-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

Omics Approaches to Erythrocyte Biology in Sickle Cell Disease

PhD Trainee
Program: Scientific Workshops @ ASH
Friday, December 4, 2020: 7:05 AM-8:10 AM
No relevant conflicts of interest to declare.
Omics Approaches to Erythrocyte Biology in Sickle Cell Disease The goal of this workshop is to raise awareness of how various new and developing ‘omics technologies are contributing to our understanding of SCD pathophysiology, as well as how these contributions can inform further basic research, drug development, and clinical trial design in inherited hematologic diseases. Thus, a major aim is to increase research activities using ‘omics in both basic and clinical research in hematology. Dr. Marilyn Telen will introduce the topic and the presenters. Dr. Pankaj Qasba will introduce the NHLBI TOPMed program. Dr. Guillaume Lettre will speak on “Using Mendelian Randomization to understand clinical heterogeneity in sickle cell disease.” Dr. Xu Zhang ill discuss “Using transcriptomes to understand hypoxic responses in stress erythropoiesis in SCD—Comparing SCD to Chuvash erythrocytosis.” Dr. Ross Hardison will discuss “Validated Systematic Integration of epigenomic data in hematopoietic cells (VISION): Painting the landscape of gene regulation.” Dr. Ambroise Wonkam will talk about “Hydroxyurea-Induced miRNA Expression in sickle cell disease.”

Pankaj Qasba, PhD

NHLBI-Division of Blood Diseases and Resources, National Institutes of Health, Bethesda, MD

Guillaume Lettre, PhD

Montreal Heart Institute Research Centre, Montreal, QC, Canada

Xu Zhang, PhD

University of Illinois At Chicago, Chicago, IL; Department of Medicine, University of Illinois at Chicago, Chicago, IL

Ross C. Hardison, Ph.D.

Department of Biochemistry and Molecular Biology; Centers for Eukaryotic Gene Regulation and for Computational Biology, The Pennsylvania State University, University Park, PA

Ambroise Wonkam, MD

University of Capetown, Cape Town, ZAF