This activity will bring together renowned experts in Cold Agglutinin Disease (CAD) treatment and clinical research together for an in-depth case-based discussion that will assess the clinical impact of recent and emerging trial data for CAD. A series of case presentations will be presented with clinical trial data tightly integrated to illuminate CAD treatment decisions related to patient and disease characteristics. Adverse events and management will be educationally tied to appropriate presentations. Future directions in the field will also be addressed and considered regarding how recent developments and highly anticipated trials may shape care in the future. Faculty will be present onstage throughout the program. Audience participation will be integrated throughout to encourage interaction with faculty and engagement with the content.