Iván Martín, PhD^1*, Eva Villamón, PhD^2*, Rosario Abellán, PhD^3*, Maria Jose Calasanz, PhD, BSc^{4,5,6,7,8,9,10*}, Aroa Irigoyen, PhD^11*, Guillermo F Sanz, MD, PhD^12,13,14, Esperanza Such, PhD^15*, Elvira Mora Casterá, MD^16*, Míriam Gutiérrez, PhD^17*, Rosa Collado, MD^18*, Míriam Vara, PhD^19*, Laura Blanco, MD^20*, Itziar Oiartzabal, MD^21*, Sara Álvarez, PhD^22*, Teresa Bernal del Castillo, MD, PhD^23,24,25*, Isabel Granada, PhD^26,27*, Blanca Xicoy, MD^28*, Lurdes Zamora, PhD^29*, Andres Jerez, MD PhD^30,31*, Raquel Fernández, PhD^32*, Marisa Calabuig, MD^33*, Francisca García^34*, Alejandro Sanz, MD^35*, Rosana Díez, MD^36*, Ángela Gil, MD^37*, Raquel de Paz, MD^38*, Francisca López, MD^39*, Teresa González, MD^40*, Carlos Solano, MD, PhD³⁴ and Mar Tormo, MD^31,33,41

¹Hematology Department, Hospital Clínico Universitario de Valencia. INCLIVA Research Institute. University of Valencia., VALENCIA, Spain
²Hematology department, Hospital Clínico Universitario de Valencia. INCLIVA Research Institute. University of Valencia., Valencia, Spain
³Biochemistry and Molecular Pathology Department., Hospital Clínico Universitario de Valencia. INCLIVA Research Institute., VALENCIA, Spain
⁴Servicio de Citogenética y de Genética Hematológica, Departamento de Genética, Universidad de Navarra, Pamplona, Spain
⁵Hematological Diseases Laboratory, CIMA LAB Diagnostics, University of Navarra, Pamplona, Spain
⁶Centro de Investigación Médica Aplicada, University of Navarra, Clínica Universidad de Navarra, Pamplona, Spain
⁷Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain
⁸Scientific co-Director of CIMA LAB Diagnostics, CIMA Lab Diagnostics, University of Navarra, Pamplona, Spain
⁹Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBERONC, Clínica Universidad de Navarra, Pamplona, Spain
¹⁰Centro de Investigación Biomédica en Red de Cáncer, CIBERONC, Pamplona, Spain
¹¹CIMA LAB Diagnostics. Universidad de Navarra., Pamplona, Spain
¹²CIBERONC, Instituto Carlos III, Madrid, Spain
¹³Hospital Universitario La Fe, Spanish MDS Cooperative Group, Valencia, Spain
¹⁴Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain
¹⁵CIBERONC, Madrid, Spain
¹⁶Dept. of Hematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
¹⁷Genetic Department. Hospital Universitario Infanta Sofía., Madrid, Spain
¹⁸Hematology Department., Hospital General Universitario, Valencia, Spain
¹⁹Hematology Department, Hospital Universitario de Cruces, Baracaldo, Spain
²⁰Hematology Department., Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain
²¹Hematology Department., Hospital Universitario Araba, Vitoria-Gasteiz, Spain
²²NIMGenetics, Genómica y Medicina. Madrid, Madrid, Spain
²³Hospital Universitario Central Asturias, ISPA, IUOPA, Oviedo, Spain
²⁴Grupo Español de Síndromes Mielodisplásicos (GESMD), Oviedo, Spain
²⁵Fundación General de la Universidad de Salamanca, Oviedo, ESP
²⁶ICO-Hospital Germans Trias i Pujol. Josep Carreras Research Institute. Universitat Autònoma de Barcelona, Badalona, Spain
²⁷CETLAM Group, Badalona, ESP
²⁸Hematology Department, Institut Català d'Oncologia-Hospital Germans Trias i Pujol; Josep Carreras Leukemia Research Institute, Universitat Autònoma de Barcelona, Badalona, Spain
²⁹Hematology Department, ICO - Hospital Germans Trias i Pujol, Badalona, Spain
³⁰Hematology and Medical Oncology Department, Hospital Morales Meseguer, IMIB, Murcia, Spain, MURCIA, Spain
³¹Grupo Español de Síndromes Mielodisplásicos (GESMD), Valencia, Spain
³²Oncohematological Cytogenetics Unit., Fundación Pública Galega de Medicina Xenómica., Santiago de Compostela, Spain
³³Hospital Clínico Universitario de Valencia, Valencia, Spain
³⁴Hematology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain
³⁵Hematology Department., Hospital HM Sanchinarro, Madrid, Spain
³⁶Hematology Department., Hospital Universitario Miguel Servet de Zaragoza., Zaragoza, Spain
³⁷Hematology Department., Hospital Universitario de Guadalajara., Guadalajara, Spain
³⁸Hematology Department, Hospital Universitario La Paz-Idipaz, Madrid, Spain
³⁹Hematology Department., Hospital Arnau de Vilanova de Valencia, Valencia, Spain
⁴⁰Hematology Department, Hospital Universitario de Salamanca., Salamanca, Spain
⁴¹Programa Español de Tratamientos en Hematologia, PETHEMA, Valencia, Spain

Sunisa Kongkiatkamon, MD^1,2*, Samuel Li, BA^3*, Tatiana Dombrovski^4*, Laila Terkawi^2*, Cassandra M Kerr, MS^5*, Vera Adema, PhD^2*, Yasunobu Nagata, MD, PhD^6*, Wencke Walter, PhD^7*, Hassan Awada, MD^5*, Bartlomiej Przychodzen^8*, Stephan Hutter, PhD^7*, Carmelo Gurnari, MD^8*, Simona Pagliuca, MD², Manja Meggendorfer, PhD⁹, Claudia Haferlach, MD¹⁰, Valeria Visconte, PhD², Torsten Haferlach, MD¹¹, Jaroslaw P. Maciejewski, MD, PhD⁵ and Thomas LaFramboise, Ph.D.^4*

¹Department of hematology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
³Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH
⁴Department of Genetics and Genome Sciences Case Western Reserve University School of Medicine, Cleveland, OH
⁵Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁶Cleveland, Ohio
⁷MLL Munich Leukemia Laboratory, Munich, Germany
⁸Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland
⁹MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany
¹⁰MLL Munich Leukemia Laboratory, Inning am Ammersee, Germany
¹¹MLL Munchner Leukamie Labor Gmbh, Munchen, Germany

Sung-Eun Lee, M.D, Ph.D.^1,2*, Feng Wang, PhD^3*, Abel Trujillo-Ocampo, PhD, MS¹, Wilfredo Ruiz Vazquez^1*, Hyun-Woo Cho^1*, Koichi Takahashi, MD, PhD^3,4, Gheath Alatrash^1,5, Jeffrey J. Molldrem^1,5, Richard E. Champlin, MD⁶, Naval Daver, MD⁷, Hagop M. Kantarjian, MD⁸, P. Andrew Futreal^9*, Guillermo Garcia-Manero, MD¹⁰ and Jin S. Im^5,11

¹Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX
²Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
³Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁵Department of Hematopoietic Biology and Malignancy, Division of Cancer Medicine, The University of Texas M.D, Anderson Cancer Center, Houston, TX
⁶Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, The University of Texas, M.D. Anderson Cancer Center, Houston, TX
⁸University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Genomic Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX
¹⁰Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹¹Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX

Marion Strullu, MD^1*, Aurélie Caye-Eude, PharmD, PhD^1,2*, Loïc Maillard, PhD^1*, Chloé Arfeuille, MD^1,2*, Elodie Lainey, PharmD, PhD^1*, Florian Piques, MD^2*, Odile Fenneteau, PharmD^3*, Bruno Cassinat, PharmD, PhD^1,4*, Fabien Guimiot, PhD^5*, Jean-Hugues Dalle, MD, PhD^6,7*, André Baruchel⁸, Christine Chomienne, MD, PhD^1,9, Dominique Bonnet, PhD¹⁰, Michele Souyri, PhD^1* and Hélène Cavé, PharmD, PhD^1,2*

¹Institut de Recherche St Louis, Université de Paris, INSERM U1131, Paris, France
²Département de Génétique, APHP, Hôpital Robert Debré, Paris, France
³Laboratoire d’Hématologie, APHP, Hôpital Robert Debré,, Paris, France
⁴Université de Paris, Cellular biology Department, Saint-Louis hospital, APHP, Paris, France
⁵Unité de Foeto-pathologie, APHP, Hôpital Robert Debré, Paris, France
⁶University of Paris, Paris, France
⁷APHP, Robert Debré Hospital, Paris, France
⁸Pediatric Hematology-Immunology Department, APHP, Robert Debré Hospital, Paris, France
⁹Unité de Biologie cellulaire, Université de Paris, Paris, France
¹⁰Hematopoietic Stem Cell lab, The Francis Crick Institute, London, United Kingdom

Carolin Brings^1*, Ron-Patrick Cadeddu, PhD^1*, Julia Fröbel, PhD^1,2*, Hubert Schelzig, MD^3*, Rainer Haas, MD^1* and Norbert Gattermann, MD⁴

¹Dept. of Hematology, Oncology and Clinical Immunology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
²Immunology, Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut (FLI), Jena, Germany
³Dept. of Vascular and Endovascular Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
⁴Dept. of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-Universitat, Dusseldorf, Germany

Matilde Y Follo, PhD^1*, Sara Mongiorgi, PhD^1*, Alessia De Stefano, BSc^1*, Valentina Indio, PhD^2*, Annalisa Astolfi, PhD^2,3*, Andrea Pellagatti^4*, Stefano Ratti, MD^1*, Miriam Fogli, PhD^5*, Sarah Parisi, MD, PhD⁵, Andrea Pession^6*, Michele Cavo^5*, Lucia Manzoli, MD^1*, Lucio Cocco, MD^1*, Jacqueline Boultwood⁴ and Carlo Finelli^7*

¹Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
²Interdepartmental Centre of Cancer Research "G. Prodi", University of Bologna, Bologna, Italy
³Dipartimento di Morfologia, chirurgia e medicina sperimentale, University of Ferrara, Ferrara, Italy
⁴Bloodwise Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
⁵Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy
⁶Sant'Orsola-Malpighi Hospital, "Lalla Seràgnoli" Institute, Bologna, Italy
⁷Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy

Christina Ganster¹, Lea Naomi Eder^1*, Katayoon Shirneshan^1*, Katharina Rittscher^1*, Paolo Mazzeo^1*, Roxana Schaab^1*, Ahmet H. Elmaagacli, Prof, MD, PhD^2*, Uwe Platzbecker, MD³, Bertram Glass^4*, Ulrich Germing^5*, Maria Kamper^1*, Elzbieta Barbara Brzuszkiewicz^1* and Detlef Haase, MD^1*

¹Clinics of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany
²Department of Hematology and Stem Cell Transplantation, Asklepios Clinic St. Georg, Hamburg, Hamburg, Germany
³Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
⁴Clinic for Hematology, Oncology, Tumorimmunology and Palliative Care, Helios Clinic Berlin-Buch, Berlin, Germany
⁵Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Faculty of Medicine, Düsseldorf, Germany

Hassan Awada, MD¹, Cassandra M. Kerr, MS^2*, Vera Adema, PhD^2*, Carmelo Gurnari, MD^3*, Simona Pagliuca, MD¹, Heesun J. Rogers, MD, PhD⁴, Hetty E. Carraway, MD, MBA⁵, Mikkael A. Sekeres, MD, MS⁶, Jaroslaw P. Maciejewski, MD, PhD² and Valeria Visconte, PhD¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
³Department of Translational Hematology and Oncology, Taussig Cancer Institute, Cleveland, OH
⁴Department of Hematopathology, Cleveland Clinic, Cleveland
⁵Department of Hematology and Medical Oncology, Leukemia Program, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁶Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH

Jonathan Feld, MD¹, Jane Houldsworth, PhD², Asha Reddy, MS^2*, Zinnia Mai, BS^2*, Shafinaz Hussein, MD^2*, Shyamala C. Navada, MD¹, Lewis R. Silverman, MD¹ and Meenakshi Mehrotra, PhD^2*

¹Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
²Department of Pathology, Mount Sinai Hospital, New York, NY