-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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703.O1.6 703. Adoptive Immunotherapy: Mechanisms and New Approaches: Optimizing CAR T cells for Improved Outcomes

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
ALL, Biological, Leukemia, SARS-CoV-2/COVID-19, CLL, Diseases, Lymphoma (any), CAR-Ts, Mantle Cell Lymphoma, Therapies, Non-Hodgkin Lymphoma, Biological Processes, cell expansion, T-Cell Lymphoma, Technology and Procedures, immunotherapy, Lymphoid Malignancies, Clinically relevant, hematopoiesis, flow cytometry, immune mechanism, mass cytometry, molecular interactions
Monday, December 7, 2020: 7:00 AM-8:30 AM
Moderators:
Jennifer N. Brudno, MD, National Cancer Institute, National Institutes of Health and Nathan Singh, MD, University of Pennsylvania
Disclosures:
No relevant conflicts of interest to declare.
7:00 AM

Inkook Chun, MS1,2*, Ki Hyun Kim, PhD1*, Yi-Hao Chiang, MD1,3*, Wei Xie, MD1*, Yong Gu Gu Lee, PhD1,2, Raymone Pajarillo, MS1,2*, Antonia Rotolo, MD, PhD1*, Olga Shestova, PhD1,2*, Seok Jae Hong, MS1*, Mohamed Abdel-Mohsen, PhD4*, Maria Wysocka, PhD5*, Hatcher J. Ballard, BS2*, David M. Barrett6*, Avery D. Posey, PhD1, Daniel Powell Jr., PhD1*, Saar I. Gill, MD, PhD1,7, Stephen J. Schuster, MD2, Stefan K. Barta, MD, MRCP, MS1,2, Alain H Rook, MD5*, Carl H June, MD1 and Marco Ruella, MD1,7

1Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA
2Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
3Division of Hematology-Oncology, MacKay Memorial Hospital, Taipei, Taiwan
4Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA
5Division of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA
6Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA
7Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA

7:15 AM

Ilaria M. Michelozzi, PhD1*, Eduardo Gomez-Castaneda, PhD2*, Ruben V.C. Pohle2*, Ferran Cardoso Rodriguez3*, Jahangir Sufi3*, Pau Puigdevall, PhD4*, Meera Subramaniyam2*, Si Wei Wu2*, Aleks Guvenel, PhD2*, Sara Ghorashian, FRCPath, PhD5,6, Martin Pule, MD PhD7*, Christopher J. Tape, PhD3*, Sergi Castellano, PhD4*, Persis J Amrolia, FRCP, FRCPath, PhD2,8* and Alice Giustacchini, PhD1*

1Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, ENG, United Kingdom
2Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom
3Cell Communication Lab, Department of Oncology, University College London Cancer Institute, London, United Kingdom
4Genetics and Genomic Medicine Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom
5Department of Haematology, Great Ormond Street Hospital, London, United Kingdom
6Developmental Biology and Cancer, UCL Great Ormond Street Institute of Child Health, London, ENG, United Kingdom
7UCL Cancer Institute, London, United Kingdom
8Bone Marrow Transplantation Department, Great Ormond Street hospital NHS Trust, London, United Kingdom

7:30 AM

Robbie G. Majzner, MD1, Matthew J. Frank, MD, PhD2, Christopher Mount, MD, PHD3*, Aidan Tousley3*, David M. Kurtz, MD, PhD4, Brian Sworder, MD, PhD5, Katherine A Murphy6*, Antigoni Manousopoulou7*, Kennedy Kohler3*, Maria Caterina Rotiroti, PhD3*, Jay Y. Spiegel, MD, FRCPC2, Yasodha Natkunam, MD, PhD8, Sheren F. Younes, MD, PhD9*, Elena Sotillo, PhD1*, Vandon Duong3*, Charles Macaulay, MSc, BA10*, Zinaida Good, PhD11, Peng Xu, MD3*, Louai Labanieh1*, Leo D Wang, MD, PhD12, Ash A. Alizadeh, MD, PhD13, Michelle Monje, MD, PHD3*, David B. Miklos, MD, PhD2 and Crystal L. Mackall, MD11

1Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA
2Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA
3Stanford University School of Medicine, Palo Alto, CA
4Stanford University, San Francisco, CA
5Department of Medicine, Divisions of Hematology & Oncology, Stanford University, Stanford, CA
6Stanford University, Palo Alto, CA
7City of Hope, Duarte, CA
8Department of Pathology, Stanford University Medical Center, Stanford, CA
9Department of Pathology, Stanford University School of Medicine, Stanford, CA
10Department of Medicine, Divisions of Hematology & Oncology, Stanford University Medical Center, Palo Alto, CA
11Center for Cancer Cell Therapy, Stanford University School of Medicine, Stanford, CA
12City of Hope National Medical Center, Beckman Research Institute, Duarte, CA
13Stanford University, Stanford, CA

7:45 AM

Nayan Jain1*, Zeguo Zhao, PhD2*, Archana S. Iyer, PhD2*, Michael Lopez2*, Judith Feucht, MD3*, Richard P. Koche, PhD4*, Yingqian Zhan4* and Michel Sadelain, MD, PhD2

1Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York City, NY
2Center for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Center, New York City, NY
3Memorial Sloan Kettering Cancer Center, New York, NY, Germany
4Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York City, NY

8:00 AM

Christopher Ronald Funk1, Shuhua Wang, MD1*, Alex Waller, BS2*, Claudia Edgar, BS1*, Aditi Sharma, PhD1*, Kevin Chen, BS1*, Vikas Gupta, MD, PhD3*, Shanmuganathan Chandrakasan, MD4*, Jaquelyn Zoine5,6*, Andrew Fedanov, BS5,6*, Sunil S. Raikar, MD7, Jean L. Koff, MD1, Christopher Flowers, MD, MS8, Silvia Coma, PhD9*, Jonathan A. Pachter, PhD9*, Sruthi Ravindranathan, PhD1*, H. Trent Spencer, Ph.D.5,10*, Mala Shanmugam, PhD1 and Edmund K. Waller, PhD, MD11

1Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA
2Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
3Emory University, Atlanta, GA
4Division of Bone Marrow Transplant, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
5Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
6Department of Pediatrics, Emory University School of Medicine, Atlanta
7Aflac Cancer and Blood Disorders Center, Emory University/Children's Healthcare of Atlanta, Atlanta, GA
8Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
9Verastem Oncology, Inc., Needham, MA
10Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
11Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA

*signifies non-member of ASH