This program will discuss the latest data, share perspectives and best practices, and forecast applications of key clinical challenges and questions regarding identification of rare hematologic disorders and the importance of differential diagnosis when treating patients who present with hematologic symptoms of unknown origin. Attendees will be challenged to play the role of the detective as they approach each patient case to ultimately uncover the underlying disease at play. Audience members will be encouraged to look for ‘clues’ as they diagnose each patient, similar to how a detective would solve a case.  After solving each case, the faculty will present a comprehensive overview of available treatment options for each rare disease. The program is designed to take an investigational approach to treating rare hematologic diseases and will encourage interaction between faculty and audience.