62nd ASH Annual Meeting and Exposition: 701. Experimental Transplantation: Basic Biology, Pre-Clinical Models

Oral and Poster Abstracts
Oral

ALL, AML, apoptosis, Biological, Leukemia, viral, Animal models, Bleeding and Clotting, bone marrow, Diseases, GVHD, platelets, Therapies, cellular interactions, MDS, Biological Processes, immune cells, Immune Disorders, Technology and Procedures, Cell Lineage, immunotherapy, Infectious Diseases, Lymphoid Malignancies, Study Population, Clinically relevant, genetic profiling, Myeloid Malignancies, Thrombocytopenias, hematopoiesis, flow cytometry, immune mechanism, transplantation, inflammation, molecular interactions, senescence, signal transduction

Moderators:

Hendrik Poeck, MD, Memorial Sloan-Kettering Cancer Center and Edmund K. Waller, PhD, MD, Winship Cancer Institute, Emory University

Disclosures:

No relevant conflicts of interest to declare.

1:30 PM

730

TCR Repertoires in Graft-Versus-Host-Disease (GVHD)-Target Tissues Reveals Tissue Specificity of the Alloimmune Response

Susan DeWolf, MD¹^*, Katherine Nichols²^*, Chi L. Nguyen²^*, Paul A Giardina³^*, John B. Slingerland³^*, Harold Elias, MD²^*, Rajya Kappangantula²^*, Priscilla Baez²^*, Rajmohan Murali, MD⁴^*, Akimasa Hayashi, MD, PhD^2,5^*, Anqi Dai²^*, Heather J Landau, MD^6,7, Roni Tamari, MD^3,7, Alan M. Hanash, MD, PhD^3,7, Robert Jenq, MD⁸^*, Sergio Giralt, MD^3,7^*, Miguel-Angel Perales, MD^3,7, Kate A Markey, MBBS, PhD, FRACP^3,7, Christine Iacobuzio-Donahue, MD, PhD⁴^*, Marcel van den Brink, MD, PhD^3,7 and Jonathan U Peled, MD, PhD^3,7^*

¹Department of Medicine, Memorial Sloan Kettering Cancer Center, New York
²Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Pathology, Kyorin University, Tokyo, Japan
⁶Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, Scarsdale, NY
⁷Department of Medicine, Weill Cornell Medical College, New York, NY
⁸Departments of Genomic Medicine and Stem Cell Transplantation, University of Texas MD Anderson Cancer Center, Houston, TX

1:45 PM

731

MHC Class II on Ccl19⁺ Reticular Cells Mitigates Graft-Versus-Host Disease Via Maintenance of Regulatory T Cells

Muhammad Haroon Shaikh, MSc^1,2^*, Juan Gamboa Vargas, MSc^1,2^*, Josefina Peña Mosca, MSc^1,2^*, Duc Dung Le, PhD¹^*, Hermann Einsele, MD³, Burkhard Ludewig, PhD⁴^* and Andreas Beilhack, MD^1,2^*

¹Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
²Graduate School of Life Sciences, Julius-Maximilians University, Würzburg, Germany
³Department of Internal Medicine II, Division of Oncology and Hematology, University Hospital Würzburg, Würzburg, Germany
⁴Institute of Immunobiology, Kantonsspital St. Gallen, St Gallen, Switzerland

2:00 PM

732

Population Distribution of GvL and GvH Minor Histocompatibility Antigens

Kelly Shea Olsen, MSc¹^*, Hancong Tang, MS²^*, Junke Wang, MS²^*, Sarah Entwistle, MSc³^*, Dante S. Bortone, PhD⁴^*, Steven Vensko, PhD³^*, Loreall Pooler⁵^*, Xin Sheng, MS⁶^*, Christopher Haiman⁷^*, David Van Den Berg, PhD⁸^*, Stephen R. Spellman, MS⁹^*, Theresa E. Hahn, PhD¹⁰, Paul M. Armistead, MD, PhD⁴, Lara E. Sucheston-Campbell, PhD, MS¹¹ and Benjamin G. Vincent, MD⁴

¹Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC
²College of Pharmacy, The Ohio State University, Columbus, OH
³University of North Carolina at Chapel Hill, Chapel Hill, NC
⁴Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
⁵University of Southern California, Los Angeles, CA
⁶University of Southern California, Keck School of Medicine of USC, Los Angeles, CA
⁷Keck School of Medicine, Los Angeles, CA
⁸Preventive Medicine, University of Southern California, Keck School of Medicine of USC, Los Angeles, CA
⁹CIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI
¹⁰Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹¹College of Veterinary Medicine, Cancer Prevention & Control, Columbus, OH

2:15 PM

733

Human Cytomegalovirus Selectively Suppresses the Megakaryo/Thrombopoiesis of PDGFR⁺ and αvβ3⁺ Megakaryocytes Via the TPO/c-Mpl Pathway after Allo-HSCT

Feng-qi Liu^1,2,3^*, Fei-er Feng^1,2,3,4^*, Gao-chao Zhang^1,2,3,4^*, Yan Su^1,2,3,4^*, Xue-yan Sun^1,2,3,4^*, Qiu-sha Huang^1,2,3,4^*, Qi Chen^1,2,3,4^*, Xiao Liu^1,2,3,5^*, Yun He^1,2,3,4^*, Xiao-lu Zhu^1,2,3,4^*, Hai-xia Fu^1,2,3,4^*, Kai-yan Liu^1,2,3,4 and Xiao-hui Zhang^1,2,3,4^*

¹Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China
²Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
³National Clinical Research Center for Hematologic Disease, Beijing, China
⁴Collaborative Innovation Centre of Hematology, Peking University, Beijing, China
⁵Collaborative Innovation Center of Hematology, Peking University, Beijing, China

2:30 PM

734

Glucagon-like Peptide-2 (GLP-2) Treatment Reduces Gvhd-Related Mortality in a Pre-Clinical Transplant Model Via Expansion of Macrophages with Tolerogenic Potential

David W Harle¹^*, Rodney J Macedo Gonzales, MD, PhD²^*, Felix D Rozenberg, BSc³^*, Alexandra Matschiner²^*, Rajat Bansal, MD⁴, Stephen M Lagana, MD⁵^*, Huihui Ma, MD, PhD²^*, Elisha Pinker²^*, Kirubel S Belay, BSc²^*, Ximi K Wang, BSc²^*, Tiffany Thomas, PhD⁵^*, Markus Y Mapara, MD, PhD^2,4, Anne-Catrin Uhlemann, MD⁶^*, Yi Zhang, MD, PhD⁷ and Ran Reshef, MD, MSc^4,8

¹Columbia Center for Translational Immunology, Columbia University Irving Medical Center, Astoria, NY
²Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY
³Vagelos College of Physicians and Surgeons, Columbia University, New York, NY
⁴Blood and Marrow Transplantation and Cell Therapy Program, Columbia University Irving Medical Center, New York, NY
⁵Department of Pathology and Laboratory Medicine, Columbia University Irving Medical Center, New York, NY
⁶Division of Infectious Diseases, Columbia University Irving Medical Center, New York, NY
⁷Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA
⁸Columbia Center for Translational Immunology, Columbia University, New York, NY

2:45 PM

735

Damage-Induced Pyroptotic Cell Death Facilitates Regeneration of the Thymus

Sinéad Kinsella, MSc, PhD¹, Cindy Evandy²^*, Kayla S Hopwo³^*, Kirsten Cooper⁴^*, Lorenzo Iovino, MD¹, Colton W Smith¹^*, Reema Jain, PhD⁵^*, Paul DeRoos⁴^* and Jarrod A Dudakov, PhD⁴

¹Fred Hutchinson Cancer Research Center, Seattle, WA
²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
³Clinical Research Division, Fred Hutch Cancer Research Center, Seattle, WA
⁴Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Fred Hutch Cancer Research Center, Seattle, WA

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^*signifies non-member of ASH

701.O1.6 701. Experimental Transplantation: Basic Biology, Pre-Clinical Models