Omics Approaches to Erythrocyte Biology in Sickle Cell Disease The goal of this workshop is to raise awareness of how various new and developing ‘omics technologies are contributing to our understanding of SCD pathophysiology, as well as how these contributions can inform further basic research, drug development, and clinical trial design in inherited hematologic diseases. Thus, a major aim is to increase research activities using ‘omics in both basic and clinical research in hematology. Dr. Marilyn Telen will introduce the topic and the presenters. Dr. Pankaj Qasba will introduce the NHLBI TOPMed program. Dr. Guillaume Lettre will speak on “Using Mendelian Randomization to understand clinical heterogeneity in sickle cell disease.” Dr. Xu Zhang ill discuss “Using transcriptomes to understand hypoxic responses in stress erythropoiesis in SCD—Comparing SCD to Chuvash erythrocytosis.” Dr. Ross Hardison will discuss “Validated Systematic Integration of epigenomic data in hematopoietic cells (VISION): Painting the landscape of gene regulation.” Dr. Ambroise Wonkam will talk about “Hydroxyurea-Induced miRNA Expression in sickle cell disease.”