62nd ASH Annual Meeting and Exposition: 501. Hematopoietic Stem and Progenitor Biology: Poster III

Oral and Poster Abstracts
Poster

Anemias, Biological, HSCs, Animal models, bone marrow, cell division, Diseases, Therapies, Genetic Disorders, Biological Processes, DNA damage, immunodeficiency, DNA repair, immune cells, Cell Lineage, Study Population, Clinically relevant, hematopoiesis, transplantation, stem cells

2730

Single Cell Resolution Mapping of Hematopoietic Stem and Progenitor Cell States throughout Human Life

Hojun Li, MD, PhD^1,2, Vincent Butty²^*, Guinevere Connelly²^*, Vivian Morris¹^*, George Q. Daley, MD, PhD^3,4, Jennifer Whangbo, MD, PhD^3,5, Edroaldo Lummertz da rocha, PhD⁶^* and Robert Grant Rowe, MD, PhD⁴

¹Boston Children's Hospital, Boston, MA
²Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA
³Harvard Medical School, Boston, MA
⁴Division of Hematology/Oncology, Stem Cell Program, Boston Children's Hospital, Boston, MA
⁵Dana-Farber Cancer Institute/Boston Children's Cancer and Blood Disorders Center, Boston, MA
⁶Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, Brazil

2731

Leptin Receptor As a Marker for a Subset of Long-Term Functional Hematopoietic Stem Cells

Thao Trinh, BS¹, James Ropa, BS, MSc, PhD², Arafat Aljoufi, MD¹, Scott Cooper, MS²^*, Edward F. Srour, PhD³, Anthony Sinn, BS⁴^* and Hal E. Broxmeyer, PhD²

¹Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN
²Department of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN
³Department of Medicine, Indiana University School of Medicine, Indianapolis, IN
⁴Indiana University School of Medicine, Indianapolis, IN

2732

Cellular Barcoding of HSCs during Development Reveals Long-Term Persistence of T Cell Progenitor Clones in the Thymus

Sara A. Rubin^1,2,3^*, Chloé S. Baron, PhD^2,3^*, Song P. Yang, PhD⁴^*, Aaron McKenna, PhD⁵^* and Leonard I. Zon, MD^1,2,6,7

¹Program in Immunology, Harvard Medical School, Boston, MA
²Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA
³Harvard Stem Cell Institute, Harvard University, Cambridge, MA
⁴Boston Children's Hospital, Boston
⁵Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Lebanon, NH
⁶Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
⁷Howard Hughes Medical Institute, Boston, MA

2733

Prdm16 Is a Critical Regulator of Adult Long-Term Hematopoietic Stem Cell Quiescence

Kristbjorn Orri Gudmundsson, PhD¹^*, Yang Du, PhD¹, Nhu Nguyen¹^*, Kevin Oakley¹^*, Yufen Han¹^*, Bjorg Gudmundsdottir²^*, Pentao Liu³^*, Lino Tessarollo⁴^*, Nancy Jenkins⁵^* and Neal Copeland⁵^*

¹Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD
²NHLBI, NIH, Bethesda, MD
³School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong
⁴CCR-NCI, Mouse Cancer Genetics Program, Frederick
⁵The University of Texas MD Anderson Cancer Center, Houston, TX

2734

Transcriptional, Protein-Level and Functional Profiling of Human Fetal Liver (FL)-Derived Hematopoietic Stem Cells (HSCs) at Single Cell Resolution

Kim Vanuytsel, PhD^1,2, Carlos Villacorta-Martin, MSc²^*, Jonathan Lindstrom-Vautrin²^*, Zhe Wang³^*, Wilfredo Garcia Beltran, MD⁴^*, Taylor Matte²^*, Todd W Dowrey, BS²^*, Vannesa Mengze Li³^*, Ruben Dries, PhD^1,3^*, Joshua D Campbell, PhD³^*, Anna C Belkina, PhD⁵^*, Alejandro Balazs, PhD⁴^* and George J Murphy, PhD^1,2

¹Section of Hematology and Medical Oncology, Boston University School of Medicine, Boston, MA
²Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, MA
³Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA
⁴Ragon Institute of MGH, MIT and Harvard, Cambridge, MA
⁵Department of Pathology, Boston University School of Medicine, Boston, MA

2735

The Neurotransmitter Receptor Gabbr1 Regulates Proliferation and Function of Hematopoietic Stem and Progenitor Cells

Adedamola Elujoba-Bridenstine, MS¹^*, Lijian Shao, MD, PhD²^*, Katherine Zink²^*, Laura Sanchez, PhD²^*, Kostandin V. Pajcini, PhD³ and Owen J. Tamplin, PhD⁴

¹Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI
²University of Illinois at Chicago, Chicago, IL
³Pharmacology, University of Illinois at Chicago, Chicago, IL
⁴Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI

2736

Ker-050, a Novel Inhibitor of Tgfβ Superfamily Signaling, Induces Red Blood Cell Production By Promoting Multiple Stages of Erythroid Differentiation

Marina Feigenson, PhD¹^*, Remya Nathan²^*, Christopher Materna²^*, Alana Gudelsky²^*, Evan Lema²^*, Claire C Tseng, PhD²^*, Ffolliott Fisher²^*, Jasbir Seehra²^* and Jenn Lachey²^*

¹Keros Therapeutics, Brighton, MA
²Keros Therapeutics, Lexington, MA

2737

Loss of the DNA Fork Remodeling Protein Smarcal1 Impairs the Replication Stress Response in Proliferating Hematopoietic Cells

Saul Kushinsky, BS^*, Matthew V Puccetti, MD/PhD^*, Clare M Adams, PhD^* and Christine M Eischen, PhD

Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA

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^*signifies non-member of ASH