The live portion of this curriculum will be presented as a (180) minute Friday Satellite Symposium proceeding the 62^nd Annual ASH Meeting. Building upon highly successful past CAR-T Friday Satellite Symposia at the ASH Annual Meeting in 2016 and 2017, participants of this educational curriculum will be brought up to date on the most recent clinical advances and applications of CAR T-cell therapies and how this novel, emerging treatment paradigm will continue to impact treatment and management of patients with lymphoid malignancies. This symposium will bring together key clinical experts for an in-depth discussion on how to best apply the CAR T-cell therapy. The theme of this program will be a practical case-based approach that incorporates recent practice-changing trial data and places these findings in the context of real-world clinical situations that allows for clinical decision-making in multidisciplinary teams. A mix of didactic presentations, case studies and panel discussions will be used by the Chair to challenge faculty on their treatment decisions and to give the opportunity for the audience to reflect on best practices and their own clinical decisions for higher educational engagement.