Vascular anomalies represent a spectrum of disorders with dysregulated blood or lymphatic vascular architecture that can result in multiple complications, including venous insufficiency, consumptive coagulopathy, thromboembolic disease, thrombophlebitis, and high output failure, among others. Over the past decade, genomic and somatic mutations have been identified as causal for many vascular anomalies. Medical therapy is now possible, targeting abnormalities in pathways associated with these mutations. These developments, as well as improved surgical and interventional techniques, are increasing the lifespan of patients with vascular anomalies

Traditionally, these patients have been treated by pediatric hematologists, however, we now have a generation of older patients that can no longer be followed in children’s hospitals. Unfortunately, there are only a few adult hematologists comfortable with these patients. Through a dynamic and interactive presentation of a pediatric hematologist-oncologist and a geneticist, the session will focus on management of 3 clinical scenarios where the adult hematologist’s knowledge and interest in vascular anomalies is essential.

Dr. Denise Adams will discuss the clinical and therapeutic aspects with a case-based approach, including: 1) Thrombotic Painful Event in a Venous Malformation; 2) Multifocal Bone Lesions and Profound Lymphopenia that is Not Langerhans Histiocytosis; and 3) Recurrent Familial Epistaxis: It is Not Always von Willebrand Disease.

Dr. Mikka Vikkula will review the genetic discoveries (genomic and somatic mutations, second hit hypotheses) in vascular anomalies, which have contributed to new targeted therapies.