Simone Claudiani^1,2*, Carolina Rosadas^3*, Myra McClure^3*, Maryam Khan^3*, Richard S. Tedder^3*, Andrew J. Innes^1,2*, Dragana Milojkovic^1,2* and Jane Apperley, FRCP, FRCPath, MB ^1,2

¹Centre for Haematology, Faculty of Medicine, Imperial College London, London, United Kingdom
²Department of Haematology, Hammersmith Hospital (Imperial College Healthcare NHS Trust), London, United Kingdom
³St Mary’s Campus, Imperial College London, Faculty of Medicine, London, United Kingdom

Carlo Gambacorti-Passerini, MD¹, Alberto Alvarez-Larrán, MD^2*, Sarit E Assouline, MD, MSc³, Patrizia Pregno^4*, Philipp D le Coutre, MD⁵, Susanne Saussele, MD⁶, Laura Antolini, PhD^7* and Brian J. Druker, MD⁸

¹Dept of Medicine and Surgery, University of Milano Bicocca, Monza, MB, Italy
²Servicio de Hematologia, Hospital Clinic de Barcelona - GEMFIN, Barcelona, Spain
³Division of Hematology, Sir Mortimer B. Davis-Jewish General Hospital, Department of Oncology, McGill University, Montreal, QC, Canada
⁴AZ OSP CITTA' DELLA SALUTE E SCIENZA TORINO, University of Torino, TORINO, Italy
⁵Charité – Universitätsmedizin Berlin, Berlin, Berlin, Germany
⁶III. Medizinische Klinik, Hämatologie und Onkologie, Universitätsmedizin Mannheim, Mannheim, Germany
⁷Dept of Medicine and Surgery, University of Milano Bicocca, Monza, Italy
⁸Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR

Veronica A Guerra, MD¹, Jorge M. Ramos Perez, MD^1*, Danielle Hammond, MD², Kelly S. Chien, MD¹, Rashmi Kanagal-Shamanna, MD³, Kiran Naqvi, MD, MPH², Koji Sasaki, MD², Shilpa Paul, PharmD^4*, Tapan M. Kadia, MD², Courtney D. DiNardo, MD, MSc², Marina Konopleva, MD, PhD², Naval Daver, MD⁵, Farhad Ravandi, MBBS², Naveen Pemmaraju, MD⁶, Nicholas J. Short, MD², Ghayas C. Issa, MD², Koichi Takahashi, MD, PhD², Zeev E. Estrov, MD¹, Sherry A. Pierce, BSN, BA^2*, Hagop M. Kantarjian, MD¹, Guillermo Garcia-Manero, MD² and Guillermo Montalban Bravo, MD¹

¹Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶University of Texas, MD Anderson Cancer Center, Houston, TX

Jitka Koblihova^1*, Vaclava Polivkova^2*, Adela Benesova^2*, Hana Zizkova^2*, Nikola Curik^2,3*, Monika Pepek^4*, Tomasz Stoklosa, MD, PhD⁵, Marketa Markova Stastna^2*, Hana Klamová^2*, Dana Srbova^2* and Katerina Machova^2,3*

¹Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic
²Institute of Hematology and Blood Transfusion, Prague, Czech Republic
³Institute of Pathophysiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
⁴Medical University of Warsaw, Warsaw, Poland
⁵Department of Tumor Biology and Genetics, Medical University of Warsaw, Warsaw, Poland

Maria Belen Sanchez^1*, Beatriz Moiraghi, MD^2*, Ana Ines Varela, MD^2*, Estrella Levy, PhD^3*, Masiel Vera^3*, Bianca Vasconcelos Cordoba^3*, Isabel Giere, PhD^4*, Josefina Freitas, MD^5*, Veronica Ventriglia, MD^5*, Maria Del Rosario Custidiano, MD^6*, Ana Garcia de Labanca, MD^7*, Georgina Bendek, MD^8*, Romina Mariano, MD^9*, María Jose Mela Osorio, MD^4*, Mariana Juni, Ms^4*, Maximiliano Riddick^10*, Miguel A. Pavlovsky, MD⁴, Maria Cecilia Foncuberta, MD⁶, Jose Mordoh, MD^3*, Isolda I. Fernandez, MD^4*, Julio Cesar Sanchez Avalos, MD⁶, Carolina Pavlovsky^4* and Michele Bianchini, PhD^3*

¹Centro de Investigaciones Oncológicas CIO-FUCA, Buenos Aires, BA, Argentina
²Hospital General De Agudos J.M. Ramos Mejia, Buenos Aires, Argentina
³Centro de Investigaciones Oncológicas CIO-FUCA, Buenos Aires, Argentina
⁴FUNDALEU, Buenos Aires, Argentina
⁵Hospital Posadas, Buenos Aires, Argentina
⁶Instituto Alexander Fleming, Buenos Aires, Argentina
⁷-, Mendoza, Argentina
⁸Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
⁹Hospital San Martin, Parana, Argentina
¹⁰Departamento de Matemática- Facultad de Ciencias Exactas- UNLP, Instituto de Cálculo- Facultad de ciencias exactas y naturales -CONICET, La Plata, Argentina

Koji Sasaki, MD¹, Elias Jabbour, MD¹, Ghayas C. Issa, MD², Guillermo Garcia-Manero, MD¹, Tapan M. Kadia, MD³, William G. Wierda, MD, PhD¹, Musa Yilmaz, MD¹, Courtney D. DiNardo, MD, MSc⁴, Jeffrey Skinner, MHA^1*, Maria Khouri^1*, Naveen Pemmaraju, MD¹, Patrice Nasnas, MD^1*, Sherry A. Pierce, BSN, BA^1*, Jorge E. Cortes, MD⁵ and Hagop M. Kantarjian, MD⁶

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, Universit Y of Texas At Houston, Houston, TX
³Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁵Georgia Cancer Center Augusta University, Augusta, GA
⁶Department of Leukemia, Professor and Chairman, Department of Leukemia, Samsung Distinguished University Chair in Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Guillermo Montalban Bravo, MD¹, Rashmi Kanagal-Shamanna, MD², Veronia Guerra^1*, Jorge M. Ramos Perez, MD^1*, Danielle Hammond, MD³, Shilpa Paul, PharmD^4*, Kiran Naqvi, MD, MPH³, Koji Sasaki, MD³, Elias Jabbour, MD¹, Courtney D. DiNardo, MD, MSc³, Koichi Takahashi, MD, PhD¹, Marina Konopleva, MD, PhD⁵, Naveen Pemmaraju, MD⁶, Tapan M. Kadia, MD³, Farhad Ravandi, MBBS³, Naval Daver, MD⁷, Gautam Borthakur, MD¹, Zeev E. Estrov, MD¹, Joseph D. Khoury, MD², Sanam Loghavi, MD², Sherry A. Pierce, BSN, BA^3*, Carlos E. Bueso-Ramos, MD, PhD², Keyur Patel, MD, PhD^8*, Hagop M. Kantarjian, MD¹ and Guillermo Garcia-Manero, MD³

¹Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX
⁶University of Texas, MD Anderson Cancer Center, Houston, TX
⁷The University of Texas MD Anderson Cancer Center, Houston, TX
⁸University of Texas MD Anderson Cancer Center, Houston, TX

Francois-Xavier Mahon, MD, PhD¹, Nelma D Clementino, MD^2*, Mikhail Fominykh, MD^3,4, Jeffrey H. Lipton, MD, PhD⁵, Anna G. Turkina, Prof., MD⁶, Beatriz Moiraghi, MD^7*, Franck E Nicolini, MD, PhD⁸, Naoto Takahashi, MD, PhD⁹, Tomasz Sacha, MD PhD^10*, Dong-Wook Kim, MD¹¹, Rafik Fellague-Chebra, MD^12*, Ranjan Tiwari, MSc^13*, Catherine Bouard^12* and Timothy P. Hughes, MD, MBBS, FRACP, FRCPA¹⁴

¹Cancer Center of Bordeaux, Institut Bergonié, INSERM U1218, University of Bordeaux, Bordeaux, France
²Hospital Das Clinicas Da UFMG, Belo Horizonte, Brazil
³Russian Research Institute of Hematology and Transfusiology, Saint Petersburg, Russian Federation
⁴Hematology With BMT, Saint-Petersburg, Russia
⁵Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada
⁶National Research Center for Hematology, Moscow, Russian Federation
⁷Hospital General De Agudos J.M. Ramos Mejia, Buenos Aires, Argentina
⁸Hematology department, Centre Leon Berard, Lyon, France
⁹Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
¹⁰Department of Hematology, Jagiellonian University Medical College, Krakow, Poland
¹¹Seoul St. Mary's Hospital The Catholic University of Korea, Seoul, Korea, Republic of (South)
¹²Novartis Pharma SAS, Paris, France
¹³Novartis Healthcare Pvt. Ltd, Hyderabad, India
¹⁴Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia

Anna Petrova, MD^1*, Ekaterina Yu. Chelysheva, MD, PhD^1*, Oleg A. Shukhov, MD, PhD^1*, Anastasiya Bykova, MD^1*, Irina Nemchenko, MD, PhD^1*, Olga Pospelova, MD^1*, Margarita Gurianova, MD^1*, Nikolay Tsyba, MD, PhD^1*, Tatiana I. Ionova, Prof.² and Anna G. Turkina, Prof., MD¹

¹National Research Center for Hematology, Moscow, Russian Federation
²University Clinic, St. Petersburg State University and Multinational Center for Quality of Life Research, Saint-Petersburg, Russia

Massimo Breccia, MD^1*, Michael J. Mauro, MD², Elias Jabbour, MD³, Giuseppe Saglio, MD, PhD⁴, Antonio Jiménez-Velasco, MD^5*, Philipp D le Coutre, MD⁶, Irene DeGutis, PharmD^7*, Wasiulla Khan, PhD^7*, Oumar Sy, PhD^7*, Rene Swanink^8* and Jorge E. Cortes, MD⁹

¹Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
²Memorial Sloan-Kettering Cancer Center, New York, NY
³The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Dept of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
⁵Hospital Universitario Carlos Haya, Malaga, Spain
⁶Charité Universitätsmedizin Berlin, Berlin, Germany
⁷Bristol-Myers Squibb Company, Princeton, NJ
⁸Bristol-Myers Squibb, Braine-l'Alleud, Belgium
⁹Georgia Cancer Center, Augusta University, Augusta, GA

Zafar Iqbal, MPhil, PhD^1,2,3,4,5, Muhammad Absar, BSc, MSc, PhD^6,7*, Abid Jamil, MD PhD^8,9*, Tanveer Akhtar, Ph.D^10*, Salman Basit, PhD^11*, Sibtain Afzal^12*, Khushnooda Ramzan^13*, Kulsoom Qureshi^14*, Muhammad Farooq Sabar, Ph.D^15*, Muhammad Arshad^16*, Aamer Aleem, MBBS, FRCP, FRCPath^17*, Ullah Anhar^12,18*, Zeenat Mirza, PhD^19*, Sajjad Karim^19*, Naila Batool Khalid^20*, Mahmood Rasool^21*, Muhammad Asif, PhD^22*, Mujib Ullah, PhD^23*, Ahmad M Khalid, PhD^24*, Amer Mahmood, PhD^25* and Nawaf Alanazi, MBBS FRCPC^26,27*

¹Cancer & Medical Genetics, CoAMS-A, King Saud Bin Abdulaziz University for Health Sciences & King Abdullah International Medical Research Centre (KAIMRC) / SSBMT, King Abdulaziz Medical City, National Guard Health Affairs, Al-Ahsa, Saudi Arabia
²Centre for Advanced Molecular Biology, University of the Punjab, Lahore, Pakistan
³Qarshi University, HOPES, Department of Biotechnology & Genomic Medicine, Lahore, Pakistan
⁴Univ. of The Punjab, Pakistan, Lahore, Pakistan
⁵Pakistan Society for Molecular and Clinical Hematology, Lahore, Pakistan
⁶Department of Pathology, King Abdulaziz Hospital, King Abdulaziz Medical City, National Guard Health Affairs, Al Ahsa, Saudi Arabia
⁷Hematology, Oncology and Pharmacogenetics Engineering Sciences (HOPES) Group, Department of Zoology, University of the Punjab, Lahore, Pakistan
⁸Hayatabad Medical Complex, Peshawar, Pakistan
⁹HMC Peshawar, Peshawar, Pakistan
¹⁰HOPES Group, Hematology, Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group Pakistan & HOPES Centre, Department of Zoology, University of the Punjab, Lahore, Pakistan
¹¹College of Medicine, Taiba University, Madinah, Saudi Arabia
¹²College of Medicine, King Saud University, Riyadh, Saudi Arabia
¹³King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
¹⁴Medical Oncology Unit, HMC, Peshawar, Khyber Pakhtunkhwa, PAK
¹⁵Core Genomics Laboratories, Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore, Pakistan., Lahore, Pakistan
¹⁶Department of Biological Sciences, International Islamic University, Islamabad, Pakistan
¹⁷Hematology/Oncology Division, Department of Medicine, College of Medicine & King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
¹⁸Hematology, Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group Pakistan & HOPES Centre, Department of Zoology, University of the Punjab, Lahore, Pakistan
¹⁹Faculty of Applied Medical Sciences & Centre of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
²⁰IMBB, University of Lahore, Lahore, Pakistan
²¹Faculty of Applied Medical Sciences & CEGMR, King Abdulaziz University, Jeddah, Saudi Arabia
²²Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, (BUITEMS), Quetta, Pakistan
²³Interventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, Stanford University School of Medicine, Stanford, CA
²⁴Department of Biotechnology & Genomic Medicine, Qarshi University, Lahore, Pakistan
²⁵College of Medicine & King Khalid University Hospital, King Saud University (CoM KSU), Riyadh, Saudi Arabia
²⁶Division of Pediatric Hematology /Oncology, Department of Medicine, King Abdulaziz Hospital, National Guard Health Affairs, Al Ahsa, Saudi Arabia
²⁷CAMS-A (College of Applied Medical Sciences Al AHSA) King Saud Bin Abdulaziz University of Health Sciences & King Abdulaziz Hospital, National Guard Health Affairs, Al Ahsa, Saudi Arabia

Jorge E. Cortes, MD¹, Philipp D le Coutre, MD², Carlo Gambacorti-Passerini, MD³, Henrik Hjorth-Hansen, MD⁴, Pia Raanani, MD⁵, Valentín Garcia-Gutiérrez, MD, PhD⁶, Vamsi Kota, MD¹, Simon Purcell^7*, Andrea Viqueira^8*, Eric Leip^9* and Tim H Brümmendorf, MD¹⁰

¹Georgia Cancer Center Augusta University, Augusta, GA
²Charité – Universitätsmedizin Berlin, Berlin, Berlin, Germany
³Dept of Medicine and Surgery, University of Milano Bicocca, Monza, MB, Italy
⁴Norwegian University of Science and Technology, Trondhein, Norway
⁵Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel
⁶Hematology, Hospital Universitario Ramón y Cajal, Madrid, Spain
⁷Pfizer Ltd, London, GBR
⁸Pfizer SLU, Madrid, Spain
⁹Pfizer Inc., Cambridge, MA
¹⁰Dept. of Hematology and Oncology, Center for Integrated Oncology (CIO), Uniklinik RWTH Aachen, Aachen, Germany

Mario Tiribelli, MD^1*, Roberto Latagliata^2*, Massimo Breccia, MD^3*, Isabella Capodanno, MD^4*, Maria Cristina Miggiano, MD^5*, Francesco Cavazzini, MD^6*, Sabrina Leonetti Crescenzi, MD^7*, Sabina Russo, MD^8*, Mario Annunziata, MD^9*, Federica Sorà, MD^10*, Massimiliano Bonifacio, MD^11*, Giovanni Caocci, MD¹², Giuseppina Loglisci, MD^13*, Alessandro Maggi^14*, Gianni Binotto, MD^15*, Elena Crisà, MD^16*, Alessandra Iurlo, MD, PhD^17*, Anna Rita Scortechini, MD^18*, Annapaola Leporace, MD^19*, Rosaria Sancetta, MD^20*, Pamela Murgano, MD^21*, Concettina Ruggiero, MD^22*, Giuseppe Saglio, MD, PhD²³ and Giorgina Specchia, MD²⁴

¹Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
²Hematology Unit, Ospedale Belcolle, Viterbo, Italy
³Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy
⁴Hematology Unit, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy
⁵Hematology Department, San Bortolo Hospital, Azienda ULSS8 "Berica" di Vicenza, Vicenza, Italy
⁶Division of Hematology, Department of Medical Sciences, University of Ferrara, Azienda Ospedaliera-Universitaria, Arcispedale S. Anna, Ferrara, Italy
⁷Hematology Unit, San Giovanni Hospital, Rome, Italy
⁸Department of Hematology, University of Messina, Messina, Italy
⁹Hematology Unit, Cardarelli Hospital, Naples, Italy
¹⁰Istituto di Ematologia, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy
¹¹Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
¹²Hematology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, ITA
¹³Hematology Unit, Vito Fazzi Hospital, Lecce, Italy
¹⁴Hematology, " Giuseppe Moscati" Hospital, Taranto, Italy
¹⁵Department of Medicine, Hematology and Clinical Immunology, Padua School of Medicine, Padua, Italy
¹⁶Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale Amedeo Avogadro, AOU Maggiore della Carità, Novara, Italy
¹⁷Hematology Division, Foundation IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milano, Italy
¹⁸Division of Hematology, Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona, Ancona, Italy
¹⁹Hematology Unit, Azienda Ospedaliero Universitaria Sant' Andrea, Rome, Italy
²⁰Hematology Unit, Ospedale dell'Angelo, Venizia-Mestre, Italy
²¹Division of Hematology, S. Elia Hospital, Caltanissetta, Italy
²²Division of Hematology, S. Eugenio Hospital, Rome, Italy
²³Dept of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
²⁴Hematology - Dept. of Emergency and Organ Transplantation, University of Bari, Bari, Italy

Ana Ines Varela, MD^1*, Georgina Bendek, MD^2*, Carolina Pavlovsky^3*, Maria Josefina Freitas, MD^4*, Veronica Ventriglia, MD^5*, Alicia Enrico, MD^6,7*, Maria Elisa Riva, MD^8*, Mariel Ana Perez, MD^9*, Romina Mariano, MD^10*, Luis Beligoy, MD^11*, Maria Pagani^12*, Ricardo Khalil Tannuri^3*, Irene Larripa, MD^13*, Raquel Bengio, MD^14*, Francisca Rojas^15*, Dardo Riveros, MD^16*, Mariana Raquel Debus, MD^17*, Erica Franceschi, MD^18*, Maria Victoria Osycka^19*, Miguel A. Pavlovsky, MD³ and Beatriz Moiraghi, MD^1*

¹Hospital General De Agudos J.M. Ramos Mejia, Buenos Aires, Argentina
²Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
³FUNDALEU, Buenos Aires, Argentina
⁴Hospital Posadas, Argentina, Buenos Aires, Argentina
⁵Hospital Posadas, Buenos Aires, Argentina
⁶Hospital Zonal de Agudos, La Plata, Argentina
⁷Hospital Italiano La Plata, La Plata, MS, Argentina
⁸Hospital Interzonal de Agudos General San Martín de La Plata, La Plata, Argentina
⁹HIGA Prof.Dr.R.Rossi. La Plata, Bs.A, La Plata, Argentina
¹⁰Hospital San Martin, Parana, Argentina
¹¹Hospital J. C. Perrando, Chaco, Argentina
¹²Hospital Ramos Mejia, Buenos Aires, Argentina
¹³Academia Nacional de Medicina, Buenos Aires, Argentina
¹⁴Academia Nacional de Medicina, IIHEMA, Buenos Aires, Argentina
¹⁵HOSPITAL DE CLINICAS JSM, Buenos Aires, ARG
¹⁶Hospital Universitario Cemic, buenos aires, Argentina
¹⁷Fundaleu, Buenos Aires, Argentina
¹⁸Hospital Militar, Buenos Aires, Argentina
¹⁹Hospital Penna, Buenos Aires, Argentina