62nd ASH Annual Meeting and Exposition: 321. Blood Coagulation and Fibrinolytic Factors: Coagulation and Fibrinolytic Factors: Regulation of Coagulation

Oral and Poster Abstracts
Oral

Bleeding Disorders, Hemophilia, Biological, Hemostasis, Bleeding and Clotting, Diseases, Animal models, Non-Biological, Therapies, cell regulation, cellular interactions, Biological Processes, Thrombosis, Technology and Procedures, infusion, gene editing, Study Population, Clinically relevant, genetic profiling, Thrombotic Disorders, inflammation, VTE, molecular testing, molecular interactions, RNA sequencing, pathogenesis

Moderators:

Sol Schulman, Beth Israel Deaconess Medical Center and Harvard Medical School and Andrew Yee, PhD, Baylor College of Medicine

Disclosures:

Schulman: CSL Behring: Research Funding.

11:30 AM

626

Cellular Fibronectin Promotes Deep Vein Thrombosis in Obese Mice

Nirav Dhanesha, PhD¹, Manish Jain²^*, Prakash Doddapattar, PhD³^*, Anetta Undas⁴^* and Anil K Chauhan, PhD⁵

¹Department of Internal Medicine, University of Iowa, Iowa City, IA
²University of Iowa, Iowa City
³University of Iowa, Iowa Cuty
⁴Jagiellonian University Medical College, Krakow, POL
⁵University of Iowa, Iowa City, IA

11:45 AM

627

Targeting Protein S Using Small Interfering RNA Is Well Tolerated and Protects Mice with Hemophilia a from Acute Hemarthrosis

Raja Eladnani Prince, PhD^1,2^*, Ute Schaeper³^*, Sibylle Dames³^*, Sara Calzavarini, PhD^1,2^*, Claudia Quarroz, BMA^1,2^*, Maria Desiré Reina Caro, BMA^1,2^*, Astrid Chanfon Bätzner⁴^*, Kathrin Löffner³^*, Mona Eisermann³^* and Anne Angelillo-Scherrer, MD, PhD^1,2

¹Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland
²Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland
³Silence Therapeutics GmbH, Berlin, Germany, Berlin, Germany
⁴Institute of Animal Pathology, University of Bern, Bern, Switzerland

12:00 PM

628

A Spacer Sequence Inserted between the A1 and A2 Domains of Factor VIII Overcomes the Requirement for Proteolytic Cleavage at Arg 372 in the Generation of Cofactor Activity

Manjunath Goolyam Basavaraj, PhD^1,2^* and Sriram Krishnaswamy, PhD³

¹Rare Disease Drug Development Unit, Takeda, Cambridge, MA
²Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
³Hematology, Children's Hosp. of Phila., Philadelphia, PA

12:15 PM

629

Differential Sialic Acid Content in Adult and Neonatal Fibrinogen Mediate Differences in Clot Polymerization

Kimberly A Nellenbach¹^*, Nina A Guzzetta, MD, FAAP^2,3^* and Ashley C Brown, PhD⁴^*

¹Biomedical Engineering, University of North Carolina At Chapel Hill, Raleigh, NC
²Department of Anesthesiology, Emory University, Atlanta, GA
³Children's Healthcare of Atlanta, Atlanta, GA
⁴Biomedical Engineering, North Carolina State University and University of North Carolina at Chapel Hill, Raleigh, NC

12:30 PM

630

Loss of Protein C in Zebrafish Results in Impaired Neutrophil Migration after Tissue Injury

Chia-Jui Ku^*, Steven Grzegorski, PhD and Jordan A. Shavit, MD, PhD

Pediatrics, University of Michigan, Ann Arbor, MI

12:45 PM

631

Overexpression of Platelet Tfpiα Rescues TFPI Deficient Embryos from Mid-Gestational, but Not Late Gestational Lethality

Amy E Siebert-Mckenzie, MS¹^*, Nicholas D. Martinez, BS¹^*, Susan A Maroney, DVM, PhD¹ and Alan E. Mast, MD, PhD²

¹Versiti Blood Research Institute, Milwaukee, WI
²Blood Center of Wisconsin, Milwaukee, WI

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^*signifies non-member of ASH

321.O1.6 321. Blood Coagulation and Fibrinolytic Factors: Coagulation and Fibrinolytic Factors: Regulation of Coagulation