris, France
5Hematology Department, Le Bocage University Hospital, Dijon, France
6Hematology Department, Dijon University Hospital, Dijon, France
7Department of Clinical Hematology and Cellular Therapy, Saint Antoine Hospital, Assistance Publique - Hôpitaux de Paris, Sorbonne Université, Paris, France
8Hematology department, CHU Amiens, Amiens, France
9Department of Clinical Hematology, Besançon University Hospital, Besançon, France
10Hematology Department, Percy Hospital, Clamart, France
11Hematology Department, Caen University Hospital, Caen, France
12Hematology Department, Rennes University Hospital, Rennes, France
13Medical Oncology Department, Antoine Lacassagne Hospital, Nice, France
14Hematology Department, Bordeaux University Hospital, Pessac, France
15Hematology Department, Orleans CHR, Orleans, France
16Hematology Department, Nancy University Hospital, Vandoeuvre Lès Nancy, France
17Hematology Department, Angers University Hospital, Angers, France
18Saint-Louis University Hospital, Paris, France
19Hematology Department, Centre Hospitalier de Versailles, LE CHESNAY CEDEX, France
20APHP, Saint-Louis University Hospital, Department of Biostatistics, PARIS, France

*signifies non-member of ASH