Robert Provenzano^1*, Steven Fishbane^2*, Lee-Jen Wei^3*, Lynda Szczech, MD^4*, Robert Leong^5*, Khalil Saikali^6*, Ming Zhong^7*, Tyson Lee^8*, Mark Houser^9*, Lars Frison^9*, John Houghton^10*, Peony Yu, MD^11* and Thomas Neff^6*

¹School of Medicine, Wayne State University, Detroit, MI
²Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY
³Harvard School of Public Health, Boston, MA
⁴FibroGen Inc.,, Durham, NC
⁵FibroGen Inc., San Francisco
⁶FibroGen, Inc., San Francisco, CA
⁷FibroGen, Inc., San Francisco
⁸FibroGen, Inc., san francisco, CA
⁹AstraZeneca, Gaithersburg, MD
¹⁰Astrazeneca, Gaithersburg, MD
¹¹FibroGen, Inc, San Francisco, CA

Senquan Liu, PhD^1,2*, Mengyao Wu, PhD^1,3*, Yongxing Gao, MS^1*, Jiusheng Deng, PhD^4*, John D Roback, MD, PhD^4*, Tong Chen, MD, PhD⁵ and Linzhao Cheng, PhD^1,2

¹Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
²School of Basic Medicine, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
³Division of Hematology, Huashan Hospital of Fudan University, Shanghai, China
⁴Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA
⁵Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China

Janice H. C. Plani-LAM, PhD^1*, Mhairi Maxwell^2*, Neli Slavova-Azmanova^3*, Nicole Kucera^1*, Alison Louw, PhD^1*, Jiulia Satiaputra^1*, Susan Wu^1*, Edward Bastow^1*, Cindy Le^1*, Cathy Quilici^4*, Margaret L Hibbs^5* and Evan Ingley, PhD, BSc^1,6

¹Harry Perkins Institute of Medical Research, Nedlands, Australia
²Monash University, Melbourne, Australia
³The University of Western Australia, Crawley, AUS
⁴Leukocyte Signalling Laboratory, Monash University, Melbourne, Australia
⁵Leukocyte Signaling Laboratory, Monash University, Melbourne, Australia
⁶College of Health, Science, Engineering and Education, Murdoch University, Murdoch, Australia

Alexander Röth, MD¹, Wilma Barcellini^2*, Shirley D'Sa^3*, Yoshitaka Miyakawa^4*, Catherine M Broome⁵, Marc Michel^6*, David J. Kuter, MD⁷, Bernd Jilma⁸, Tor Henrik Anderson Tvedt^9*, Ilene C. Weitz¹⁰, Parija Patel^11*, Xiaoyu Jiang^11*, Caroline Reuter^11*, Jun Su¹², Frank Shafer^11*, Michelle Lee^11*, William Hobbs¹¹ and Sigbjørn Berentsen^13*

¹Department of Hematology, University Hospital Essen, Essen, Germany
²Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
³UCLH Centre for Waldenström’s Macroglobulinemia and Related Conditions, University College London Hospitals NHS Foundation Trust, London, United Kingdom
⁴Thrombosis and Hemostasis Center, Saitama Medical University Hospital, Saitama, Japan
⁵Division of Hematology, MedStar Georgetown University Hospital, Washington, DC
⁶Department of Internal Medicine, National Referral Center for Adult Immune Cytopenias, Henri-Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, UPEC, Créteil, France
⁷Hematology Division, Massachusetts General Hospital, Boston, MA
⁸Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
⁹Section for Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway
¹⁰Keck School of Medicine of USC, Los Angeles, CA
¹¹Sanofi, Cambridge, MA
¹²Medical Affairs, Sanofi, Cambridge, MA
¹³Department of Research and Innovation, Haugesund Hospital, Haugesund, Norway

Aldo A. Acosta-Medina, MD¹, Ann M. Moyer, MD PhD^2*, Ronald S. Go, MD³, Maria Alice V. Willrich, PhD^2*, Hassan B. Alkhateeb, MD^3*, Christianne Bourlon De Los Rios, MD, MSc¹, Dong Chen, M.D., Ph.D.², Fernando C. Fervenza, MD PhD^4*, Nahla M. Heikal, MD^2*, Nelson Leung, MD^3,5, Ariela L. Marshall, MD³, Cheryl L. Tran, MD^6*, Jeffrey L. Winters, MD² and Meera Sridharan, MD, PhD^3,7

¹Department of Hematology and Oncology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
²Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN
⁵Mayo Clinic Rochester, Division of Hematology, Rochester, MN
⁶Division of Pediatric Nephrology, Mayo Clinic, Rochester, MN
⁷on behalf of the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group, Rochester, MN

Bruno Fattizzo, MD^1*, Marc Michel^2*, Juri Alessandro Giannotta, MD^3*, Dennis Lund Hansen^4*, Montserrat Lopez Rubio, PhD^5*, Emanuele Sutto, MD^6*, Nicola Bianchetti, MD^7*, Andrea Patriarca, MD^8,9*, Silvia Cantoni^10*, Maria Eva Mingot-Castellano, PhD, MD^11*, Vickie McDonald, MD^12*, Marco Capecchi, MD^13*, Josephine M.I Vos^14*, Paola Bianchi, BSc, PhD¹⁵, Nicola Vianelli, MD^16*, Frederick Chen, MD^12*, Henrik Frederiksen, MD, PhD, Prof^17*, Tomas Jose Gonzalez-Lopez^18* and Wilma Barcellini^19*

¹UOC Ematologia, Fondazione IRCCS Ca' Grande Ospedale Maggiore Policlinico and University of Milan, Milano, Milano, Italy
²Service de Médecine Interne, Centre national de référence des cytopénies auto-immunes de l’adulte, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, Assistance Publique Hôpitaux de Paris, Université Paris Est Créteil, 94000 Créteil, Créteil, France
³Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlincio and University of Milan, MILANO, Italy
⁴Department of Haematology, Odense University Hospital, Denmark, Odense, Denmark
⁵Hospital Universitario Principe de Asturias (Alcala de Henares), Madrid, Spain, Madrid, Spain
⁶Institute of Hematology “L. and A. Seràgnoli”, Sant’Orsola-Malpighi University Hospital, Bologna, Bologna, ITA
⁷Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
⁸Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
⁹UO di Ematologia, AOU Maggiore della Carità, Novara, Novara, Italy
¹⁰Division of Hematology, Niguarda Cancer Center, ASST Niguarda Hospital, Milan, MILAN, Italy
¹¹Hospital Universitario Virgen del Rocio, Sevilla, Spain
¹²Clinical Haematology, Barts Health NHS Trust &Queen Mary University, London, UK, London, United Kingdom
¹³1. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico and University of Milan, Italy, Milan, Italy
¹⁴Dept of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, NLD
¹⁵Ospedale Maggiore Policlinico di Milano, Foundation IRCCS Ca' Granda,, Milano, Italy
¹⁶Institute of Hematology "L. & A. Seragnoli", Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
¹⁷Department of Hematology, Odense University Hospital, Odense, Denmark
¹⁸Hematology, Hospital Universitario de Burgos, Burgos, Burgos, ESP
¹⁹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Priti Azad, PhD¹, Francisco Villafuerte^2* and Gabriel Haddad^3*

¹University of California San Diego, La Jolla, CA
²Universidad Peruana Cayetano Heredia Lima, lima, Peru
³University of California, La Jolla, CA

Marit Jalink^1,2*, Sigbjørn Berentsen^3*, Jorge J. Castillo, MD⁴, Steven Treon⁵, Bruno Fattizzo, MD^6*, Ramona Cassin, MD^7*, Masja De Haas^1,8,9*, Andrea Patriarca, MD^10*, Shirley D'Sa, MD, FRCPath^11* and Josephine M.I Vos^2,12*

¹Center for Clinical Transfusion Research, Sanquin Research, Amsterdam, Netherlands
²Department of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
³Department of Research and Innovation, Haugesund Hospital, Haugesund, Norway
⁴Bing Center for Waldenström Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA
⁵Bing Center for Waldenstrom Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA
⁶UOC Ematologia, Fondazione IRCCS Ca' Grande Ospedale Maggiore Policlinico and University of Milan, Milano, Milano, Italy
⁷Hematology Department, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy
⁸Department of Hematology, Leiden University Medical Center, Leiden, Netherlands
⁹Department of Immunohematology Diagnostics, Sanquin, Amsterdam, Netherlands
¹⁰Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
¹¹UCLH Centre for Waldenström’s Macroglobulinemia and Related Conditions, University College London Hospitals NHS Foundation Trust, London, United Kingdom
¹²Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, Netherlands

Hanny Al-Samkari, MD¹, Rachael F. Grace, MD², Andreas Glenthoej, MD^3*, Oliver Andres, MD^4*, Wilma Barcellini^5*, Frédéric Galactéros, MD PhD^6*, Kevin H.M. Kuo, MD, MSc, FRCPC⁷, D. Mark Layton, MB BS^8*, Marta Morado, PhD^9*, Vip Viprakasit^10*, Yan Dong, PhD^11*, Feng Tai, PhD^11*, Peter Hawkins, PhD^11*, Sarah Gheuens, MD, PhD^11*, Chris Bowden, MD^11*, John B. Porter, MA, M.D., FRCP, FRCPath^12* and Eduard van Beers, MD, PhD^13*

¹Division of Hematology, Massachusetts General Hospital, Boston, MA
²Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Boston, MA
³Herlev University Hospital, Herlev, Denmark
⁴Department of Paediatrics, University of Würzburg, University of Würzburg, Würzburg, Germany
⁵Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
⁶Unité des Maladies Génétiques du Globule Rouge, CHU Henri Mondor, Créteil, France
⁷Department of Medicine, University of Toronto, Toronto, ON, Canada
⁸Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
⁹Hematology Department, Hospital Universitario La Paz, Madrid, Spain
¹⁰Siriraj-Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
¹¹Agios Pharmaceuticals, Inc., Cambridge, MA
¹²Haematology Department, University College London Hospitals, London, United Kingdom, United Kingdom
¹³Department of Hematology, Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands

Xilin Chen, MD, PhD, Xiaogang Cheng, PhD^*, Qingde Liu, PhD^*, Saritha Muppa, MS^*, Cynthia Parker, BS^*, Fugang Zhu, PhD^*, Krishnan Raman, PhD^*, Pravin L Kotian, PhD^* and Yarlagadda S. Babu, PhD^*

BioCryst Pharmaceuticals, Inc., Birmingham, AL

Regis Peffault De Latour, MD, PhD^1*, Carlos M. de Castro, MD², Jeffrey Szer, MBBS³, Kensuke Usuki, MD, PhD⁴, Peter Hillmen, MBChB, PhD^5*, Morag Griffin, MBChB, FRCPath^5*, Mohamed Hamdani, MS^6*, Temitayo Ajayi^6*, Hisakazu Nishimori, MD, PhD^7* and Ilene C. Weitz⁸

¹French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Assistance Publique – Hôpitaux de Paris, Université de Paris, Paris, France
²Duke University School of Medicine, Durham, NC
³Department of Clinical Haematology, Royal Melbourne Hospital, Melbourne, VIC, Australia
⁴Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
⁵Department of Haematology, St James University Hospital, Leeds, United Kingdom
⁶Apellis Pharmaceuticals, Inc., Waltham, MA
⁷Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
⁸Jane Anne Nohl Division of Hematology, Keck-USC School of Medicine, Los Angeles, CA

Austin G Kulasekararaj, MD, MBBS, MRCP, FRCPath¹, Guangsheng He, MD, PhD^2*, Talha Munir, MBBS^3*, Jeffrey Pu, MD, PhD^4*, Antonio Risitano, MD, PhD^5,6, Alexander Röth, MD⁷, Camelia S. Sima, MD^8*, Anita Appius, PhD^9*, Alexandre Sostelly, PhD^9*, Sasha Sreckovic, MD⁹, Charlotte Vignal, PhD^9* and Jun-Ichi Nishimura, MD, PhD¹⁰

¹King’s College Hospital NHS Foundation Trust, King’s College, London, UK, and NIHR Wellcome King’s Clinical Research Facility, London, United Kingdom
²Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
³St James University Hospital, Leeds, United Kingdom
⁴Hollings Cancer Center of the Medical University of South Carolina, Charleston, SC
⁵Hematology, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy
⁶Hematology and BMT Unit, AORN Moscati Avellino, Avellino, Italy
⁷Department of Hematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
⁸Genentech, Inc., South San Francisco, CA
⁹F. Hoffmann-La Roche Ltd, Basel, Switzerland
¹⁰Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Brian Sandri, PhD^1*, Gabriele Lubach, PhD^2*, Eric Lock, PhD^3*, Pam Kling, MD^4*, Michael Georgieff, MD^3*, Christopher Coe, PhD^2* and Raghavendra Rao, MD^3*

¹Pediatrics, University of Minnesota, Minneapolis, MN
²University of Wisconsin, Madison, WI
³University of Minnesota, Minneapolis, MN
⁴Univ. of WI and Meriter Hosp. Div. of Neonatology, Madison, WI

Louise Arnold^1*, Richard Kelly, BSc, MD^2*, Talha Munir, MBBS^3*, Petra Muus, MD, PhD², Alexandra Pike, MBBS^4*, Kathryn Riley^2*, Briony Forrest^2*, Jeanifer Gachev^2*, Morag Griffin, MBChB, FRCPath^2* and Peter Hillmen, MBChB, PhD^2*

¹Department of Haematology, St James University Hospital, Leeds, LS97TF, United Kingdom
²Department of Haematology, St James University Hospital, Leeds, United Kingdom
³St James University Hospital, Leeds, United Kingdom
⁴Department of Haematology, St James University Hospital, Leeds, ENG, United Kingdom

Wilma Barcellini^1*, Bruno Fattizzo, MD^2*, Luisa Quattrocchi^3*, Juri Alessandro Giannotta, MD^4*, Semra Aydin, MD, PhD^5*, Federica Barone, MD^6*, Cecilia Carbone, MD^7*, Eloise Beggiato^8*, Paola Bianchi, BSc, PhD⁹, Eros Di Bona, MD^10*, Rosario Notaro, MD^11* and Anna Paola Iori^12*

¹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
²UOC Ematologia, Fondazione IRCCS Ca' Grande Ospedale Maggiore Policlinico and University of Milan, Milano, Milano, Italy
³Ematologia, Dipartimento di Ematologia, Oncologia e Dermatologia, AOU Policlinico Umberto I, Rome, Italy, Rome, Italy
⁴Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlincio and University of Milan, MILANO, Italy
⁵Department of Oncology and Hematology, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy
⁶Department of Hematology, University of Florence, Florence, Italy
⁷Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
⁸Dipartimento di Oncologia/Ematologia, presidio Molinette, Citta della salute e della scienza di Torino, Turin, Italy
⁹Ospedale Maggiore Policlinico di Milano, Foundation IRCCS Ca' Granda,, Milano, Italy
¹⁰Hematology, San Bortolo Hospital, Vicenza, Italy
¹¹Core Research Laboratory, Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Firenze, Italy
¹²Ematologia, Dipartimento di Ematologia, Oncologia e Dermatologia, AOU Policlinico Umberto I, Rome, Italy

Hubert Schrezenmeier¹, Jong Wook Lee, M.D., Ph.D.², Anita Hill^3*, Vadim V Ptushkin^4*, Viviani Pessoa^5*, Rosario Notaro^6*, Jimmy Wang^3*, Masayo Ogawa, MD, FAAP^7*, Shinichiro Okamoto, MD, PhD^8*, Lily LL Wong, MD, FRCPath^9*, Regis Peffault De Latour, MD, PhD^10* and Austin G Kulasekararaj, MD, MBBS, MRCP, FRCPath¹¹

¹Institute of Transfusion Medicine, University of Ulm, Ulm, Germany, and Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen, and University Hospital Ulm, Ulm, Germany
²Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
³Alexion Pharmaceuticals, Inc., Boston, MA
⁴Outpatient Department for Hematology, Oncology and Chemotherapy, S. P. Botkin Hospital, Moscow, Russian Federation
⁵Leeds Teaching Hospitals, Leeds, United Kingdom
⁶Laboratory of Cancer Genetics and Gene Transfer, Core Research Laboratory - Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Florence, Italy
⁷Alexion Pharmaceuticals Inc., Cheshire, CT
⁸Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
⁹Hematology Unit, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia
¹⁰Hematology Transplant Unit, Hôpital Saint-Louis, Paris, France
¹¹King’s College Hospital NHS Foundation Trust, King’s College, London, UK, and NIHR Wellcome King’s Clinical Research Facility, London, United Kingdom

Katharina Versmold^1*, Carina Raiser^1*, Imi Faghmous, BS, MSc, MA, MPH^2*, Pablo Katz, MD^2*, Aijing Shang, MD, PhD^2*, Tao Xu^2* and Alexander Röth, MD³

¹Department of Hematology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
²F. Hoffmann-La Roche Ltd, Basel, Switzerland
³Department of Hematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany