Malini Rethnam^*, Darren Qiancheng Tan, PhD^*, Shi Hao Tan, PhD^*, Li Ying^*, Henry Yang, PhD^* and Toshio Suda, MD, PhD

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

Shunfeng Hu, MM^1*, Xiangxiang Zhou, MD^1,2*, Juan Yang, PhD^1*, Shuai Ren, MM^1*, Yiqing Cai^1*, Yang Han, MM^1*, Jiarui Liu^1*, Yi Zhao, MM^1* and Xin Wang, MD, PhD^1,2

¹Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
²Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

Christopher Peter Mill, PhD, BA^1*, Warren Fiskus, BSc, PhD², Courtney D. DiNardo, MD, MSc³, Christine Birdwell^4*, Bernardo H Lara^5*, Joseph D. Khoury, MD⁶ and Kapil N. Bhalla, MD²

¹MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁴The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Leukemia, MD Anderson Cancer Center, Houston, TX
⁶Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX

Qiang Liu, PhD, BSc¹, Olga I. Gan, PhD^2*, Gabriela Krivdova, BSc³, Aaron Trotman-Grant^4*, Stephanie M. Dobson, PhD^5*, Karin G. Hermans^5*, Mark D. Minden⁶, Shai Izraeli, MD⁷, John E. Dick, PhD, FRS², Jean C.Y. Wang, MD, PhD^5,8 and Eric R. Lechman,, PhD⁵

¹Princess Margaret, University Health Network, Toronto, ON, Canada
²Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, ON, Canada
³Princess Margaret Cancer Centre, University Health Network, Mississauga, ON, Canada
⁴Immunology, University of Toronto, Toronto, Canada
⁵Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁶Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁷Pediatric Hematology-Oncology, Sheba Medical Center, Petach Tikva, Israel
⁸Department of Medicine, University of Toronto, Toronto, ON, Canada

June Takeda, MD^1*, Kenichi Yoshida, MD, PhD², Akinori Yoda, PhD^3*, Lee-Yung Shih, MD⁴, Yasuhito Nannya, MD, PhD¹, Yotaro Ochi, MD^1*, Ayana Kon, MD, PhD^1*, Kenichi Chiba^5*, Yuichi Shiraishi, PhD^6*, Yusuke Shiozawa, MD, PhD^7*, Tetsuichi Yoshizato, MD, PhD³, Cassandra M Kerr, MS^8*, Yasunobu Nagata, MD, PhD^9*, Toshiyuki Kitano, MD, PhD^10*, Akira Hangaishi, MD, PhD^11*, Ken Ishiyama, MD, PhD¹², Hisashi Tsurumi, MD, PhD¹³, Yasushi Miyazaki, MD, PhD¹⁴, Nobuhiro Hiramoto, MD^15*, Takayuki Ishikawa, MD, PhD¹⁵, Masahiro Marshall Nakagawa, MD, PhD³, Akifumi Takaori-Kondo, MD, PhD¹⁶, Shigeru Chiba, MD, PhD^17*, Hideyuki Nakazawa, MD, PhD^18*, Ming-Chung Kuo, M.D.^4*, Keisuke Kataoka, MD, PhD¹, Ryunosuke Saiki, MD^3*, Hiroko Tanaka^19*, Kensuke Usuki, MD, PhD¹¹, Shuichi Miyawaki, MD, PhD²⁰, Satoru Miyano, PhD^6*, Jaroslaw P. Maciejewski, MD, PhD⁹, Arnold Ganser²¹, Michael Heuser, Prof., MD^22*, Felicitas Thol²¹, Hideki Makishima, MD, PhD³ and Seishi Ogawa, MD, PhD^3,23,24

¹Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan
²Kyoto Univeristy, Kyoto, Japan
³Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁴Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan
⁵Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan
⁶The University of Tokyo, Human Genome Centre, Institute of Medical Science, Tokyo, Japan
⁷The University of Tokyo, Department of Pediatrics, Graduate School of Medicine, Tokyo, Japan
⁸Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
¹⁰Department of Hematology, Medical Research Institute Kitano Hospital, Osaka, Japan
¹¹Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
¹²Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan
¹³Hematology, Gifu University Graduate School of Medicine, Gifu, Japan
¹⁴Atomic Bomb Disease Institute, Nagasaki University Hospital, Nagasaki, Japan
¹⁵Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan
¹⁶Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
¹⁷Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
¹⁸Department of Hematology, Shinshu University School of Medicine, Matsumoto, Japan
¹⁹Department of Integrated Data Science, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
²⁰Division of Hematology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo, JPN
²¹Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²²Department for Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²³Department of Medicine, Center for Haematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden
²⁴Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan

Ricardo De Matos Simoes, PhD^1,2*, Ryosuke Shirasaki, MD^1,2*, Huihui Tang, PhD^1,2*, Shizuka Yamano^1,2*, Benjamin G Barwick, PhD³, Sara Gandolfi, MD^1,2*, Eugen Dhimolea, PhD^1,2*, Sondra L. Downey-Kopyscinski, PhD^1,2*, Olga Dashevsky, PhD^1,2*, Brian Glassner, PhD^1,2*, Michal Sheffer, PhD^1,2*, Dhvanir Kansara^1*, Megan Bariteau, BSc^1,2*, Jeffrey Sorrell, BA^1*, Vikas Gupta, MD, PhD^3*, Aedin Culhane, PhD^4*, Aviad Tsherniak, PhD^2*, Francisca Vazquez, Phd^2*, Larry H. Boise, PhD³, Jonathan D. Licht, MD⁵ and Constantine S. Mitsiades, MD, PhD^2,6

¹Dept. of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Broad Institute of MIT and Harvard, Cambridge, MA
³Emory University, Atlanta, GA
⁴Dept. of Biostatistics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁵University of Florida College of Medicine, Gainesville, FL
⁶Dept. of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Brookline, MA

Astrid Behnert, MD^1*, Julia Meyer, PhD^2*, Jahan-Yar Parsa, PhD^3*, Aaron Hechmer, PhD^4*, Mignon L. Loh, MD⁵, Adam B. Olshen, PhD^4*, Adam J de Smith, PhD⁶ and Elliot Stieglitz, MD⁷

¹Department of Pediatrics, Division of Hematology-Oncology, University of California, San Francisco and Benioff Children's Hospital, San Francisco, CA
²Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA
³Tecan, San Jose, CA
⁴Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA
⁵Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California Benioff Children’s Hospital, San Francisco, CA
⁶Center for Genetic Epidemiology, Department of Preventive Medicine, University of Southern California, Los Angeles, CA
⁷Department of Pediatrics, Division of Hematology-Oncology, UCSF, San Francisco, CA

Lauren Pommert, MD, MS¹, Robert Burns, MD^2*, Quinlan Furumo^3*, Kirthi Pulakanti^4*, Jon Brandt^5*, Michael J Burke, MD^6,7 and Sridhar Rao, MD, PhD^8,9

¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Blood Research Institute, Blood Research Institute, BloodCenter of Wisconsin, part of Versiti, Milwaukee, WI
³Blood Research Institute, BloodCenter of Wisconsin, part of Versiti, Milwaukee, WI
⁴Blood Research Institute, Versiti, Wauwatosa, WI
⁵Hospital Sisters Heath System St. Vincent Hospital, Green Bay, WI
⁶Children's Hospital of Wisconsin, Milwaukee, WI
⁷Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
⁸Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, Children's Hospital of Wisconsin, Milwaukee
⁹Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI

Sara Deola, MD, PhD¹, Dhanya Kizhakayil^1*, Sheanna M Herrera^1*, Muhammad Elnaggar, MD, PhD^1*, Che-Ann Lachica^1*, Giusy Gentilcore, PhD^1*, Ayman Saleh, MD^2*, Anila Ejaz, MD^3*, Zehra Fadoo, MBBS, MD^4*, Kulsoom Ghias, PhD^5*, Irene Pusceddu, PhD^6*, Irene M Cavattoni^7*, Ramzi Temanni, PhD^8*, Najeeb A Syed, M.Tech^8*, Fazulur R Vempalli, M.Bioinformatics^8*, Patrizia Comoli, MD^9*, Tommaso Mina, MD^10* and Chiara Cugno, MD¹

¹Research, Sidra Medicine, Doha, Qatar
²Sidra Medicine, Doha, QAT
³Sidra Medicine, Doha, Qatar
⁴Department of Oncology, Aga Khan University, Karachi, Pakistan
⁵Biological and Biomedical Sciences, Aga Khan University, Karachi, PAK
⁶Department of Clinical Pathology, General Hospital of Bolzano, Bolzano, Italy
⁷Hematology and BMT Unit, General Hospital of Bolzano, Bolzano, Italy
⁸Genomic Data Science Core, Sidra Medicine, Doha, Qatar
⁹Cell Factory, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹⁰Pediatric Hematology/Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy