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Checkpoint Blockade: Defining A New Treatment Paradigm in Hodgkin Lymphoma and Allogeneic Transplantation

Sponsor: SCIENTIFIC
Program: Spotlight Sessions
Hematology Disease Topics & Pathways:
Biological, Therapies, Adverse Events, checkpoint inhibitors, Clinically relevant
Sunday, December 6, 2020: 11:55 AM-12:00 PM
Chair:
Leslie Kean, MD, PhD, Boston Children's Hospital
Disclosures:
Kean: magenta: Research Funding; fortyseven: Consultancy; bluebird bio: Research Funding; gilead: Research Funding; novartis: Consultancy; regeneron: Research Funding; hifibio: Consultancy; kymab: Consultancy; Bristol Meyers Squibb: Research Funding.
Discussed will be the current role of allogeneic hematopoietic cell transplantation in Hodgkin Lymphoma.  With the advent of novel therapies including the antibody drug conjugate brentuximab vedotin and the checkpoint inhibitors nivolumab and pembrolizumab, outcomes in patients with Hodgkin Lymphoma have continued to improve, even in patients with more high risk disease.  Concomitant with this progress, the number of patients referred for allogeneic HCT has decreased.  Nevertheless, recent data suggest that patients with Hodgkin Lymphoma who undergo allogeneic HCT after exposure to checkpoint inhibitors have remarkable overall survival.  The discussion will review recent data for allogeneic HCT in the era of checkpoint inhibitors including sequencing of therapies, and the impact of checkpoint inhibitors on GVHD, GVL and immune-related adverse events.

Margaret A. Shipp, MD

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA

Miguel-Angel Perales, MD

Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY

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