-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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Ticketed Session denotes that this is a ticketed session.

615.O2.6 615. Acute Myeloid Leukemias: Commercially Available Therapies, Excluding Transplantation and Cellular Immunotherapies: Current approach to FLT3 mutated AML Clinically Relevant Abstract

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Acute Myeloid Malignancies, AML, Non-Biological therapies, Diseases, Therapies, Myeloid Malignancies
Monday, December 13, 2021: 2:45 PM-4:15 PM
B308-B309, Level 3, Building B (Georgia World Congress Center)
Moderators:
Felicetto Ferrara, MD, Cardarelli Hospital and Luca Maurillo, MD, Policlinico Tor Vergata
Disclosures:
No relevant conflicts of interest to declare.
The session will cover the most recent evidences of FLT3i in newly diagnosed and relapsed/refractory AML. Safety and efficacy of several combinations will be analyzed, both as single drug and in combination with other targeted drugs, HMA and standard chemotherapy. The use in long term maintenance will be explored as well.
2:45 PM

Naval Daver, MD1, Alexander E. Perl, MD2, Joseph Maly, MD3, Mark Levis, MD4, Ellen Ritchie, MD 5, Mark R. Litzow, MD6, James McCloskey, MD7*, Catherine C. Smith, MD8, Gary J. Schiller, MD9, Terrence Bradley, MD10,11, Ramon V. Tiu, MD12, Kiran Naqvi, MD13*, Monique Dail, PhD13*, Satya Siddani, PhD14*, Jing Wang, PhD14*, Brenda Chyla, PhD14, Paul Lee, MD, PhD14* and Jessica K. Altman, MD15

1MD Anderson Cancer Center, Houston, TX
2Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
3Norton Cancer Institute, Louisville, KY
4Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
5Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY
6Division of Hematology, Mayo Clinic, Rochester, MN
7John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ
8Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
9David Geffen School of Medicine at UCLA, Los Angeles, CA
10Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
11University of Miami, Department of Medicine, Miami, FL
12Astellas Pharma US, Northbrook, IL
13Genentech Inc., South San Francisco, CA
14AbbVie Inc., North Chicago, IL
15Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL

3:00 PM

Nicholas Short, MD1, Courtney D. DiNardo, MD, MSCE2, Naval Daver, MD2, Daniel Nguyen2*, Musa Yilmaz, MD2, Tapan M. Kadia, MD2, Guillermo Garcia-Manero, MD2, Ghayas C. Issa, MD2, Xuelin Huang, PhD3*, Wei Qiao, PhD3*, Koji Sasaki, MD2, Guillermo Montalban-Bravo, MD2, Kelly S. Chien, MD2, Gautam Borthakur, MD2, Ricardo Delumpa, BSN2*, Anna Milton2*, Sherry A. Pierce, BSN, BA2*, Elias Joseph Jabbour, MD4, Marina Konopleva, MD, PhD2, Hagop Kantarjian, MD2 and Farhad Ravandi, MB Bs2

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, HOUSTON, TX
2Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
3Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
4Department of Leukemia, University of Texas M.D. Anderson Cancer Ctr., Houston, TX

3:15 PM

Maher Hanoun, MD1*, Leo Ruhnke2*, Michael Kramer, MSc2*, Kerstin Schäfer-Eckhard, MD3*, Björn Steffen, MD4*, Tim Sauer, MD5*, Stefan W. Krause, MD6*, Christoph Schliemann, Prof., MD7*, Martin Kaufmann, MD8, Mathias Haenel, MD9*, Edgar Jost10*, Tim H Brummendorf, MD11, Lars Fransecky, MD12*, Sabrina Kraus, MD13*, Hermann Einsele14, Dirk Niemann, MD15*, Andreas Neubauer16, Johannes Kullmer17*, Ruth Seggewiss-Bernhard18*, Martin Goerner, MD19*, Gerhard Held20*, Ulrich Kaiser, MD21*, Sebastian Scholl, MD, PhD22*, Hans Christian Reinhardt, MD1*, Uwe Platzbecker, MD23, Claudia D. Baldus, MD12*, Carsten Mueller-Tidow, MD5, Martin Bornhaeuser, MD24, Hubert Serve, MD4 and Christoph Rollig, MD, MSC25*

1Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany
2Department of Internal Medicine I, University Hospital Dresden, Dresden, Germany
3Department of Internal Medicine 5, Hospital Nürnberg, Nürnberg, Germany
4Department of Medicine II, Hematology/Oncology, Goethe University, University Hospital, Frankfurt, Germany
5Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
6Department of Hematology and Medical Oncology, University Hospital Erlangen, Erlangen, Germany
7Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany
8Department of Hematology, Oncology and Palliative Medicine, Robert-Bosch-Hospital, Stuttgart, Germany
9Department of Internal Medicine III, Chemnitz Hospital, Chemnitz, Germany
10Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, University Hospital Aachen, Aachen, Germany
11Department of Internal Medicine IV, University Hospital RWTH Aachen, Aachen, Germany
12Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany
13Department of Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany
14Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
15Department of Hematology/Oncology and Palliative Medicine, Ev. Stift St. Martin, Koblenz, Germany
16Department of Hematology, Oncology and Immunology, University Hospital Marburg, Marburg, Germany
17Department of Internal Medicine II, DIAKO Bremen, Bremen, Germany
18Department of Internal Medicine V, Sozialstiftung Bamberg, Bamberg, Bavaria, Germany
19Department of Hematology, Oncology and Palliative Medicine, Klinikum Bielefeld Mitte, Bielefeld, Germany
20Department of Hematology, Oncology, Clinical Immunology, Rheumatology, University of Saarland, Homburg, Germany
21Department of Hematology and Oncology, St. Bernward Krankenhaus, Hildesheim, Germany
22University Hospital Jena, Jena, Germany
23Department for Internal Medicine I, University Hospital Leipzig, Leipzig, Germany
24Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
25Department of Internal Medicine I, University Hospital, Dresden, Germany

3:30 PM

Abhishek Maiti, MBBS1, Courtney D. DiNardo, MD, MSCE2, Caitlin R. Rausch, PharmD3*, Naveen Pemmaraju, MD2, Guillermo Garcia-Manero, MD2, Maro Ohanian, DO2*, Naval Daver, MD4, Ghayas C. Issa, MD2, Gautam Borthakur, MD2, Farhad Ravandi, MB Bs5, Yesid Alvarado, MD2, Tapan M. Kadia, MD6, Elias Joseph Jabbour, MD7, Nicholas Short, MD5, Guillermo Montalban-Bravo, MD2, Nitin Jain, MD8, Steven Kornblau, MD9, Lucia Masarova, MD2*, William G. Wierda10, Koji Sasaki, MD8, Koichi Takahashi, MD, PhD11, Musa Yilmaz, MD8, Jan A. Burger, MD, PhD11, Zeev E. Estrov, MD11, Srdan Verstovsek, MD, PhD6, Michael Andreeff, MD, PhD2, Prithviraj Bose, MD4, Alessandra Ferrajoli, MD2, Philip A. Thompson4, Kathryn Montalbano12*, Kenneth Vaughan, RN2*, Carol A. Bivins, RN2*, Sherry A. Pierce, BSN, BA2*, Wei Qiao, PhD13*, Jing Ning14*, John S. Welch, MD, PhD15, Hagop Kantarjian, MD2 and Marina Konopleva, MD, PhD2

1Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
2Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
3Pharmacy, MD Anderson Cancer Center, Houston, TX
4MD Anderson Cancer Center, Houston, TX
5Department of Leukemia, The University of Texas MD Anderson Cancer Center, HOUSTON, TX
6Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX
7Department of Leukemia, University of Texas M.D. Anderson Cancer Ctr., Houston, TX
8Department of Leukemia, MD Anderson Cancer Center, Houston, TX
9Leukemia / Stem cell Transplantation & Cellular Therapy, UT MD Anderson Cancer Center, HOUSTON, TX
10Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX
11Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
12Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
13Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
14department of biostatics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX
15Department of Medicine, Division of Oncology, Washington University, Saint Louis, MO

3:45 PM

Jianxiang Wang, MD1, Bin Jiang, MD2*, Jian Li, MD3, Ligen Liu, MD4, Xin Du, PhD5*, Hao Jiang6*, Jianda Hu, M.D. & Ph.D.7, Menghe Yuan, MD8*, Taishi Sakatani, MSc9*, Takeshi Kadokura, PhD9*, Masato Takeuchi9*, Shunsuke Izuka, MSc9*, Larisa Girshova, MD10*, Jerome Tan, MD11*, Sergey N. Bondarenko12*, Lily LL Wong, MD13*, Archrob Khuhapinant, MD14, Elena Martynova, MD15*, Nahla Hasabou, MD16* and Ramon V. Tiu, MD16

1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
2Department of Hematology, Peking University International Hospital, Beijing, China
3Department of Hematology, Peking Union Medical College Hospital, Beijing, China
4Department of Hematology, Shanghai Tongren Hospital, Shanghai, China
5Department of Hematology, Guangdong Provincial People's Hospital, Guangzhou, China
6Department of Hematology, Peking University Peoples Hospital, Beijing, China
7Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China
8Astellas Pharma, Inc., Beijing, China
9Astellas Pharma, Inc., Tokyo, Japan
10Almazov National Medical Research Centre, St. Petersburg, Russian Federation
11Department of Hematology, Ampang Hospital, Selangor, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Sarawak, Malaysia
12Clinical Research Institution of Pediatric Hematology and Transplantation under the Name of Raisa Gorbacheva, State Medical University, St. Petersburg, Russian Federation
13Department of Hematology, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia
14Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
15Skolkovo Institute of Science and Technology, Moscow, Russian Federation
16Astellas Pharma, Inc., Northbrook, IL

4:00 PM

Hartmut Döhner, MD1, Daniela Weber, MSc1*, Julia Krzykalla, PhD2*, Walter Fiedler, MD3, Gerald Wulf, MD4*, Helmut R. Salih5, Michael Lübbert6*, Michael W.M. Kühn, MD7*, Thomas Schroeder8*, Hans Salwender, MD9*, Katharina S. Götze10*, Jörg Westermann, MD, PhD11*, Lars Fransecky, MD12*, Karin Mayer, MD13*, Bernd Hertenstein, MD14*, Mark Ringhoffer, MD15*, Hans-Joachim Tischler, MD16*, Sigrid Machherndl-Spandl, MD17*, Anika Schrade, PhD18*, Peter Paschka, MD18, Verena I Gaidzik, MD19, Frauke Theis, MD20*, Felicitas R Thol, MD21, Michael Heuser, MD22, Richard F. Schlenk, MD23, Lars Bullinger, MD24, Maral Saadati, PhD25*, Axel Benner, PhD2*, Konstanze Döhner18* and Arnold Ganser, MD22

1Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
2Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
4Department of Hematology and Oncology, Georg-August-University of Göttingen, Göttingen, Germany
5Department of Hematology and Oncology, Eberhard Karls University, Tuebingen, Tuebingen, Germany
6Department of Internal Medicine I, University Medical Center Freiburg, Freiburg, Germany
7Department of Hematology, Oncology and Pneumology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany
8Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, Medical Faculty, Düsseldorf, Germany
9Asklepios Tumorzentrum Hamburg, AK Altona and AK St. Georg, Hamburg, Germany
10Department of Medicine III, Technical University of Munich (TUM), Klinikum rechts der Isar, Munich, Germany
11Charité-University Medical Center Berlin, Campus Virchow Clinic, Berlin, Germany
12Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany
13Department of Internal Medicine III, University Hospital of Bonn, Bonn, Germany
14Department of Internal Medicine I, Klinikum Bremen Mitte, Bremen, Germany
15Department of Internal Medicine III, Municipal Hospital of Karlsruhe, Karlsruhe, Germany
16Mühlenkreiskliniken, Minden, Germany
171st Medical Department, Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz GmbH Elisabethinen, Linz, Austria
18Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
19Internal Medicine III, Internal Medicine III, Ulm, Germany
20Department of Internal Medicine III, University Hospital of Ulm, Ulm, Baden-Württemberg, Germany
21Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hanover, Germany
22Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
23University Hospital of Ulm, Ulm, Germany
24Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine, Berlin, Germany
25Saadati Solutions, Ladenburg, Germany

*signifies non-member of ASH