Marta Davidson, MD, PhD¹, Alexandra Rice, MD^2*, Douglas A. Stewart, MD, FRCPC³ and Carolyn Owen, MD FRCPC⁴

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Family Medicine, University of British Columbia, Vancouver, BC, CAN
³Department of Oncology, University of Calgary/Tom Baker Cancer Centre, Calgary, AB, Canada
⁴Foothills Hospital & Tom Baker Cancer Ctr., Calgary, AB, Canada

David G. Maloney, MD, PhD¹, John Kuruvilla, MD², Christopher P Fox, MD, PhD^3*, Guillaume Cartron, MD, PhD^4*, Daniel Li, PhD^5*, Jens Hasskarl, MD^6*, Ashley Bonner, PhD^7*, Yixie Zhang, PhD^7* and Fei Fei Liu, BSc, MBA^8*

¹Fred Hutchinson Cancer Research Center, Seattle, WA
²Princess Margaret Cancer Centre, Toronto, ON, Canada
³Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
⁴Centre Hospitalier Universitaire de Montpellier, Montpellier, France
⁵Juno Therapeutics, a Bristol-Meyers Squibb Company, Seattle, WA
⁶Celgene, a Bristol-Myers Squibb Company, Boudry, Switzerland
⁷Eversana, Burlington, ON, Canada
⁸Bristol Myers Squibb, Princeton, NJ

Gloria Iacoboni, MD^1,2,3*, Josu Iraola-Truchuelo^3*, Nuria Martinez-Cibrian, MD^4*, Rebeca Bailén, MD^5,6*, Lucia Lopez Corral, PhD, MD^7,8*, Jose M. Sanchez, MD^9*, Manuel Guerreiro, MD^10*, ANA Carolina Carolina CABALLERO González^11,12*, Alberto Mussetti, MD^13,14*, Juan-Manuel Sancho, MD, PhD^15*, Rafael Hernani, MD^16,17*, Carlos Solano, MD, PhD^17,18,19, Anna Sureda Balari, MD, PhD^13*, Javier Briones, MD, PhD^20*, Alejandro Martin Garcia-Sancho, MD, PhD^7*, Mi Kwon, MD, PhD^5,6*, Juan Luis Reguera, MD, PhD^4* and Pere Barba, MD, PhD^1,2,3*

¹Department of Hematology, University Hospital Vall d'Hebron, Barcelona, Spain
²Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain
³Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁴Department of Hematology, University Hospital Virgen del Rocio, Sevilla, Spain
⁵Department of Hematology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
⁶Gregorio Marañón Health Research Institute (IiSGM), Madrid, Spain
⁷Hematology Department, Hospital Clínico Universitario de Salamanca, IBSAL, Salamanca, Spain
⁸Centro de Investigación del Cáncer-IBMCC, Salamanca, Spain
⁹Hospital 12 de Octubre, Madrid, ESP
¹⁰Department of Hematology, Hospital La Fe, Valencia, Spain
¹¹Josep Carreras Leukaemia Research Institute, Barcelona, Spain
¹²Hematology Department, Hospital de la Santa Creu i Sant Pau, BARCELONA, Spain
¹³Hematology Department, Institut Catala d'Oncologia, Hospital Duran i Reynals, L'Hospitalet De Llobregat, Spain
¹⁴Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet De Llobregat, Barcelona, Spain
¹⁵Hematology Department, ICO-IJC Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
¹⁶Department of Hematology, Hospital Clínico Universitario de Valencia, Valencia, Spain
¹⁷Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain
¹⁸Department of Medicine, University of Valencia, Valencia, Spain
¹⁹Hematology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain
²⁰Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Christiane Copie Bergman, MD PhD^1*, Elodie Bohers, PhD^2*, Peggy Dartigues-Cuillères, MD^3*, Pierre-Julien Viailly^4*, Philippe Ruminy, PhD^2*, Vinciane Marchand^2*, Marie-Helene Delfau-Larue^5*, Corinne Haioun, MD PhD⁶, Cyrielle Robe^7*, Elsa Poullot, MD^8*, Steven Le Gouill, MD, PhD⁹, Yannick Le Bris, PharmD^10*, Céline Bossard, MD^11*, Anne Moreau, MD^12*, Vincent Ribrag, MD¹³, Valérie Camara-clayette, PhD^13*, Cyril Quivoron, PhD^14*, Gilles Salles, MD, PhD¹⁵, Sophie Cotteret, MD, PhD^13*, Pierre Sujobert, MD, PhD^16*, Alexandra Traverse-Glehen, MD, PhD^17*, Claire Mauduit^18*, Pascaline Etancelin^19*, Sarah Huet^20*, Liana Veresezan, MD^21*, Krimo Bouabdallah, MD^22*, Marie Parrens, MD^23*, Audrey Gros, PhD^24*, Samuel Amintas^25*, David Sibon, MD, PhD^26*, Ludovic Lhermitte, MD, PhD^27*, Thomas Steimle^28*, Sophie Kaltenbach^29*, Bettina Fabiani, MD^30*, Camille Laurent, MD, PhD^31*, Barbara Burroni^32*, Laurent Martin, MD, PhD^33*, Thierry Jo Molina, MD, PhD^34*, Lysa LYSARC study group^35* and Fabrice Jardin, MD, PhD^36*

¹Department of Pathology, CHU Henri Mondor, AP HP, Paris, France
²INSERM U1245, Centre Henri Becquerel, UNIROUEN, University of Normandie, Rouen, France
³DITEP, Gustave Roussy, Villejuif, France
⁴INSERM U1245, Rouen, FRA
⁵Hematology Biology Department, Hopital Henri Mondor, Creteil, France
⁶Clinical Hematology, Henri Mondor University Hospital, UPEC, Creteil, France
⁷INSERMU955 équipe 9, Institut Mondor de Recherche Biomédicale, Créteil, France
⁸Pathology, Henri Mondor Hospital, Creteil, France
⁹Service d’hématologie clinique du CHU de Nantes, INSERM CRCINA Nantes-Angers, NeXT Université de Nantes, Nantes, France
¹⁰Biological Hematology, N, Nantes, France
¹¹Département de Pathologie, Centre Hospitalier Universitaire de Nantes, Nantes, France
¹²Pathology Department, Nantes University Hospital, Nantes, France
¹³Gustave Roussy, Villejuif, France
¹⁴Gustave Roussy, INSERM U1170, Université Paris-Saclay, Villejuif, France
¹⁵Hematology Department, Memorial Kettering Cancer Center, New York, NY
¹⁶Laboratory of Hematology, Centre Hospitalier Lyon Sud, Pierre Bénite, France
¹⁷Department of Pathology, Lyon-Sud Hospital, Pierre-Benite, France
¹⁸Inserm U1065, C3m-Control of Gene Expression, Nice, FRA
¹⁹Centre Henri Becquerel, Rouen, FRA
²⁰Laboratoire d'Hématologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre Bénite, France
²¹Department of Pathology, Centre Henri Becquerel, Rouen, France
²²Department of Hematology, University Hospital of Bordeaux, Pessac, France
²³Hôpitaux de Bordeaux CHU, Bordeaux, France
²⁴Bordeaux University, Bordeaux, France
²⁵CHU Bordeaux, Bordeaux University, Bordeaux, France
²⁶INSERM UMR 1163 & CNRS URL 8254, Hematology Department, Necker University Hospital, APHP, Paris, France, Paris, France
²⁷Laboratory of Onco-Hematology, Necker-Enfants Malades Hospital, APHP, Paris, Paris, France
²⁸Necker Hospital, Necker University, Paris, France
²⁹Necker University, Paris, France
³⁰Pathology Department, AP-HP Hôpital Saint Antoine, Paris, France
³¹Department of Pathology, Institut Universitaire Cancerologie Toulouse-Oncopole, Toulouse, France
³²Pathology Department, Hopital Cochin, Paris, France
³³Pathology Department, University Hospital F. Mitterrand and Inserm UMR 1231, Dijon, France
³⁴Pathology Department, Necker University Hospital, Paris, France
³⁵Lyon, LYSA, Lyon, France
³⁶Department of Hematology, Centre Henri Becquerel, Rouen, France

Paolo Strati, MD¹, Haleigh Mistry^2*, Brittany Pulsifer^3*, Luis Fayad⁴, Sairah Ahmed, MD⁵, Hun Ju Lee, MD⁶, Swami P. Iyer, MD⁷, Ranjit Nair, MD⁸, Loretta J. Nastoupil, MD⁹, Simrit Parmar, M.D., MSCI¹⁰, Maria Alma Rodriguez, MD^6*, Felipe Samaniego, MD⁶, Raphael Eric Steiner, MD⁶, Michael Wang, MD¹¹, Chelsea C. Pinnix, MD, PhD^12*, Bouthaina S. Dabaja, MD^13*, Mansoor Noorani^14*, Catherine M. Claussen, MS^15*, Elizabeth J. Shpall, MD¹⁶, Partow Kebriaei, MD¹⁶, Chris R. Flowers, MD, MS¹⁷, Jason R. Westin, MD¹⁸ and Sattva S. Neelapu, MD⁶

¹Department of Lymphoma and Myeloma; Department of Translational Molecular Pathology, MD Anderson Cancer Center:, Houston, TX
²MD Anderson Cancer Center:, Houston, TX
³The University of Texas MD Anderson Cancer Center, Houston
⁴Department of Lymphoma and Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁵Department of Lymphoma/Myeloma, MD Anderson Cancer Center, Houston, TX
⁶Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Lymphoma and Myeloma, University of Texas M.D. Anderson Cancer Center, Houston, TX
⁸Department of Lymphoma/Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX
⁹The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁰Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
¹¹Department of Lymphoma and Myeloma, U.T. M.D. Anderson Cancer Center, Houston, TX
¹²Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
¹³Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁴UTMDACC, Houston
¹⁵Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center., Houston, TX
¹⁶Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁷MD Anderson Cancer Center, Houston, TX
¹⁸Department of Lymphoma and Myeloma, MD Anderson, Houston, TX

Anthony Cutts^1*, Edward Wilson, FRCPath, MRCP^2*, Pek Sang Tang, MBBS^3*, Andrew Davies, MD, PhD^4*, Peter Johnson, MD, FRCP⁵, Louise Stanton^6*, Katy Mercer^6*, Josh Caddy^6*, Anna Schuh, MD^7,8, Laura Lopez Pascua, PhD^1* and Helene Marie-Pierre Dreau, MSc^9*

¹Department of Oncology, University of Oxford, Oxford, United Kingdom
²Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom
³St. Vincent Hospital and University of Melbourne, Melbourne, Australia
⁴Cancer Research UK Centre/Experimental Cancer Medicines Centre, University of Southampton, Southampton, United Kingdom
⁵Southampton General Hospital School of Medicine, Southampton, United Kingdom
⁶CRUK Southampton Clinical Trials Unit, University of Southampton, Southampton, United Kingdom
⁷Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁸Molecular Diagnostic Centre, Department of Oncology, University of Oxford, Oxford, United Kingdom
⁹Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

Luis Villela Villela, MD, MC^1*, Ana Ramirez-Ibarguen, MD^2*, Brady E Beltran, MD^3,4*, Camila Peña, MD^5*, Denisse A. Castro, MD^6,7, Gladys P Agreda-Vasquez, MD^8*, Myrna Candelaria, MD, PharmD⁹, Maria Alejandra Torres Viera, MD^10,11*, Henry Idrobo, MD^12,13*, Lorena Fiad, MD^14*, Fabiola Valvert, MD¹⁵, Efreen Montaño Figueroa, MD, PhD^16*, Juan Ospina Idarraga^17*, Alana Von Glasenapp, MD^18*, Sally Paredes, MD^6*, Melani Otañez, MD^19*, Fernando Perez-Jacobo^20*, Daniela Zambrano^21*, Humberto Martínez Cordero, MD^22*, Virginia Otero, MD^23*, Lidiane Andino^24*, Mercedes Royg Arriola, MD^25*, Maria Elvira Enciso, MD^18*, Maria Prates, MD²⁶, Cristaldo Nancy, MD^27*, Ivan Perdomo, MD^28*, Maria E Cabrera, MD^21*, María Lorena Cardozo, MD^29*, Cristobal Augusto Frutos Ortiz, MD^30*, Eloisa Riva, MD³¹, Juan Antonio Choque, MD^32*, Alfredo Reinaldo Quiroz, MD^18*, Guilherme Fleury Perini, MD^33*, David Gomez-Almaguer, MD ³⁴, Guillermo J. Ruiz-Arguelles, FRCP, MACP³⁵, Marcos Distefano^36*, Katerine Garcia^37*, Carolina Feres, MD^33*, Mariana Kalmus^38*, Julian Cordova^39*, Magali DelosRios, MD^40*, Rosio Baena, MD^41*, Luis Malpica Castillo, MD^42,43, Eduardo Sotomayor, MD⁴⁴ and Jorge J. Castillo, MD⁴⁵

¹Campus Hermosillo, Universidad del Valle de Mexico, Hermosillo, Mexico
²Instituto Nacional de Cancerologia, Mexico, Mexico
³Departamento de Oncología y Radioterapia,, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru
⁴4Centro de Investigación de Medicina de Precisión, Universidad de San Martin de Porres, Lima, Peru
⁵Hematología del Hospital del Salvador, Santiago de Chile, Hematología del Hospital del Salvador, Santiago de Chile, Santiago, Chile
⁶Departamento de Oncología y Radioterapia, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru
⁷Centro de Investigación de Medicina de Precisión, Universidad de San Martin de Porres, Lima, Peru
⁸Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
⁹Research Division, Instituto Nacional de Cancerología, Mexico City, Mexico
¹⁰Universidad Central de Venezuela, Caracas, Venezuela (Bolivarian Republic of)
¹¹Clinica Santa Sofia, Caracas, Miranda, Venezuela
¹²Facultad de Medicina., Universidad Del Valle, Cali, Colombia
¹³Hospital Universitario del Valle, Cali, Colombia
¹⁴Hematología, Hospital Italiano de La Plata, La Plata, Argentina
¹⁵Instituto De Cancerología y Hospital Dr. Bernardo Del Valle (INCAN), Ciudad de Guatemala, Guatemala
¹⁶Hospital General de México, SSA, mexico, EM, Mexico
¹⁷Grupo Hemato-Oncologia, Insituto Nacional de Cancerología, Bogotá, Colombia
¹⁸Department of Hematology, Instituto de Prevision Social, Asuncion, Paraguay
¹⁹Hematology, Hospital General del Estado, Hermosillo, SO, Mexico
²⁰Hematology and blood bank services, Hospital Central Norte PEMEX, CDMX, Mexico
²¹Hematology Service, Hospital del Salvador, Santiago, Chile
²²Facultad de Medicina, Maestría en Epidemiología, Universidad el Bosque, Bogota, Colombia
²³Hematology Service, Hospital Italiano, Buenos Aires, Argentina
²⁴Hematology Service, Hospital Central del Instituto de Previsión Social, Asuncion, Paraguay
²⁵Hospital Declinicas-Instituto Prev. Social, San Lorenzo, Central, PRY
²⁶Hematology, Hospital Italiano La Plata, La Plata, Argentina
²⁷Hospital Italiano de Buenos Aires (HIBA), Buenos Aires, Argentina
²⁸Clínica Los Nogales, Bogota, Colombia
²⁹Hematology Service, Hospital Central del Instituto de Previsión Social, Montevideo, URY
³⁰Hospital Central Del Instituto De Prevision Social, Asuncion, Paraguay
³¹hematology service, Hospital de Clinicas & Hospital Britanico, Montevideo, Uruguay
³²Servicio de Hematologia, Caja Nacional de Salud - Hospital de Especialidades Materno Infantil La Paz, La Paz, La Paz, Bolivia
³³Hospital Israelita Albert Einstein, São Paulo, Brazil
³⁴University of Nuevo Leon, Monterrey, Mexico
³⁵Centro De Hematologia Medicina Interna, Puebla, Pue, Mexico
³⁶Hematology Service, Hospital Solon Espinoza Ayala, Quito, Ecuador
³⁷Hematology Service, Hospital de SOLCA, Guayaquil, Ecuador
³⁸Inst. De Investigaciones Hematológicas Dr. M. R. Castex, Academia Nacional De Me, Buenos Aires, ARG
³⁹Hematology Service, Clinica La Estancia, Popayan, Colombia
⁴⁰Hematology Service, Clinica del Country, Bogota, Colombia
⁴¹Instituto Oncológico Nacional Caja Petrolera de Salud, Cochabamba, Bolivia
⁴²Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴³University of North Carolina at Chapel Hill, Chapel Hill, NC
⁴⁴George Washington University Cancer Center, Washington, DC
⁴⁵Bing Center for Waldenström Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA

Xiao Li^1*, Skander Jemaa^1*, Richard AD Carano^1*, Thomas Bengtsson^1*, Joseph N Paulson^1*, Gunther Jansen^2*, Tina G Nielsen^2* and Derrek P Hibar^1*

¹Genentech, Inc., South San Francisco, CA
²F. Hoffmann-La Roche Ltd, Basel, Switzerland

Omer M Ali, MD¹, Sahil S Nalawade, MS^2*, Yin Xi, PhD^2*, Ben Wagner, BM^2*, Alexander Mazal, MD^2*, Shane Ahlers, MD¹, Syed M Rizvi, MD^1*, Farrukh T Awan, MD¹, Kiran A Kumar, MD, MBA^3*, Neil B Desai, MD, MHS^3*, Joseph A Maldjian, MD^2*, Marco C Pinho, MD^2* and Praveen Ramakrishnan Geethakumari, MD, MS¹

¹Division of Hematologic Malignancies and Stem Cell Transplantation, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX
²Advanced Neuroscience Imaging Research Lab, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX
³Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX

M. Christina Cox, MD, PhD^1,2, Luigi Marcheselli^3*, Gerardo Musuraca, MD^4*, Maria Cantonetti, MD^5*, Carlo Visco^6*, Stefan Hohaus, MD^7*, Ombretta Annibali^8*, Alberto Fabbri, MD^9*, Monica Tani, MD^10*, Stefano Luminari, MD¹¹, Roberta Battistini, MD^12*, Luigi Petrucci, MD^13*, Francesca Re, MD^14*, Francesco Marchesi^15*, Paola Anticoli Borza^16*, Fiammetta Natalino, MD^17*, Elisabetta Abruzzese, MD ¹⁸, Sabrina Pelliccia, MD^19*, Fabiana Mammoli, PhD^20*, Livio Pupo^21*, Giuseppe Carli, MD^22*, Eleonora Alma^23*, Valeria Tomarchio, MD^24*, Emanuele Cencini, MD^9*, Francesca Fabbri^25*, Federico Meconi^26*, Emanuele D'Amore^27*, Luigi Maria Larocca, MD^28*, Silvia Asioli^29*, Giorgia Scafetta^30*, Cristiano Tesei^31*, Luigi Ruco^32* and Arianna Di Napoli^33*

¹Haematology Department, King's College NHS Trust, London, United Kingdom
²Hematology unit, Azienda Ospedaliera-Universitaria Sant'Andrea, ROMA, Italy
³Fondazione Italiana Linfomi, Modena, Italy
⁴Hematology Unit, IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), Meldola (FC), Italy
⁵Hematology unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Rome, Italy
⁶Department of Medicine, section of Hematology, University of Verona, Verona, Italy
⁷University Policlinico Gemelli Foundation, IRCCS, Catholic University of the Sacred Heart, Roma, Italy
⁸Unit of Hematology, Stem Cell Transplantation, University "Campus Bio-Medico", Rome, Italy
⁹Unit of Hematology, Azienda Ospedaliera Universitaria Senese, Siena, Italy
¹⁰Haematology Unit, Santa Maria delle Croci Hospital, Ravenna, Italy
¹¹Hematology, Universita Di Modena A Reggio Emilia, Reggio Emilia, Italy
¹²Hematology, San Camillo Hospital, Rome, Italy
¹³Division of Haematology, University La Sapienza, Rome, Italy
¹⁴Hematology Clinic, A.O.U. di Parma, Parma, Italy
¹⁵Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute Rome, Italia, Roma, ITA
¹⁶UOC of Hematology, Azienda Ospedaliera San Giovanni - Addolorata, Roma, ITA
¹⁷UOC of hematology, ASL Viterbo, Hosp Belcolle, Viterbo, Italy
¹⁸Hematology Unit, S. Eugenio Hospital, Roma, Italy
¹⁹Department of Clinic and Molecular Medicine, Sapienza University of Rome,Sant’Andrea University Hospital, Division of Hematology, roma, Italy
²⁰RCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), Meldola (FC), Italy
²¹Hematology Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Rome, Italy
²²Hematology Department, Ospedale San Bortolo, Vicenza, Italy
²³University Policlinico Gemelli Foundation, IRCCS, Catholic University of the Sacred Heart, Roma, ITA
²⁴Unit of Hematology, Stem Cell Transplantation, University "Campus Bio-Medico", ROMA, Italy
²⁵Hematology Unit, IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), meldola, Italy
²⁶Hematology unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, rome, Italy
²⁷Ospedale San Bortolo, Vicenza, ITA
²⁸Division of Pathology and Histology, Catholic University of the Sacred Heart, Rome, Italy
²⁹Anatomia Patologica, Ausl Romagna, forlì, Italy
³⁰Pathology unit, Azienda Ospedaliera-Universitaria Sant'Andrea, Rome, ITA
³¹RELLI, Rete Linfomi Lazio, Rome, Italy
³²Pathology unit,, Azienda Ospedaliera-Universitaria Sant'Andrea, ROMA, Italy
³³Pathology unit, Azienda Ospedaliera-Universitaria Sant'Andrea, Rome, Italy

Christopher J. Walker, PhD¹, Yao Shen, PhD^2*, Mariano Alvarez, PhD^2*, Hua Chang, PhD^1*, Jatin Shah, MD¹, Sharon Shacham, PhD, MBA^1*, Andrea Califano, Dr^2* and Yosef Landesman, PhD^1*

¹Karyopharm Therapeutics, Newton, MA
²Darwinhealth Inc., New York, NY

Matthew J Cortese, MD, MPH¹, Wei Wei, MS^2*, Sebastian Cerdena, PharmD^3*, Marcus Watkins, PhD^3*, Marissa Olson, PharmD^3*, Gray Jodon, MD⁴, Jeff Kaiser, PharmD^4*, Bradley Haverkos, MD, MPH, MS^4*, Mitchell E. Hughes, PharmD^5*, Natalie S Grover, MD⁶, Anson Snow, MD⁶, Victor M. Orellana-Noia, MD⁷, Magdalena A Rainey, MS⁸, Mohammad Ahsan Sohail, MD^8*, Joslyn Rudoni, PharmD^9*, Craig A. Portell, MD⁷, Timothy J Voorhees, MD⁶, Daniel J. Landsburg, MD⁵, Manali Kamdar, MD, MDDS^4*, Brad S. Kahl, MD¹⁰ and Brian T. Hill, MD¹¹

¹Taussig Cancer Institute, Department of Hematology and Medical Oncology, Cleveland Clinic, South Euclid, OH
²Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH
³Barnes-Jewish Hospital, Washington University in St. Louis, St. Louis, MO
⁴University of Colorado Cancer Center, Aurora, CO
⁵Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
⁶Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
⁷Division of Hematology/Oncology, University of Virginia, Charlottesville, VA
⁸Cleveland Clinic, Cleveland, OH
⁹Department of Pharmacy, Cleveland Clinic, Cleveland, OH
¹⁰Division of Oncology, Washington University, St Louis, Washington University School of Medicine in St. Louis, Saint Louis, MO
¹¹Taussig Cancer Institute, Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, OH

Xiaoxiao Wang^1*, Yan Gao, MD, PhD^2*, Changguo Shan^3*, Mingyao Lai^3*, Haixia He^4*, Bing Bai^5*, Li-qin Ping^6*, Qixiang Rong^5*, Ruyu Ai^3*, Lei Wen^3*, Zhaoming Zhou^3*, Ruoying Yu^7*, Qiuxiang Ou^8*, Xue Wu^8*, Xiaoxia Wang^9*, Yang Shao^9*, Linbo Cai^3* and Hui-qiang Huang¹⁰

¹Sun Yat-sen University cancer center, guangzhou, China
²Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
³Guangdong Sanjiu Brain Hospital, Guangzhou, China
⁴Sun Yat-Sen University Cancer Center, Guangzhou, CHN
⁵Sun Yat-sen University Cancer Center, guangzhou, China
⁶Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China
⁷Geneseeq Technology Inc, Toronto, ON, Canada
⁸Geneseeq Technology Inc, Toronto, Canada
⁹Nanjing Geneseeq Technology Inc, Nanjing, China
¹⁰Sun Yat-Sen University Cancer Center, GuangZhou, China

Neeraj Saini, MD¹, Chia-Chi Chang, PhD^2*, Paolo Strati, MD³, Loretta J. Nastoupil, MD⁴, Jason Westin, MD⁵, Ranjit Nair, MD⁶, Luis Fayad⁷, Sairah Ahmed, MD⁸, Hun Ju Lee, MD⁵, Swaminathan P Iyer, MD⁵, Raphael Eric Steiner, MD⁵, Uri Greenbaum, MD⁹, Partow Kebriaei, MD¹, Elizabeth J. Shpall, MD¹, Nitin Jain, MD¹⁰, Michael R Green, PhD^2,6, Nadim J Ajami^11*, Christopher Flowers, MD, MS⁵, Richard E. Champlin, MD¹, Jennifer Wargo, MD^12*, Sattva S. Neelapu, MD^4,5 and Robert R. Jenq, MD¹³

¹Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX
³Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Lymphoma/Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Lymphoma and Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁸Department of Lymphoma/Myeloma, MD Anderson Cancer Center, Houston, TX
⁹MD Anderson Cancer Center, Houston, TX
¹⁰University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX
¹¹Department of Genomic Medicine, MD Anderson Cancer, Houston, TX
¹²Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Houston, TX
¹³Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX

Carla Casulo, MD¹, Myla Strawderman, MS^2*, Raphael Steiner, MD^3*, Carolyne Delage, MD^4*, Tina Faugh^5*, Matthew J. Maurer, MS⁶, Brian K. Link, MD⁷, Allison C. Rosenthal, D.O.⁸, Colleen Ramsower, B.S. M.B.^9*, Richard Burack, MD, PhD¹⁰, Sergei Syrbu, MD, PhD^11*, Andrew L. Feldman, MD¹², Philip J Rock^10*, James R. Cerhan, MD, PhD¹³, Christopher Flowers, MD, MS³, Lisa M. Rimsza, MD¹⁴ and Jonathan W. Friedberg, MD, MSSc¹⁵

¹Department of Medicine , Hematology/Oncology, James P. Wilmot Cancer Center, Rochester, NY
²Wilmot Cancer Institute, University of Rochester, Rochester, NY
³MD Anderson Cancer Center, Houston, TX
⁴Strong Memorial Hospital, Rochester, NY
⁵Wilmot Cancer Insitute, University of Rochester Medical Center, Rochester
⁶Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN
⁷Division of Hematology, Oncology, and Blood & Marrow Transplantation, University of Iowa, Iowa City, IA
⁸Mayo Clinic, Phoenix, AZ
⁹Department of Research, Mayo Clinic, Scottsdale, AZ
¹⁰Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY
¹¹Department of Pathology, University of Iowa, Iowa City, IA
¹²Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
¹³Division of Hematology, Mayo Clinic, Rochester, MN
¹⁴Mayo Clinic - Scottsdale, Scottsdale, AZ
¹⁵Division of Hematology/Oncology, University of Rochester, Rochester, NY

Edith Tama Robin, MD¹, Esther Drill, DrPH^2*, Connie Lee Batlevi, MD, PhD³, Philip Caron, MD, PhD⁴, Lorenzo Falchi, MD⁴, Audrey Hamilton, MD^4*, Paul A. Hamlin, MD⁴, Steven M. Horwitz, MD⁴, Andrew M. Intlekofer, MD, PhD⁴, Erel Joffe, MD, MSc⁴, Anita Kumar, MD⁴, Matthew J Matasar, MD, MS⁴, Ariela Noy, MD³, Colette Owens, MD⁴, Maria Lia Palomba, MD⁴, Ildefonso Rodriguez-Rivera, MD^4*, David J. Straus, MD⁴, Santosha Vardhana, MD, PhD^4*, Gottfried R. von Keudell, MD, PhD⁴, Andrew D Zelenetz, MD, PhD⁴, Craig H. Moskowitz, MD⁵ and Alison J. Moskowitz, MD⁴

¹Ichan School of Medicine/Mount Sinai Morningside and Mount Sinai West, New York, NY
²Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
³Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Lymphoma Department, Memorial Sloan-Kettering Cancer Center, New York, NY

Alessandra Tucci, MD^1*, Alessandro Re, MD^1*, Chiara Pagani, MD^2*, Anna Guidetti³, Anna Dodero^4*, Fabrizio Marino, MD^5*, Ivana Casaroli, MD^6*, Giulia Soverini, MD^1*, Rosa Daffini, MD^1*, Monica Balzarotti^7*, Giulia Campostrini^1*, Luisa Lorenzi, MD^8*, Piera Balzarini^8*, Fabio Facchetti^8*, Carmelo Carlo-Stella, MD⁹, Paolo Corradini³ and Giuseppe Rossi, MD²

¹Department of Hematology, ASST Spedali Civili, Brescia, Italy
²Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
³Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori and Università degli Studi di Milano, Milano, Italy
⁴Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
⁵Department of Hematology, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy
⁶Haematology Unit, Ospedale San Gerardo, Monza, Italy
⁷Department of Haematology, Istituto Clinico Humanitas, Rozzano, Italy
⁸Pathology, Dpt Molecular and Translational Medicine, University of Brescia, Brescia, Italy
⁹Humanitas Cancer Center, Rozzano, Milano, Italy

Jithma P. Abeykoon, MD^1,2, Paul J. Hampel, MD^1,2, Rebecca L. King, MD³, Adam J Wood, MD^4*, Melissa L. Larson, MD⁵, Kevin E. Nowakowski^1*, Saurabh Zanwar, MD, MBBS⁶, Aishwarya Ravindran, MBBS⁷, Matthew J. Maurer, MS⁸, Linda Wellik^9*, Jonas Paludo, MD¹, Brian K. Link, MD¹⁰, James R. Cerhan, MD, PhD¹, Xiaosheng Wu, MD^1*, Thomas M. Habermann, MD¹ and Thomas E. Witzig, MD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁴Department of Laboratory Medicine and Pathology, Mayo Clinic, ROCHESTER
⁵Department of Health Sciences Research, Mayo Clinic, Rochester, MN
⁶Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁷Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁸Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN
⁹Mayo Clinic, Rochester, MN
¹⁰Division of Hematology, Oncology, and Blood & Marrow Transplantation, University of Iowa, Iowa City, IA

Yan Ma, Dr^1*, Dina Suolitiken^2*, Bobin Chen, MD, PhD¹, Xiaoping Xu^3*, Hui Kang, Dr^2* and Lin Zhiguang, Dr^2*

¹Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China
²Huashan Hospital, Fudan University, Shanghai, China
³Department of Hematology, Huashan Hospital of Fudan University, Shanghai, China

Luis Alberto de Padua Covas Lage, MD, PhD^1,2,3,4*, Gisele Rodrigues Gouveia, PhD^5*, Suzete Cleusa Ferreira, PhD^6*, Sheila Aparecida Coelho de Siqueira, MD, PhD^7*, Abrahão Elias Hallack Neto, MD, PhD^8,9*, Renata Oliveira Costa, MD, PhD¹⁰ and Juliana Pereira, MD, PhD^1,11,12

¹Division of Hematology, Transfusion Medicine and Cell Therapy, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
²Medical Research Laboratory on Molecular Hematology (LIM-31), Universidade de São Paulo, São Paulo, Brazil
³Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
⁴Departament of Hematology, Hemotherapy and Cell Therapy, Hospital Das Clinicas Da Universidade De Sao Paulo, São Caetano do Sul, SP, Brazil
⁵Department of Hematology, Hemotherapy and Cell Therapy, Universidade de São Paulo (USP), Sao Paulo, Brazil
⁶Department of Molecular Biology, Fundação Pró-Sangue, Sao Paulo, Brazil
⁷Department of Pathology, Universidade de São Paulo (USP), Sao Paulo, Brazil
⁸Division of Hematology and Oncology, Universidade Federal de Juiz de Fora, São Pedro, Brazil
⁹Universidade Federal De Juiz De Fora, Juiz de Fora, BRA
¹⁰Department of Hematology and Hemotherapy, Centro Universitário Lusíadas, Santos, Brazil
¹¹MEDICINE SCHOOL OF SAO PAULO UNIVERSITY, SAO PAULO, BRA
¹²Instituto do Cancer do Estado de Sao Paulo da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil

Shakthi Bhaskar, MD¹, Priyanka Pullarkat^2*, Fei Wan^2*, Sara Butler^2* and Neha Mehta-Shah, MD³

¹Vanderbilt University Medical Center, Nashville, TN
²Washington University in St. Louis, St. Louis, MO
³Siteman Cancer Center, Washington University, St. Louis, MO

Jose V. Forero, MD^1*, Paula A. Lengerke Diaz, MD², Eider F. Moreno Cortes, MD^3*, Megan Melody, MD⁴, Allison C. Rosenthal, D.O.⁵, Mohamed A. Kharfan-Dabaja, MD, MBA⁴ and Januario E. Castro, MD⁵

¹Division of Hematology, Mayo Clinic, Phoenix, AZ
²Division of Hematology, Mayo Clinic, Scottsdale, AZ
³Mayo Clinic, Scottsdale, AZ
⁴Mayo Clinic, Jacksonville, FL
⁵Mayo Clinic, Phoenix, AZ

Yazan Samhouri, MD¹, Thejus Jayakrishnan, MBBS², Lynna Alnimer, MD^3*, Deanna Huffman, DO^4*, Veli Bakalov, MD⁵, Rodney E Wegner, MD^6*, Salman Fazal, MD¹, Cyrus Kahn, MD^1* and John Lister, MD¹

¹Division of Hematology and Cellular Therapy, Allegheny Health Network Cancer Institute, Pittsburgh, PA
²Department of Internal Medicine, Allegheny Helath Network, Pittsburgh, PA
³Department of Internal Medicine, Ascension Providence Hospital, Michigan State University, College of Human Medicine, Southfield, MI
⁴Department of Internal Medicine, Allegheny Health Network, Pittsburgh, PA
⁵Allegheny Health Network Cancer Institute, Pittsburgh, PA
⁶Division of Radiation Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA

Carolina Velez-Mejia, MD^1*, Daniela Hernandez, MD², Joel E Michalek, PhD^3*, Qianqian Liu, PhD^4* and Adolfo Enrique Diaz Duque, MD, MSc⁵

¹Internal Medicine, University of Texas Health at San Antonio, San Antonio, TX
²Internal Medicine Residency at Doctors Hospital at Renaissance, University of Texas Rio Grande Valley, McAllen, TX
³The University of Texas Health Science Center At San Antonio, San Antonio, TX
⁴Department of Epidemiology and Biostatistics, University of Texas Health at San Antonio, San Antonio, TX
⁵Hematology-Oncology Division, Mays Cancer Center UT Health San Antonio MD Anderson, San Antonio, TX

Farheen Manji, MD¹ and Carolyn Owen, MD FRCPC²

¹Department of Medicine, University of Calgary, Calgary, AB, Canada
²Foothills Hospital & Tom Baker Cancer Ctr., Calgary, AB, Canada

Alessandra Sottini, BS^1*, Luisa Imberti, MD^1*, Simone Paghera, BS^1*, Vanessa Previcini, BS^1*, Chiara Cattaneo^2*, Eugenia Quiros-Roldan, MD^3*, Ruggero Capra, MD^4*, Giuseppe Rossi, MD², Kerry Dobbs, BS^5*, Elana Shaw, BS^5*, Luigi D. Notarangelo, MD^5*, Peter Burbelo, PhD^6* and Jeffrey Cohen, MD^7*

¹CREA (AIL Center for Hemato-Oncologic Research), Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy
²Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
³DSCS, Università degli studi di Brescia ASST Spedali Civili di Brescia, Brescia, Italy
⁴Multiple Sclerosis Center, ASST Spedali Civili di Brescia, Brescia, Italy
⁵Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
⁶National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD
⁷Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

Eyal Lebel^1,2*, Neta Goldschmidt^1*, Tali Siegal, MD^3*, Alexander Lossos, MD^4*, Moshe Gatt, MD¹, Alexander Gural, MD^1*, Adir Shaulov, MD^1*, Revital Saban, MD^1*, David Lavie, MD^1* and Boaz Nachmias, MD, PhD^1*

¹Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
²Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada
³Center of Neuro-Oncology, Davidoff Institute of Oncology, Rabin Medical Center, Campus Beilinson, Petach Tikva, Israel
⁴Center of Neuro-Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Rola El Sayed, MD^*, Haidar El Darsa, MD^*, Jeries Kort, MD, Farouk Al Chami, MD^*, Charafeddine Maya^*, Ali Bazarbachi, MD, PhD, Iman Abou Dalle, MD^* and Jean Elcheikh, MD^*

American University of Beirut Medical Center, Beirut, Lebanon

Jianqiu Wu^1*, Yanyan Liu^2*, Li Fei³, Zhi-Jun Wuxiao^4*, Fancong Kong^3*, Zhihua Yao^2*, Weilun Zhou^4* and Jifeng Feng^1*

¹Jiangsu Province Cancer Hospital, Nanjing, China
²Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
³the First Affiliated Hospital of Nanchang University, Nanchang, China
⁴The First Affiliated Hospital, Hainan Medical College, Haikou, China