Kristie Ramos, MD^*, Amy E Mirro, MEng^*, Michael M Binkley, PhD^*, Luisa Gil Diaz^*, Kristin P Guilliams, MD, MSCI^*, Andria L Ford, MD, MSCI^*, Hongyu An, DSc^*, Jin-Moo Lee, MD, PhD^* and Melanie E Fields, MD

Washington University in St. Louis, Saint Louis, MO

Elliott Vichinsky, MD¹, Victor R. Gordeuk, MD², Paul Telfer, DM, FRCP^3*, Adlette Inati, MD, FAAP⁴, Margaret Tonda, PharmD^5*, Sarah Gray, PhD^5*, Irene Agodoa, MD^5* and Kenneth I. Ataga, MD⁶

¹UCSF Benioff Children's Hospital, Oakland, CA
²Sickle Cell Center, Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL
³Barts Health NHS Trust, London, United Kingdom
⁴Lebanese American University, Beirut and Nini Hospital, Tripoli, Lebanon
⁵Global Blood Therapeutics, South San Francisco, CA
⁶University of Tennessee Health Science Center at Memphis, Memphis, TN

Wally R Smith, MD¹, Kenneth I. Ataga, MD², Santosh L. Saraf, MD³, Olufolake A. Adisa, MD, MSc⁴, Miranda Bailey^5*, Nicholas Ramscar, MBBS^6*, Ashley Bonner, PhD^7*, Stephen Brown, PhD^7* and Laura Pastor, MSc^7*

¹Virginia Commonwealth University, Richmond, VA
²University of Tennessee Health Science Center at Memphis, Memphis, TN
³Comprehensive Sickle Cell Center, Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL
⁴Emory University, East Hanover, NJ
⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ
⁶Novartis Pharma AG, Basel, Switzerland
⁷Eversana, Burlington, ON, Canada

Kristine Anne Karkoska, MD¹, Kevin E Todd Jr., MD¹, Kelly Clapp, NP^2*, Lynette Fenchel, NP^2*, Theodosia A. Kalfa, MD, PhD², Punam Malik, MD², Omar Niss, MD³, Charles T. Quinn, MD², Russell E. Ware, MD, PhD² and Patrick T. McGann, MD⁴

¹Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Division of Hematology, Cincinnati Children's Hospital, Cincinnati, OH
⁴Division of Hematology, Children's Hospital Medical Center, Cincinnati, OH

Elizabeth Williams, BA¹, Elizabeth Linton, MPH^2*, Rosalyn Stewart, MBA., MD, MS^3*, Sophie M. Lanzkron, MD, MHS⁴ and Lydia H. Pecker, MD⁵

¹West Virginia University School of Medicine, Morgantown, WV
²Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
³Division of General Internal Medicine, Department of Medicine, Johns Hopkins Medicine, Baltimore, MD
⁴Department of Medicine, Division of Hematology, Johns Hopkins Medicine, Baltimore, MD
⁵Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

Abdoul Karim Dembele, MD^1,2,3*, Patricia Hermand-Tournamille, PhD^4*, Florence Missud, MD^5*, Emmanuelle Lesprit, MD^6*, Malika Benkerrou, MD^7*, Yves Colin Aronovicz, PhD^8,9, Caroline Le Van Kim, PhD^2,10,11* and Bérengère Koehl, MD, PhD^8,12,13,14*

¹Laboratoire d’Excellence GR-Ex, Paris, France
²Université de Paris, UMR_S1134, BIGR, Inserm, F-75015, Paris, France
³Centre de Recherche et de Lutte contre la Drépanocytose (CRLD), Bamako, Mali
⁴University of Paris, INSERM UMR_S1134, BIGR, Institut National de Transfusion Sanguine, F-75015 Paris, France;, Paris, FRA
⁵Referral Center for Sickle Cell Disease, Robert Debré Hospital, Paris, France
⁶Etablissement Français du sang, Robert Debré Hospital, APHP, Paris, France
⁷Pediatrics, Referral Center for Sickle Cell Disease, Robert Debré Hospital, APHP, Paris, France
⁸Laboratory of Excellence GR-Ex, Paris, France
⁹UMR_S1134, Université de Paris/Inserm/INTS, Paris, France
¹⁰Laboratoire d'Excellence GrEx, Paris, France
¹¹Institut National de la Transfusion Sanguine, F-75015, Paris, France
¹²Institut National de la Transfusion Sanguine, Paris, France
¹³UMR_S1134 Inserm/University Paris Diderot/INTS, Paris, France
¹⁴Reference Center of Sickle Cell Disease, Hopital Robert Debré, Paris, France

Rita V Masese, MSc, MD^1*, Dominique Bulgin, BSN, RN^2*, Liliana Preiss^3*, Mitchell Knisely, PhD, RN^1*, Eleanor Stevenson, PhD, RN^1*, Jane S. Hankins, MD, MS⁴, Marsha Treadwell, PhD^5,6*, Allison A. King, MD, MPH, PhD⁷, Victor R. Gordeuk, MD⁸, Julie Kanter, MD⁹, Robert Gibson, MD^10*, Jeffrey A. Glassberg, MD^11,12, Paula Tanabe, PhD, RN¹³ and Nirmish Shah, MD¹⁴

¹School of Nursing, Duke University, Durham, NC
²Duke University School of Nursing, Durham, NC
³RTI International, Durham, NC
⁴Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁵Children's Hospital and Research Center, Oakland, Oakland, CA
⁶UCSF Benioff Children's Hospital Oakland, Oakland, CA
⁷Program in Occupational Therapy, Washington University in St. Louis, School of Medicine, Clayton, MO
⁸Sickle Cell Center, Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL
⁹Director, Adult Sickle Cell Program, Comprehensive Sickle Cell Center,, Birmingham, AL
¹⁰Medical College of Georgia, Augusta University, Augusta, GA
¹¹Division of Hematology and Oncology, Department of Medicine and Department of Emergency Medicine, Mount Sinai Medical Center, New York, NY
¹²Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
¹³School of Nursing/ School of Medicine, Duke University, Durham, NC
¹⁴Duke University Health System, Durham, NC

Raffaella Colombatti, MD, PhD¹, John James, MSc^2*, Biree Andemariam, MD³, Baba PD Inusa, MD, MBBS⁴, Fuad A El Rassi, MD⁵, Beverley Francis-Gibson, MA^6*, Alecia C Nero, MD^7*, Caterina P. Minniti, MD⁸, Cassandra Trimnell, BA^9*, Miguel R Abboud, MD¹⁰, Jean-Benoît Arlet, MD^11*, Mariane de Montalembert, MD, PhD^12*, Suman Jain, MD^13*, Wasil Jastaniah, MD^14*, Erfan Nur, MD, PhD¹⁵, Marimilia Pita, MD^16*, Nicholas Ramscar, MBBS^17*, Tom Bailey, MSci^18*, Olivera Rajkovic-Hooley, PhD^18* and Ifeyinwa Osunkwo, MD, MPH^19*

¹Azienda Ospedale-Università di Padova, Padova, Italy
²Sickle Cell Society, London, United Kingdom
³New England Sickle Cell Institute at the University of Connecticut, Farmington, CT
⁴Evelina Children's Hospital and Guy’s and St Thomas’ Hospital, London, United Kingdom
⁵Emory University School of Medicine and Georgia Comprehensive Sickle Cell Center at Grady Health System, Atlanta, GA
⁶Sickle Cell Disease Association of America, Baltimore, MD
⁷University of Texas Southwestern Medical Center, Dallas, TX
⁸Albert Einstein College of Medicine, New York, NY
⁹Sickle Cell 101, San Jose, CA
¹⁰American University of Beirut Medical Center, Beirut, Lebanon
¹¹Hôpital Européen Georges-Pompidou, Paris, France
¹²Hôpital Universitaire Necker-Enfants Malades, Paris, France
¹³Thalassemia and Sickle Cell Society, Hyderabad, India
¹⁴Umm Al-Qura University, Mecca, Saudi Arabia
¹⁵Academic Medical Center, Amsterdam, Netherlands
¹⁶Laureate University-UAM, Pediatric-Hematology, Hospital Samaritano, São Paulo, Brazil
¹⁷Novartis Pharma AG, Basel, Switzerland
¹⁸Adelphi Real World, Bollington, United Kingdom
¹⁹Sickle Cell Disease Enterprise at the Levine Cancer Institute/Atrium Health, Charlotte, NC

Wally R Smith, MD¹, Jane S. Hankins, MD, MS², Miguel R Abboud, MD³, Ze Cong, PhD^4*, Jonathan Sorof, MD^4*, Sarah Gray, PhD^4*, Carolyn Hoppe, MD^4* and Paul Telfer, DM, FRCP^5*

¹Virginia Commonwealth University, Richmond, VA
²Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
³American University of Beirut Medical Center, Beirut, Lebanon
⁴Global Blood Therapeutics, South San Francisco, CA
⁵Barts Health NHS Trust, London, United Kingdom

Khushali Jhaveri, MD^1*, Raj Patel, MD^2*, Christopher Barnett, MD^1* and Hedy Smith, MD, PhD¹

¹Medstar Washington Hospital Center, Washington, DC
²Louis A Weiss Memorial Hospital, Chicago, IL

Seung Yup Lee^1*, Eashani Sathilingam, BS^1*, Kyle R. Cowdrick, MS^1*, Rowan O. Brothers, BS^1*, Wilbur A. Lam, MD, PhD^1,2,3, R. Clark Brown, MD, PhD^2,3, Clinton H. Joiner, MD, PhD^2,3, Claudia R. Morris, MD^3,4 and Erin M. Buckley, PhD^1,3,4*

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA
²Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, Atlanta, GA
³Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
⁴Children's Healthcare of Atlanta, Atlanta, GA

Jordan Milner, MD¹, Deborah Friedman, MD^1*, Marise D’Souza, MD, MSc^1*, Krishnan Sankaran, MD^1*, Liana Klejmont, Pharm D^1*, Erin Morris, RN, BSN^1*, Harshini Mahanti, BS, MSCR^1*, Neida Otero^1*, Jessica C. Hochberg, MD^1*, Adele Brudnicki, MD^2*, Ken R. Cooke, MD³ and Mitchell S Cairo, MD¹

¹Pediatrics, New York Medical College, Valhalla, NY
²Radiology, New York Medical College, Valhalla, NY
³Oncology, John Hopkins University, Baltimore, MD

Satish Maharaj, MBBS, MD¹, Simone Chang, MBBS¹, Karan Seegobin, MBBS², Marwan Shaikh, MD² and Kamila I. Cisak, MD¹

¹University of Louisville, Louisville, KY
²Mayo Clinic, Jacksonville, FL

Kaitlin Strumph, DO¹, Michael Hafeman, MD^2*, Saritha Ranabothu, MD^3*, William Gomes, MD^4*, Steven Benitez, MD^5*, Frederick Kaskel, MD^6*, Deepa Manwani, MD⁷ and Joseph Mahgerefteh, MD^8*

¹Division of Pediatric Hematology/Oncology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, New York, NY
²Department of Anesthesiology, Stony Brook University, Renaissance School of Medicine, Stony Brook, NY
³Department of Nephrology, Department of Pediatrics, Arkansas Children’s Hospital, Little Rock, AR
⁴Department of Radiology, Westchester Medical Center, Valhalla, NY
⁵Department of Radiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
⁶Department of Nephrology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY
⁷Division of Pediatric Hematology/Oncology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY
⁸Division of Cardiology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, Kravis Children's Hospital, New York, NY

Ifeyinwa Osunkwo, MD, MPH^1*, John James, MSc^2*, Biree Andemariam, MD³, Fuad A El Rassi, MD⁴, Beverley Francis-Gibson, MA^5*, Alecia C Nero, MD^6*, Caterina P. Minniti, MD⁷, Cassandra Trimnell, BA^8*, Miguel R Abboud, MD⁹, Jean-Benoît Arlet, MD^10*, Raffaella Colombatti, MD, PhD¹¹, Mariane de Montalembert, MD, PhD^12*, Suman Jain, MD^13*, Wasil Jastaniah, MD^14*, Erfan Nur, MD, PhD¹⁵, Marimilia Pita, MD^16*, Nicholas Ramscar, MBBS^17*, Tom Bailey, MSci^18*, Olivera Rajkovic-Hooley, PhD^18* and Baba PD Inusa, MD, MBBS¹⁹

¹Sickle Cell Disease Enterprise at The Levine Cancer Institute, Atrium Health, Charlotte, NC
²Sickle Cell Society, London, United Kingdom
³New England Sickle Cell Institute, University of Connecticut, Farmington, CT
⁴Emory University School of Medicine and Georgia Comprehensive Sickle Cell Center at Grady Health System, Atlanta, GA
⁵Sickle Cell Disease Association of America, Baltimore, MD
⁶University of Texas, Southwestern Medical Center, Dallas, TX
⁷Albert Einstein College of Medicine, New York, NY
⁸Sickle Cell 101, San Jose, CA
⁹American University of Beirut Medical Center, Beirut, Lebanon
¹⁰Hôpital Européen Georges-Pompidou, Paris, France
¹¹Azienda Ospedale-Università di Padova, Padova, Italy
¹²Hôpital Universitaire Necker-Enfants Malades, Paris, France
¹³Thalassemia and Sickle Cell Society, Hyderabad, India
¹⁴Umm Al-Qura University, Mecca, Saudi Arabia
¹⁵Academic Medical Center, Amsterdam, Netherlands
¹⁶Laureate University-UAM, Pediatric-Hematology, Hospital Samaritano, São Paulo, Brazil
¹⁷Novartis Pharma AG, Basel, Switzerland
¹⁸Adelphi Real World, Bollington, United Kingdom
¹⁹Evelina Children's Hospital and Guy’s and St Thomas’ Hospital, London, United Kingdom

Cassondra Bour^1*, Robert Emeh^2*, Seyed Mehdi Nouraie, PhD, MD³, Nargues Weir, MD^4*, Nicole Ruopp, MD^5*, Amy Parker Ruhl, MD, MPH^6* and Elizabeth S Klings, MD⁷

¹Internal Medicine, Henry Ford Hospital, Detroit, MI
²Howard University College of Medicine, Washington DC, DC
³Division of Pulmonary, Allergy and Critical Care Medicine, UPMC Montefiore, Pittsburgh, PA
⁴Federal Drug Administration, Silver Spring, MD
⁵Brigham & Women's Hospital, Boston, MA
⁶National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
⁷Boston University Sch. of Med. The Pulmonary Center, R-304, Boston, MA

Almuhalb Ismail^1* and Baba PD Inusa, MD, MBBS^2,3

¹King's college London, Women and children's academic unit, London, United Kingdom
²Paediatric Haematology, Evelina Children's Hospital, Guy's and St Thomas' Hospital, London, United Kingdom
³Department of Women and Children, King's College London, London, United Kingdom

Ameet Patel, MD¹, Karina L Wilkerson, NP, MSN^2*, Kathryn A. Culos, PharmD^3*, Jennifer Green, MD⁴, Michael T. Byrne, DO⁵, Salyka M. Sengsayadeth, MD^6*, Bhagirathbhai Dholaria, MBBS^7,8, Bipin N. Savani, MD^9,10, Stacey Ann Goodman, MD^7,11, Wichai Chinratanalab, MD¹², Reena Jayani, MD¹³, Katie S. Gatwood, PharmD^3*, Brian G. Engelhardt, MD¹² and Adetola A. Kassim, MD, MS^12,14

¹Department of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN
²Hematology/Oncology Department Sickle Cell Disease Center of Excellence, Vanderbilt University Medical Center, Nashville, TN
³Department of Pharmacy, Vanderbilt University Medical Center, Nashville, TN
⁴Department of Hematology / Oncology, Vanderbilt University Medical Center, Nashville, TN
⁵Department of Medicine, Hematology and Stem Cell Transplant Section, Vanderbilt University Medical Center, Nashville, TN
⁶Department of Medicine, Division of Hematology-Oncology, Vanderbilt University Medical Center; Tennessee Valley Health System Veterans Affairs Medical Center, Nashville, TN
⁷Vanderbilt University Medical Center, Nashville, TN
⁸Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical center, Nashville, TN
⁹Tennessee Valley Healthcare System Veteran Affairs, Nashville, TN
¹⁰Department of Medicine, Division of Hematology-Oncology, Vanderbilt University, Brentwood, TN
¹¹VA Medical Center, Nashville, TN
¹²Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN
¹³Vanderbilt University Medical Center, Tampa, FL
¹⁴Vanderbilt-Meharry Center of Excellence in Sickle Cell Disease, Nashville, TN

Stephen Zachary Peeke, MD^1,2, Qi Gao, Ph.D.^3*, Jaeun Choi, PhD^3*, Khadijah Abdallah, MPH^4*, Ashley Buscetta, MSN, FNP-BC, CWOCN^5*, Andrew Crouch^6*, Shuo You, MD, PhD^3*, Vence L. Bonham, JD⁷ and Caterina P. Minniti, MD^8,9

¹Maimonides Medical Center, Brooklyn
²Hematology/Oncology, Montefiore Medical Center, New York, NY
³Albert Einstein College of Medicine, Bronx, NY
⁴Social and Behavioral Research Branch, National Human Genome Research Institute/National Institutes of Health, Bethesda, MD
⁵Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD
⁶Albert Einstein College of Medicine, Bronx
⁷National Human Genome Research Institute,Social and Behavioral Research Branch, NIH, Bethesda, MD
⁸Albert Einstein College of Medicine, New York, NY
⁹Montefiore Medical Center, Bronx, NY

Chekwube Nwabueze, MSW, MS

Medstar Washington Hospital Center, Silver Spring, MD