62nd ASH Annual Meeting and Exposition: 711. Cell Collection and Processing: Poster III

Oral and Poster Abstracts
Poster

Adult, AML, apheresis, Biological, Coronaviruses, HSCs, multiple myeloma, SARS-CoV-2/COVID-19, bioengineering, Diseases, iPSCs, Therapies, Genetic Disorders, Biological Processes, cell expansion, gene therapy, immune cells, Technology and Procedures, Cell Lineage, immunotherapy, Plasma Cell Disorders, gene editing, Lymphoid Malignancies, Study Population, Clinically relevant, Myeloid Malignancies, NK cells, hematopoiesis, flow cytometry, transplantation, molecular testing, stem cells, NGS, RNA sequencing

3279

cGMP Mass Production of FT538, a First-of-Kind, Off-the-Shelf, Multiplexed Engineered Natural Killer Cell Cancer Immunotherapy Derived from a Clonal Master Induced Pluripotent Stem Cell Line

Betsy Rezner, BS ^*, Luis Solchaga, PhD^*, Luane Reyes^*, Alice Lin, PhD^*, Ramzey Abujarour, PhD^*, Tom Lee, PhD^*, Bahram Valamehr, PhD and Wen Bo Wang, PhD^*

Fate Therapeutics, Inc., San Diego, CA

3280

Sars-Cov-2 Spike Protein Induces Cellular Changes in Primitive and Mature Hematopoietic Cells

James Ropa, BS, MSc, PhD, Scott Cooper, MS^*, Maegan L. Capitano, PhD and Hal E. Broxmeyer, PhD

Department of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN

3281

Hematopoietic Progenitor Cell Mobilization and Collection for Autologous Hematopoietic Cell Transplantation in AL Amyloidosis: A Single Center Experience

Anne K Hubben, MD¹, Lisa Rybicki, MS²^*, Kristin Ricci, MD²^*, Navneet S. Majhail, MD, MS³, Matt Kalaycio, MD², Betty K. Hamilton, MD³, Brian T. Hill, MD², Allison M. Winter, MD⁴, Brad Pohlman, MD⁴, Deepa Jagadeesh, MD, MPH², Faiz Anwer, MD⁴, Robert M. Dean, MD², Ronald Sobecks, MD², Chakra P Chaulagain, MD⁵, Hien D. Liu, MD⁶ and Jack Khouri, MD⁴

¹Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Blood and Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
³Department of Hematology and Medical Oncology, Leukemia Program, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁴Taussig Cancer Institute, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH
⁵Department of Hematology and Oncology, Maroone Cancer Center, Cleveland Clinic Florida, Weston, FL
⁶Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

3282

Successful Manufacturing of CAR T-Cells with Small Volume Peripheral Blood from Healthy Donors Using the Clinimacs Prodigy Device

Katie Palen¹^*, Parameswaran Hari, MBBS, MD², Nirav N. Shah, MD³ and Bryon Johnson, PhD⁴

¹Medical College of Wisconsin, Milwaukee, WI
²Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Brookfield, WI
³Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
⁴Division of Hematology, Oncology and Bone Marrow Transplantation, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI

3283

A Comprehensive High Resolution Scrna-Seq Analytical Platform for Characterizing Human Hematopoietic Stem/Progenitor Cells States in Ex Vivo Drug Products

Cristina Baricordi, PhD^1,2^*, Mariana Loperfido, PhD^1,2^*, Aimin Yan, PhD¹^*, Luigi Barbarossa¹^*, Mercedes Segura, PhD¹^*, Azadeh Golipour, PhD¹^*, Chris Mason, PhD, MD^3,4 and Luca Biasco, PhD^1,5

¹AVROBIO Inc, Cambridge, MA
²Equal Author Contribution, Cambridge
³Advanced Centre for Biochemical Engineering, University College London, London, United Kingdom
⁴AVROBIO, Cambridge, MA
⁵UCL Great Ormond Street Institute of Child Health, London, United Kingdom

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^*signifies non-member of ASH