62nd ASH Annual Meeting and Exposition: 701. Experimental Transplantation: Basic Biology, Pre-Clinical Models: Poster III

Oral and Poster Abstracts
Poster

Adult, ALL, AML, Biological, Leukemia, Animal models, bone marrow, Diseases, GVHD, Therapies, Adverse Events, MDS, Pediatric, Biological Processes, Immune Disorders, Technology and Procedures, Young Adult, Cell Lineage, epigenetics, immunotherapy, Lymphoid Malignancies, Study Population, Clinically relevant, genetic profiling, genomics, Myeloid Malignancies, flow cytometry, immune mechanism, transplantation, inflammation, stem cells, NGS, radiation, molecular interactions, pathogenesis, WGS, pathways

3249

Tissue-Derived IL-33 Is a Critical Local Signal That Targets Th1 Cells in the Small Intestine to Sustain Graft Versus Host Disease in the Absence of IL-12

Gaelen K Dwyer¹^*, Lisa R Mathews²^*, Anna Lucas²^*, Bruce R. Blazar, MD³, Warren D Shlomchik, MD^4,5 and Heth Turnquist, PhD²^*

¹Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA
²Department of Surgery, University of Pittsburgh, Pittsburgh, PA
³Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN
⁴Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁵Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, PA

3250

Associations of Clinical Outcomes after Allogeneic Hematopoietic Cell Transplantation with Number of Predicted Class II Restricted mHA

Othmane Jadi, BS, BA¹, Hancong Tang, MS²^*, Junke Wang, MS²^*, Dante Bortone, PhD³^*, Steven Vensko, PhD⁴^*, Loreall Pooler⁵^*, Xin Sheng, MS⁶^*, Christopher A. Haiman, Ph.D.⁶^*, David Van Den Berg, PhD⁷^*, Stephen R. Spellman, MS⁸^*, Marcelo C. Pasquini, MD, MS⁹, Theresa E. Hahn, PhD¹⁰, Paul M. Armistead, MD, PhD¹¹, Benjamin G. Vincent, MD¹¹ and Lara E. Sucheston-Campbell, PhD, MS¹²

¹UNC School of Medicine, Chapel HIll, NC
²College of Pharmacy, The Ohio State University, Columbus, OH
³UNC Chapel Hill, Chapel Hill, NC
⁴University of North Carolina at Chapel Hill, Chapel Hill, NC
⁵University of Southern California, Los Angeles, CA
⁶University of Southern California, Keck School of Medicine of USC, Los Angeles, CA
⁷Preventive Medicine, University of Southern California, Keck School of Medicine of USC, Los Angeles, CA
⁸CIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI
⁹CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
¹⁰Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹¹Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
¹²College of Veterinary Medicine, Cancer Prevention & Control, Columbus, OH

3251

A Novel View of the Role of Prostaglandin E2 (PGE2) in Facilitating Engraftment of HSPCs By Activating the NOX2–ROS–Nlrp3 Inflammasome Axis to Incorporate the CXCR4 Receptor into Membrane Lipid Rafts

Magdalena Kucia, PhD, DSci^1,2, Kamila Bujko, MSc³^*, Arjun Thapa, PhD⁴^*, Janina Ratajczak, MD, PhD, DSci³ and Mariusz Z Ratajczak, MD, PhD, DSc^2,3

¹Stem Cell Institute, University Of Louisville Brown Cancer Center, Louisville, KY
²Department of Regenerative Medicine, Warsaw Medical University, Warsaw, Poland
³Stem Cell Institute at JGB CC, University of Louisville, Louisville, KY
⁴Stem Cell Program at JGB Cancer Center, University of Louisville, Louisville, KY

3252

A Murine Immunocompetent Acute Myeloid Leukemia (AML) Model for Testing Immunotherapies

Hui Mei Lee^*, Niloofar Zandvakilli^*, Rhea Desai, PhD^*, Purvi M Kakadia, PhD^*, Peter Browett, BMedSci, MBChB, FRACP, FRCPA and Stefan K. Bohlander, MD

Leukaemia & Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand

3253

Endothelial Microparticles Delivering Lncrna NEAT1 Are Involved in the Pathophysiology of aGVHD Following Allogeneic Hematopoietic Stem Cell Transplantation

Ran Zhang¹^*, Weijie Cao¹^*, Li Li¹^*, Dingming Wan, MD¹^*, Zhongxing Jiang, MD¹^*, Kai Sun, MD² and Linghui Xia³^*

¹Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
²Department of Hematology, Zhengzhou Univsersity People's Hospital & Henan Provincial, Zhengzhou, Henan, China
³Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

3254

LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease Via Skewing T Cells Polarization Towards Treg Cells

Huihui Liu, PhD^*, Zhengyu Yu, MD^*, Bo Tang, MD^*, Shengchao Miao, MD^*, Chenchen Qin^*, Yuan Li, MD^*, Zeyin Liang, MD^*, Yang Zhang^*, Hanyun Ren, MD and Yujun Dong, MD^*

Department of Hematology, Peking University First Hospital, Beijing, China

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^*signifies non-member of ASH