denotes an abstract that is clinically relevant.
denotes that this is a recommended PHD Trainee Session.
denotes that this is a ticketed session.Hematology Disease Topics & Pathways:
AML, HSCs, Diseases, platelets, cellular interactions, Genetic Disorders, red blood cells, Biological Processes, MPN, white blood cells, immune cells, Technology and Procedures, Cell Lineage, epigenetics, Clinically relevant, genetic profiling, Myeloid Malignancies, hematopoiesis, imaging, integrative -omics, microenvironment, molecular interactions, RNA sequencing, pathogenesis
Description:
Dr. Vijay Sankaran will describe how single cell genomic assays, including single-cell RNA-seq and single-cell ATAC-seq, can be valuable to gain insights into how normal hematopoiesis occurs and how this process goes awry in disease. He will discuss recent work involving the use of mitochondrial DNA mutations with single-cell genomic assays to enable lineage tracing and also discuss how human disorders can be studied using single cell genomic approaches.
Dr. Margaret Goodell will discuss recent findings and implications surrounding subclonal complexity in myeloid malignancies. DNMT3A is one of the most frequently mutated genes in hematologic malignancies. While the R882 hotspot mutation dominates in AML, other mutations spread throughout the protein are collectively more common in other disorders. By profiling over 250 mutations, we can classify some types of mutation that may have prognostic and therapeutic value.
Dr. Margaret Goodell will discuss recent findings and implications surrounding subclonal complexity in myeloid malignancies. DNMT3A is one of the most frequently mutated genes in hematologic malignancies. While the R882 hotspot mutation dominates in AML, other mutations spread throughout the protein are collectively more common in other disorders. By profiling over 250 mutations, we can classify some types of mutation that may have prognostic and therapeutic value.