62nd ASH Annual Meeting and Exposition: 113. Hemoglobinopathies, Excluding Thalassemia—New Genetic Approaches to Sickle Cell Disease: New Insights Into Sickle Cell Disease Pathophysiology

Oral and Poster Abstracts
Oral

sickle cell disease, Anemias, Diseases, Animal models, Bleeding and Clotting, Non-Biological, Therapies, red blood cells, Biological Processes, Hemoglobinopathies, Cell Lineage, Study Population, Clinically relevant, hematopoiesis, inflammation, metabolomics, pathogenesis, pathways

Moderators:

Satheesh Chonat, MD, Cincinnati Children's Hospital and Wassim El Nemer, PhD, Université Paris Diderot/Inserm/INTS

Disclosures:

No relevant conflicts of interest to declare.

2:00 PM

224

Fetal Hemoglobin Rescues Ineffective Erythropoiesis in Sickle Cell Disease

Sara El Hoss, PhD^1,2,3^*, Sylvie Cochet^1,2,3^*, Auria Godard, MS^1,2,3^*, Hongxia Yan, MS⁴^*, Michaël Dussiot, PhD^1,3,5^*, Giacomo Frati, PhD^1,6^*, Bénédicte Boutonnat-Faucher, MD⁷^*, Sandrine Laurance, PhD^1,2,3^*, Olivier Renaud, PhD⁸^*, Laure Joseph, MD⁹^*, Annarita Miccio, PhD^1,6, Valentine Brousse, MD/PhD^1,2,3,7^*, Mohandas Narla, DSc⁴ and Wassim El Nemer, PhD^1,2,3^*

¹University of Paris, Paris, France
²Integrated Biology of the Red Cell, INSERM Unit 1134, Paris, France
³Laboratory of Excellence GR-Ex, Paris, France
⁴Laboratory of Red Cell Physiology, New York Blood Center, New York, NY
⁵Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic Implications, Institut Imagine U1163, INSERM, Paris, France
⁶Imagine Institute, Laboratory of chromatin and gene regulation during development, INSERM UMR1163, Paris, France
⁷Pediatrics Department, Hopital Universitaire Necker-Enfants Malades, Paris, France
⁸Paris Sciences et Lettres Research University, Institut Curie - CNRS, Paris, France
⁹Biotherapy Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

2:15 PM

225

Palmitoylethanolamide-Mediated Inhibition of Nogo-a Signaling Attenuates Pain in Sickle Mice

Donovan A Argueta, PhD, BSc¹, Hanan Chweih, Ph.D.²^*, Bryant Avalos, BSc³^*, Huy Tran, BS⁴^*, Aithanh Nguyen⁴^*, Anupam Aich, PhD²^*, Nicholas V DiPatrizio, PhD³^* and Kalpna Gupta, PhD²

¹Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Los Angeles, CA
²Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Irvine, CA
³University of California, Riverside, Riverside, CA
⁴Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Blaine, MN

2:30 PM

226

Biased PAR-1 Signaling Regulates Thrombo-Inflammation in a Mouse Model of Sickle Cell Disease

Erica Sparkenbaugh, PhD¹, John H. Griffin, PhD², Laurent O Mosnier³ and Rafal Pawlinski, PhD⁴

¹Blood Research Center, UNC Chapel Hill, Chapel Hill, NC
²Scripps Research Institute, La Jolla, CA
³The Scripps Research Institute, La Jolla, CA
⁴Blood Research Center, University of North Carolina, Chapel Hill, NC

2:45 PM

227

Restoration of Normal Blood Flow in Mouse Models of Sickle Cell Vaso-Occlusion Following Intravenous or Subcutaneous Administration of a Highly Potent E-Selectin Specific Inhibitor

Madhan Thamilarasan, PhD¹^*, William E. Fogler, PhD², John L. Magnani, PhD² and Rahima Zennadi, PhD¹

¹Duke University, Durham, NC
²GlycoMimetics, Rockville, MD

3:00 PM

228

The T117S Variant of Cytochrome b5 Reductase 3 Increases the Risk for Ischemic Stroke with Enhanced Anemia in Mice with Sickle Cell Disease

Katherine C Wood, PhD¹^*, Heidi M Schmidt^2,3, Scott Hahn, MS⁴^*, Subramaniam Sanker, PhD²^*, Samit Ghosh, PhD⁴, Solomon Fiifi Ofori-Acquah, PhD^5,6,7, Seyed Mehdi Nouraie, MD, PhD⁸^*, Mark T. Gladwin, MD^9,10 and Adam C Straub, PhD^3,11^*

¹Pittsburgh Heart, Lung and Blood Vascular Medicine Institute; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
²Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, Department of Medicine, Univeristy of Pittsburgh, Pittsburgh, PA
³Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA
⁴Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁵School of Biomedical and Allied Health Sciences, University of Pittsburgh, Pittsburgh, PA
⁶School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana
⁷Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁸Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁹Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh
¹⁰University of Pittsburgh, Pittsburgh, PA
¹¹Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

3:15 PM

229

Nonhematopoietic Nrf2 Deficiency Worsens Chronic Intravascular Hemolysis but Not Cardiomyopathy in Transgenic Sickle Cell Mice

Maureen Mburu¹^*, Samit Ghosh, PhD², Xucai Chen, PhD¹^*, Solomon Fiifi Ofori-Acquah, PhD³ and Flordeliza S Villanueva, MD¹^*

¹Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, PA
²Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
³Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

113.O1.6 113. Hemoglobinopathies, Excluding Thalassemia—New Genetic Approaches to Sickle Cell Disease: New Insights Into Sickle Cell Disease Pathophysiology