Traditionally, these patients have been treated by pediatric hematologists, however, we now have a generation of older patients that can no longer be followed in children’s hospitals. Unfortunately, there are only a few adult hematologists comfortable with these patients. Through a dynamic and interactive presentation of a pediatric hematologist-oncologist and a geneticist, the session will focus on management of 3 clinical scenarios where the adult hematologist’s knowledge and interest in vascular anomalies is essential.
Dr. Denise Adams will discuss the clinical and therapeutic aspects with a case-based approach, including: 1) Thrombotic Painful Event in a Venous Malformation; 2) Multifocal Bone Lesions and Profound Lymphopenia that is Not Langerhans Histiocytosis; and 3) Recurrent Familial Epistaxis: It is Not Always von Willebrand Disease.
Dr. Mikka Vikkula will review the genetic discoveries (genomic and somatic mutations, second hit hypotheses) in vascular anomalies, which have contributed to new targeted therapies.