62nd ASH Annual Meeting and Exposition: 101. Red Cells and Erythropoiesis, Structure and Function, Metabolism, and Survival, Excluding Iron: Mechanisms and Regulation of Erythropoiesis

Oral and Poster Abstracts
Oral

Adult, Anemias, aplasia, Animal models, Diseases, Bone Marrow Failure, cell regulation, red blood cells, Genetic Disorders, Biological Processes, Technology and Procedures, Cell Lineage, Study Population, erythropoiesis, hematopoiesis, flow cytometry, inflammation, molecular testing, NGS, microenvironment, RNA sequencing, molecular interactions, pathways, signal transduction

Moderators:

Theodosia A. Kalfa, MD, PhD, Cincinnati Children's Hospital Medical Center and Lionel Blanc, PhD, The Feinstein Institutes For Medical Research, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Disclosures:

No relevant conflicts of interest to declare.

7:30 AM

IRF5 Regulates the Balance between Erythropoiesis and Myelopoiesis during Aging

Anshul Vagrecha, MBBS¹^*, Margaret Lapan¹^*, Miriam Fein¹^*, Julien Papoin, MS¹^*, Young Min Cho¹^*, Theodosia A. Kalfa, MD, PhD², Lionel Blanc, PhD¹ and Betsy Barnes, PhD¹^*

¹The Feinstein Institute for Medical Research, Manhasset, NY
²Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

7:45 AM

“RHEX” / C1ORF186 Governs JAK2 Activation, Differentially Modulates STAT-5 and -3, Balances Human Erythroblast Development, and Becomes Essential during Red Cell Formation

Paul Toran, PhD^*, Matthew A Held, PhD^* and Don M Wojchowski, PhD

Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH

8:00 AM

A Novel Lncrna, Lncery, Interacts with Wdr82 to Regulate Erythroid Differentiation By Promoting Globin Gene Transcription

Shangda Yang, MD¹^*, Guohuan Sun²^*, Peng Wu, MD, PhD³^*, Yijin Kuang⁴^*, Cong Chen⁵^*, Zhaofeng Zheng²^*, Quan Gu, PhD⁶^*, Caiying Zhu²^*, Fanglin Gou⁷^*, Zining Yang⁷^*, Xiangnan Zhao⁷^*, Liu Yang⁷^*, Shihong Lu⁷^*, Shi Lihong⁷^*, Xue Lv⁷^*, Fang Dong, PhD⁸^*, Lihong Shi⁹^*, Lai Guang Ng¹⁰^*, Jing Liu, PhD¹¹^*, Hui Cheng²^* and Tao Cheng⁷

¹Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³University of Pittsburgh School of Medicine, Tianjin, China
⁴Molecular Biology Research Center, Center for Medical Genetics, Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University, Changsha, China
⁵State Key Laboratory of Experimental Hematology, Tianjin, China
⁶State Key Laboratory of Experimental Hematology, Tianjin, AL, China
⁷State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
⁸State Key Laboratory of Hematology, Institute of Hematology & Blood Diseases Hospital, Tianjin, China
⁹Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
¹⁰Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis, Singapore
¹¹Department of Hematology, Third Xiangya Hospital of Central South University, Changsha, China

8:15 AM

RASA3 Regulates Stage-Specific AKT Signaling and Cell Cycle Progression in Mammalian Erythropoiesis

Elena C. Brindley, BS¹, Emily Hartman, BS²^*, Julien Papoin, MS³^*, Jeffrey M Lipton, MD, PhD⁴, Luanne L. Peters, PhD⁵^* and Lionel Blanc, PhD⁶

¹Feinstein Institutes for Medical Research, Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY
²Feinstein Institutes for Medical Research, Manhasset, NY
³The Feinstein Institute for Medical Research, Manhasset, NY
⁴Hematology/Oncology and Stem Cell Transplantation, Cohen Children's Medical Center of NY, New Hyde Park, NY
⁵The Jackson Laboratory, Bar Harbor, ME
⁶The Feinstein Institutes For Medical Research, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY

8:30 AM

An Essential Role for the RNA Editor-Exonuclease Axis in Terminal Erythroid Differentiation

Areum Han, PhD^1,2, Alena V. Yermalovich, PhD²^*, Vanessa Lundin, PhD²^*, Daniel S. Pearson, MD, PhD²^*, Mariam Hachimi, PhD²^*, Patricia Sousa²^*, Brianna Hilton²^*, Michael Morse²^*, John Atwater²^*, Yosra Zhang²^*, Pheobe Hunter²^*, Vivian Morris²^*, Jihan K. Osborne, PhD²^*, Jenna M. Frame, PhD², Ran Jing, PhD²^*, Yu Chung Huang, MD²^*, Caroline Kubaczka, PhD²^*, Trista E. North, PhD^3,4,5, Thorsten Schlaeger, PhD²^* and George Q. Daley, MD, PhD^2,4

¹Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
²Division of Hematology/Oncology, Stem Cell Program, Boston Children's Hospital, Boston, MA
³Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA
⁴Harvard Medical School, Boston, MA
⁵Boston Children's Hospital, Boston, MA

8:45 AM

Whole Exome Sequencing of a Patient with Atypical Congenital Pure Red Cell Aplasia Has Enabled the Identification of a Novel Key Actor of Erythropoiesis That May be Involved in CDAI Physiopathology

Elia Colin¹^*, Genevieve Courtois, PhD²^*, Lydie Da Costa³^*, Carine Lefevre, PhD⁴^*, Michael Dussiot¹^*, Julie Galimand⁵^*, Joël Veiga⁶^*, Sandra Manceau⁷^*, David Rizzo⁸^*, Julie Abraham, MD⁹^*, Sylvie Fabrega¹⁰^*, Stephane Moreau¹¹^*, Marion Delous¹²^*, Patrick Mayeux, PhD¹³, Leila maouche-Chretien, PhD¹⁴^*, Olivier Hermine¹ and Lucile Couronné¹^*

¹INSERM U1163, Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications, Imagine Institute, University of Paris, Laboratory of Excellence GR-Ex, Paris, France
²INSERM U1163, Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications, Imagine Institute, University of Paris, Laboratory of Excellence GR-Ex, Paris, FRA
³AP-HP, Hôpital Robert Debré, Hematology lab, UMR S1134-Inserm, University of Paris, Laboratory of Excellence GR-Ex, Paris, France
⁴INSERM U1016-CNRS UMR8104, University of Paris, Paris, FRA
⁵AP-HP, Hôpital Robert Debré, Service d'Hématologie Biologique, University of Paris, Paris, France
⁶University of Paris, Laboratory of Excellence GR-Ex, Paris, France
⁷University of Paris, Laboratory of Excellence GR-Ex, Paris, FRA
⁸Hematology Laboratory, CHU Limoges, Limoges, France
⁹Clinical Hematology Service, CHU Limoges, Limoges, FRA
¹⁰IFR94, VVTG platform, SFR Necker, Paris, France
¹¹Clinical hematology service, CHU Limoges, Limoges, FRA
¹²INSERM U1163, Laboratory of Hereditary Kidney Diseases, Imagine Institute, Paris, France
¹³INSERM U1016-CNRS UMR8104, Laboratory of Excellence GR-Ex, Paris, France
¹⁴INSERM U1163, Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications, Imagine Institute, Paris, France

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^*signifies non-member of ASH

101.O1.6 101. Red Cells and Erythropoiesis, Structure and Function, Metabolism, and Survival, Excluding Iron: Mechanisms and Regulation of Erythropoiesis