62nd ASH Annual Meeting and Exposition: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections: Pathogenesis and Immunotherapy

Oral and Poster Abstracts
Oral

Biological, ALL, AML, Leukemia, Lymphoma (any), Diseases, iPSCs, bioengineering, Animal models, Non-Biological, CAR-Ts, Therapies, cell regulation, Non-Hodgkin Lymphoma, B-Cell Lymphoma, white blood cells, Biological Processes, cell expansion, immune cells, Technology and Procedures, Immune Disorders, T-Cell Lymphoma, immunotherapy, Cell Lineage, Xenograft models, Lymphocytopenia, gene editing, Study Population, Lymphoid Malignancies, Myeloid Malignancies, NK cells, Clinically relevant, hematopoiesis, pharmacology, imaging, Proliferative disorders, immune mechanism, flow cytometry, mass cytometry, microenvironment, RNA sequencing, pathogenesis, signal transduction

Moderators:

Zhengqi Wang, PhD, Emory University School of Medicine and Renren Wen, PhD, BloodCenter of Wisconsin, part of Versiti

Disclosures:

No relevant conflicts of interest to declare.

9:30 AM

CAR19 iPSC-Derived NK Cells Utilize the Innate Functional Potential Mediated through NKG2A-Driven Education and Override the HLA-E Check Point to Effectively Target B Cell Lymphoma

Minoru Kanaya, PhD¹^*, Camille Philippon, MSc¹^*, Artur Cieslar-Pobuda, PhD¹^*, Frank Cichocki, PhD²^*, Michelle Saetersmoen, MSc¹^*, Sajid Mahmood, PhD³^*, Quirin Hammer, PhD⁴^*, Marianna Vincenti, MD¹^*, Merete Thune Wiiger, PhD¹^*, Hanna Julie Hoel, MSc¹^*, Lise Kveberg, PhD¹^*, Svetlana Gaidarova, MS³^*, Ryan Bjordahl, PhD³^*, Hui-yi Chu, PhD³^*, Brian Groff³^*, Matthew Denholtz, PhD³^*, Jeffrey S. Miller, MD⁵, Tom Lee, PhD⁶^*, Dan S Kaufman, MD, PhD⁷, Jode P Goodridge, PhD⁸^*, Bahram Valamehr, PhD⁶ and Karl-Johan Malmberg, MD, PhD^1,4^*

¹Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
²Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
³Fate Therapeutics Inc., San Diego, CA
⁴Center for Infectious Medicine, Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden
⁵Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
⁶Fate Therapeutics, Inc., San Diego, CA
⁷Department of Medicine, Division of Regenerative Medicine, University of California San Diego, La Jolla, CA
⁸Fate Therapeutics Inc., SAN DIEGO, CA

9:45 AM

Single Cell Immune Profiling Reveals Distinct T Cell Clones and Functional States in in-Vitro Expanded Cord Blood Derived Gamma Delta T Cells

Kar Wai Tan, PhD^1,2^*, Zhihui Li³^*, Joey Lai⁴^*, Dianyan Guo¹^*, Yeh Ching Linn, MBBS, MRCP⁴^*, William YK Hwang, MBBS^4,5, Shang Li, MD, PhD⁶^*, Connie J. Eaves, PhD⁷, Yeow Tee Goh, MBBS⁴ and Alice Cheung, PhD⁴

¹Department of Clinical Translational Research, Singapore General Hospital, Singapore, Singapore
²Tessa Therapeutics Ltd, Singapore, Singapore
³Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
⁴Department of Hematology, Singapore General Hospital, Singapore, Singapore
⁵National Cancer Center Singapore, Singapore, Singapore
⁶Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore
⁷Terry Fox Laboratory BC Cancer Agency, Vancouver, BC, CAN

10:00 AM

The ITK Inhibitor Cpi-818 Blocks Activation of T Cells from Autoimmune Lymphoproliferative Syndrome (ALPS) Patients and Is Active in a Murine Model of ALPS

V. Koneti Koneti Rao, MD, FRCPA¹, Patrick P. Ng, PhD²^*, Craig M. Hill, PhD²^*, Richard A. Miller, MD², Joseph J. Buggy, PhD² and James W. Janc, PhD³^*

¹ALPS Unit, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD
²Corvus Pharmaceuticals, Inc., Burlingame, CA
³Corvus Pharmaceuticals, Burlingame, CA

10:15 AM

Role of Mir-29b in T-Cell Development and in Cutaneous T-Cell Lymphoma Pathogenesis

Anthony Mansour, MD¹^*, David Clever²^*, Colleen Isabelle³^*, Amy E Boles, BS³^*, Kathleen McConnell³^*, Zhiyao Li¹^*, Logan A Chrislip²^*, Michael A. Caligiuri, MD¹ and Anjali Mishra, PhD³

¹City of Hope National Medical Center, Duarte, CA
²The Ohio State University, Columbus, OH
³Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA

10:30 AM

Sting Negatively Regulates Allogeneic T-Cell Responses By Constraining Antigen-Presenting Cell Function

Yongxia Wu, PhD, MD¹, Chih-Hang Anthony Tang²^*, Corey Mealer³^*, David Bastian, PhD⁴^*, Mohammed Hanief Sofi, PhD, MS⁵^*, Linlu Tian, PhD⁴^*, Steven Douglas Schutt, PhD⁶^*, Hee-Jin Choi, PhD⁷^*, Taylor Ticer⁸^*, Mengmeng Zhang, MD⁹^*, Lei Huang¹⁰^*, Andrew L. Mellor¹⁰^*, Chih-Chi Andrew Hu²^* and Xue-Zhong Yu, MD, MS¹¹

¹Microbiology and Immunology, Medical University of South Carolina, CHARLESTON, SC
²The Wistar Institute, Philadelphia, PA
³Medical university of south carolina, Charleston, SC
⁴Medical University of South Carolina, Charleston, SC
⁵Microbiology and Immunology, Medical University South Carolina, Charleston, SC
⁶Microbiology and Immunology, Medical University South Carolina, Charleston, SC
⁷Microbiology and Immunology, Medical University of South Carolina, Charleston, SC
⁸Medical University of South Carolina, Charleston
⁹Medical University of South Carolina, CHARLESTON, SC
¹⁰Newcastle University, Newcastle-upon-Tyne, United Kingdom
¹¹Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC

10:45 AM

Stromal Notch Ligands Drive Notch2-Dependent Transdifferentiation of Follicular B Cells into Marginal Zone-like B Cells in Lymphopenic Environments

Daniela Gómez Atria, PhD¹^*, Brian T. Gaudette, PhD²^*, Eric Perkey, BS³^*, Jennifer Londregan, BS¹^*, Samantha Kelly, BS¹^*, Burkhard Ludewig, PhD⁴^*, Chris Siebel, PhD, BA⁵^*, Russell J. H. Ryan, MD⁶, Warren S. Pear, MD, PhD², David Allman, PhD²^* and Ivan Maillard, MD, PhD¹

¹Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA
²Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
³University of Michigan, Ann Arbor, MI
⁴Institute of Immunobiology, Kantonsspital St. Gallen, St Gallen, Switzerland
⁵Department of Oncology, Genentech Inc, South San Francisco, CA
⁶Department of Pathology, University of Michigan, Ann Arbor, MI

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^*signifies non-member of ASH

203.O2.6 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections: Pathogenesis and Immunotherapy