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Description:
Disorders of iron homeostasis can cause iron overload as well as iron deficiency. Iron deficiency anaemia (IDA) remains amongst the five leading causes of years lived with disability in humans, It is a global health concern affecting children, women and the elderly, whilst also being a common comorbidity in multiple medical conditions including chronic inflammatory disorders.
Dr. Kleber Fertrin will discuss the challenge of diagnosing and managing iron deficiency in patients with chronic inflammatory conditions. He will review the evidence for how biomarkers of iron status behave in true iron deficiency in the setting of low grade inflammation and how this can be applied to identify patients more likely to benefit from iron supplementation. Dr. Fertrin will also highlight risks and benefits of oral and intravenous iron supplementation in chronic inflammatory conditions.
Dr. M.Domenica Cappellini will discuss the inherited microcytic anemias which can be broadly classified into three subgroups: (i) defects in globin chains (hemoglobinopathies or thalassemias), (ii) defects in heme synthesis, and (iii) defects in iron availability or iron acquisition by the erythroid precursors. Besides the very common microcytic anemias due to acquired iron deficiency, a range of hereditary abnormalities that result in actual or functional iron deficiency are now being recognized and they will be discussed in this presentation.
Dr. Michael Zimmermann will discuss the global problem of nutritional and functional iron deficiency presenting the experience in Africa. He found that Iron given to infants in Africa can reduce anemia, but can also increase gut inflammation, dysbiosis and diarrhea. Iron deficiency anemia in African infants may impair adaptive immunity and may be a previously unrecognized contributor to vaccine failure.
Dr. Kleber Fertrin will discuss the challenge of diagnosing and managing iron deficiency in patients with chronic inflammatory conditions. He will review the evidence for how biomarkers of iron status behave in true iron deficiency in the setting of low grade inflammation and how this can be applied to identify patients more likely to benefit from iron supplementation. Dr. Fertrin will also highlight risks and benefits of oral and intravenous iron supplementation in chronic inflammatory conditions.
Dr. M.Domenica Cappellini will discuss the inherited microcytic anemias which can be broadly classified into three subgroups: (i) defects in globin chains (hemoglobinopathies or thalassemias), (ii) defects in heme synthesis, and (iii) defects in iron availability or iron acquisition by the erythroid precursors. Besides the very common microcytic anemias due to acquired iron deficiency, a range of hereditary abnormalities that result in actual or functional iron deficiency are now being recognized and they will be discussed in this presentation.
Dr. Michael Zimmermann will discuss the global problem of nutritional and functional iron deficiency presenting the experience in Africa. He found that Iron given to infants in Africa can reduce anemia, but can also increase gut inflammation, dysbiosis and diarrhea. Iron deficiency anemia in African infants may impair adaptive immunity and may be a previously unrecognized contributor to vaccine failure.