-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

641. CLL: Biology and Pathophysiology, excluding Therapy: Poster III

Program: Oral and Poster Abstracts
Type: Poster
Hematology Disease Topics & Pathways:
Adult, apoptosis, Biological, Leukemia, viral, bacterial, CLL, Diseases, Non-Biological, Combinations, Therapies, chemotherapy, B-Cell Lymphoma, Biological Processes, DNA damage, enzyme inhibitors, Technology and Procedures, cytogenetics, Infectious Diseases, Lymphoid Malignancies, Study Population, Clinically relevant, genetic profiling, genomics, immune mechanism, metabolomics, microenvironment, pathways, signal transduction
Monday, December 7, 2020: 7:00 AM-3:30 PM

Charles Herbaux, MD, MSc1, Imelda Raczkiewicz2*, Kamel Laribi, MD3*, Loic Ysebaert, MD, PhD4*, Agnes Daudignon5*, Sabine Tricot6*, Aurelie Caillault-Venet7*, Alain Jacques Delmer, MD, PhD8, Pascale Cornillet-Lefebvre9*, Cymbalista Florence10*, Virginie Eclache11*, Pierre Morel, MD12*, Gauthier Decool7*, Morgane Nudel13*, Romain Guieze, MD14*, Liam Hackett, BS15*, Stephen Jun Fei Chong16*, Mary C Collins, BS16*, Florence Nguyen-Khac, MD, PhD17*, Fatiha Merabet, MD18*, Jasmine Chauzeix19*, Stéphanie Struski, MD20*, Jennifer R. Brown, MD, PhD21*, Matthew S. Davids, MD21 and Stéphanie Poulain, MD, PhD22*

1Department of Medical Oncology, Dana-Farber Cancer Institute, BROOKLINE, MA
2CHU Lille, Lille, FRA
3Centre Hospitalier Du Mans, Le Mans, France
4Department of Hematology, Institut Universitaire Cancerologie Toulouse-Oncopole, Toulouse, France
5CHU de Lille, Cytogenetic Unit, Lille, France
6Hematology Unit, Arras, France
7Centre de Biologie Pathologie, Service d’Hématologie Cellulaire, Lille, France
8Hematology Department, Robert Debré University Hospital, Reims, Cedex, France
9Hematology Biology, Reims University Hospital, Reims, France
10Service d’hématologie biologique, Bobigny Cedex, France
11APHP, Bobigny, FRA
12Department of Hematology, Chu Amiens, Salouel, France
13Hematology Unit, Lille, France
14CHU Estaing, Unit of adult cell therapy and clinical hematology, University Hospital of Clermont-Ferrand, Brookline, MA
15Dana-Farber Cancer Institute, Boston, MA
16Dana Farber Cancer Institute, Boston
17Hematologie Biologique, APHP Pitié Salpêtrière, Paris, France
18Service Hématologie et Oncologie, Hôpital André Mignot, Le Chesnay, France
19Service d’Hématologie Biologique, Limoges, France
20Institut Universitaire du Cancer de Toulouse, Toulouse, France
21Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
22Service d'Hématologie Cellulaire, Centre de Biologie et Pathologie, CHRU de Lille, France/ INSERM UMR-S 1172, IRCL, Lille, FRA

Hanyin Wang, MD1*, Shulan Tian, MS, PhD2*, Qing Zhao3*, Wendy Blumenschein3*, Jennifer H. Yearley, PhD3*, Charla R. Secreto4*, Sutapa Sinha, PhD4, Timothy G. Call, MD4, Yucai Wang, MD, PhD4, Sameer A. Parikh, MD4, Saad S. Kenderian, MD4, Rong He, MD5, Jose F. Leis, MD, PhD6, Min Shi, MD, PhD5, Neil E. Kay, MD4, Susan L. Slager, PhD2*, Esteban Braggio, PhD7, Huihuang Yan, PhD2* and Wei Ding, MD, PhD4

1Department of Hospital Medicine, Mayo Clinic Health System, Mankato, MN
2Department of Health Sciences Research, Mayo Clinic, Rochester, MN
3Merck & Co., Inc., Kenilworth, NJ
4Division of Hematology, Mayo Clinic, Rochester, MN
5Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
6Division of Hematology and Medical Oncology, Mayo Clinic Health System, Phoenix, AZ
7Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ

Riccardo Moia, MD1*, Chiara Favini, PhD1*, Valentina Ferri, PhD1*, Riccardo Bomben, PhD2*, Sruthi Sagiraju, MSc1*, Tamara Bittolo, PhD2*, Lydia Scarfo3*, Silvia Bonfiglio3*, Rossana Maffei4, Stefano Baldoni5*, Sara Raponi, PhD6*, Valeria Spina, PhD7*, Alessio Bruscaggin, PhD7, Lodovico Terzi di Bergamo8*, Lorenzo De Paoli1*, Gloria Margiotta Casaluci1*, Clara Deambrogi, PhD1*, Silvia Rasi1*, Adalgisa Condoluci, MD8*, Ahad Ahmed Kodipad, Msc1*, Ramesh Adhinaveni, Msc1*, Katia Mokabari1*, Abdurraouf Mokhtar Mahmoud, MSc1*, Andrea Patriarca, MD1*, Jacopo Olivieri9*, Giovanni D'Arena, MD10, Francesco Zaja11*, Annalisa Chiarenza, MD, PhD12*, Giovanni Del Poeta, MD13, Antonella Zucchetto, PhD2*, Francesca Maria Rossi, PhD2*, Ilaria Del Giudice, MD, PhD6*, Paolo Sportoletti, MD5*, Roberto Marasca, MD14, Paolo Ghia, MD, PhD3, Robin Foà, MD6, Gianluca Gaidano1, Davide Rossi, MD, PhD8 and Valter Gattei, MD15

1Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
2Clinical and Experimental Onco-Hematology Unit, IRCCS Centro Di Riferimento Oncologico, Aviano, Italy
3Division of Experimental Oncology, Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, Italy
4Hematology Unit, A.O.U of Modena-Policlinico Department of Oncology and Hematology, Italy, Modena, Italy
5Department of Medicine, Division of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
6Hematology, Department of Translational and Precision Medicine, 'Sapienza' University, Rome, Italy
7Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland
8Institute of Oncology Research, Bellinzona, Switzerland
9Clinica Ematologica, Centro Trapianti e Terapie Cellulari "Carlo Melzi" Dipartimento Interaziendale di Salute Mentale, AO Universitaria S. Maria Misericordia, Udine, Italy., Udine, Italy
10IRCCS Centro Di Riferimento Oncologico Della Basilicata, Rionero In Vulture, ITA
11Institute of Hematology, University and Hospital of Trieste, Trieste, Italy
12AOU Policlinico, University of Catania, Division of Hematology, Catania, Italy
13Hematology, Department of Biomedicine and Prevention, University Tor Vergata, Roma, Italy
14Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
15Clinical and Experimental Onco-Hematology Unit, Centro Di Riferimento Oncologico, Aviano, Italy

Andrea Visentin, MD PhD1*, Gian Matteo Rigolin2*, Francesca Romana Mauro, MD, PhD3*, Annalisa Martines, PhD4*, Federica Frezzato, PhD5*, Silvia Imbergamo, MD6*, Stefano Pravato, MD6*, Leila Romano Gargarella, MD6*, Maria Antonella Bardi7*, Mauro Nanni, PhD3*, Francesco Piazza8, Monica Facco, MS9*, Robin Foà, MD3, Gianpietro Semenzato, MD10*, Laura Bonaldi, MD11*, Antonio Cuneo, MD12* and Livio Trentin, MD13

1Hematology and Clinical Immunology Unit, Department of Medicine, Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padova, Italy
2Hematology, St. Anna University Hospital, Cona, Ferrara, Italy
3Hematology, Department of Translational and Precision Medicine, 'Sapienza' University, Rome, Italy
4Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCSS, Padova, Italy
5Hematology and Clinical Immunology unit, Department of Medicine, University of Padua, Padova, Italy
6Hematology and Clinical Immunology unit, Department of Medicine, University of Padua, Padua, Italy
7Haematology Section, Ferrara, ITA
8Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padua, Italy
9Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padova, Pa, ITA
10Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padua, Italy
11Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCSS, Padua, Italy
12Hematology section, Department of Medical Sciences, University of Ferrara - Azienda Ospedaliera-Universitaria di Ferrara, University of Ferrara, Ferrara, Italy
13Hematology and Clinical Immunology Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy

Selcen Oeztuerk1*, Murat Iskar, PhD1*, Murat Sunbul, PhD2*, Philipp M Rößner, MD1*, Marc Zapatka, PhD1* and Martina Seiffert1*

1Molecular Genetics, German Cancer Research Center, Heidelberg, Germany
2Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany

Zhenghao Chen1,2*, Gaspard Cretenet1*, Valeria Carnazzo1,3*, Gerritje J. W. van der Windt1*, Arnon P. Kater, MD, PhD2,4 and Eric Eldering, PhD1,2*

1Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
2Amsterdam Institute of Infection and Immunity, Cancer Center Amsterdam, and Lymphoma and Myeloma Center (LYMMCARE), Amsterdam, Netherlands
3Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy
4Department of Hematology, Academic Medical Center, Amsterdam, NH, Netherlands

Geffen Kleinstern, PhD1, J. Brice Weinberg, MD2,3,4,5, Sameer A. Parikh, MD6, Esteban Braggio, PhD7, Dennis P. Robinson8*, Aaron D. Norman, MPH8*, Kari G Rabe8*, Celine M. Vachon, PhD9, Connie E. Lesnick8*, Timothy G. Call, MD6, Danielle M. Brander, MD10,11, Janet E. Olson, PhD8*, James R. Cerhan, MD, PhD8, Neil E. Kay, MD6, Curtis A. Hanson, MD6*, Richard R. Furman, MD12,13, Tait Shanafelt, MD14 and Susan L. Slager, PhD1

1Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN
2Durham VA Medical Center, Durham, NC
3Division of Hematology, VA & Duke Medical Centers, Durham, NC
4Duke University Medical Center, Durham, NC
5Department of Hematology, Duke University, Durham, NC
6Division of Hematology, Mayo Clinic, Rochester, MN
7Mayo Clinic, Phoenix, AZ
8Department of Health Sciences Research, Mayo Clinic, Rochester, MN
9Division of Epidemiology, Mayo Clinic, Rochester, MN
10Department of Medicine, Duke University Medical Center, Durham, NC
11Duke Cancer Institute, Duke University, Durham, NC
12Morton Coleman, M.D. Distinguished Professor of Medicine Weill Cornell Medical College, New York, NY
13Weill Cornell Medical College, New York, NY
14Stanford University Medical Center, Stanford, CA

Zhenghao Chen1,2*, Gaspard Cretenet1*, Beatriz Valle-Argos3*, Francesco Forconi, MD, PhD, FRCPath4*, Arnon P. Kater, MD, PhD2,5, Graham Packham, PhD3* and Eric Eldering, PhD1,2*

1Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
2Amsterdam Institute of Infection and Immunity, Cancer Center Amsterdam, and Lymphoma and Myeloma Center (LYMMCARE), Amsterdam, Netherlands
3Cancer Research UK Centre, Cancer Sciences, University of Southampton, Southampton, United Kingdom
4Department of Haematology, Southampton University Hospital Trust, Southampton, United Kingdom
5Department of Hematology, Academic Medical Center, Amsterdam, NH, Netherlands

Monica Else, MA, MSc1*, Stuart J Blakemore, PhD2,3*, Jonathan C Strefford, PhD2 and Daniel Catovsky, MD, FRCP4

1Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom
2Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
3Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany
4The Institute of Cancer Research, London, United Kingdom

Yang Liang, MD1, Han-ying Huang2*, Yun Wang, MD, PhD2*, Weida Wang, MD, PhD2* and Huan-xin Lin2*

1Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China
2State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China

*signifies non-member of ASH