Women with hematologic conditions can face unique challenges during pregnancy. Understanding pathophysiology of pregnancy and associated hematologic changes is paramount in optimal management of patients with bleeding and coagulation disorders, sickle cell disease and thrombotic microangiopathies associated with pregnancy. This workshop will focus on recent insights on the role that the distinctive biology of pregnancy plays on development, diagnosis, clinical course, and treatment of hematologic disorders. The workshop’s interactive format will feature brief didactic presentations from speakers on key topics, followed by question and answer session. Audience polling questions will be utilized to facilitate the interactive nature of the workshop. Ash Scientific Workshop: Friday December 4th, 2020 10:00 AM – 1:00 PM EST Session: Hematology and Pregnancy Chairs: Henny H Billett MD MSc Irina Murakhovskaya MD Shannon Bates MDCM MSc 10:00 - 10:05 Opening Remarks: Henny H Billett MD MSc Professor of Medicine and Pathology, Montefiore Health Systems Albert Einstein College of Medicine 10:05 – 11:05 Thrombosis and Bleeding in Pregnancy Moderator: Shannon Bates MDCM MSc Professor, Department of Medicine McMaster University 10:05 - 10:10 Moderator Introduction Shannon Bates MDCM MSc Professor, Department of Medicine McMaster University 10:10 – 10:25 Approach to pregnancy and delivery in women with bleeding disorders Michelle Sholzberg MD Assistant Professor, Department of Medicine University of Toronto 10:25 – 10:40 Diagnosis and management of NAIT Ruchika Sharma MD Assistant Professor of Pediatrics Medical College of Wisconsin 10:40 – 10:55 Prevention and treatment of venous thromboembolism in pregnancy Leslie Skeith MD Assistant Professor, Department Medicine University of Calgary 10:55-11:05 Q&A 11:05 – 11:50 Interplay of Pregnancy and Sickle Cell Disease Moderator: Caterina P Minniti MD 11:05 – 11:10 Moderator Introduction Caterina P Minniti MD Professor of Medicine and Pediatrics, Montefiore Health Systems Albert Einstein College of Medicine 11:10 – 11:25 Expecting more: fertility assessment and preservation in sickle cell disease Lydia Pecker MD Assistant Professor in Medicine, Depts of Medicine and Obstetrics & Gynecology Johns Hopkins University 11:25 – 11:40 Pathophysiology of SCD complications during pregnancy Eugene Oteng-Ntim PhD MBBS, DTropM Professor of Obstetrics King’s College London 11:40 – 11:50 Q&A 11:50- 12:50 Complement Activation and Thrombotic Microangiopathies in Pregnancy Moderator: Fadi Fakhouri MBBS 11:50 – 11:55 Moderator Introduction Fadi Fakhouri MBBS Professor of Medicine Université de Nantes 11:55– 12:10 COVID and Pregnancy Rasha Khoury MD MPH Assistant Professor of Obstetrics and Gynecology, Montefiore Health Systems Albert Einstein College of Medicine 12:10 – 12:25 CAPS and Complement in Pregnancy Shruti Chaturvedi MD Assistant Professor of Medicine Johns Hopkins University 12:25 – 12:40 AHUS in Pregnancy Fadi Fakhouri MBBS Professor of Medicine, Université de Nantes 12:40 – 12:50 Q&A 12:50 – 1:00 Closing Remarks Irina Murakhovskaya MD Assistant Professor of Medicine, Montefiore Health Systems Albert Einstein College of Medicine