Mignon L. Loh, MD¹, Natalie DelRocco^2*, Michael J Borowitz, MD, PhD³, Karen R Rabin, MD, PhD⁴, Patrick A Zweidler-McKay, MD, PhD⁵, Kelly W Maloney, MD⁶, Leonard A. Mattano, MD⁷, Eric C Larsen, MD^8*, Anne L Angiolillo, MD^9*, Reuven J Schore, MD¹⁰, Michael J Burke, MD¹¹, Wanda L Salzer, MD¹², Brent L Wood, MD, PhD^13,14, Andrew J Carroll, PhD¹⁵, Nyla A Heerema, PhD¹⁶, Shalini C Reshmi, PhD¹⁷, Julie M Gastier-Foster, PhD¹⁸, Richard C Harvey, PhD¹⁹, I-Ming L Chen, DVM, MS²⁰, Cheryl L Willman, MD²¹, Naomi J Winick, MD²², William Carroll, MD^23*, Stephen P Hunger, MD²⁴, Elizabeth A. Raetz, MD²⁵, Meenakshi Devidas, PhD^26*, John Kairalla^27*, Kathryn G Roberts, PhD²⁸ and Charles G Mullighan, MBBS, MD²⁸

¹UCSF Benioff Children’s Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
²Department of Biostatistics, University of Florida, Gainesville, Gainesville, FL
³Departments of Pathology and Oncology, Johns Hopkins University, Baltimore, MD
⁴Baylor College of Medicine TX Children's Cancer Center, Houston, TX
⁵ImmunoGen, Lincoln, MA
⁶Department of Pediatrics, Division of Pediatric Hematology/Oncology/BMT, Children’s Hospital Colorado and University of Colorado School of Medicine, Aurora, CO
⁷HARP Pharma Consulting, Mystic, CT
⁸Department of Pediatrics, Maine Children's Cancer Program, Scarborough, ME
⁹Children’s National Health System/George Washington University SMHS, Washington, DC
¹⁰Children's National Medical Center, Washington, DC
¹¹Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
¹²U.S. Army Medical Research and Materiel Command, Olney, MD
¹³Department of Laboratory Medicine, University of Washington, Seattle, WA
¹⁴Department of Laboratory Medicine,, University of Washington, Seattle, WA
¹⁵Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
¹⁶Department of Pathology, The Ohio State University, Columbus, OH
¹⁷Nationwide Children's Hospital, Columbus, OH
¹⁸Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX
¹⁹University of New Mexico School of Medicine, Albuquerque, NM
²⁰Department of Pathology, University of New Mexico Cancer Research Facility, Albuquerque, NM
²¹Department of Pathology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM
²²Department of Pediatrics, Division of Pediatric Hematology/Oncology, UT Southwestern, Simmons Cancer Center, and Perlmutter Cancer Center, Dallas, TX
²³Department of Pediatrics, Perlmutter Cancer Center, New York University Medical Center, New York
²⁴Department of Pediatrics, Division of Oncology and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
²⁵New York University Langone Medical Center, New York, NY
²⁶Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN
²⁷Department of Biostatistics, Colleges of Medicine, Public Health & Health Professions, University of Florida, Gainesville, FL
²⁸Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN

Sarah Mc Dermott, DO¹, Midhat S. Farooqi, MD, PhD^2,3*, Azhar Saeed, MD^4*, Byunggil Yoo, MS^2*, Emily Farrow, PhD, CGC^2*, Neil Miller^2*, Patrick A. Brown, MD⁵ and Erin Guest, MD¹

¹Division of Hematology/Oncology/Bone Marrow Transplantation, Children's Mercy, Kansas City, MO
²Center for Pediatric Genomic Medicine, Children's Mercy, Kansas City, MO
³Department of Pathology, University of Missouri-Kansas City School of Medicine, Kansas City, MO
⁴University of Kansas Medical Center, Kansas City, KS
⁵Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD

Rashmi Kanagal-Shamanna, MD¹, Hagop M. Kantarjian, MD², Joseph D. Khoury, MD³, Koichi Takahashi, MD, PhD⁴, Guillermo Montalban-Bravo, MD^2*, Nicholas J. Short, MD², C. Cameron Yin, MD, PhD¹, Keyur Patel, MD, PhD^3*, Sanam Loghavi, MD³, Farhad Ravandi, MBBS², Marina Konopleva, MD, PhD⁵, Nitin Jain, MD², Guillermo Garcia-Manero, MD⁶, Naval Daver, MD⁶, Tapan M. Kadia, MD², Courtney D. DiNardo, MD, MSc⁶, Susan M. O'Brien, MD⁷, Rajyalakshmi Luthra, PhD^1* and Elias Jabbour, MD²

¹Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX
⁶The University of Texas MD Anderson Cancer Center, Houston, TX
⁷UCI Cancer Center, Orange, CA

Laura Rachele Bettini^1*, Claudia Saitta^1*, Barbara Buldini^2*, Geertruij Te Kronnie^2*, Stefano Rebellato^1*, Daniela Silvestri^3*, Elena Barisone^4*, Andrea Pession^5*, Marco Rabusin^6*, Concetta Micalizzi^7*, Franco Locatelli, MD, PhD⁸, Carmelo Rizzari^9*, Maria Grazia Valsecchi, PhD^3,10*, Andrea Biondi, MD⁹, Grazia Fazio^1* and Giovanni Cazzaniga, PhD^1,11

¹Tettamanti Research Center, Dept. Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
²Woman and Child Health Department, OncoHematology Lab, University of Padua, Padua, Italy
³Centro Operativo di Ricerca Statistica, Fondazione Tettamanti, School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy
⁴Regina Margherita Children's Hospital, Torino, Italy
⁵Sant'Orsola-Malpighi Hospital, "Lalla Seràgnoli" Institute, Bologna, Italy
⁶Institute of Maternal and Child Health, Trieste, Italy
⁷Haematology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy
⁸Dept of Pediatric Hematology/Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, Sapienza, University of Rome, Italy, Rome, Italy
⁹Dept. Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
¹⁰Bicocca Bioinformatics, Biostatistics and Bioimaging Centre, Department of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy
¹¹Genetics, Univ. Milan Bicocca, Monza, Italy

Karen R Rabin, MD, PhD^1,2, Meenakshi Devidas, PhD^3*, Zhiguo Chen^4*, Yunfeng Dai, PhD^5*, Sarah K Tasian, MD⁶, Johann K Hitzler, MD⁷, Kathryn G Roberts, PhD⁸, Andrew J Carroll, PhD⁹, Nyla A Heerema, PhD¹⁰, Michael J Borowitz, MD, PhD¹¹, Brent L Wood, MD, PhD¹², Charles G Mullighan, MBBS, MD⁸, Richard C Harvey, PhD¹³, I-Ming L Chen¹⁴, Cheryl L Willman, MD¹⁵, Shalini C Reshmi, PhD¹⁶, Julie M Gastier-Foster, PhD¹⁷, Kelly W Maloney, MD¹⁸, Eric C Larsen, MD^19*, Reuven J Schore, MD²⁰, Michael J Burke, MD²¹, Wanda L Salzer, MD²², Naomi J Winick, MD²³, William L. Carroll, MD²⁴, Elizabeth A. Raetz, MD²⁵, Anne Angiolillo, MD^26*, Mignon L. Loh, MD²⁷ and Stephen P Hunger, MD²⁸

¹Baylor College of Medicine TX Children's Cancer Center, Houston, TX
²Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX
³Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN
⁴Department of Biostatistics, Colleges of Medicine, Public Health, and Health Professions, University of Florida, Gainesville, FL
⁵Department of Biostatistics, University of Florida, Gainesville, FL
⁶Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
⁷The Hospital for Sick Children, Toronto, ON, Canada
⁸Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁹Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
¹⁰Department of Pathology, The Ohio State University, Columbus, OH
¹¹Departments of Pathology and Oncology, Johns Hopkins University, Baltimore, MD
¹²Department of Laboratory Medicine, University of Washington, Seattle, WA
¹³University of New Mexico School of Medicine, Albuquerque, NM
¹⁴Department of Pathology, University of New Mexico Cancer Research Facility, Albuquerque, NM
¹⁵Department of Pathology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM
¹⁶Nationwide Children's Hospital, Columbus, OH
¹⁷Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX
¹⁸Department of Pediatrics, Division of Pediatric Hematology/Oncology/BMT, Children’s Hospital Colorado and University of Colorado School of Medicine, Aurora, CO
¹⁹Department of Pediatrics, Maine Children's Cancer Program, Scarborough, ME
²⁰Children's National Medical Center, Washington, DC
²¹Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
²²U.S. Army Medical Research and Materiel Command, Olney, MD
²³Department of Pediatrics, Division of Pediatric Hematology/Oncology, UT Southwestern, Simmons Cancer Center, and Perlmutter Cancer Center, Dallas, TX
²⁴Division of Pediatric Hematology and Oncology, Perlmutter Cancer Center, NYU Cancer Institute, New York, NY
²⁵Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, New York, NY
²⁶Chiildren's National Medical Center, Washington, DC
²⁷Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California Benioff Children’s Hospital, San Francisco, CA
²⁸Department of Pediatrics, Division of Oncology and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Sarah K Tasian, MD^1,2, Yunfeng Dai, PhD^3*, Meenakshi Devidas, PhD^4*, Kathryn G Roberts, PhD⁵, Richard C Harvey, PhD⁶, I-Ming L Chen, DVM, MS⁷, Andrew J Carroll, PhD⁸, Nyla A Heerema, PhD⁹, Shalini C Reshmi, PhD¹⁰, Julie M Gastier-Foster, PhD¹¹, Michael J Borowitz, MD, PhD¹², Brent L Wood, MD, PhD¹³, Charles G Mullighan, MBBS, MD⁵, Cheryl L Willman, MD¹⁴, Kelly W Maloney, MD¹⁵, Eric C Larsen, MD^16*, Anne L Angiolillo, MD^17*, Reuven J Schore, MD¹⁷, Michael J Burke, MD¹⁸, Wanda L Salzer, MD¹⁹, Naomi J Winick, MD²⁰, William L. Carroll, MD²¹, Stephen P Hunger, MD²², Elizabeth A. Raetz, MD²³, Karen R Rabin, MD, PhD²⁴ and Mignon L. Loh, MD²⁵

¹Department of Pediatrics and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
²Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Biostatistics, University of Florida, Gainesville, FL
⁴Department of Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, TN
⁵Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁶University of New Mexico School of Medicine, Albuquerque, NM
⁷Department of Pathology, University of New Mexico Cancer Research Facility, Albuquerque, NM
⁸Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
⁹Department of Pathology, The Ohio State University, Columbus, OH
¹⁰Nationwide Children's Hospital, Columbus, OH
¹¹Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX
¹²Departments of Pathology and Oncology, Johns Hopkins University, Baltimore, MD
¹³Department of Laboratory Medicine, University of Washington, Seattle, WA
¹⁴Department of Pathology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM
¹⁵Department of Pediatrics, Division of Pediatric Hematology/Oncology/BMT, Children’s Hospital Colorado and University of Colorado School of Medicine, Aurora, CO
¹⁶Department of Pediatrics, Maine Children's Cancer Program, Scarborough, ME
¹⁷Children’s National Health System/George Washington University SMHS, Washington, DC
¹⁸Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
¹⁹U.S. Army Medical Research and Materiel Command, Olney, MD
²⁰Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Texas Southwestern Medical Center, Dallas, TX
²¹Division of Pediatric Hematology and Oncology, Perlmutter Cancer Center, NYU Cancer Institute, New York, NY
²²Department of Pediatrics, Division of Oncology and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
²³New York University Langone Medical Center, New York, NY
²⁴Baylor College of Medicine TX Children's Cancer Center, Houston, TX
²⁵Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California Benioff Children’s Hospital, San Francisco, CA

Hui Yu, M.D., Ph.D^1*, Yuxin DU, M.D., M.S.^1*, Ji Xu, M.D., Ph.D^2*, Zhenchang Sun, M.D., Ph.D^1*, Xiaorui Fu, M.D., Ph.D^1*, Ken H. Young, M.D., Ph.D³ and Mingzhi Zhang, MD^1*

¹Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
²School of Basic Medical Science, Neuroscience Research Institute, Academy of Medical Sciences, Zhengzhou University, zhengzhou, China
³Duke Medical Center and Duke Cancer institute, Duke University School of Medicine, Durham, NC

Yiqing Cai^1*, Xiangxiang Zhou, MD^1,2*, Juan Yang, PhD^1*, Jiarui Liu^1*, Yi Zhao, MM^1*, Shunfeng Hu, MM^1*, Shuai Ren, MM^1* and Xin Wang, MD, PhD^1,3

¹Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
²Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
³Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

Bor-Sheng Ko, MD, PhD^1,2*, Yu-Fen Wang, MS^3,4*, Jeng-Lin Li, BS^5*, Hsin-An Hou^6*, Wen-Chien Chou, MD, PhD⁷, Hwei-Fang Tien, M.D., Ph.D.¹, Ting-Yu Chang, M.S.^4* and Chi-Chun Lee, Ph.D.^5*

¹Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
²Department of Hematological Oncology, National Taiwan University Cancer Center, Taipei, Taiwan
³Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
⁴AHEAD Medicine, Berkeley, CA
⁵Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan
⁶National Taiwan University Hospital, Taipei, TWN
⁷Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

Guangsi Zhang^1*, Cao Panxiang^1*, Fang Wang, MD², Xue Chen, MD^3*, Yang Zhang, MD^1*, Mingyu Wang^4*, Xiaoli Ma, MD^3*, Jiaqi Chen, MD^3*, Daijing Nie^5* and Hongxing Liu^4*

¹Divison of Laboratory Medicine, Hebei Yanda Lu Daopei Hospita, Langfang, China
²Beijing Lu Daopei Institute of Hematology, Beijing, China
³Division of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
⁴Hebei Yanda Lu Daopei Hospital, Langfang, CHN
⁵Division of Laboratory Medicine, Hebei Yanda Lu Daopei Hospita, Langfang, China

Mandy W.E. Smeets^1,2,3*, Femke Stalpers, BSc^1,3*, Myrthe M.P. Vermeeren, BSc^1,3*, Alex Q. Hoogkamer, BSc^1,3*, Stefan Nierkens, PhD^1,4*, Cesca Van De Ven, PhD^1,3* and Monique L. Den Boer, PhD^1,2,3

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Erasmus MC-Sophia Children's Hospital, Department of Pediatric Oncology/Hematology, Rotterdam, Netherlands
³Oncode Institute, Utrecht, Netherlands
⁴Center for Translational Immunology, University Medical Center, Utrecht, Netherlands